hayashi hisaki
Physiology | Senior Assistant Professor |
Profile
Research area
生理学
分子細胞生物学Main lectures
生理学Graduating school
東京理科大学理工学部（1997年）Final Education
筑波大学大学院農学研究科（2002年）Previous workplace
産業技術総合研究所（2001年4月〜2003年3月）
奈良県立医科大学（2008年9月〜2013年10月）Study abroad experience
University of California, Irvine（2003年３月〜2004年9月）
Vanderbilt University（2004年9月〜2008年8月）Main academic activities
日本生理学会
日本病態生理学会
日本分子生物学会Main research topic
血管発生・血管新生におけるシグナル伝達と遺伝子発現調節機構の解明
Paper
- Imatinib mesylate inhibits androgen-independent PC-3 cell viability, proliferation, migration, and tumor growth by targeting platelet-derived growth factor receptor-α
Md Junayed Nayeem; Aya Yamamura; Hisaki Hayashi; Hiroyuki Muramatsu; Kogenta Nakamura; Naoto Sassa; Motohiko Sato
Life Sciences, Jun. 2022
120171, 120171, 10.1016/j.lfs.2021.120171 - Seasonal differences in clock gene expression levels in buccal epithelial cells of obese men: a pilot study
Maki Sato; Hisaki Hayashi; Dominika Kanikowska
International Journal of Biometeorology, Feb. 2021, Reviewed, No invitation
10.1007/s00484-021-02092-2 - Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells
Abdullah Al Mamun; Hisaki Hayashi; Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
The Journal of Physiological Sciences, Dec. 2020, Reviewed, No invitation
70(1), 10.1186/s12576-020-00773-y - Platelet-derived growth factor up-regulates Ca2+-sensing receptors in idiopathic pulmonary arterial hypertension.
Yamamura A; Nayeem MJ; Al Mamun A; Takahashi R; Hayashi H; Sato M
FASEB Journal, Mar. 2019, Reviewed, No invitation
33(6), 7363, 7374, 10.1096/fj.201802620R - Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization
Hisaki Hayashi; Abdullah Al Mamun; Masayuki Takeyama; Aya Yamamura; Masahiro Zako; Rina Yagasaki; Tsutomu Nakahara; Motohiro Kamei; Motohiko Sato
Scientific reports, Feb. 2019, Reviewed, No invitation
9(1), 1560, 1560, 10.1038/s41598-018-38067-4 - VEGFR-3 signaling is regulated by a G-protein activator, activator of G-protein signaling 8, in lymphatic endothelial cells
Miho Sakima; Hisaki Hayashi; Abdullah Al Mamun; Motohiko Sato
Experimental Cell Research, Jul. 2018, Reviewed, No invitation
368(1), 13, 23, 10.1016/j.yexcr.2018.04.007 - G蛋白活性調節因子による脈絡膜血管新生の制御
林 寿来; Al MA.; 山村 彩; 佐喜眞 未帆; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
日本生理学雑誌, Feb. 2018
80(1), 15, 15 - 脈絡膜血管新生におけるG蛋白活性調節因子の機能
林 寿来; Mamun Abdullah; 山村 彩; 佐喜眞 未帆; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
生命科学系学会合同年次大会, Dec. 2017
2017年度, [2P, 1032] - Human serum albumin and oxidative stress in preeclamptic women and the mechanism of albumin for stress reduction
Hiroyuki Kinoshita; Kazushi Watanabe; Toshiharu Azma; Guo-Gang Feng; Takahiko Akahori; Hisaki Hayashi; Motohiko Sato; Yoshihiro Fujiwara; Akihiko Wakatsuki
Heliyon, Aug. 2017, Reviewed, No invitation
3(8), e00369, 10.1016/j.heliyon.2017.e00369 - 脈絡膜血管新生におけるAGS8の意義
林 寿来; Al Mamun Abdullah; 佐喜眞 未帆; 山村 彩; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
日本病態生理学会雑誌, Jul. 2017
26(2), 60, 60 - Adenosine triphosphate is a critical determinant for VEGFR signal during hypoxia
Abdullah Al Mamun; Hisaki Hayashi; Miho Sakima; Motohiko Sato
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Dec. 2016, Reviewed, No invitation
311(6), C985, C995, 10.1152/ajpcell.00145.2016 - High oxygen modifies vasodilator effect of cysteine via enhanced oxidative stress and thromboxane production in the rat mesenteric artery
Yoshitaka Yasuda; Guo-Gang Feng; Jiazheng Li; Emi Nakamura; Hisaki Hayashi; Motohiko Sato; Yoshihiro Fujiwara; Hiroyuki Kinoshita
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, Sep. 2016, Reviewed, No invitation
468(9), 1555, 1564, 10.1007/s00424-016-1857-y - Sevoflurane Inhalation Accelerates the Long-Term Memory Consolidation via Small GTPase Overexpression in the Hippocampus of Mice in Adolescence
Emi Nakamura; Hiroyuki Kinoshita; Guo-Gang Feng; Hisaki Hayashi; Maiko Satomoto; Motohiko Sato; Yoshihiro Fujiwara
PLOS ONE, Sep. 2016, Reviewed, No invitation
11(9), e0163151, 10.1371/journal.pone.0163151 - Activator of G-protein signaling 8 is involved in VEGF-mediated signal processing during angiogenesis
Hisaki Hayashi; Abdullah Al Mamun; Miho Sakima; Motohiko Sato
JOURNAL OF CELL SCIENCE, Mar. 2016, Reviewed, No invitation
129(6), 1210, 1222, 10.1242/jcs.181883 - Tmem100, an ALK1 receptor signaling-dependent gene essential for arterial endothelium differentiation and vascular morphogenesis
Satoshi Somekawa; Keiichi Imagawa; Hisaki Hayashi; Masahide Sakabe; Tomoko Ioka; Genki E. Sato; Ken Inada; Takaaki Iwamoto; Toshio Mori; Shiro Uemura; Osamu Nakagawa; Yoshihiko Saito
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2012, Reviewed, No invitation
109(30), 12064, 12069, 10.1073/pnas.1207210109 - Foxc2 transcription factor as a regulator of angiogenesis via induction of integrin beta 3 expression
Hisaki Hayashi; Tsutomu Kume
CELL ADHESION & MIGRATION, Jan. 2009, Reviewed, No invitation
3(1), 24, 26, 10.4161/cam.3.1.7252 - The Foxc2 transcription factor regulates angiogenesis via induction of integrin beta 3 expression
Hisaki Hayashi; Hideto Sano; Seungwoon Seo; Tsutomu Kume
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2008, Reviewed, No invitation
283(35), 23791, 23800, 10.1074/jbc.M800190200 - Foxc Transcription Factors Directly Regulate Dll4 and Hey2 Expression by Interacting with the VEGF-Notch Signaling Pathways in Endothelial Cells
Hisaki Hayashi; Tsutomu Kume
PLOS ONE, Jun. 2008, Reviewed, No invitation
3(6), e2401, 10.1371/journal.pone.0002401 - Forkhead transcription factors regulate expression of the chemokine receptor CXCR4 in endothelial cells and CXCL12-induced cell migration
Hisaki Hayashi; Tsutomu Kume
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2008, Reviewed, No invitation
367(3), 584, 589, 10.1016/j.bbrc.2007.12.183 - Smad mediates BMP-2-induced upregulation of FGF-evoked PC12 cell differentiation
Hisaki Hayashi; Akira Ishisaki; Toru Imamura
FEBS Letters, Feb. 2003, Reviewed, No invitation
536(1-3), 30, 34, 10.1016/s0014-5793(03)00005-x - Human umbilical vein endothelium-derived cells retain potential to differentiate into smooth muscle-like cells
A Ishisaki; H Hayashi; AJ Li; T Imamura
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2003, Reviewed, No invitation
278(2), 1303, 1309, 10.1074/jbc.M207329200 - BMP-2 augments FGF-induced differentiation of PC12 cells through upregulation of FGF receptor-1 expression
Hayashi H; Ishisaki A; Suzuki M; Imamura T
Journal of Cell Science, Apr. 2001, Reviewed, No invitation
Lead, 14(7), 1387, 1395 - Glutathione S-transferase Pi is a dopamine-inducible suppressor of dopamine-induced apoptosis in PC12 cells
Akira Ishisaki; Hisaki Hayashi; Seigo Suzuki; Kazuo Ozawa; Eiichi Mizukoshi; Kazuko Miyakawa; Masashi Suzuki; Toru Imamura
Journal of Neurochemistry, 2001, Reviewed, No invitation
77(5), 1362, 1371, 10.1046/j.1471-4159.2001.00351.x - Molecular cloning of mouse alpha-1,6-fucosyltransferase and expression of its mRNA in the developing cerebrum
H Hayashi; A Yoneda; M Asada; M Ikekita; T Imamura
DNA SEQUENCE, 2000, Reviewed, No invitation
11(1-2), 91, 96 - Fibroblast growth factor-1 interacts with the glucose-regulated protein GRP75/mortalin
E Mizukoshi; M Suzuki; A Loupatov; T Uruno; H Hayashi; T Misono; SC Kaul; R Wadhwa; T Imamura
BIOCHEMICAL JOURNAL, Oct. 1999, Reviewed, No invitation
343(2), 461, 466
MISC
- 交感神経と循環制御 G蛋白活性調節因子による心血管細胞制御
佐藤 元彦; Al Mamun Abdullah; 林 寿来
循環制御, Dec. 2017, Not reviewed, No invitation
38(3), 193, 194, 10.11312/ccm.38.193 - 肥満者における口腔内上皮細胞での時計遺伝子発現の季節差
佐藤 麻紀; 林 寿来; 池本 辰則; 牛田 享宏; カニコフスカ・ドミニカ; 佐藤 元彦
生命科学系学会合同年次大会, Dec. 2017, Not reviewed, No invitation
2017年度, [2P, 1045] - Activator of G-protein signaling 8 is involved in VEGF-induced choroidal angiogenesis
Hisaki Hayashi; Abdullah Al Mamun; Miho Sakima; Masayuki Takeyama; Rina Yagasaki; Masahiro Zako; Tsutomu Nakahara; Motohiko Sato
FASEB JOURNAL, Apr. 2017, Not reviewed, No invitation
31 - Determination of seasonal differences of clock gene expressions in obese men using saliva sample
Maki Sato; Hisaki Hayashi; Tatsunori Ikemoto; Takahiro Ushita; Dominika Kanikowska; Motohiko Sato
FASEB JOURNAL, Apr. 2017, Not reviewed, No invitation
31 - G蛋白活性調節因子AGS8はVEGF2型受容体の細胞内調節を介して血管新生を制御する
林 寿来; Mamun A.A.; 佐喜眞 未帆; 高橋 理恵; 佐藤 麻紀; 西村 直記; 犬飼 洋子; 岩瀬 敏; 佐藤 元彦
日本生理学雑誌, Mar. 2016
78(2), 50, 50 - 血管新生におけるG蛋白活性調節因子の役割
林 寿来; Al Mamun A.; 佐喜眞 未帆; 鈴木 洋子; 西村 直記; 犬飼 洋子; 岩瀬 敏; 佐藤 元彦
日本生理学雑誌, May 2015
77(3), 68, 69 - Activator of G-Protein Signaling 8, an Ischemia-Inducible G-Protein Activator, is Required for Vascular Endothelial Growth Factor-Mediated Collateral Development
Hisaki Hayashi; Abdullah A. Mamun; Miho Sakima; Hiroko Suzuki; Motohiko Sato
CIRCULATION, Nov. 2014, Not reviewed, No invitation
130 - 心疾患とシグナル伝達 再生医療と創薬への展開 低酸素誘導心筋アポトーシスにおける三量体G蛋白活性調節因子(activator of G-protein signaling 8,AGS8)の役割
佐藤 元彦; 林 寿来; アブドゥラアル・マムン; 鈴木 洋子; 佐喜眞 未帆; 岩瀬 敏; 犬飼 洋子; 西村 直記; 佐藤 麻紀
日本生化学会大会プログラム・講演要旨集, Oct. 2014
87回, [1S07, 4] - 動脈形成に関与する新規BMP9/BMP10依存的血管内皮遺伝子の同定
染川 智; 坂部 正英; 林 寿来; 稲田 賢; 佐藤 玄基; 上村 史朗; 中川 修; 斎藤 能彦
血管, Oct. 2013, Not reviewed, No invitation
36(3), 95, 102 - Essential Function of Tmem100 for Endothelial Differentiation and Vascular Development Downstream of ALK1 Signaling
Satoshi Somekawa; Masahide Sakabe; Hisaki Hayashi; Genki E. Sato; Ken Inada; Munehiro Ito; Shiro Uemura; Osamu Nakagawa; Yoshihiko Saito
CIRCULATION, Nov. 2012, Not reviewed, No invitation
126(21) - Tmem100, a Novel BMP9/10-Dependent Endothelial Gene Essential for Arterial Development and Morphogenesis
Satoshi Somekawa; Hisaki Hayashi; Masahide Sakabe; Tomoko Ioka; Genki Sato; Ken Inada; Shiro Uemura; Osamu Nakagawa; Yoshihiko Saito
CIRCULATION, Nov. 2011, Not reviewed, No invitation
124(21) - Generation and Analysis of Neural Crest- and Endothelial-specific Mutant Mice for Foxc1
Seungwoon See; Hisaki Hayashi; Tsutomu Kume
CIRCULATION, Oct. 2008, Not reviewed, No invitation
118(18), S505, S505
Research Themes
- Elucidation and application of mechanisms for pain signal induction and modulation caused by physical disuse
Grant-in-Aid for Scientific Research (B)
Kanazawa Medical University
01 Apr. 2023 - 31 Mar. 2028
大道 裕介; 大道 美香; 西園 啓文; 大須賀 浩二; 池本 竜則; 林 寿来, 大道 裕介; 大道 美香; 西園 啓文; 大須賀 浩二; 池本 竜則; 林 寿来, 日本学術振興会, Japan Society for the Promotion of Science - The roles of extracellular vesicles on regenerative therapy of age-related macular degeneration
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2020 - 31 Mar. 2023
林 寿来, 林 寿来, 日本学術振興会, Japan Society for the Promotion of Science - 小児におけるLED光暴露がホルモンリズムおよび時計遺伝子の発現に及ぼす影響
基盤研究(C)
愛知医科大学
01 Apr. 2018 - 31 Mar. 2023
佐藤 麻紀; 林 寿来, 佐藤 麻紀; 林 寿来, 日本学術振興会, 日本学術振興会 - A role of Activator of G-protein signaling 8 in pulmonary hypertension
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2019 - 31 Mar. 2022
佐藤 元彦; 山村 彩; 林 寿来, Sato Motohiko, 日本学術振興会, Japan Society for the Promotion of Science - Regulation of angiogenesis by a novel VEGF receptor binding protein
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2016 - 31 Mar. 2019
林 寿来; 中原 努; 雑喉 正泰, Hayashi Hisaki; Zako Masahiro, 日本学術振興会, Japan Society for the Promotion of Science - Regulation of angiogenic events by regulatory protein for G-protein
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2016 - 31 Mar. 2019
佐藤 元彦; 林 寿来, Sato Motohiko, 日本学術振興会, Japan Society for the Promotion of Science - Significance of a new endothelial gene TMEM100 in vascular development and disease
Grant-in-Aid for Challenging Exploratory Research
01 Apr. 2013 - 31 Mar. 2016
中川 修; 坂部 正英; 林 寿来, NAKAGAWA Osamu; SAKABE Masahide; HAYASHI Hisaki, 日本学術振興会, Japan Society for the Promotion of Science - Regulation of vascular endothelial cells by signaling molecules
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2013 - 31 Mar. 2016
林 寿来; 中川 修; 坂部 正英, Hisaki Hayashi, 日本学術振興会, Japan Society for the Promotion of Science - 心臓形態形成を制御する新規シグナル伝達ネットワークの解明とその意義
基盤研究(C)
奈良県立医科大学
01 Apr. 2013 - 31 Mar. 2016
坂部 正英; 中川 修; 林 寿来, 坂部 正英; 中川 修; 林 寿来, 日本学術振興会, 日本学術振興会 - Transcriptional regulation of cardiovascular development
Grant-in-Aid for Scientific Research (B)
01 Apr. 2011 - 31 Mar. 2015
中川 修; 坂部 正英; 林 寿来; 小西 登; 林 環; 山岸 敬幸, NAKAGAWA Osamu; SAKABE Masahide; HAYASHI Hisaki; KONISHI Noboru; HAYASHI Tamaki; YAMAGISHI Hiroyuki, 日本学術振興会, Japan Society for the Promotion of Science - New Transgenic Mouse System to Analyze Functional Mechanisms of Transcription Factors
Grant-in-Aid for Challenging Exploratory Research
Nara Medical University
2011 - 2013
中川 修; 林 寿来; 坂部 正英, NAKAGAWA Osamu; HAYASHI Hisaki; SAKABE Masahide, 日本学術振興会, Japan Society for the Promotion of Science - The roles of transcriptional regulation of angiogenesis and tissue repair in cell transplantation
Grant-in-Aid for Young Scientists (B)
Nara Medical University
2011 - 2012
林 寿来, HAYASHI Hisaki, 日本学術振興会, Japan Society for the Promotion of Science - Significance of novel protein kinase in muscle function and disease
Grant-in-Aid for Scientific Research (C)
Nara Medical University
2008 - 2011
中川 修; 林 寿来; 坂部 正英, NAKAGAWA Osamu; HAYASHI Hisaki; SAKABE Masahide, 日本学術振興会, Japan Society for the Promotion of Science - Significance of transcriptional regulation in postnatal angiogenesis
Grant-in-Aid for Young Scientists (B)
Nara Medical University
2009 - 2010
林 寿来, HAYASHI Hisaki, 日本学術振興会, Japan Society for the Promotion of Science
