神経変性疾患

Neurodegenerative Diseases

Oct. 1998
愛知県医師会難病研究功労賞
道勇 学

Sep. 1997
かなえ医薬振興財団 研究助成金
Japan

Dorfin Ameliorates Phenotypes in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis
Jun Sone; Jun-ichi Niwa; Kaori Kawai; Shinsuke Ishigaki; Shin-ichi Yamada; Hiroaki Adachi; Masahisa Katsuno; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
JOURNAL OF NEUROSCIENCE RESEARCH, Jan. 2010, Not reviewed, No invitation
88(1), 123, 135, 10.1002/jnr.22175

Phase 2 Trial of Leuprorelin in Patients with Spinal and Bulbar Muscular Atrophy
Haruhiko Banno; Masahisa Katsuno; Keisuke Suzuki; Yu Takeuchi; Motoshi Kawashima; Noriaki Suga; Motoko Takamori; Mizuki Ito; Tomohiko Nakamura; Koji Matsuo; Shinichi Yamada; Yumiko Oki; Hiroaki Adachi; Makoto Minamiyama; Masahiro Waza; Naoki Atsuta; Hirohisa Watanabe; Yasushi Fujimoto; Tsutomu Nakashima; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
ANNALS OF NEUROLOGY, Feb. 2009, Not reviewed, No invitation
65(2), 140, 150, 10.1002/ana.21540

Neuropathic pain correlates with myelinated fibre loss and cytokine profile in POEMS syndrome
H. Koike; M. Iijima; K. Mori; M. Yamamoto; N. Hattori; H. Watanabe; F. Tanaka; M. Doyu; G. Sobue
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, Oct. 2008, Not reviewed, No invitation
79(10), 1171, 1179, 10.1136/jnnp.2007.135681

Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1
Jun-ichi Niwa; Shin-ichi Yamada; Shinsuke Ishigaki; Jun Sone; Miho Takahashi; Masahisa Katsuno; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2007, Not reviewed, No invitation
282(38), 28087, 28095, 10.1074/jbc.M704465200

Gene expressions specifically detected in motor neurons (Dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to Pathologic markers in sporadic amyotrophic lateral sclerosis
Yue-Mei Jiang; Masahiko Yamamoto; Fumiaki Tanaka; Shinsuke Ishigaki; Masahisa Katsuno; Hiroaki Adachi; Jun-ichi Niwa; Manabu Doyu; Marl Yoshida; Yoshio Hashizume; Gen Sobue
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, Jul. 2007, Not reviewed, No invitation
66(7), 617, 627, 10.1097/nen.0b013e318093ece3

CHIP overexpression reduces mutant androgen receptor protein and ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model
Hiroaki Adachi; Masahiro Waza; Keisuke Tokui; Masahisa Katsuno; Makoto Minamiyama; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
JOURNAL OF NEUROSCIENCE, May 2007, Not reviewed, No invitation
27(19), 5115, 5126, 10.1523/JNEUROSCI.1242-07.2007

Reversible disruption of dynactin 1-mediated retrograde axonal transport in polyglutamine-induced motor neuron degeneration
Masahisa Katsuno; Hiroaki Adachi; Makoto Minamiyama; Masahiro Waza; Keisuke Tokui; Haruhiko Banno; Keisuke Suzuki; Yu Onoda; Fumiaki Tanaka; Manabu Doyu; Gen Sobue
JOURNAL OF NEUROSCIENCE, Nov. 2006, Not reviewed, No invitation
26(47), 12106, 12117, 10.1523/JNEUROSCI.3032-06.2006

Archaeal proteasomes effectively degrade aggregation-prone proteins and reduce cellular toxicities in mammalian cells
Shin-ichi Yamada; Jun-ichi Niwa; Shinsuke Ishigaki; Miho Takahashi; Takashi Ito; Jun Sone; Manabu Doyu; Gen Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2006, Not reviewed, No invitation
281(33), 23842, 23851, 10.1074/jbc.M601274200

Mutant androgen receptor accumulation in spinal and bulbar muscular atrophy scrotal skin: A pathogenic marker
H Banno; H Adachi; M Katsuno; K Suzuki; N Atsuta; H Watanabe; F Tanaka; M Doyu; G Sobue
ANNALS OF NEUROLOGY, Mar. 2006, Not reviewed, No invitation
59(3), 520, 526, 10.1002/ana.20735

Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease
M Katsuno; C Sang; H Adachi; M Minamiyama; M Waza; F Tanaka; M Doyu; G Sobue
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2005, Not reviewed, No invitation
102(46), 16801, 16806, 10.1073/pnas.0506249102

17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
M Waza; H Adachi; M Katsuno; M Minamiyama; C Sang; F Tanaka; A Inukai; M Doyu; G Sobue
NATURE MEDICINE, Oct. 2005, Not reviewed, No invitation
11(10), 1088, 1095, 10.1038/nm1298

Widespread nuclear and cytoplasmic accumulation of mutant androgen receptor in SBMA patients
H Adachi; M Katsuno; M Minamiyama; M Waza; C Sang; Y Nakagomi; Y Kobayashi; F Tanaka; M Doyu; A Inukai; M Yoshida; Y Hashizume; G Sobue
BRAIN, Mar. 2005, Not reviewed, No invitation
128, 659, 670, 10.1093/brain/awh381

Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis
YM Jiang; M Yamamoto; Y Kobayashi; T Yoshihara; YD Liang; S Terao; H Takeuchi; S Ishigaki; M Katsuno; H Adachi; J Niwa; F Tanaka; M Doyu; M Yoshida; Y Hashizume; G Sobue
ANNALS OF NEUROLOGY, Feb. 2005, Not reviewed, No invitation
57(2), 236, 251, 10.1002/ana.20379

Dorfin localizes to Lewy bodies and ubiquitylates synphilin-1
T Ito; J Niwa; N Hishikawa; S Ishigaki; M Doyu; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2003, Not reviewed, No invitation
278(31), 29106, 29114, 10.1074/jbc.M302763200

Dorfin localizes to the ubiquitylated inclusions in Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and amyotrophic lateral sclerosis
N Hishikawa; J Niwa; M Doyu; T Ito; S Ishigaki; Y Hashizume; G Sobue
AMERICAN JOURNAL OF PATHOLOGY, Aug. 2003, Not reviewed, No invitation
163(2), 609, 619

Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
M Katsuno; H Adachi; M Doyu; M Minamiyama; C Sang; Y Kobayashi; A Inukai; G Sobue
NATURE MEDICINE, Jun. 2003, Not reviewed, No invitation
9(6), 768, 773, 10.1038/nm878

Heat shock protein 70 chaperone overexpression ameliorates phenotypes of the spinal and bulbar muscular atrophy transgenic mouse model by reducing nuclear-localized mutant androgen receptor protein
H Adachi; M Katsuno; M Minamiyama; C Sang; G Pagoulatos; C Angelidis; M Kusakabe; A Yoshiki; Y Kobayashi; M Doyu; G Sobue
JOURNAL OF NEUROSCIENCE, Mar. 2003, Not reviewed, No invitation
23(6), 2203, 2211

Differentially expressed genes in sporadic amyotrophic lateral sclerosis spinal cords - screening by molecular indexing and subsequent cDNA microarray analysis
S Ishigaki; J Niwa; Y Ando; T Yoshihara; K Sawada; M Doyu; M Yamamoto; K Kato; Y Yotsumoto; G Sobue
FEBS LETTERS, Nov. 2002, Not reviewed, No invitation
531(2), 354, 358, 10.1016/S0014-5793(02)03546-9

Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
J Niwa; S Ishigaki; N Hishikawa; M Yamamoto; M Doyu; S Murata; K Tanaka; N Taniguchi; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2002, Not reviewed, No invitation
277(39), 36793, 36798, 10.1074/jbc.M206559200

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy
M Katsuno; H Adachi; A Kume; M Li; Y Nakagomi; H Niwa; C Sang; Y Kobayashi; M Doyu; G Sobue
NEURON, Aug. 2002, Not reviewed, No invitation
35(5), 843, 854, 10.1016/S0896-6273(02)00834-6

Progression and prognosis in multiple system atrophy - An analysis of 230 Japanese patients
H Watanabe; Y Saito; S Terao; T Ando; T Kachi; E Mukai; Aiba, I; Y Abe; A Tamakoshi; M Doyu; M Hirayama; G Sobue
BRAIN, May 2002, Not reviewed, No invitation
125, 1070, 1083

X-linked inhibitor of apoptosis protein is involved in mutant SOD-1 mediated neuronal degeneration
Ishigaki S; Liang Y; Yamamoto M; Niwa J; Ando Y; Yoshihara T; Takeuchi H; Doyu M; Sobue G
J Neurochem, 2002, Not reviewed, No invitation
82(3), 576, 584, 10.1046/j.1471-4159.2002.00998.x

Differential expression of inflammation- and apoptosis-related genes in spinal coeds of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
Yoshihara T; Ishigaki S; Yamamoto M; Liang Y; Niwa J; Takeuchi H; Doyu M; Sobue G
J Neurochem, 2002, Not reviewed, No invitation
80(1), 158, 167, 10.1046/j.0022-3042.2001.00683.x

A novel centrosomal RING-finger protein, Dorfin, mediates ubiquitin ligase activity
J Niwa; S Ishigaki; M Doyu; T Suzuki; K Tanaka; G Sobue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2001, Not reviewed, No invitation
281(3), 706, 713, 10.1006/bbrc.2001.4414

Gene expression profile in Alzheimer's brain screened by molecular indexing
Manabu Doyu; Ko-ichi Sawada; Norimasa Mitsuma; Jun-ichi Niwa; Makoto Yoshimoto; Yasuyuki Fujii; Gen Sobue; Kikuya Kato
Molecular Brain Research, 19 Feb. 2001, Not reviewed, No invitation
87(1), 1, 11, 10.1016/S0169-328X(00)00223-0

A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and A-beta
Hashimoto Y; Niikura T; Tajima H; Yasukawa T; Sudo H; Ito Y; Kita Y; Kawasumi M; Kouyama K; Doyu M; Sobue G; Koide T; Tsuji S; Lang J; Kurokawa K; Nishimoto I
Proc Natl Acad Sci USA, 2001, Not reviewed, No invitation
98(11), 6336, 6341, 10.1073/pnas.101133498

Transgenic mice with an expanded CAG repeat controlled by human AR promoter show widespread but tissue-selective polyglutamine nuclear inclusions and neuronal dysfunction without neuronal cell death
Adachi H; Kume A; Li M; Nakagomi Y; Niwa H; Do J; Sang C; Kobayashi Y; Doyu M; Sobue G
Hum Mol Genet, 2001, Not reviewed, No invitation
10, 1039, 1048

Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11R alpha and OSMR beta) in peripheral nerve injury
Y Ito; M Yamamoto; M Li; N Mitsuma; F Tanaka; M Doyu; A Suzumura; T Mitsuma; G Sobue
NEUROCHEMICAL RESEARCH, Aug. 2000, Not reviewed, No invitation
25(8), 1113, 1118, 10.1023/A:1007674113440

Sisters homozygous for the spinocerebellar ataxia type 6 (SCA6)/CACNA1A gene associated with different clinical phenotypes
T Kato; F Tanaka; M Yamamoto; E Yosida; T Indo; H Watanabe; T Yoshiwara; M Doyu; G Sobue
CLINICAL GENETICS, Jul. 2000, Not reviewed, No invitation
58(1), 69, 73, 10.1034/j.1399-0004.2000.580112.x

Tumor necrosis factor-alpha expression in muscles of polymyositis and dermatomyositis
S Kuru; A Inukai; YD Liang; M Doyu; A Takano; G Sobue
ACTA NEUROPATHOLOGICA, May 2000, Not reviewed, No invitation
99(5), 585, 588

Chaperones Hsp70 and Hsp40 suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract
Y Kobayashi; A Kume; M Li; M Doyu; M Hata; K Ohtsuka; G Sobue
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2000, Not reviewed, No invitation
275(12), 8772, 8778, 10.1074/jbc.275.12.8772

Expression of HLA-DR and its enhancing molecules in muscle fibers in polymyositis
A Inukai; S Kuru; YD Liang; A Takano; Y Kobayashi; M Sakai; M Doyu; G Sobue
MUSCLE & NERVE, Mar. 2000, Not reviewed, No invitation
23(3), 385, 392, 10.1002/(SICI)1097-4598(200003)23:3<385::AID-MUS10>3.0.CO;2-T

An autopsy case with clinically and molecular genetically diagnosed Huntington's disease with only minimal non-specific neuropathological findings
H Mizuno; H Shibayama; F Tanaka; M Doyu; G Sobue; H Iwata; H Kobayashi; K Yamada; K Iwai; T Takeuchi; N Hashimoto; R Ishihara; Y Ibuki; S Ogasawara; M Ozeki
CLINICAL NEUROPATHOLOGY, Mar. 2000, Not reviewed, No invitation
19(2), 94, 103

特発性CD4陽性Tリンパ球減少症にともなう中枢神経系クリプトコッカス症の1例
臨床神経学, 2000, Not reviewed, No invitation
40, 249, 253

Two novel genes, human neugrin and mouse m-neugrin, are upregulated with neuronal differentiation in neuroblastoma cells
Ishigaki S; Niwa J; Yoshihara T; Mitsuma N; Doyu M; Sobue G
Biochem Biophys Res Commun, 2000, Not reviewed, No invitation
279(2), 526, 533, 10.1006/bbrc.2000.3971

Mutations in the peripheral myelin protein zero and connexin32 genes detected by non-isotopic RNase cleavage assay and their phenotypes in Japanese patients with Charcot-Marie-Tooth disease
Tsuyoshi Yoshihara; Masahiko Yamamoto; Manabu Doyu; Ken-Ichiro Mis; Naoki Hattori; Yasuhiro Hasegawa; Kenji Mokuno; Terunori Mitsuma; Gen Sobue
Human mutation, 2000, Not reviewed, No invitation
16(2), 177, 178, 10.1002/1098-1004(200008)16:2<177::AID-HUMU14>3.0.CO;2-5

Tissue-specific somatic mosaicism in spinal and bulbar muscular atrophy is dependent on CAG-repeat length and androgen receptor-gene expression level
F Tanaka; MF Reeves; Y Ito; M Matsumoto; M Li; S Miwa; A Inukai; M Yamamoto; M Doyu; M Yoshida; Y Hashizume; S Terao; T Mitsuma; G Sobue
AMERICAN JOURNAL OF HUMAN GENETICS, Oct. 1999, Not reviewed, No invitation
65(4), 966, 973, 10.1086/302578

Nerve growth factor prevention of aged-rat sympathetic neuron injury by cisplatin, vincristine and taxol - in vitro explant study
K Hayakawa; T Itoh; H Niwa; M Yamamoto; YD Liang; M Doyu; G Sobue
NEUROSCIENCE LETTERS, Oct. 1999, Not reviewed, No invitation
274(2), 103, 106, 10.1016/S0304-3940(99)00689-8

ニューロサイエンスの新しい研究方法； 「分子インデックス法（Molecular indexing）」
道勇 学; 祖父江元
CLINICAL NEUROSCIENCE, 1999, Not reviewed, No invitation
17, 366, 367

Differential temporal expression of mRNAs for ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), and their receptors (CNTFR a alpha, LIFR beta, IL-6R alpha and gp130) in injured peripheral nerves
Y Ito; M Yamamoto; M Li; M Doyu; F Tanaka; T Mutch; T Mitsuma; G Sobue
BRAIN RESEARCH, May 1998, Not reviewed, No invitation
793(1-2), 321, 327, 10.1016/S0006-8993(98)00242-X

運動ニューロン疾患ーupdate；「球脊髄性筋萎縮症」
道勇 学; 祖父江元
CLINICAL NEUROSCIENCE, 1998, Not reviewed, No invitation
16, 867, 869

発症年齢特異性のある中枢神経疾患；「脊髄小脳変性症と好発年齢」
田中章景; 道勇 学; 祖父江元
CLINICAL NEUROSCIENCE, 1998, Not reviewed, No invitation
16, 43, 46

Caspase-3 cleaves the expanded androgen receptor protein of spinal and bulbar muscular atrophy in a polyglutamine repeat length-dependent manner(共著)
Biochemical and Biophysical Research Communications, 1998, Not reviewed, No invitation
252(1), 145, 150, 10.1006/bbrc.1998.9624

CAG repeat number correlates with the rate of brainstem and cerebellar atrophy in Machado-Joseph disease(共著)
Neurology, 1998, Not reviewed, No invitation
51, 882

Nonneural nuclear inclusions of androgen receptor protein in spinal and bulbar muscular atrophy(共著)
American Journal of Pathology, 1998, Not reviewed, No invitation
153, 695

Nuclear inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy(共著)
Annals of Neurology, 1998, Not reviewed, No invitation
44, 249

Advanced glycation endproducte co-localized with astrocytes and microglial cells in Alzheimer's disease brain(共著)
Acta Neuropathologica, 1998, Not reviewed, No invitation
95, 555, 10.1007/s004010050839

Somatic mosaicism of the expanded CAG trinucleotide repeat in mRNAs for the responsible gene of Machado-Joseph disease(MJD), dentatorubural-pallidoluysian atrophy(DRPLA), and spinal and bulbar muscular atrophy(SBMA)(共著)
Neurochemical Research, 1998, Not reviewed, No invitation
23(1), 25, 32, 10.1023/A:1022441101801

Expression of Fas antigen is not associated with apoptosis in human myopathies
A Inukai; Y Kobayashi; K Ito; M Doyu; A Takano; H Honda; G Sobue
MUSCLE & NERVE, Jun. 1997, Not reviewed, No invitation
20(6), 702, 709, 10.1002/(SICI)1097-4598(199706)20:6<702::AID-MUS7>3.0.CO;2-C

運動ニューロン疾患研究の最近の進歩；「球脊髄性筋萎縮症における変異アンドロゲン受容体と運動ニューロン死」
李 めい; 三輪 茂; 田中章景; 道勇 学; 祖父江元
神経研究の進歩, 1997, Not reviewed, No invitation
41(6), 904, 910, 10.11477/mf.1431901010

Triplet repeat diseases；「球脊髄性筋萎縮症 (SBMA)」
道勇 学; 田中章景; 祖父江元
神経研究の進歩, 1997, Not reviewed, No invitation
41, 357, 366

抗GM1抗体、良性M蛋白血症を認め、免疫グロブリンの大量療法が著効した慢性再発性脱髄性多発ニューロパチー
水野桂子; 斎藤浩一; 道勇 学; 安田武司; 祖父江元
神経内科, 1997, Not reviewed, No invitation
46, 247, 252

球脊髄性筋萎縮症(SBMA)
神経研究の進歩, 1997, Not reviewed, No invitation
41(3), 357

CAG repeat length and disease duration in Machado-Joseph disease : a new clinical classification(共著)
Journal of Neurological Sciennce, 1997, Not reviewed, No invitation
152, 166, 10.1016/S0022-510X(97)00155-X

Axonal pathology in Japanese Guillain-Barr(]J1117[) syndrome : a study of 15 antopsied cases(共著)
Neurology, 1997, Not reviewed, No invitation
48(6), 1694

Spinal and bulbar muscular atrophy and CAG repeat expansion in androgen receptor gene
Advances in Neurological Sciences, 1997, Not reviewed, No invitation
41(3), 357

Founder effect in spinal and bulbar muscular atrophy (SBMA)
F Tanaka; M Doyu; Y Ito; M Matsumoto; T Mitsuma; K Abe; M Aoki; Y Itoyama; KH Fischbeck; G Sobue
HUMAN MOLECULAR GENETICS, Sep. 1996, Not reviewed, No invitation
5(9), 1253, 1257

球脊髄性筋萎縮症におけるアンドロゲンレセプターの機能異常
道勇 学; 祖父江元
BRAIN MEDICAL, 1996, Not reviewed, No invitation
8, 27, 33

Differential pattern in tissue-specific somatic mosaicism of expanded CAG trinucleotide repeat in dentatorubral-pallidoluysian atrophy, Machado-Joseph disease, and X-linked recessive spinal and bulbar muscular atrophy
Fumiaki Tanaka; Gen Sobue; Manabu Doyu; Yasuhiro Ito; Masahiko Yamamoto; Noriko Shimada; Koji Yamamoto; Shigeo Riku; Yoshio Hshizume; Terunori Mitsuma
Journal of the Neurological Sciences, 1996, Not reviewed, No invitation
135(1), 43, 50, 10.1016/0022-510X(95)00249-2

脊髄性筋萎縮症
道勇 学; 祖父江元
CLINICAL NEUROSCIENCE, 1995, Not reviewed, No invitation
13, 1300, 1301

高齢発症の家族性アミロイドポリニューロパチー（FAP type I）の１家系：発症に関する保因者同胞間の変異
梅村敏隆; 祖父江元; 森下真次; 田中章景; 道勇 学; 榊原敏正
臨床神経学, 1995, Not reviewed, No invitation
35, 505, 508

Charcot-Marie-Tooth病におけるPMP-22遺伝子の異常 ーPMP-22遺伝子重複の検索におけるサザン法とPCR法との対比ー
山本正彦; 祖父江元; 熊沢和彦; 道勇 学; 満間照典; 早坂 清
脳と神経, 1995, Not reviewed, No invitation
47, 687, 691

Primary sensory neurons in X-linked recessive bulbospinal neuronopathy : histopathological and androgen receptor gene expression.
Muscle Nerve, 1995, Not reviewed, No invitation
18, 301, 308

Molecular features of the CAG repeats and clinical manifestation of Machado-Joseph disease.
Hum Mol Genet, 1995, Not reviewed, No invitation
4, 808, 812

Unique features of the CAG repeats in Machado-Joseph disease.
Nature Genetics, 1995, Not reviewed, No invitation
9, 344

X-linked recessive bulbospinal neuronopathy : clinical phenotypes and CAG repeat size in androgen receptor gene.
Muscle and Nerve, 1995, Not reviewed, No invitation
18, 1378

ANDROGEN RECEPTOR MESSENGER-RNA WITH INCREASED SIZE OF TANDEM CAG REPEAT IS WIDELY EXPRESSED IN THE NEURAL AND NONNEURAL TISSUES OF X-LINKED RECESSIVE BULBOSPINAL NEURONOPATHY
M DOYU; G SOBUE; K KIMATA; K YAMAMOTO; T MITSUMA
JOURNAL OF THE NEUROLOGICAL SCIENCES, Dec. 1994, Not reviewed, No invitation
127(1), 43, 47

ABERRANT ANDROGEN ACTION AND INCREASED SIZE OF TANDEM CAG REPEAT IN ANDROGEN RECEPTOR GENE IN X-LINKED RECESSIVE BULBOSPINAL NEURONOPATHY
G SOBUE; M DOYU; T MORISHIMA; E MUKAI; T YASUDA; T KACHI; T MITSUMA
JOURNAL OF THE NEUROLOGICAL SCIENCES, Feb. 1994, Not reviewed, No invitation
121(2), 167, 171

伴性劣性球脊髄性筋萎縮症のアンドロゲン受容体遺伝子異常と臨床徴候
祖父江元; 道勇 学
神経内科, 1994, Not reviewed, No invitation
41, 349, 356

道勇 学、祖父江元 アンドロゲン受容体遺伝子異常と細胞内情報伝達系
道勇 学; 祖父江元
神経内科, 1994, Not reviewed, No invitation
41, 329, 337

FAMILIAL AMYLOIDOTIC POLYNEUROPATHY WITH LATE-ONSET AND WELL-PRESERVED AUTONOMIC FUNCTION - A JAPANESE KINDRED WITH NOVEL MUTANT TRANSTHYRETIN (ALA(97) TO GLY)
T YASUDA; G SOBUE; M DOYU; M NAKAZATO; K SHIOMI; T YANAGI; T MITSUMA
JOURNAL OF THE NEUROLOGICAL SCIENCES, Jan. 1994, Not reviewed, No invitation
121(1), 97, 102

GENE-EXPRESSION OF HIGH-AFFINITY (P140(TRK)) AND LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR (LNGFR) IN THE ADULT AND AGED HUMAN PERIPHERAL NERVOUS-SYSTEM
M YAMAMOTO; G SOBUE; T MUTOH; M LI; M DOYU; T MITSUMA; K KIMATA
NEUROSCIENCE LETTERS, Aug. 1993, Not reviewed, No invitation
158(1), 39, 43, 10.1016/0304-3940(93)90607-M

SUBCLINICAL PHENOTYPIC EXPRESSIONS IN HETEROZYGOUS FEMALES OF X-LINKED RECESSIVE BULBOSPINAL NEURONOPATHY
G SOBUE; M DOYU; T KACHI; T YASUDA; E MUKAI; T KUMAGAI; T MITSUMA
JOURNAL OF THE NEUROLOGICAL SCIENCES, Jul. 1993, Not reviewed, No invitation
117(1-2), 74, 78

LAMININ-A, LAMININ-B1, AND LAMININ-B2 CHAIN GENE-EXPRESSION IN TRANSECTED AND REGENERATING NERVES - REGULATION BY AXONAL SIGNALS
M DOYU; G SOBUE; E KEN; K KIMATA; T SHINOMURA; Y YAMADA; T MITSUMA; A TAKAHASHI
JOURNAL OF NEUROCHEMISTRY, Feb. 1993, Not reviewed, No invitation
60(2), 543, 551, 10.1111/j.1471-4159.1993.tb03183.x

古典型Pelizeus-Merzbacher病の成人男性例 ー神経病理所見とMRI所見の対比ー
斉藤由扶子; 安藤哲朗; 道勇 学; 高橋 昭; 橋詰良夫
臨床神経学, 1993, Not reviewed, No invitation
33, 187, 193

Very late-onset X-linked recessive bulbospinal neuronopathy : mild clinical features and a mild increase in the size of tandem CAG repeat in androgen receptor gene.
Journal of Neurdogy neurosurgery and Psyclriatry, 1993, Not reviewed, No invitation
56, 832

伴性劣性球脊髄性筋萎縮症におけるアンドロゲンレセプター遺伝子異常 ーCAGくりかえし配列部位の異常延長とその診断的意義ー
道勇 学; 祖父江元; 向井栄一郎; 高橋 昭; 満間照典
臨床神経学, 1992, Not reviewed, No invitation
32(336), 336, 339

Severity of X-linked recessive bulbospinal neuronopathy correlates with size of the tandem CAG repeat in androgen receptor gene.
Annals of Neurology, 1992, Not reviewed, No invitation
32(5), 707

整形外科学大系 第22巻 末梢神経障害、筋疾患、循環障害 球脊髄性筋萎縮症」
中山書店, 2006, Not reviewed

老年期痴呆の治療と看護 ８ 痴呆の予防のために
南江堂, 2002, Not reviewed

医学大事典「アンドロゲン受容体」「アンドロゲン受容体遺伝子」「アンドロゲン受容体遺伝子異常」「AIP遺伝子」「XS2G3」「ケネディ病」
医学書院, 2002, Not reviewed

看護のための最新医学講座、第４巻、脳・神経疾患 球脊髄性筋萎縮症、脊髄性筋萎縮症
中山書店, 2002, Not reviewed

Amelioration of motor neuron disease model with molecular chaperons ---- with special reference to spinal and bulbar muscular atrophy---. Abe K (Eds), Molecular Mechanism and Therapeutics of Amyotrophic Lateral Sclerosis
Elsevier Science New York, 2001, Not reviewed

KEYWORD 1998-'99 神経変性疾患 球脊髄性筋萎縮症と変異アンドロゲン受容体
先端医学社, 1998, Not reviewed

Molecular Medicine Vol.34 増刊、ノックアウトマウス・データブック Huntington's disease gene homolog (Hdh), IT15 / Huntingtin
中山書店, 1997, Not reviewed

臨床検査 増刊 神経系疾患と臨床検査 I. 生化学・遺伝子；9. 球脊髄性筋萎縮症 (SBMA)
医学書院, 1996, Not reviewed

分子神経病学 伴性劣性球脊髄性筋萎縮症
南江堂, 1996, Not reviewed

Molecular Medicine 増刊 遺伝子病マニュアル 伴性劣性球脊髄性筋萎縮症
中山書店, 1995, Not reviewed

Molecular Medicine 増刊 遺伝子病マニュアル 脊髄性筋萎縮症
中山書店, 1995, Not reviewed

モダンコンセプト神経内科５ 伴性劣性球脊髄性筋萎縮症
医学書院, 1995, Not reviewed

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