イオンチャネル創薬

受容体創薬

Pulmonary arterial smooth muscle

Ion channel

Calcium signaling

Calcium-sensing receptor

Pulmonary hypertension

Apr. 2019 - Present
日本生理学会, 学術評議員

Apr. 2017 - Present
日本薬理学会, 学術評議員

Aug. 2013 - Present
日本平滑筋学会, 若手の会世話人

Apr. 2013 - Present
日本薬学会, 薬理系薬学部会 若手世話人

Apr. 2015 - Mar. 2017
日本薬学会, ファルマシアトピックス小委員

Aug. 2022
令和3年度 日本薬学会 薬理系薬学部会 奨励賞, 日本薬学会 薬理系薬学部会

Jul. 2015
平成27年度 学術奨励賞, 日本薬学会東海支部
山村 彩

Mar. 2014
優秀発表賞, 第87回 日本薬理学会年会
山村 彩

Aug. 2013
第9回 栗山熙賞, 日本平滑筋学会
山村 彩

Melatonin inhibits voltage-gated potassium KV4.2 channels and negatively regulates melatonin secretion in rat pineal glands.
Hiroki Mishima; Shunsuke Ando; Hibiki Kuzuhara; Aya Yamamura; Rubii Kondo; Yoshiaki Suzuki; Yuji Imaizumi; Hisao Yamamura
American journal of physiology. Cell physiology, Oct. 2024
327(4), C1023-C1034, 10.1152/ajpcell.00664.2023

Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.
Aya Yamamura; Moe Fujiwara; Akiko Kawade; Taiki Amano; Alamgir Hossain; Md Junayed Nayeem; Rubii Kondo; Yoshiaki Suzuki; Yasumichi Inoue; Hidetoshi Hayashi; Susumu Suzuki; Motohiko Sato; Hisao Yamamura
European journal of pharmacology, Apr. 2024
Lead, 176564, 176564, 10.1016/j.ejphar.2024.176564

Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.
Natsumi Shima; Aya Yamamura; Moe Fujiwara; Taiki Amano; Kazuyuki Matsumoto; Taiga Sekine; Haruka Okano; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Frontiers in cardiovascular medicine, 2024
11, 1343804, 1343804, 10.3389/fcvm.2024.1343804

Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
Masashi Ishida; Aya Yamamura; Moe Fujiwara; Taiki Amano; Mina Ota; Yukari Hikawa; Rubii Kondo; Yoshiaki Suzuki; Yuji Imaizumi; Hisao Yamamura
Journal of pharmacological sciences, Oct. 2023
153(2), 84, 88, 10.1016/j.jphs.2023.08.001

Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling.
Akiko Kawade; Aya Yamamura; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Journal of pharmacological sciences, Feb. 2023
151(2), 119, 127, 10.1016/j.jphs.2022.12.007

Upregulated ClC3 channels/transporters elicit swelling-activated Cl- currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension.
Taiki Amano; Aya Yamamura; Moe Fujiwara; Seiji Hirai; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Biological & pharmaceutical bulletin, Aug. 2022
45(11), 1684, 1691, 10.1248/bpb.b22-00513

SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells.
Riko Miyaki; Aya Yamamura; Akiko Kawade; Moe Fujiwara; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Biochemical and biophysical research communications, Jun. 2022
607, 44, 48, 10.1016/j.bbrc.2022.03.121

Imatinib mesylate inhibits androgen-independent PC-3 cell viability, proliferation, migration, and tumor growth by targeting platelet-derived growth factor receptor-α.
Md Junayed Nayeem; Aya Yamamura; Hisaki Hayashi; Hiroyuki Muramatsu; Kogenta Nakamura; Naoto Sassa; Motohiko Sato
Life sciences, Jan. 2022
288, 120171, 120171, 10.1016/j.lfs.2021.120171

Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats.
Akiko Kawade; Aya Yamamura; Moe Fujiwara; Saki Kobayashi; Shiho Mori; Chihiro Horii; Akari Hiraku; Sayo Suzumura; Kikuo Tsukamoto; Naoki Ohara; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Journal of pharmacological sciences, Sep. 2021
147(1), 81, 85, 10.1016/j.jphs.2021.05.012

Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.
Keizo Hiraishi; Lin Hai Kurahara; Jianlin Feng; Aya Yamamura; Yuanyuan Cui; Eiji Yahiro; Hiroyasu Yokomise; Tetsuhiko Go; Kaori Ishikawa; Naoya Yokota; Atsushi Fujiwara; Miki Onitsuka; Kohtaro Abe; Shoji Ohga; Toru Satoh; Yasumasa Okada; Lixia Yue; Ryuji Inoue; Katsuya Hirano
Translational research : the journal of laboratory and clinical medicine, Jul. 2021
233, 127, 143, 10.1016/j.trsl.2021.03.004

[Preface].
Aya Yamamura; Masanari Umemura
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2021
156(3), 145, 145, 10.1254/fpj.21007

[Roles of growth factors on vascular remodeling in pulmonary hypertension].
Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2021
156(3), 161, 165, 10.1254/fpj.21006

MAZ51 Blocks the Tumor Growth of Prostate Cancer by Inhibiting Vascular Endothelial Growth Factor Receptor 3.
Aya Yamamura; Md Junayed Nayeem; Hiroyuki Muramatsu; Kogenta Nakamura; Motohiko Sato
Frontiers in pharmacology, 2021, Reviewed
Lead, 12, 667474, 667474, 10.3389/fphar.2021.667474

The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension.
Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
Biochemical and biophysical research communications, Jan. 2021, Reviewed
Lead, 534, 795, 801, 10.1016/j.bbrc.2020.10.106

Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Lin Hai Kurahara; Keizo Hiraishi; Aya Yamamura; Ying Zhang; Kohtaro Abe; Eiji Yahiro; Mikiko Aoki; Kaori Koga; Hiroyasu Yokomise; Tetsuhiko Go; Kaori Ishikawa; Zhang Bo; Hiroko Kishi; Sei Kobayashi; Narumi Aoki-Shoi; Satoh Toru; Ryuji Inoue; Katsuya Hirano
Journal of molecular and cellular cardiology, Nov. 2020
148, 50, 62, 10.1016/j.yjmcc.2020.08.013

Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells.
Abdullah Al Mamun; Hisaki Hayashi; Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
The journal of physiological sciences : JPS, Sep. 2020
70(1), 44, 44, 10.1186/s12576-020-00773-y

[Pathophysiological roles of TRPC6 channels in pulmonary arterial hypertension].
Hisao Yamamura; Yoshiaki Suzuki; Aya Yamamura
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2020
155(4), 230, 235, 10.1254/fpj20001

MicroRNA-mediated Downregulation of K⁺ Channels in Pulmonary Arterial Hypertension.
Babicheva A; Ayon RJ; Zhao T; Ek Vitorin JF; Pohl NM; Yamamura A; Yamamura H; Quinton BA; Ba M; Wu L; Ravellette KS; Rahimi S; Balistrieri F; Harrington A; Vanderpool RR; Thistlethwaite PA; Makino A; Yuan JX
American journal of physiology. Lung cellular and molecular physiology, Sep. 2019, Reviewed, No invitation
318(1), L10-L26, 10.1152/ajplung.00010.2019

Platelet-derived growth factor up-regulates Ca²⁺-sensing receptors in idiopathic pulmonary arterial hypertension.
Yamamura A; Nayeem MJ; Al Mamun A; Takahashi R; Hayashi H; Sato M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Jun. 2019, Reviewed, No invitation
Lead, 33(6), 7363, 7374, 10.1096/fj.201802620R

Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells.
Yamamura A; Nayeem MJ; Sato M
Journal of pharmacological sciences, Mar. 2019, Reviewed, No invitation
139(3), 254, 257, 10.1016/j.jphs.2019.01.008

Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization.
Hayashi H; Mamun AA; Takeyama M; Yamamura A; Zako M; Yagasaki R; Nakahara T; Kamei M; Sato M
Scientific reports, Feb. 2019, Reviewed, No invitation
9(1), 1560, 1560, 10.1038/s41598-018-38067-4

Calcium-Sensing Receptor Is Functionally Expressed in the Cochlear Perilymphatic Compartment and Essential for Hearing.
Toshiya Minakata; Akira Inagaki; Aya Yamamura; Hisao Yamamura; Shinji Sekiya; Shingo Murakami
Frontiers in molecular neuroscience, 2019, Reviewed, No invitation
12, 175, 175, 10.3389/fnmol.2019.00175

チロシンキナーゼFYNが肺動脈高血圧の病態生理に果たす役割
倉原 琳; 平石 敬三; 張 影; 山村 彩; 岸 博子; 小林 誠; 古賀 佳織; 鬼塚 美樹; 阿部 弘太郎; 塩井 成留実; 井上 隆司
日本生理学雑誌, May 2018
80(2), 31, 31

G蛋白活性調節因子による脈絡膜血管新生の制御
林 寿来; Al MA.; 山村 彩; 佐喜眞 未帆; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
日本生理学雑誌, Feb. 2018
80(1), 15, 15

脈絡膜血管新生におけるG蛋白活性調節因子の機能
林 寿来; Mamun Abdullah; 山村 彩; 佐喜眞 未帆; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
生命科学系学会合同年次大会, Dec. 2017
2017年度, [2P, 1032]

Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro
Aya Yamamura; Eri Fujitomi; Naoki Ohara; Kikuo Tsukamoto; Motohiko Sato; Hisao Yamamura
EUROPEAN JOURNAL OF PHARMACOLOGY, Sep. 2017, Reviewed, No invitation
810, 44, 50, 10.1016/j.ejphar.2017.06.010

Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension
Jiwang Chen; Justin R. Sysol; Sunit Singla; Shuangping Zhao; Aya Yamamura; Daniela Valdez-Jasso; Taimur Abbasi; Krystyna M. Shioura; Sakshi Sahni; Vamsi Reddy; Arvind Sridhar; Hui Gao; Jaime Torres; Sara M. Camp; Haiyang Tang; Shui Qing Ye; Suzy Comhair; Raed Dweik; Paul Hassoun; Jason X. -J. Yuan; Joe G. N. Garcia; Roberto F. Machado
CIRCULATION, Apr. 2017, Reviewed, No invitation
135(16), 1532, +, 10.1161/CIRCULATIONAHA.116.024557

Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH
Shanshan Song; Ramon J. Ayon; Aya Yamamura; Hisao Yamamura; Swetaleena Dash; Aleksandra Babicheva; Haiyang Tang; Xutong Sun; Arlette G. Cordery; Zain Khalpey; Stephen M. Black; Ankit A. Desai; Franz Rischard; Kimberly M. McDermott; Joe G. N. Garcia; Ayako Makino; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Mar. 2017, Reviewed, No invitation
312(3), 1309, 1325, 10.1152/ajplung.00357.2016

Molecular Mechanism of Dihydropyridine Ca2+ Channel Blockers in Pulmonary Hypertension
Aya Yamamura
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2016, Reviewed, No invitation
136(10), 1373, 1377, 10.1248/yakushi.16-00086

Calcilytics enhance sildenafil-induced antiproliferation in idiopathic pulmonary arterial hypertension
Aya Yamamura; Satomi Yagi; Naoki Ohara; Kikuo Tsukamoto
EUROPEAN JOURNAL OF PHARMACOLOGY, Aug. 2016, Reviewed, No invitation
784, 15, 21, 10.1016/j.ejphar.2016.04.059

Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension
Haiyang Tang; Aya Yamamura; Hisao Yamamura; Shanshan Song; Dustin R. Fraidenburg; Jiwang Chen; Yali Gu; Nicole M. Pohl; Tong Zhou; Laura Jimenez-Perez; Ramon J. Ayon; Ankit A. Desai; David Goltzman; Franz Rischard; Zain Khalpey; Stephan M. Black; Joe G. N. Garcia; Ayako Makino; Jason X. J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, May 2016, Reviewed, No invitation
310(9), L846, L859, 10.1152/ajplung.00050.2016

Changes by canola (rapeseed) oil ingestion of steroid hormone metabolism in SHRSP
Yagi Satomi; Nishikawa Mai; Hanai Hitomi; Suzumura Sayo; Naito Yukiko; Tatematsu Kenjiro; Miyazawa Daisuke; Hashimoto Yoko; Yamamura Aya; Ohnishi Hiroyuki; Ohara Naoki; Okayama Harumi
JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2016, Reviewed, No invitation
130(3), S221

Upregulation/downregulation of ion channels in pulmonary hypertension.
Yamamura A
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2016, Reviewed, No invitation
148(5), 226, 230, 10.1254/fpj.148.226

Calcium-sensing receptor.
Yamamura A
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2016, Reviewed, No invitation
148(5), 278, 280, 10.1254/fpj.148.278

Notch Activation of Ca2+ Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension
Kimberly A. Smith; Guillaume Voiriot; Haiyang Tang; Dustin R. Fraidenburg; Shanshan Song; Hisao Yamamura; Aya Yamamura; Qiang Guo; Jun Wan; Nicole M. Pohl; Mohammad Tauseef; Rolf Bodmer; Karen Ocorr; Patricia A. Thistlethwaite; Gabriel G. Haddad; Frank L. Powell; Ayako Makino; Dolly Mehta; Jason X. -J. Yuan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Sep. 2015, Reviewed, No invitation
53(3), 355, 367, 10.1165/rcmb.2014-0235OC

Peripheral gene expression profile of mechanical hyperalgesia induced by repeated cold stress in SHRSP5/Dmcr rats
Yasuko Kozaki; Rena Umetsu; Yukako Mizukami; Aya Yamamura; Kazuya Kitamori; Satoru Tsuchikura; Katsumi Ikeda; Yukio Yamori
JOURNAL OF PHYSIOLOGICAL SCIENCES, Sep. 2015, Reviewed, No invitation
65(5), 417, 425, 10.1007/s12576-015-0380-9

Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension
Aya Yamamura; Naoki Ohara; Kikuo Tsukamoto
PLOS ONE, Sep. 2015, Reviewed, No invitation
10(9), e0138384, 10.1371/journal.pone.0138384

Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
Shanshan Song; Aya Yamamura; Hisao Yamamura; Ramon J. Ayon; Kimberly A. Smith; Haiyang Tang; Ayako Makino; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, Aug. 2014, Reviewed, No invitation
307(4), C373, C383, 10.1152/ajpcell.00115.2014

Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells
Hisao Yamamura; Aya Yamamura; Eun A. Ko; Nicole M. Pohl; Kimberly A. Smith; Amy Zeifman; Frank L. Powell; Patricia A. Thistlethwaite; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, May 2014, Reviewed, No invitation
306(9), C871, C878, 10.1152/ajpcell.00221.2013

Protective Effects of Fluvoxamine against Ischemia/Reperfusion Injury in Isolated, Perfused Guinea-Pig Hearts
Tatsuya Muto; Haruki Usuda; Aya Yamamura; Koji Yoshida; Ai Ohashi; Kumiko Mitsui-Saitoh; Junichi Sakai; Yumi Sugimoto; Hideki Mizutani; Tsunemasa Nonogaki; Yoshihiro Hotta
BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2014, Reviewed, No invitation
37(5), 731, 739, 10.1248/bpb.b13-00552

Inhibition of the Ca2+-sensing receptor rescues pulmonary hypertension in rats and mice
Qiang Guo; Jian-an Huang; Aya Yamamura; Hisao Yamamura; Adriana M. Zimnicka; Ruby Fernandez; Jason X-J Yuan
HYPERTENSION RESEARCH, Feb. 2014, Reviewed, No invitation
37(2), 116, 124, 10.1038/hr.2013.129

Pathological function of Ca2+-sensing receptor in pulmonary arterial hypertension.
Yamamura A
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2014, Reviewed, No invitation
50, 8, 17, 10.1540/jsmr.50.8

Enhanced Ca2+-sensing Receptor Function in Pulmonary Hypertension
Aya Yamamura; Hisao Yamamura; Jason X. -J. Yuan
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2013, Reviewed, No invitation
133(12), 1351, 1359, 10.1248/yakushi.13-00228-3

Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Ca(v)1.2 and Ca(v)3.2
Jun Wan; Aya Yamamura; Adriana M. Zimnicka; Guillaume Voiriot; Kimberly A. Smith; Haiyang Tang; Ramon J. Ayon; Moumita S. R. Choudhury; Eun A. Ko; Jun Wang; Chen Wang; Ayako Makino; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, Jul. 2013, Reviewed, No invitation
305(2), L154, L164, 10.1152/ajplung.00313.2012

Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS.
Ko EA; Wan J; Yamamura A; Zimnicka AM; Yamamura H; Yoo HY; Tang H; Smith KA; Sundivakkam PC; Zeifman A; Ayon RJ; Makino A; Yuan JX
American journal of physiology. Cell physiology, Jun. 2013, Reviewed, No invitation
304(11), C1042, 52, 10.1152/ajpcell.00304.2012

Dihydropyridine Ca2+ Channel Blockers Increase Cytosolic [Ca2+] by Activating Ca2+-sensing Receptors in Pulmonary Arterial Smooth Muscle Cells
Aya Yamamura; Hisao Yamamura; Qiang Guo; Adriana M. Zimnicka; Jun Wan; Eun A. Ko; Kimberly A. Smith; Nicole M. Pohl; Shanshan Song; Amy Zeifman; Ayako Makino; Jason X. -J. Yuan
CIRCULATION RESEARCH, Feb. 2013, Reviewed, No invitation
112(4), 640, +, 10.1161/CIRCRESAHA.113.300897

Enhanced Ca2+-Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
Aya Yamamura; Qiang Guo; Hisao Yamamura; Adriana M. Zimnicka; Nicole M. Pohl; Kimberly A. Smith; Ruby A. Fernandez; Amy Zeifman; Ayako Makino; Hui Dong; Jason X-J Yuan
CIRCULATION RESEARCH, Aug. 2012, Reviewed, No invitation
111(4), 469, U259, 10.1161/CIRCRESAHA.112.266361

Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells.
Yamamura A; Yamamura H; Zeifman A; Yuan JX
Pulmonary circulation, Apr. 2011, Reviewed, No invitation
1(2), 269, 279, 10.4103/2045-8932.83447

Mibefradil-sensitive component involved in the plateau potential in submucosal interstitial cells of the murine proximal colon
Aya Hotta; Noriko Okada; Hikaru Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2007, Reviewed, No invitation
353(1), 170, 176, 10.1016/j.bbrc.2006.12.003

Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine
Noriko Okada; Suzuka Asai; Aya Hotta; Noriko Miura; Naohito Ohno; Imre Farkas; Lewis Hau; Hidechika Okada
MICROBIOLOGY AND IMMUNOLOGY, 2007, Reviewed, No invitation
51(4), 439, 443

The effects of flufenamic acid on spontaneous activity of smooth muscle tissue isolated from the guinea-pig stomach antrum
Aya Hotta; Yoshihiko Kito; Hikaru Suzuki
Journal of Smooth Muscle Research, 2005, Reviewed, No invitation
41(4), 207, 220, 10.1540/jsmr.41.207

Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum
Aya Hotta; Young Chul Kim; Eri Nakamura; Yoshihiko Kito; Yoshimichi Yamamoto; Hikaru Suzuki
Journal of Smooth Muscle Research, 2005, Reviewed, No invitation
41(6), 313, 327, 10.1540/jsmr.41.313

Molecular basis of pimarane compounds as novel activators of large-conductance Ca2+-activated K+ channel alpha-subunit
Y Imaizumi; K Sakamoto; A Yamada; A Hotta; S Ohya; K Muraki; M Uchiyama; T Ohwada
MOLECULAR PHARMACOLOGY, Oct. 2002, Reviewed, No invitation
62(4), 836, 846

Hot, Heat and Stretch All Contribute to the Enhanced Ca2+ Signaling in Pulmonary Arterial Hypertension
Shanshan Song; Aya Yamamura; Hisao Yamamura; Aleksandra Babicheva; Haiyang Tang; Ramon J. Ayon; Kimberly M. McDermott; Xutong Sun; Stephen M. Black; Ayako Makino; Jason X. -J. Yuan
FASEB JOURNAL, Apr. 2016, Not reviewed, No invitation
30

Calcium-sensing Receptor, Coupled with Transient Receptor Potential Canonical Channels 6, Regulates Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension
Haiyang Tang; Aya Yamamura; Dustin R. Fraidenburg; Shanshan Song; Hisao Yamamura; Jiwang Chen; Yali Gu; Ramon J. Ayon; Stephan M. Black; Joe G. N. Garcia; Ayako Makino; Jason X. -J. Yuan
FASEB JOURNAL, Apr. 2016, Not reviewed, No invitation
30

miRNA-29b Directly Downregulates K+ Channel Expression and Function in IPAH-PASMC
Ramon Ayon; Nicole Pohl; Aya Yamamura; Hisao Yamamura; Ayako Makino; Jason Yuan
FASEB JOURNAL, Apr. 2015, Not reviewed, No invitation
29

Functional coupling of TRPC6 channel with Ca2+-sensing receptor in pulmonary hypertension
Aya Yamamura; Kikuo Tsukamoto; Naoki Ohara; Jason X. -J. Yuan
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Not reviewed, No invitation
124, 89P, 89P

Cutaneous mechanical hyperalgesia induced by a high -fat- cholesterol diet in SHRSP5/Dmcr rats : upregulation of Mss4 in dorsal root ganglion cells
Yasuko Kozaki; Yuka Hasegawa; Yukako Mizukami; Rena Umetsu; Chinami Ishikawa; Yukie Nakagawa; Yuri Morikawa; Haruhi Yasue; Aya Yamamura; Kazuya Kitamori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, Not reviewed, No invitation
63, S162, S162

Hypoxia-Mediated Activation of Notch Signaling Enhances Store-Operated Calcium Entry in Pulmonary Arterial Smooth Muscle Cells
Kimberly A. Smith; Qiang Gou; Aya Yamamura; Hisao Yamamura; Jason X. Yuan
CIRCULATION, Nov. 2012, Not reviewed, No invitation
126(21)

microRNA 29b is upregulated in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension and inhibits K plus channel expression and function
Nicole Monique Pohl; Aya Yamamura; Hisao Yamamura; Ayako Makino; Jason X. -J. Yuan
FASEB JOURNAL, Apr. 2012, Not reviewed, No invitation
26

Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells
Hisao Yamamura; Aya Yamamura; Eun A. Ko; Nicole M. Pohl; Amy Zeifman; Patricia A. Thistlethwaite; Jason X. -J. Yuan
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Not reviewed, No invitation
118, 91P, 91P

Pathophysiological roles of Hippo signaling in pulmonary arterial hypertension
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2023 - Mar. 2026
山村 彩, 山村 彩, 日本学術振興会, Japan Society for the Promotion of Science

Drug discovery targeting ion channels for the treatment of pulmonary hypertension
Grant-in-Aid for Scientific Research (B)
Nagoya City University
01 Apr. 2022 - 31 Mar. 2025
山村 寿男; 中山 貴文; 正木 彩子; 近藤 るびい; 山村 彩, 山村 寿男; 中山 貴文; 正木 彩子; 近藤 るびい; 山村 彩, 日本学術振興会, Japan Society for the Promotion of Science

Ｇ蛋白活性調節因子を標的とした治療の基礎検討
基盤研究(C)
愛知医科大学
01 Apr. 2022 - 31 Mar. 2025
佐藤 元彦; 山村 彩, 佐藤 元彦; 山村 彩, 日本学術振興会, 日本学術振興会

Signal pathways of calcium-sensing receptor in pulmonary hypertension
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2020 - Mar. 2023
山村 彩, 山村 彩, 日本学術振興会, Japan Society for the Promotion of Science

A role of Activator of G-protein signaling 8 in pulmonary hypertension
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2019 - 31 Mar. 2022
佐藤 元彦; 山村 彩; 林 寿来, Sato Motohiko, 日本学術振興会, Japan Society for the Promotion of Science

カルシウム感受性受容体を創薬標的とした新規肺高血圧症治療薬の探索
Mar. 2017 - Apr. 2020
山村 彩, 山村 彩, Principal investigator

肺高血圧症で機能亢進するカルシウム感受性受容体の発現調節機構の解明
Apr. 2015 - Mar. 2017
山村 彩, 山村 彩, Principal investigator

肺高血圧症においてカルシウム感受性受容体と機能連関するカルシウムシグナルの同定
Apr. 2013 - Mar. 2015
山村 彩, 山村 彩, Principal investigator

特願2020-070003, 肺動脈性肺高血圧症等の治療剤及びその利用
山村寿男, 鈴木良明, 澤井優輝, 藤原萌園, 山村彩