genome editing

cell division

Nov. 2012
6th Anniversary International Symposium on Nanomedicine, Poster Encouragement Award, MINK1 is a novel component of STRIPAK and is required for the completion of cytokinesis, 新学術領域研究「ナノメディシン分子科学」

Sep. 2007
学術奨励賞, SHP-2変異株を用いたSHP-2の機能解析とコネキシン43への発現制御シグナル伝達経路の解析及びCD44ノックアウトマウスを用いた癌細胞浸潤転移の解析, 名古屋大学

Targeting fatty acid synthase suppresses tumor development inNF2/CDKN2A-deficient malignant pleural mesothelioma
Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Md Towhid Ahmed Shihan; Nushrat Jahan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Yinzhi Lin; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Jul. 2024
10.1101/2024.07.14.603191

ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells.
Sivasundaram Karnan; Ichiro Hanamura; Akinobu Ota; Lam Quang Vu; Kaori Uchino; Tomohiro Horio; Satsuki Murakami; Shohei Mizuno; Md Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Mrityunjoy Biswas; Toshinori Hyodo; Hideaki Ito; Atsushi Suzuki; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Akiyoshi Takami
Cell death discovery, Jan. 2024
10(1), 56, 56, 10.1038/s41420-024-01814-w

★Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis
Toshinori Hyodo; Eri Asano‐Inami; Satoko Ito; Mai Sugiyama; Akihiro Nawa; Md Lutfur Rahman; Muhammad Nazmul Hasan; Yuko Mihara; Vu Quang Lam; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Michinari Hamaguchi; Yoshitaka Hosokawa; Hiroyuki Konishi
The FEBS Journal, Nov. 2023, Reviewed
Lead, 10.1111/febs.17017

CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell Death Discovery, Jul. 2023, Reviewed
10.1038/s41420-023-01552-5

The association of UBAP2L and G3BP1 mediated by small nucleolar RNA is essential for stress granule formation.
Eri Asano-Inami; Akira Yokoi; Mai Sugiyama; Toshinori Hyodo; Tomonari Hamaguchi; Hiroaki Kajiyama
Communications biology, Apr. 2023, Reviewed
6(1), 415, 415, 10.1038/s42003-023-04754-w

PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells.
Mikako Kato; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Toshinori Hyodo; Md Lutfur Rahman; Muhammad Nazmul Hasan; Maho Onda; Sayuri Kondo; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Oral diseases, Feb. 2023, Reviewed
10.1111/odi.14533

★Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene.
Muhammad Nazmul Hasan; Toshinori Hyodo; Mrityunjoy Biswas; Md Lutfur Rahman; Yuko Mihara; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
PloS one, 2023, Reviewed
18(11), e0294146, 10.1371/journal.pone.0294146

Plumbagin-induced anticancer effects are associated with mitochondrial- encoded respiratory gene downregulation in oral squamous cell carcinoma
Takayuki Ono; Akinobu Ota; Mikako Kato; Sivasundaram Karnan; Toshinori Hyodo; Md Lutfur Rahman; Muhammad Nazmul Hasan; Maho Onda; Yoshitomo Nishio; Remi Matsuyama; Yukako Takigawa; Sayuri Kondo; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY, Nov. 2022, Reviewed
34(6), 805, 812, 10.1016/j.ajoms.2022.04.006

BCL6 inhibition ameliorates ruxolitinib resistance in CRLF2-rearranged acute lymphoblastic leukemia.
Shinobu Tsuzuki; Takahiko Yasuda; Hiroaki Goto; Naoko Maeda; Koshi Akahane; Takeshi Inukai; Hideyuki Yamamoto; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Yoshitaka Hosokawa; Hitoshi Kiyoi; Fumihiko Hayakawa
Haematologica, Aug. 2022, Reviewed
10.3324/haematol.2022.280879

★Correction of a CD55 mutation to quantify the efficiency of targeted knock-in via flow cytometry.
Md Lutfur Rahman; Toshinori Hyodo; Muhammad Nazmul Hasan; Yuko Mihara; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Molecular biology reports, Apr. 2022, Reviewed
10.1007/s11033-022-07422-0

★Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP.
Md Lutfur Rahman; Toshinori Hyodo; Muhammad Nazmul Hasan; Yuko Mihara; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Bioscience reports, Dec. 2021, Reviewed
41(12), 10.1042/BSR20212231

★Experimental strategies to achieve efficient targeted knock-in via tandem paired nicking.
Md Lutfur Rahman; Toshinori Hyodo; Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Yuko Mihara; Md Wahiduzzaman; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Scientific reports, Nov. 2021, Reviewed
11(1), 22627, 22627, 10.1038/s41598-021-01978-w

CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia.
Sivasundaram Karnan; Ichiro Hanamura; Akinobu Ota; Souichi Takasugi; Ayano Nakamura; Miyuki Takahashi; Kaori Uchino; Satsuki Murakami; Md Wahiduzzaman; Lam Quang Vu; Md Lutfur Rahman; Muhammad Nazmul Hasan; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Kazuhiro Yoshikawa; Susumu Suzuki; Ryuzo Ueda; Masayuki Ejiri; Yoshitaka Hosokawa; Akiyoshi Takami
Cell death discovery, May 2021, Reviewed
7(1), 121, 121, 10.1038/s41420-021-00446-8

PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer.
Akira Koshino; Aya Nagano; Akinobu Ota; Toshinori Hyodo; Akane Ueki; Masayuki Komura; Akane Sugimura-Nagata; Masahide Ebi; Naotaka Ogasawara; Kenji Kasai; Yoshitaka Hosokawa; Kunio Kasugai; Satoru Takahashi; Shingo Inaguma
Frontiers in pharmacology, 2021, Reviewed
12, 772926, 772926, 10.3389/fphar.2021.772926

Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma.
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md Lutfur Rahman; Muhammad Nazmul Hasan; Md Wahiduzzaman; Ichiro Hanamura; Lam Quang Vu; Akihito Inoko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell death discovery, Nov. 2020, Reviewed
6(1), 127, 127, 10.1038/s41420-020-00364-1

Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells.
Akinobu Ota; Ichiro Hanamura; Sivasundaram Karnan; Shingo Inaguma; Norio Takei; Vu Quang Lam; Shohei Mizuno; Jo Kanasugi; Md Wahiduzzaman; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Hiroshi Ikeda; Akiyoshi Takami; Yoshitaka Hosokawa
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Aug. 2020, Reviewed, No invitation
40(8), 389, 405, 10.1089/jir.2020.0111

Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia
Shinobu Tsuzuki; Takahiko Yasuda; Shinya Kojima; Masahito Kawazu; Koshi Akahane; Takeshi Inukai; Masue Imaizumi; Takanobu Morishita; Koichi Miyamura; Toshihide Ueno; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Masashi Sanada; Hirokazu Nagai; Keizo Horibe; Akihiro Tomita; Kyogo Suzuki; Hideki Muramatsu; Yoshiyuki Takahashi; Yasushi Miyazaki; Itaru Matsumura; Hitoshi Kiyoi; Yoshitaka Hosokawa; Hiroyuki Mano; Fumihiko Hayakawa
Blood Cancer Discovery, Jul. 2020, Reviewed, No invitation
1(1), 82, 95, 10.1158/2643-3230.bcd-19-0080

Cover Image
Sayuri Kondo; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Md Wahiduzzaman; Toshinori Hyodo; Md Lutfur Rahman; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cancer Medicine, Apr. 2020
10.1002/cam4.3049

Bi‐allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells
Jo Kanasugi; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Lam Quang Vu; Shohei Mizuno; Md Wahiduzzaman; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Akiyoshi Takami
Cancer Science, Mar. 2020, Reviewed, No invitation
10.1111/cas.14386

Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma.
Sayuri Kondo; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Md Wahiduzzaman; Toshinori Hyodo; Md Lutfur Rahman; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cancer medicine, Feb. 2020, Reviewed, No invitation
10.1002/cam4.2931

★Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53.
Toshinori Hyodo; Md Lutfur Rahman; Sivasundaram Karnan; Takuji Ito; Atsushi Toyoda; Akinobu Ota; Md Wahiduzzaman; Shinobu Tsuzuki; Yohei Okada; Yoshitaka Hosokawa; Hiroyuki Konishi
Cell reports, Jan. 2020, Reviewed, No invitation
Lead, 30(4), 1195, 1207, 10.1016/j.celrep.2019.12.064

Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma.
Md Wahiduzzaman; Sivasundaram Karnan; Akinobu Ota; Ichiro Hanamura; Hideki Murakami; Akihito Inoko; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cancer science, Jan. 2019, Reviewed, No invitation
110(1), 180, 193, 10.1111/cas.13871

Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo.
Md Wahiduzzaman; Akinobu Ota; Sivasundaram Karnan; Ichiro Hanamura; Shohei Mizuno; Jo Kanasugi; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Akiyoshi Takami; Yoshitaka Hosokawa
Cancer letters, Oct. 2018, Reviewed, No invitation
433, 117, 130, 10.1016/j.canlet.2018.06.027

Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells
Masayuki Yamaji; Akinobu Ota; Md Wahiduzzaman; Sivasundaram Karnan; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Masayuki Haniuda
CANCER MEDICINE, Nov. 2017, Reviewed, No invitation
6(11), 2646, 2659, 10.1002/cam4.1179

Phosphorylation of DEPDC1 at Ser110 is required to maintain centrosome organization during mitosis
Dan Chen; Satoko Ito; Toshinori Hyodo; Eri Asano-Inami; Hong Yuan; Takeshi Senga
EXPERIMENTAL CELL RESEARCH, Sep. 2017, Reviewed, No invitation
358(2), 101, 110, 10.1016/j.yexcr.2017.06.005

FAM98A associates with DDX1-C14orf166-FAM98B in a novel complex involved in colorectal cancer progression
Khondker Ayesha Akter; Mohammed A. Mansour; Toshinori Hyodo; Takeshi Senga
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Mar. 2017, Reviewed, No invitation
84, 1, 13, 10.1016/j.biocel.2016.12.013

★A regulatory subunit of protein phosphatase 2A, PPP2R5E, regulates the abundance of microtubule crosslinking factor 1
Toshinori Hyodo; Satoko Ito; Eri Asano-Inami; Dan Chen; Takeshi Senga
FEBS JOURNAL, Oct. 2016, Reviewed, No invitation
Lead, 283(19), 3662, 3671, 10.1111/febs.13835

Erratum to: FAM98A is a novel substrate of PRMT1 required for tumor cell migration, invasion and colony formation (Tumor Biol., DOI 10.1007/s13277-015-4310-5)
Khondker Ayesha Akter; Mohammed A. Mansour; Toshinori Hyodo; Satoko Ito; Michinari Hamaguchi; Takeshi Senga
Tumor Biology, May 2016, Reviewed, No invitation
37(5), 7001, 10.1007/s13277-016-4833-4

Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells (Tumor Biol., DOI 10.1007/s13277-015-3863-7)
Khondker Ayesha Akter; Toshinori Hyodo; Eri Asano; Naoki Sato; Mohammed A. Mansour; Satoko Ito; Michinari Hamaguchi; Takeshi Senga
Tumor Biology, May 2016, Reviewed, No invitation
37(5), 6999, 10.1007/s13277-016-4832-5

Arginine methylation of ubiquitin-associated protein 2-like is required for the accurate distribution of chromosomes
Masao Maeda; Hitoki Hasegawa; Mai Sugiyama; Toshinori Hyodo; Satoko Ito; Dan Chen; Eri Asano; Akio Masuda; Yoshinori Hasegawa; Michinari Hamaguchi; Takeshi Senga
FASEB JOURNAL, Jan. 2016, Reviewed, No invitation
30(1), 312, 323, 10.1096/fj.14-268987

SATB1 and SATB2 play opposing roles in c-Myc expression and progression of colorectal cancer
Mohammed A. Mansour; Toshinori Hyodo; Khondker Ayesha Akter; Toshio Kokuryo; Keisuke Uehara; Masato Nagino; Takeshi Senga
ONCOTARGET, Jan. 2016, Reviewed, No invitation
7(4), 4993, 5006, 10.18632/oncotarget.6651

EML4 promotes the loading of NUDC to the spindle for mitotic progression
Dan Chen; Satoko Ito; Hong Yuan; Toshinori Hyodo; Kenji Kadomatsu; Michinari Hamaguchi; Takeshi Senga
CELL CYCLE, May 2015, Reviewed, No invitation
14(10), 1529, 1539, 10.1080/15384101.2015.1026514

SATB2 suppresses the progression of colorectal cancer cells via inactivation of MEK5/ERK5 signaling
Mohammed A. Mansour; Toshinori Hyodo; Satoko Ito; Kenji Kurita; Toshio Kokuryo; Keisuke Uehara; Masato Nagino; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
FEBS JOURNAL, Apr. 2015, Reviewed, No invitation
282(8), 1394, 1405, 10.1111/febs.13227

Special AT-rich sequence-binding protein 2 suppresses invadopodia formation in HCT116 cells via palladin inhibition
Mohammed A. Mansour; Eri Asano; Toshinori Hyodo; K. A. Akter; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
EXPERIMENTAL CELL RESEARCH, Mar. 2015, Reviewed, No invitation
332(1), 78, 88, 10.1016/j.yexcr.2014.12.003

Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells
Naoki Sato; Masao Maeda; Mai Sugiyama; Satoko Ito; Toshinori Hyodo; Akio Masuda; Nobuyuki Tsunoda; Toshio Kokuryo; Michinari Hamaguchi; Masato Nagino; Takeshi Senga
CANCER MEDICINE, Feb. 2015, Reviewed, No invitation
4(2), 268, 277, 10.1002/cam4.366

Silencing of STRN4 suppresses the malignant characteristics of cancer cells
Meihong Wong; Toshinori Hyodo; Eri Asano; Kohei Funasaka; Ryoji Miyahara; Yoshiki Hirooka; Hidemi Goto; Michinari Hamaguchi; Takeshi Senga
CANCER SCIENCE, Dec. 2014, Reviewed, No invitation
105(12), 1526, 1532, 10.1111/cas.12541

PLAGL2 regulates actin cytoskeletal architecture and cell migration
Ryuichiro Sekiya; Masao Maeda; Hong Yuan; Eri Asano; Toshinori Hyodo; Hitoki Hasegawa; Satoko Ito; Kiyosumi Shibata; Michinari Hamaguchi; Fumitaka Kikkawa; Hiroaki Kajiyama; Takeshi Senga
CARCINOGENESIS, Sep. 2014, Reviewed, No invitation
35(9), 1993, 2001, 10.1093/carcin/bgu081

SHCBP1 is required for midbody organization and cytokinesis completion
Eri Asano; Hitoki Hasegawa; Toshinori Hyodo; Satoko Ito; Masao Maeda; Dan Chen; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
CELL CYCLE, Sep. 2014, Reviewed, No invitation
13(17), 2744, 2751, 10.4161/15384101.2015.945840

Silencing of TBC1D15 promotes RhoA activation and membrane blebbing
Yuko Takahara; Masao Maeda; Hitoki Hasegawa; Satoko Ito; Toshinori Hyodo; Eri Asano; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
MOLECULAR AND CELLULAR BIOCHEMISTRY, Apr. 2014, Reviewed, No invitation
389(1-2), 9, 16, 10.1007/s11010-013-1921-2

ALX1 Induces Snail Expression to Promote Epithelial-to-Mesenchymal Transition and Invasion of Ovarian Cancer Cells
Hong Yuan; Hiroaki Kajiyama; Satoko Ito; Nobuhisa Yoshikawa; Toshinori Hyodo; Eri Asano; Hitoki Hasegawa; Masao Maeda; Kiyosumi Shibata; Michinari Hamaguchi; Fumitaka Kikkawa; Takeshi Senga
CANCER RESEARCH, Mar. 2013, Reviewed, No invitation
73(5), 1581, 1590, 10.1158/0008-5472.CAN-12-2377

The Aurora-B-mediated phosphorylation of SHCBP1 regulates cytokinetic furrow ingression
Eri Asano; Hitoki Hasegawa; Toshinori Hyodo; Satoko Ito; Masao Maeda; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
Journal of Cell Science, 2013, Reviewed, No invitation
126(15), 3263, 3270, 10.1242/jcs.124875

The role of PLK1-phosphorylated SVIL in myosin II activation and cytokinetic furrowing
Hitoki Hasegawa; Toshinori Hyodo; Eri Asano; Satoko Ito; Masao Maeda; Hirokazu Kuribayashi; Atsushi Natsume; Toshihiko Wakabayashi; Michinari Hamaguchi; Takeshi Senga
Journal of Cell Science, 2013, Reviewed, No invitation
126(16), 3627, 3637, 10.1242/jcs.124818

★Misshapen-like kinase 1 (MINK1) Is a Novel Component of Striatin-interacting Phosphatase and Kinase (STRIPAK) and Is Required for the Completion of Cytokinesis
Toshinori Hyodo; Satoko Ito; Hitoki Hasegawa; Eri Asano; Masao Maeda; Takeshi Urano; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2012, Reviewed, No invitation
Lead, 287(30), 25019, 25029, 10.1074/jbc.M112.372342

Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration
Jhon Alberto Ochoa-Alvarez; Harini Krishnan; Yongquan Shen; Nimish K. Acharya; Min Han; Dean E. McNulty; Hitoki Hasegawa; Toshinori Hyodo; Takeshi Senga; Jian-Guo Geng; Mary Kosciuk; Seung S. Shin; James S. Goydos; Dmitry Temiakov; Robert G. Nagele; Gary S. Goldberg
PLOS ONE, Jul. 2012, Reviewed, No invitation
7(7), e41845, 10.1371/journal.pone.0041845

Role of Palladin Phosphorylation by Extracellular Signal-Regulated Kinase in Cell Migration
Eri Asano; Masao Maeda; Hitoki Hasegawa; Satoko Ito; Toshinori Hyodo; Hong Yuan; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
PLOS ONE, Dec. 2011, Reviewed, No invitation
6(12), e29338, 10.1371/journal.pone.0029338

ARHGAP18, a GTPase-activating protein for RhoA, controls cell shape, spreading, and motility
Masao Maeda; Hitoki Hasegawa; Toshinori Hyodo; Satoko Ito; Eri Asano; Hong Yuang; Kohei Funasaka; Kaoru Shimokata; Yoshinori Hasegawa; Michinari Hamaguchi; Takeshi Senga
MOLECULAR BIOLOGY OF THE CELL, Oct. 2011, Reviewed, No invitation
22(20), 3840, 3852, 10.1091/mbc.E11-04-0364

Recovery of Anoikis in Src-Transformed Cells and Human Breast Carcinoma Cells by Restoration of the SIRP alpha 1/SHP-2 Signaling System
Kazuo Hara; Takeshi Senga; Md Helal Uddin Biswas; Hitoki Hasegawa; Satoko Ito; Toshinori Hyodo; Yoshiki Hirooka; Yasumasa Niwa; Hidemi Goto; Michinari Hamaguchi
CANCER RESEARCH, Feb. 2011, Reviewed, No invitation
71(4), 1229, 1234, 10.1158/0008-5472.CAN-10-3431

The Roles of Two Distinct Regions of PINCH-1 in the Regulation of Cell Attachment and Spreading
Satoko Ito; Yuko Takahara; Toshinori Hyodo; Hitoki Hasegawa; Eri Asano; Michinari Hamaguchi; Takeshi Senga
MOLECULAR BIOLOGY OF THE CELL, Dec. 2010, Reviewed, No invitation
21(23), 4120, 4129, 10.1091/mbc.E10-05-0459

PI3K/Akt signaling is involved in the disruption of gap junctional communication caused by v-Src and TNF-alpha
Satoko Ito; Toshinori Hyodo; Hitoki Hasegawa; Hong Yuan; Michinari Hamaguchi; Takeshi Senga
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2010, Reviewed, No invitation
400(2), 230, 235, 10.1016/j.bbrc.2010.08.045

S-Nitrosylation at Cysteine 498 of c-Src Tyrosine Kinase Regulates Nitric Oxide-mediated Cell Invasion
Mohammad Aminur Rahman; Takeshi Senga; Satoko Ito; Toshinori Hyodo; Hitoki Hasegawa; Michinari Hamaguchi
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2010, Reviewed, No invitation
285(6), 3806, 3814, 10.1074/jbc.M109.059782

Human papillomavirus type 16 oncoprotein E7 suppresses cadherin-mediated cell adhesion via ERK and AP-1 signaling
Hong Yuan; Satoko Ito; Takeshi Senga; Toshinori Hyodo; Tohru Kiyono; Fumitaka Kikkawa; Michinari Hamaguchi
INTERNATIONAL JOURNAL OF ONCOLOGY, Aug. 2009, Reviewed, No invitation
35(2), 309, 314, 10.3892/ijo_00000341

A novel FIRRM-FIGNL1 interaction enhances the viability of multiple myeloma cells.
太田明伸; 太田明伸; 花村一朗; シバスンダラン カルナン; シバスンダラン カルナン; 武井則雄; IFTEKHAR Chowdhury Sajid; 兵頭寿典; 小西裕之; 都築忍; 高見昭良; 細川好孝
International Journal of Myeloma (Web), 2024
14(3)

LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis.
兵頭 寿典; Hasan Muhammad Nazmul; Biswas Mrityunjoy; 稲見(浅野)恵理; Karnan Sivasundaram; 太田 明伸; 都築 忍; 細川 好孝; 小西 裕之
第46回日本分子生物学会, Dec. 2023
Lead

A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene
HASAN Muhammad Nazmul; HYODO Toshinori; BISWAS Mrityunjoy; RAHMAN MD. Lutfur; MIHARA Yuko; KARNAN Sivasundaram; OTA Akinobu; TSUZUKI Shinobu; HOSOKAWA Yoshitaka; KONISHI Hiroyuki
日本分子生物学会年会プログラム・要旨集(Web), 2023
46th

CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析
Sivasundaram Karnan; 太田 明伸; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本生化学会大会プログラム・講演要旨集, Sep. 2019, Not reviewed, No invitation
92回, [3P, 277]

p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Establishment and characterization of human mesothelial cell lines with CRISPR/Cas9-mediated disruption of NF2 and p16)
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2019, Not reviewed, No invitation
78回, P, 1221

Tandem paired nicking using Cas9 nickases permits targeted knock-in without significant inhibition by p53
Toshinori Hyodo; Md Lutfur Rahman; Atsushi Toyoda; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Jun. 2019

Experimental conditions permitting efficient targeted knock-in using CRISPR/Cas9 nickases.
Md Lutfur Rahman, Toshinori Hyodo, Sivasundaram Karnan, Akinobu Ota, Shinobu Tsuzuki, Yoshitaka Hosokawa, Hiroyuki Konishi
Jun. 2019

★CRISPR/Cas9 nickase-mediated targeted knock-in does not activate p53
Toshinori Hyodo; Rahman Md. Lutfur; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Jun. 2019
Lead

DNA二重鎖切断を介さない変異ノックイン法
兵頭寿典; LUTFUR Rahman Md; 豊田敦; 豊田敦; SIVASUNDARAM Karnan; 太田明伸; 都築忍; 細川好孝; 小西裕之
日本分子生物学会年会プログラム・要旨集(Web), 2019
42nd

p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Identification of malignant mesothelioma-specific molecule whose expression is induced by deficiency of p16 / NF2 gene)
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; ムハマド・ワヒドゥーズマン; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation
77回, 1541, 1541

p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Identification of malignant mesothelioma-specific molecule whose expression is induced by deficiency of p16 / NF2 gene)
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; ムハマド・ワヒドゥーズマン; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation
77回, 1541, 1541

悪性中皮腫細胞の増殖を特異的に抑制するAkt阻害剤の探索と同定
太田明伸; 山地雅之; ワヒドッジャマン ムハマド; カルナン シバスンダラン; 兵頭寿典; 小西裕之; 都築忍; 羽生田正行; 細川好孝
日本生化学会大会(Web), Sep. 2018, Not reviewed, No invitation
91回, [1P, 293]

Synergistic antiproliferative effect of combined arsenic trioxide-cisplatin treatment in Bcr-Abl positive leukemic cells
Ota Akinobu; Wahiduzzaman Md; Karnan Sivasundaram; Hyodo Toshinori; Konishi Hiroyuki; Tsuzuki Shinobu; Hosokawa Yoshitaka
CANCER SCIENCE, Jan. 2018, Reviewed, No invitation
109, 685

CRISPR/Cas9を用いたNF2ノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; 兵頭 寿典; ムハマド・ワヒドゥ-ズマン; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2017, Not reviewed, No invitation
76回, P, 1075

亜ヒ酸とシスプラチンによる併用療法はBcr-Abl陽性白血病細胞に対して相乗的な増殖抑制効果を示す
太田 明伸; ワヒドゥージャマン・ムハマド; カルナン・シバスンダラン; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2017, Not reviewed, No invitation
76回, P, 2235

Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells
WAHIDUZZAMAN Md; OTA Akinobu; KARNAN Sivasundaram; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th

新規Interleukin-6誘導因子PDZ binding kinaseは骨髄腫細胞の増殖と進展に関与する
OTA Akinobu; HANAMURA Ichiro; KARNAN Sivasundaram; WAHIDUZZAMAN Md.; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th

悪性胸膜中皮腫の早期診断腫瘍マーカーの検討
シバスンダラン カルナン; OTA Akinobu; HANAMURA Ichiro; MURAKAMI Hideki; HYODO Toshinori; MD Wahiduzzaman; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th

★protein phosphatase2Aの調節サブユニットPPP2R5Eは微小管架橋因子MTCL1の発現量を制御する。
兵頭寿典; 稲見恵理; 太田明伸; シバスンダラン カルナン; 小西裕之; 細川好孝
日本生化学会大会(Web), 2017, Not reviewed, No invitation
90th, ROMBUNNO.2P‐0471 (WEB ONLY)

PLK1によるアクチンミオシン結合蛋白質Supervillin(SVIL)のリン酸化とそれによる収縮溝の制御
HASEGAWA HITOKI; HYODO TOSHINORI; ASANO ERI; ITO SATOKO; HAMAGUCHI MICHINARI; SENGA TAKESHI
日本分子生物学会年会プログラム・要旨集(Web), 2012, Not reviewed, No invitation
35th, 4P-0326 (WEB ONLY)

★MINK1はSTRIPAKの新規構成タンパク質であり,細胞質分裂終了に必要である
HYODO TOSHINORI; ITO SATOKO; HASEGAWA HITOKI; ASANO ERI; MAEDA MASAO; HAMAGUCHI MICHINARI; SENGA TAKESHI
日本分子生物学会年会プログラム・要旨集(Web), 2012, Not reviewed, No invitation
35th, 1LBA-0774 (WEB ONLY)

ゲノム編集技術 : 実験上のポイント/産業利用に向けた研究開発動向と安全性周知
小西裕之、兵頭寿典, Joint work, 第２章第６節Tandem Paired Nicking法によるノックイン
情報機構, Jan. 2023
9784865022421
xiii, 315p

PBKリン酸化標的遺伝子を介した大腸癌悪性形質制御機構の解析と治療応用の可能性
基盤研究(C)
名古屋市立大学
01 Apr. 2023 - 31 Mar. 2026
稲熊 真悟; 太田 明伸; 兵頭 寿典, 稲熊 真悟; 太田 明伸; 兵頭 寿典, 日本学術振興会, 日本学術振興会

★高活性な改良型クリスパーキャス９ゲノム編集システムの研究開発
Oct. 2022 - Sep. 2023
国立研究開発法人新エネルギー・産業技術総合開発機構, 国立研究開発法人新エネルギー・産業技術総合開発機構, Principal investigator

臨床応用を目指す高効率・高精度なCRISPRノックイン法の確立
基盤研究(C)
愛知医科大学
01 Apr. 2020 - 31 Mar. 2023
小西 裕之; 兵頭 寿典, 小西 裕之; 兵頭 寿典, 日本学術振興会, 日本学術振興会

★The regulatory mechanism analysis of the constriction "velocity" at the contractile ring during mitosis
Grant-in-Aid for Early-Career Scientists
Aichi Medical University
01 Apr. 2018 - 31 Mar. 2022
兵頭 寿典, Hyodo Toshinori, 日本学術振興会, Japan Society for the Promotion of Science

Genome editing without DNA double-strand breaks mediated by CRISPR-Cas9 nickases
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2017 - 31 Mar. 2021
小西 裕之; 兵頭 寿典; シバスンダラン カルナン, Konishi Hiroyuki, 日本学術振興会, Japan Society for the Promotion of Science

★The analysis of new mitosis regulating protein LUZP1
Grant-in-Aid for Young Scientists (B)
Nagoya University
01 Apr. 2015 - 31 Mar. 2017
兵頭 寿典, HYODO Toshinori, 日本学術振興会, Japan Society for the Promotion of Science

DNA切断1本だけで安全ゲノム編集
（日刊）中日新聞, 19 Feb. 2020, Paper

DNAの2カ所切断避けてゲノム配列高効率書き換え
（週刊）科学新聞The Science News, 14 Feb. 2020, Paper