hatano sonoko
Institute for Molecular Science of Medicine | Assistant Professor |
Profile
Research area
分子生物学
栄養学
薬膳学Graduating school
名古屋大学農学部（1990年）Final Education
名古屋大学大学院農学研究科（1992年）Previous workplace
名古屋大学医学部（1995年4月～2003年1月）Main academic activities
日本癌学会
日本臨床栄養学会Main research topic
コンドロイチン硫酸プロテオグリカン・バーシカンの生体への制御機構の解明
コンドロイチン硫酸合成酵素の生体内機能の解明
間葉系幹細胞と老化Self-introduction
農学部で栄養学を学び，その後，医学部で血液腫瘍の研究をしながら，学位を取らせて頂きました。従って，臨床医ではなく研究者です。
長年，生体内の分子ばかりを追いかけてきましたが，「ヒトの健康は食がベースである。」というごく当たり前のことが，現代社会では疎かになっているということに気付きました。そこで中医学から派生した薬膳学を学び，北京中医薬大学認定の国際中医薬膳師という免許を取得し，食に関するアドバイスができるようになりました。健康維持のための薬膳は，苦くて臭い生薬を使わず，身近な食材でできます。一人ひHobby
映画や舞台鑑賞
コンサート
美術館巡りなど芸術を鑑賞すること
旅行
Paper
- Regulatory role of Heparan sulfate in leptin signaling
Naoko Nagai; Tatsumasa Shioiri; Sonoko Hatano; Nobuo Sugiura; Hideto Watanabe
Cellular Signalling, Dec. 2024
124, 111456, 111456, 10.1016/j.cellsig.2024.111456 - Fibulin-1 Integrates Subendothelial Extracellular Matrices and Contributes to Anatomical Closure of the Ductus Arteriosus
Satoko Ito; Utako Yokoyama; Taichi Nakakoji; Marion A. Cooley; Takako Sasaki; Sonoko Hatano; Yuko Kato; Junichi Saito; Naoki Nicho; Shiho Iwasaki; Masanari Umemura; Takayuki Fujita; Munetaka Masuda; Toshihide Asou; Yoshihiro Ishikawa
Arteriosclerosis, Thrombosis, and Vascular Biology, Sep. 2020, Reviewed
40(9), 2212, 2226, 10.1161/atvbaha.120.314729 - Effects of Fibroblast Growth Factor 2 on Burn Injury and Repair Process: Analysis Using a Refined Mouse Model.
Kensaku Hishida; Sonoko Hatano; Hiroshi Furukawa; Kazuhisa Yokoo; Hideto Watanabe
Plastic and reconstructive surgery. Global open, Apr. 2020, Reviewed, No invitation
8(4), e2757, 10.1097/GOX.0000000000002757 - Regulation of Macrophage and Dendritic Cell Function by Chondroitin Sulfate in Innate to Antigen-Specific Adaptive Immunity.
Sonoko Hatano; Hideto Watanabe
Frontiers in immunology, 2020, Reviewed, No invitation
Lead, 11, 232, 232, 10.3389/fimmu.2020.00232 - Accumulation of versican facilitates wound healing: Implication of its initial ADAMTS-cleavage site
Shamima Islam; Kantinan Chuensirikulchai; Saichit Khummuang; Tanyaporn Keratibumrungpong; Prachya Kongtawelert; Watchara Kasinrerk; Sonoko Hatano; Akiko Nagamachi; Hiroaki Honda; Hideto Watanabe
Matrix Biology, Oct. 2019, Reviewed, No invitation - The plant alkaloid conophylline inhibits matrix formation of fibroblasts.
Takehiko Tezuka; Akinobu Ota; Sivasundaram Karnan; Katsuhiko Matsuura; Kazuhisa Yokoo; Yoshitaka Hosokawa; Davide Vigetti; Alberto Passi; Sonoko Hatano; Kazuo Umezawa; Hideto Watanabe
The Journal of biological chemistry, Dec. 2018, Reviewed, No invitation
293(52), 20214, 20226, 10.1074/jbc.RA118.005783 - Versican A-subdomain is required for its adequate function in dermal development.
Sonoko Hatano; Naoko Nagai; Nobuo Sugiura; Jun Tsuchimoto; Zenzo Isogai; Koji Kimata; Akinobu Ota; Sivasundaram Karnan; Yoshitaka Hosokawa; Hideto Watanabe
Connective tissue research, Mar. 2018, Reviewed, No invitation
Lead, 59(2), 178, 190, 10.1080/03008207.2017.1324432 - Host stromal versican is essential for cancer-associated fibroblast function to inhibit cancer growth
Kanda Fanhchaksai; Futoshi Okada; Naoko Nagai; Peraphan Pothacharoen; Prachya Kongtawelert; Sonoko Hatano; Shinji Makino; Tomoyuki Nakamura; Hideto Watanabe
INTERNATIONAL JOURNAL OF CANCER, Feb. 2016, Reviewed, No invitation
138(3), 630, 641, 10.1002/ijc.29804 - Versican/PG-M is essential for ventricular septal formation subsequent to cardiac atrioventricular cushion development
Sonoko Hatano; Koji Kimata; Noriko Hiraiwa; Moriaki Kusakabes; Zenzo Isogai; Eijiro Adachi; Tamayuki Shinomura; Hideto Watanabe
GLYCOBIOLOGY, Sep. 2012, Reviewed, No invitation
Lead, 22(9), 1268, 1277, 10.1093/glycob/cws095 - Chondroitin Sulfate Synthase-2 Is Necessary for Chain Extension of Chondroitin Sulfate but Not Critical for Skeletal Development
Hiroyasu Ogawa; Sonoko Hatano; Nobuo Sugiura; Naoko Nagai; Takashi Sato; Katsuji Shimizu; Koji Kimata; Hisashi Narimatsu; Hideto Watanabe
PLOS ONE, Aug. 2012, Reviewed, No invitation
7(8), e43806, 10.1371/journal.pone.0043806 - Chondroitin Sulfate Synthase-2/Chondroitin Polymerizing Factor Has Two Variants with Distinct Function
Hiroyasu Ogawa; Masafumi Shionyu; Nobuo Sugiura; Sonoko Hatano; Naoko Nagai; Yukihiko Kubota; Kiyoji Nishiwaki; Takashi Sato; Masanori Gotoh; Hisashi Narimatsu; Katsuji Shimizu; Koji Kimata; Hideto Watanabe
JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, Reviewed, No invitation
285(44), 34155, 34167, 10.1074/jbc.M110.109553 - Versican Facilitates Chondrocyte Differentiation and Regulates Joint Morphogenesis
Kanyamas Choocheep; Sonoko Hatano; Hidekazu Takagi; Hiroki Watanabe; Koji Kimata; Prachya Kongtawelert; Hideto Watanabe
JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2010, Reviewed, No invitation
285(27), 21114, 21125, 10.1074/jbc.M109.096479 - Versican/PG-M Assembles Hyaluronan into Extracellular Matrix and Inhibits CD44-mediated Signaling toward Premature Senescence in Embryonic Fibroblasts
Keittisak Suwan; Kanyamas Choocheep; Sonoko Hatano; Prachya Kongtawelert; Koji Kimata; Hideto Watanabe
JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2009, Reviewed, No invitation
284(13), 8596, 8604, 10.1074/jbc.M806927200 - Alteration of chondroitin sulfate composition on proteoglycan produced by knock-in mouse embryonic fibroblasts whose versican lacks the A subdomain
Keittisak Suwan; Sonoko Hatano; Prachya Kongtawelert; Peraphan Pothacharoen; Hideto Watanabe
UPSALA JOURNAL OF MEDICAL SCIENCES, 2009, Reviewed, No invitation
114(2), 73, 81, 10.1080/03009730902761722 - Mutations and aberrant DNA methylation of the PROX1 gene in hematologic malignancies
H Nagai; YH Li; S Hatano; O Toshihito; M Yuge; E Ito; M Utsumi; H Saito; T Kinoshita
GENES CHROMOSOMES & CANCER, Sep. 2003, Reviewed, No invitation
38(1), 13, 21, 10.1002/gcc.10248 - The MAGE-A1 gene expression is not determined solely by methylation status of the promoter region in hematological malignancies
T Suyama; H Ohashi; H Nagai; S Hatano; H Asano; T Murate; H Saito; T Kinoshita
LEUKEMIA RESEARCH, Dec. 2002, Reviewed, No invitation
26(12), 1113, 1118, 10.1016/S0145-2126(02)00048-6 - Aberrant DNA methylation of p57(KIP2) gene in the promoter region in lymphoid malignancies of B-cell phenotype
YH Li; H Nagai; T Ohno; M Yuge; S Hatano; E Ito; N Mori; H Saito; T Kinoshita
BLOOD, Oct. 2002, Reviewed, No invitation
100(7), 2572, 2577, 10.1182/blod-2002-11-0026 - Avoidance of bone marrow suppression using A-5021 as a nucleoside analog for retrovirus-mediated herpes simplex virus type I thymidine kinase gene therapy
Y Hasegawa; Y Nishiyama; K Imaizumi; N Ono; T Kinoshita; S Hatano; H Saito; K Shimokata
CANCER GENE THERAPY, Apr. 2000, Reviewed, No invitation
7(4), 557, 562, 10.1038/sj.cgt.7700134 - Histone deacetylase inhibitors are the potent inducer/enhancer of differentiation in acute myeloid leukemia: a new approach to anti-leukemia therapy
H Kosugi; M Towatari; S Hatano; K Kitamura; H Kiyoi; T Kinoshita; M Tanimoto; T Murate; K Kawashima; H Saito; T Naoe
LEUKEMIA, Sep. 1999, Reviewed, No invitation
13(9), 1316, 1324 - Identification and mapping of novel tumor suppressor loci on 6p in diffuse large B-cell non-Hodgkin's lymphoma
H Nagai; T Kinoshita; H Suzuki; S Hatano; T Murate; H Saito
GENES CHROMOSOMES & CANCER, Jul. 1999, Reviewed, No invitation
25(3), 277, 283, 10.1002/(SICI)1098-2264(199907)25:3<277::AID-GCC10>3.0.CO;2-L - Clonality analysis of granulocytes and T lymphocytes in healthy females by the PCR-based HUMARA method
Y Nakahara; H Suzuki; H Ohashi; S Hatano; A Tomita; T Kinoshita; T Murate; H Saito; T Hotta
INTERNATIONAL JOURNAL OF HEMATOLOGY, Jun. 1999, Reviewed, No invitation
69(4), 237, 243 - Mutational analysis of the PTEN/MMAC1 gene in non-Hodgkin's lymphoma
Y Nakahara; H Nagai; T Kinoshita; T Uchida; S Hatano; T Murate; H Saito
LEUKEMIA, Aug. 1998, Reviewed, No invitation
12(8), 1277, 1280 - Production and effects of interleukin-6 and other cytokines in patients with non-Hodgkin's lymphoma
H Kato; H Kinoshita; S Suzuki; T Nagasaka; S Hatano; T Murate; H Saito; T Hotta
LEUKEMIA & LYMPHOMA, Mar. 1998, Reviewed, No invitation
29(1-2), 71, +, 10.3109/10428199809058383 - The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis
T Murate; K Yamashita; C Isogai; H Suzuki; M Ichihara; S Hatano; Y Nakahara; T Kinoshita; T Nagasaka; S Yoshida; N Komatsu; Y Miura; T Hotta; N Fujimoto; H Saito; T Hayakawa
BRITISH JOURNAL OF HAEMATOLOGY, Oct. 1997, Reviewed, No invitation
99(1), 181, 189 - A SIMPLIFIED 2-TIME-POINT METHOD FOR MEASURING WHOLE-BODY PROTEIN-SYNTHESIS IN CHICKEN EMBRYOS CULTURED IN-VITRO - RESPONSE TO FRAGMENTED BOVINE GROWTH-HORMONE
T MURAMATSU; S SHIMOMURA; S HATANO; K KITA; J OKUMURA
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY, Dec. 1993, Reviewed, No invitation
106(4), 635, 639
MISC
- Chondroitin sulfate regulates bone marrow mesenchymal stem cell differentiation.
Sonoko Hatano; Hideto Watabane
89th Harden Conference - Proteoglycans: Matrix Master Regulators 2023, Sep. 2023
Lead - 骨髄間葉系幹細胞の分化を制御するコンドロイチン硫酸の構造
幡野その子、渡辺秀人
第7回日本骨免疫学会抄録集, Jun. 2022
Lead - コノフィリンは,TGFβ媒介経路を介して線維芽細胞におけるヒアルロナン生合成を阻害する
手塚剛彦; 手塚剛彦; 太田明伸; KARNAN S; 横尾和久; 幡野その子; 梅澤一夫; 渡辺秀人
日本結合組織学会学術大会抄録集, Jun. 2018, Not reviewed, No invitation
50回, 92, 92 - バーシカンがつくるがん微小環境とその制御
FANHCHAKSAI Kanda; FANHCHAKSAI Kanda; KLANGJORHOR Jeerawan; KHUMMUANG Saichit; KHUMMUNG Saichit; ISLAM Shamima; 永井尚子; 幡野その子; KONTAWELERT Prachya; KASINRERK Watchara; 岡田太; 渡辺秀人
日本結合組織学会学術大会抄録集, 16 Jun. 2017, Not reviewed, No invitation
49th, 55 - 心血管系平滑筋細胞特異的バーシカン欠失マウスの疾患モデルマウスとしての有用性
幡野 その子; 高木 秀和; 木全 弘治; 渡辺 秀人
愛知医科大学加齢医科学研究所紀要, Jan. 2016, Not reviewed, No invitation
11, 47, 48 - 細胞外マトリックスプロテオグリカンによる腫瘍微小環境の形成と腫瘍制御
FANHCHAKSAI Kanda; FANHCHAKSAI Kanda; 岡田太; 永井尚子; KONGTAWELERT Prachya; 幡野その子; 渡辺秀人
日本結合組織学会学術大会抄録集, May 2015, Not reviewed, No invitation
47th, 115, 115 - Versican Secretion from Endocardium is Required for Chamber Formation via The Recruitment of Cardiac Progenitors
Sung-Han Yoon; Yuta Higashikuse; Toshimi Kageyama; Mayumi Oda; Ruri Kaneda; Motoaki Sano; Shinsuke Yuasa; Misato Fujita; Atsushi Kawakami; Atsushi Shimizu; Sonoko Hatano; Hideto Watanabe; Akira Kudo; Shinji Makino; Keiichi Fukuda
CIRCULATION, Nov. 2012, Not reviewed, No invitation
126(21) - Chondroitin sulfate synthase-2/chondroitin polymerizing factor: Characterization and impact on chondroitin sulfate biosynthesis
Hideto Watanabe; Hiroyasu Ogawa; Masafumi Shionyu; Nobuo Sugiura; Sonoko Hatano; Naoko Nagai; Takashi Sato; Hisashi Narimatsu; Katsuji Shimizu; Koji Kimata
GLYCOBIOLOGY, Nov. 2012, Not reviewed, No invitation
22(11), 1598, 1599 - 細胞外マトリックス成分の新規機能 生体内におけるバーシカン/PG-Mの機能:ノックインマウスを用いた解析
渡辺 秀人; 幡野 その子; 平岩 典子; 日下部 守昭; 安達 栄治郎; 篠村 多摩之; 木全 弘治
日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, May 2007
39回・54回, 53, 53 - Versican/PG-Mの器官形成における役割:ノックインマウスからの解析
幡野その子; 木全弘治; 安達栄治郎; 平岩典子; 日下部守昭; 篠村多摩之; 渡辺秀人
日本糖質学会年会要旨集, 2005
25th - In vitro effects of recombinant human IL-11 on human malignant lymphoma cells.
Sonoko Hatano; Haruhiko Asano; Hirokazu Nagai; Takashi Murate; Naoyoshi Mori; Kouhei Kawashima; Hidehiko Saito; Tomohiro Kinoshita
J Clin Exp Hematopathol, 2002, Not reviewed, No invitation
42(2), 55, 60, 10.3960/jslrt.42.55 - Correlation of gene expression between FKLF/FKLF-2 and gamma globin gene in individual BFU-E colonies of a patient with anemia.
E Aoki; H Asano; S Hatano; G Stamatoyannopoulos; T Kinoshita; T Murate; H Saito
BLOOD, Nov. 2001, Not reviewed, No invitation
98(11), 500A, 500A - PROX1 as a candidate tumor suppressor gene of lymphoid malignancies.
H Nagai; T Kinoshita; S Hatano; M Yuge; T Ohno; E Ito; H Saito
BLOOD, Nov. 2000, Not reviewed, No invitation
96(11), 175B, 175B - In vitro differentiation of leukemia blasts isolated from AML patients by histone deacetylase inhibitors: A new approach of anti-leukemic therapy.
H Kosugi; M Towatari; S Hatano; K Kitamura; T Kinoshita; M Tanimoto; K Kawashima; T Naoe; H Saito
BLOOD, Nov. 1998, Not reviewed, No invitation
92(10), 509A, 509A
Books and other publications
- Autoimmune Reaction and Bile Acid in the Atherosclerotic Aorta
Tomofumi Nagareda; Nobuaki Hirata; Sonoko Hatano
GlobeEdit, Sep. 2019
6139417651
72
Research Themes
- コンドロイチン硫酸による免疫応答制御：糖鎖構造とシグナル伝達機構
基盤研究(C)
愛知医科大学
01 Apr. 2020 - 31 Mar. 2023
幡野 その子, 幡野 その子, 日本学術振興会, 日本学術振興会 - Roles of chondroitin sulfate proteoglycan in maintenance of tissue structure and its remodeling under pathological conditions
Grant-in-Aid for Scientific Research (B)
Aichi Medical University
2010 - 2012
渡辺 秀人; 杉浦 信夫; 永井 尚子; 幡野 その子, 渡辺 秀人; 杉浦 信夫; 永井 尚子; 幡野 その子, 日本学術振興会, Japan Society for the Promotion of Science - The extracellular microenvironment and its signal regulations operated by proteoglycans
Grant-in-Aid for Scientific Research (B)
Aichi Medical University
2007 - 2009
渡辺 秀人; 幡野 その子, WATANABE Hideto; HATANO Sonoko, 日本学術振興会, Japan Society for the Promotion of Science
