山村 彩
<基礎医学部門>生理学講座 | 講師 |
プロフィール
専門分野
薬理学
循環生理学主な担当講義
生理学（消化器）
病態生理学（消化器・肺高血圧症）出身大学
名城大学薬学部（2001年）最終学歴
名古屋市立大学大学院医学研究科博士課程修了博士（医学）（2007年）これまでの勤務先
イリノイ大学シカゴ校（博士研究員）（2010年10月～2012年4月）
金城学院大学薬学部助教（生物系）（2012年4月～2017年4月）
愛知医科大学医学部生理学講座（2017年5月～現在）海外留学経験
イリノイ大学シカゴ校（米国）（2010年10月～2012年3月）
アリゾナ大学ツーソン校（米国）（2016年2月～2016年3月）主な学会活動
日本薬理学会
日本生理学会
日本薬学会主な研究課題
カルシウム感受性受容体と血管機能
性ホルモンによる肺高血圧症の発症制御機構の解明
肺高血圧症治療薬を目指した創薬研究自己紹介
将来医師になる学生の方に理解してもらえる講義や講義資料の作成を目指しています。一人でも研究マインドを持った学生さんの育成に微力ながら尽力できればと思っています！趣味
家族旅行
ピアノ
書道
委員歴
受賞
論文
- Melatonin inhibits voltage-gated potassium KV4.2 channels and negatively regulates melatonin secretion in rat pineal glands.
Hiroki Mishima; Shunsuke Ando; Hibiki Kuzuhara; Aya Yamamura; Rubii Kondo; Yoshiaki Suzuki; Yuji Imaizumi; Hisao Yamamura
American journal of physiology. Cell physiology, 2024年10月
327(4), C1023-C1034, 10.1152/ajpcell.00664.2023 - Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension.
Aya Yamamura; Moe Fujiwara; Akiko Kawade; Taiki Amano; Alamgir Hossain; Md Junayed Nayeem; Rubii Kondo; Yoshiaki Suzuki; Yasumichi Inoue; Hidetoshi Hayashi; Susumu Suzuki; Motohiko Sato; Hisao Yamamura
European journal of pharmacology, 2024年04月
筆頭著者, 176564, 176564, 10.1016/j.ejphar.2024.176564 - Up-regulated expression of two-pore domain K+ channels, KCNK1 and KCNK2, is involved in the proliferation and migration of pulmonary arterial smooth muscle cells in pulmonary arterial hypertension.
Natsumi Shima; Aya Yamamura; Moe Fujiwara; Taiki Amano; Kazuyuki Matsumoto; Taiga Sekine; Haruka Okano; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Frontiers in cardiovascular medicine, 2024年
11, 1343804, 1343804, 10.3389/fcvm.2024.1343804 - Pimaric acid reduces vasoconstriction via BKCa channel activation and VDCC inhibition in rat pulmonary arterial smooth muscles.
Masashi Ishida; Aya Yamamura; Moe Fujiwara; Taiki Amano; Mina Ota; Yukari Hikawa; Rubii Kondo; Yoshiaki Suzuki; Yuji Imaizumi; Hisao Yamamura
Journal of pharmacological sciences, 2023年10月
153(2), 84, 88, 10.1016/j.jphs.2023.08.001 - Corosolic acid ameliorates vascular remodeling in pulmonary arterial hypertension via the downregulation of STAT3 signaling.
Akiko Kawade; Aya Yamamura; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Journal of pharmacological sciences, 2023年02月
151(2), 119, 127, 10.1016/j.jphs.2022.12.007 - Upregulated ClC3 channels/transporters elicit swelling-activated Cl- currents and induce excessive cell proliferation in idiopathic pulmonary arterial hypertension.
Taiki Amano; Aya Yamamura; Moe Fujiwara; Seiji Hirai; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Biological & pharmaceutical bulletin, 2022年08月
45(11), 1684, 1691, 10.1248/bpb.b22-00513 - SKF96365 activates calcium-sensing receptors in pulmonary arterial smooth muscle cells.
Riko Miyaki; Aya Yamamura; Akiko Kawade; Moe Fujiwara; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Biochemical and biophysical research communications, 2022年06月
607, 44, 48, 10.1016/j.bbrc.2022.03.121 - Imatinib mesylate inhibits androgen-independent PC-3 cell viability, proliferation, migration, and tumor growth by targeting platelet-derived growth factor receptor-α.
Md Junayed Nayeem; Aya Yamamura; Hisaki Hayashi; Hiroyuki Muramatsu; Kogenta Nakamura; Naoto Sassa; Motohiko Sato
Life sciences, 2022年01月
288, 120171, 120171, 10.1016/j.lfs.2021.120171 - Comparative analysis of age in monocrotaline-induced pulmonary hypertensive rats.
Akiko Kawade; Aya Yamamura; Moe Fujiwara; Saki Kobayashi; Shiho Mori; Chihiro Horii; Akari Hiraku; Sayo Suzumura; Kikuo Tsukamoto; Naoki Ohara; Rubii Kondo; Yoshiaki Suzuki; Hisao Yamamura
Journal of pharmacological sciences, 2021年09月
147(1), 81, 85, 10.1016/j.jphs.2021.05.012 - Substantial involvement of TRPM7 inhibition in the therapeutic effect of Ophiocordyceps sinensis on pulmonary hypertension.
Keizo Hiraishi; Lin Hai Kurahara; Jianlin Feng; Aya Yamamura; Yuanyuan Cui; Eiji Yahiro; Hiroyasu Yokomise; Tetsuhiko Go; Kaori Ishikawa; Naoya Yokota; Atsushi Fujiwara; Miki Onitsuka; Kohtaro Abe; Shoji Ohga; Toru Satoh; Yasumasa Okada; Lixia Yue; Ryuji Inoue; Katsuya Hirano
Translational research : the journal of laboratory and clinical medicine, 2021年07月
233, 127, 143, 10.1016/j.trsl.2021.03.004 - [Preface].
Aya Yamamura; Masanari Umemura
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2021年
156(3), 145, 145, 10.1254/fpj.21007 - [Roles of growth factors on vascular remodeling in pulmonary hypertension].
Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2021年
156(3), 161, 165, 10.1254/fpj.21006 - MAZ51 Blocks the Tumor Growth of Prostate Cancer by Inhibiting Vascular Endothelial Growth Factor Receptor 3.
Aya Yamamura; Md Junayed Nayeem; Hiroyuki Muramatsu; Kogenta Nakamura; Motohiko Sato
Frontiers in pharmacology, 2021年, 査読有り
筆頭著者, 12, 667474, 667474, 10.3389/fphar.2021.667474 - The Rho kinase 2 (ROCK2)-specific inhibitor KD025 ameliorates the development of pulmonary arterial hypertension.
Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
Biochemical and biophysical research communications, 2021年01月, 査読有り
筆頭著者, 534, 795, 801, 10.1016/j.bbrc.2020.10.106 - Eicosapentaenoic acid ameliorates pulmonary hypertension via inhibition of tyrosine kinase Fyn.
Lin Hai Kurahara; Keizo Hiraishi; Aya Yamamura; Ying Zhang; Kohtaro Abe; Eiji Yahiro; Mikiko Aoki; Kaori Koga; Hiroyasu Yokomise; Tetsuhiko Go; Kaori Ishikawa; Zhang Bo; Hiroko Kishi; Sei Kobayashi; Narumi Aoki-Shoi; Satoh Toru; Ryuji Inoue; Katsuya Hirano
Journal of molecular and cellular cardiology, 2020年11月
148, 50, 62, 10.1016/j.yjmcc.2020.08.013 - Hypoxia induces the translocation of glucose transporter 1 to the plasma membrane in vascular endothelial cells.
Abdullah Al Mamun; Hisaki Hayashi; Aya Yamamura; Md Junayed Nayeem; Motohiko Sato
The journal of physiological sciences : JPS, 2020年09月
70(1), 44, 44, 10.1186/s12576-020-00773-y - [Pathophysiological roles of TRPC6 channels in pulmonary arterial hypertension].
Hisao Yamamura; Yoshiaki Suzuki; Aya Yamamura
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2020年
155(4), 230, 235, 10.1254/fpj20001 - MicroRNA-mediated Downregulation of K+ Channels in Pulmonary Arterial Hypertension.
Babicheva A; Ayon RJ; Zhao T; Ek Vitorin JF; Pohl NM; Yamamura A; Yamamura H; Quinton BA; Ba M; Wu L; Ravellette KS; Rahimi S; Balistrieri F; Harrington A; Vanderpool RR; Thistlethwaite PA; Makino A; Yuan JX
American journal of physiology. Lung cellular and molecular physiology, 2019年09月, 査読有り, 招待無し
318(1), L10-L26, 10.1152/ajplung.00010.2019 - Platelet-derived growth factor up-regulates Ca2+-sensing receptors in idiopathic pulmonary arterial hypertension.
Yamamura A; Nayeem MJ; Al Mamun A; Takahashi R; Hayashi H; Sato M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019年06月, 査読有り, 招待無し
筆頭著者, 33(6), 7363, 7374, 10.1096/fj.201802620R - Calcilytics inhibit the proliferation and migration of human prostate cancer PC-3 cells.
Yamamura A; Nayeem MJ; Sato M
Journal of pharmacological sciences, 2019年03月, 査読有り, 招待無し
139(3), 254, 257, 10.1016/j.jphs.2019.01.008 - Activator of G-protein signaling 8 is involved in VEGF-induced choroidal neovascularization.
Hayashi H; Mamun AA; Takeyama M; Yamamura A; Zako M; Yagasaki R; Nakahara T; Kamei M; Sato M
Scientific reports, 2019年02月, 査読有り, 招待無し
9(1), 1560, 1560, 10.1038/s41598-018-38067-4 - Calcium-Sensing Receptor Is Functionally Expressed in the Cochlear Perilymphatic Compartment and Essential for Hearing.
Toshiya Minakata; Akira Inagaki; Aya Yamamura; Hisao Yamamura; Shinji Sekiya; Shingo Murakami
Frontiers in molecular neuroscience, 2019年, 査読有り, 招待無し
12, 175, 175, 10.3389/fnmol.2019.00175 - チロシンキナーゼFYNが肺動脈高血圧の病態生理に果たす役割
倉原 琳; 平石 敬三; 張 影; 山村 彩; 岸 博子; 小林 誠; 古賀 佳織; 鬼塚 美樹; 阿部 弘太郎; 塩井 成留実; 井上 隆司
日本生理学雑誌, 2018年05月
80(2), 31, 31 - G蛋白活性調節因子による脈絡膜血管新生の制御
林 寿来; Al MA.; 山村 彩; 佐喜眞 未帆; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
日本生理学雑誌, 2018年02月
80(1), 15, 15 - 脈絡膜血管新生におけるG蛋白活性調節因子の機能
林 寿来; Mamun Abdullah; 山村 彩; 佐喜眞 未帆; 武山 正行; 雑喉 正泰; 矢ヶ崎 莉菜; 中原 努; 瓶井 資弘; 佐藤 元彦
生命科学系学会合同年次大会, 2017年12月
2017年度, [2P, 1032] - Tadalafil induces antiproliferation, apoptosis, and phosphodiesterase type 5 downregulation in idiopathic pulmonary arterial hypertension in vitro
Aya Yamamura; Eri Fujitomi; Naoki Ohara; Kikuo Tsukamoto; Motohiko Sato; Hisao Yamamura
EUROPEAN JOURNAL OF PHARMACOLOGY, 2017年09月, 査読有り, 招待無し
810, 44, 50, 10.1016/j.ejphar.2017.06.010 - Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension
Jiwang Chen; Justin R. Sysol; Sunit Singla; Shuangping Zhao; Aya Yamamura; Daniela Valdez-Jasso; Taimur Abbasi; Krystyna M. Shioura; Sakshi Sahni; Vamsi Reddy; Arvind Sridhar; Hui Gao; Jaime Torres; Sara M. Camp; Haiyang Tang; Shui Qing Ye; Suzy Comhair; Raed Dweik; Paul Hassoun; Jason X. -J. Yuan; Joe G. N. Garcia; Roberto F. Machado
CIRCULATION, 2017年04月, 査読有り, 招待無し
135(16), 1532, +, 10.1161/CIRCULATIONAHA.116.024557 - Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH
Shanshan Song; Ramon J. Ayon; Aya Yamamura; Hisao Yamamura; Swetaleena Dash; Aleksandra Babicheva; Haiyang Tang; Xutong Sun; Arlette G. Cordery; Zain Khalpey; Stephen M. Black; Ankit A. Desai; Franz Rischard; Kimberly M. McDermott; Joe G. N. Garcia; Ayako Makino; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2017年03月, 査読有り, 招待無し
312(3), 1309, 1325, 10.1152/ajplung.00357.2016 - Molecular Mechanism of Dihydropyridine Ca2+ Channel Blockers in Pulmonary Hypertension
Aya Yamamura
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2016年10月, 査読有り, 招待無し
136(10), 1373, 1377, 10.1248/yakushi.16-00086 - Calcilytics enhance sildenafil-induced antiproliferation in idiopathic pulmonary arterial hypertension
Aya Yamamura; Satomi Yagi; Naoki Ohara; Kikuo Tsukamoto
EUROPEAN JOURNAL OF PHARMACOLOGY, 2016年08月, 査読有り, 招待無し
784, 15, 21, 10.1016/j.ejphar.2016.04.059 - Pathogenic role of calcium-sensing receptors in the development and progression of pulmonary hypertension
Haiyang Tang; Aya Yamamura; Hisao Yamamura; Shanshan Song; Dustin R. Fraidenburg; Jiwang Chen; Yali Gu; Nicole M. Pohl; Tong Zhou; Laura Jimenez-Perez; Ramon J. Ayon; Ankit A. Desai; David Goltzman; Franz Rischard; Zain Khalpey; Stephan M. Black; Joe G. N. Garcia; Ayako Makino; Jason X. J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016年05月, 査読有り, 招待無し
310(9), L846, L859, 10.1152/ajplung.00050.2016 - Changes by canola (rapeseed) oil ingestion of steroid hormone metabolism in SHRSP
Yagi Satomi; Nishikawa Mai; Hanai Hitomi; Suzumura Sayo; Naito Yukiko; Tatematsu Kenjiro; Miyazawa Daisuke; Hashimoto Yoko; Yamamura Aya; Ohnishi Hiroyuki; Ohara Naoki; Okayama Harumi
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2016年03月, 査読有り, 招待無し
130(3), S221 - Upregulation/downregulation of ion channels in pulmonary hypertension.
Yamamura A
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2016年, 査読有り, 招待無し
148(5), 226, 230, 10.1254/fpj.148.226 - Calcium-sensing receptor.
Yamamura A
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2016年, 査読有り, 招待無し
148(5), 278, 280, 10.1254/fpj.148.278 - Notch Activation of Ca2+ Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension
Kimberly A. Smith; Guillaume Voiriot; Haiyang Tang; Dustin R. Fraidenburg; Shanshan Song; Hisao Yamamura; Aya Yamamura; Qiang Guo; Jun Wan; Nicole M. Pohl; Mohammad Tauseef; Rolf Bodmer; Karen Ocorr; Patricia A. Thistlethwaite; Gabriel G. Haddad; Frank L. Powell; Ayako Makino; Dolly Mehta; Jason X. -J. Yuan
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2015年09月, 査読有り, 招待無し
53(3), 355, 367, 10.1165/rcmb.2014-0235OC - Peripheral gene expression profile of mechanical hyperalgesia induced by repeated cold stress in SHRSP5/Dmcr rats
Yasuko Kozaki; Rena Umetsu; Yukako Mizukami; Aya Yamamura; Kazuya Kitamori; Satoru Tsuchikura; Katsumi Ikeda; Yukio Yamori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2015年09月, 査読有り, 招待無し
65(5), 417, 425, 10.1007/s12576-015-0380-9 - Inhibition of Excessive Cell Proliferation by Calcilytics in Idiopathic Pulmonary Arterial Hypertension
Aya Yamamura; Naoki Ohara; Kikuo Tsukamoto
PLOS ONE, 2015年09月, 査読有り, 招待無し
10(9), e0138384, 10.1371/journal.pone.0138384 - Flow shear stress enhances intracellular Ca2+ signaling in pulmonary artery smooth muscle cells from patients with pulmonary arterial hypertension
Shanshan Song; Aya Yamamura; Hisao Yamamura; Ramon J. Ayon; Kimberly A. Smith; Haiyang Tang; Ayako Makino; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2014年08月, 査読有り, 招待無し
307(4), C373, C383, 10.1152/ajpcell.00115.2014 - Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells
Hisao Yamamura; Aya Yamamura; Eun A. Ko; Nicole M. Pohl; Kimberly A. Smith; Amy Zeifman; Frank L. Powell; Patricia A. Thistlethwaite; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2014年05月, 査読有り, 招待無し
306(9), C871, C878, 10.1152/ajpcell.00221.2013 - Protective Effects of Fluvoxamine against Ischemia/Reperfusion Injury in Isolated, Perfused Guinea-Pig Hearts
Tatsuya Muto; Haruki Usuda; Aya Yamamura; Koji Yoshida; Ai Ohashi; Kumiko Mitsui-Saitoh; Junichi Sakai; Yumi Sugimoto; Hideki Mizutani; Tsunemasa Nonogaki; Yoshihiro Hotta
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2014年05月, 査読有り, 招待無し
37(5), 731, 739, 10.1248/bpb.b13-00552 - Inhibition of the Ca2+-sensing receptor rescues pulmonary hypertension in rats and mice
Qiang Guo; Jian-an Huang; Aya Yamamura; Hisao Yamamura; Adriana M. Zimnicka; Ruby Fernandez; Jason X-J Yuan
HYPERTENSION RESEARCH, 2014年02月, 査読有り, 招待無し
37(2), 116, 124, 10.1038/hr.2013.129 - Pathological function of Ca2+-sensing receptor in pulmonary arterial hypertension.
Yamamura A
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi, 2014年, 査読有り, 招待無し
50, 8, 17, 10.1540/jsmr.50.8 - Enhanced Ca2+-sensing Receptor Function in Pulmonary Hypertension
Aya Yamamura; Hisao Yamamura; Jason X. -J. Yuan
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2013年12月, 査読有り, 招待無し
133(12), 1351, 1359, 10.1248/yakushi.13-00228-3 - Chronic hypoxia selectively enhances L- and T-type voltage-dependent Ca2+ channel activity in pulmonary artery by upregulating Ca(v)1.2 and Ca(v)3.2
Jun Wan; Aya Yamamura; Adriana M. Zimnicka; Guillaume Voiriot; Kimberly A. Smith; Haiyang Tang; Ramon J. Ayon; Moumita S. R. Choudhury; Eun A. Ko; Jun Wang; Chen Wang; Ayako Makino; Jason X. -J. Yuan
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2013年07月, 査読有り, 招待無し
305(2), L154, L164, 10.1152/ajplung.00313.2012 - Functional characterization of voltage-dependent Ca(2+) channels in mouse pulmonary arterial smooth muscle cells: divergent effect of ROS.
Ko EA; Wan J; Yamamura A; Zimnicka AM; Yamamura H; Yoo HY; Tang H; Smith KA; Sundivakkam PC; Zeifman A; Ayon RJ; Makino A; Yuan JX
American journal of physiology. Cell physiology, 2013年06月, 査読有り, 招待無し
304(11), C1042, 52, 10.1152/ajpcell.00304.2012 - Dihydropyridine Ca2+ Channel Blockers Increase Cytosolic [Ca2+] by Activating Ca2+-sensing Receptors in Pulmonary Arterial Smooth Muscle Cells
Aya Yamamura; Hisao Yamamura; Qiang Guo; Adriana M. Zimnicka; Jun Wan; Eun A. Ko; Kimberly A. Smith; Nicole M. Pohl; Shanshan Song; Amy Zeifman; Ayako Makino; Jason X. -J. Yuan
CIRCULATION RESEARCH, 2013年02月, 査読有り, 招待無し
112(4), 640, +, 10.1161/CIRCRESAHA.113.300897 - Enhanced Ca2+-Sensing Receptor Function in Idiopathic Pulmonary Arterial Hypertension
Aya Yamamura; Qiang Guo; Hisao Yamamura; Adriana M. Zimnicka; Nicole M. Pohl; Kimberly A. Smith; Ruby A. Fernandez; Amy Zeifman; Ayako Makino; Hui Dong; Jason X-J Yuan
CIRCULATION RESEARCH, 2012年08月, 査読有り, 招待無し
111(4), 469, U259, 10.1161/CIRCRESAHA.112.266361 - Activity of Ca -activated Cl channels contributes to regulating receptor- and store-operated Ca entry in human pulmonary artery smooth muscle cells.
Yamamura A; Yamamura H; Zeifman A; Yuan JX
Pulmonary circulation, 2011年04月, 査読有り, 招待無し
1(2), 269, 279, 10.4103/2045-8932.83447 - Mibefradil-sensitive component involved in the plateau potential in submucosal interstitial cells of the murine proximal colon
Aya Hotta; Noriko Okada; Hikaru Suzuki
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007年02月, 査読有り, 招待無し
353(1), 170, 176, 10.1016/j.bbrc.2006.12.003 - Increased inhibitory capacity of an anti-C5a complementary peptide following acetylation of N-terminal alanine
Noriko Okada; Suzuka Asai; Aya Hotta; Noriko Miura; Naohito Ohno; Imre Farkas; Lewis Hau; Hidechika Okada
MICROBIOLOGY AND IMMUNOLOGY, 2007年, 査読有り, 招待無し
51(4), 439, 443 - The effects of flufenamic acid on spontaneous activity of smooth muscle tissue isolated from the guinea-pig stomach antrum
Aya Hotta; Yoshihiko Kito; Hikaru Suzuki
Journal of Smooth Muscle Research, 2005年, 査読有り, 招待無し
41(4), 207, 220, 10.1540/jsmr.41.207 - Effects of inhibitors of nonselective cation channels on the acetylcholine-induced depolarization of circular smooth muscle from the guinea-pig stomach antrum
Aya Hotta; Young Chul Kim; Eri Nakamura; Yoshihiko Kito; Yoshimichi Yamamoto; Hikaru Suzuki
Journal of Smooth Muscle Research, 2005年, 査読有り, 招待無し
41(6), 313, 327, 10.1540/jsmr.41.313 - Molecular basis of pimarane compounds as novel activators of large-conductance Ca2+-activated K+ channel alpha-subunit
Y Imaizumi; K Sakamoto; A Yamada; A Hotta; S Ohya; K Muraki; M Uchiyama; T Ohwada
MOLECULAR PHARMACOLOGY, 2002年10月, 査読有り, 招待無し
62(4), 836, 846
MISC
- Hot, Heat and Stretch All Contribute to the Enhanced Ca2+ Signaling in Pulmonary Arterial Hypertension
Shanshan Song; Aya Yamamura; Hisao Yamamura; Aleksandra Babicheva; Haiyang Tang; Ramon J. Ayon; Kimberly M. McDermott; Xutong Sun; Stephen M. Black; Ayako Makino; Jason X. -J. Yuan
FASEB JOURNAL, 2016年04月, 査読無し, 招待無し
30 - Calcium-sensing Receptor, Coupled with Transient Receptor Potential Canonical Channels 6, Regulates Cytosolic [Ca2+] in the Development and Progression of Pulmonary Hypertension
Haiyang Tang; Aya Yamamura; Dustin R. Fraidenburg; Shanshan Song; Hisao Yamamura; Jiwang Chen; Yali Gu; Ramon J. Ayon; Stephan M. Black; Joe G. N. Garcia; Ayako Makino; Jason X. -J. Yuan
FASEB JOURNAL, 2016年04月, 査読無し, 招待無し
30 - miRNA-29b Directly Downregulates K+ Channel Expression and Function in IPAH-PASMC
Ramon Ayon; Nicole Pohl; Aya Yamamura; Hisao Yamamura; Ayako Makino; Jason Yuan
FASEB JOURNAL, 2015年04月, 査読無し, 招待無し
29 - Functional coupling of TRPC6 channel with Ca2+-sensing receptor in pulmonary hypertension
Aya Yamamura; Kikuo Tsukamoto; Naoki Ohara; Jason X. -J. Yuan
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014年, 査読無し, 招待無し
124, 89P, 89P - Cutaneous mechanical hyperalgesia induced by a high -fat- cholesterol diet in SHRSP5/Dmcr rats : upregulation of Mss4 in dorsal root ganglion cells
Yasuko Kozaki; Yuka Hasegawa; Yukako Mizukami; Rena Umetsu; Chinami Ishikawa; Yukie Nakagawa; Yuri Morikawa; Haruhi Yasue; Aya Yamamura; Kazuya Kitamori
JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013年, 査読無し, 招待無し
63, S162, S162 - Hypoxia-Mediated Activation of Notch Signaling Enhances Store-Operated Calcium Entry in Pulmonary Arterial Smooth Muscle Cells
Kimberly A. Smith; Qiang Gou; Aya Yamamura; Hisao Yamamura; Jason X. Yuan
CIRCULATION, 2012年11月, 査読無し, 招待無し
126(21) - microRNA 29b is upregulated in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension and inhibits K plus channel expression and function
Nicole Monique Pohl; Aya Yamamura; Hisao Yamamura; Ayako Makino; Jason X. -J. Yuan
FASEB JOURNAL, 2012年04月, 査読無し, 招待無し
26 - Jagged-1 enhances store-operated Ca2+ entry in human pulmonary arterial smooth muscle cells
Hisao Yamamura; Aya Yamamura; Eun A. Ko; Nicole M. Pohl; Amy Zeifman; Patricia A. Thistlethwaite; Jason X. -J. Yuan
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012年, 査読無し, 招待無し
118, 91P, 91P
共同研究・競争的資金等の研究課題
- 肺動脈性肺高血圧症におけるHippoシグナルの病態生理学的意義の解明
基盤研究(C)
愛知医科大学
2023年04月 - 2026年03月
山村 彩, 山村 彩, 日本学術振興会, Japan Society for the Promotion of Science - 新規肺高血圧症治療薬を指向したイオンチャネル創薬
基盤研究(B)
名古屋市立大学
2022年04月01日 - 2025年03月31日
山村 寿男; 中山 貴文; 正木 彩子; 近藤 るびい; 山村 彩, 山村 寿男; 中山 貴文; 正木 彩子; 近藤 るびい; 山村 彩, 日本学術振興会, Japan Society for the Promotion of Science - Ｇ蛋白活性調節因子を標的とした治療の基礎検討
基盤研究(C)
愛知医科大学
2022年04月01日 - 2025年03月31日
佐藤 元彦; 山村 彩, 佐藤 元彦; 山村 彩, 日本学術振興会, 日本学術振興会 - 肺高血圧症リモデリングに関与するカルシウム感受性受容体の新規下流シグナルの探索
基盤研究(C)
愛知医科大学
2020年04月 - 2023年03月
山村 彩, 山村 彩, 日本学術振興会, Japan Society for the Promotion of Science - G蛋白活性調節因子制御による肺高血圧の治療
基盤研究(C)
愛知医科大学
2019年04月01日 - 2022年03月31日
佐藤 元彦; 山村 彩; 林 寿来, Sato Motohiko, 日本学術振興会, Japan Society for the Promotion of Science - カルシウム感受性受容体を創薬標的とした新規肺高血圧症治療薬の探索
2017年03月 - 2020年04月
山村 彩, 山村 彩, 研究代表者 - 肺高血圧症で機能亢進するカルシウム感受性受容体の発現調節機構の解明
2015年04月 - 2017年03月
山村 彩, 山村 彩, 研究代表者 - 肺高血圧症においてカルシウム感受性受容体と機能連関するカルシウムシグナルの同定
2013年04月 - 2015年03月
山村 彩, 山村 彩, 研究代表者
