変形性関節症

フレイル

関節リウマチ

Factors associated with discrepancies in disease activity as assessed by SDAI and RAPID3 in patients with rheumatoid arthritis: Data from a multicenter observational study (T-FLAG).
Mochihito Suzuki; Shuji Asai; Yoshifumi Ohashi; Yasumori Sobue; Hisato Ishikawa; Nobunori Takahashi; Kenya Terabe; Ryo Sato; Hironobu Kosugiyama; Junya Hasegawa; Yusuke Ohno; Takaya Sugiura; Shiro Imagama
Modern rheumatology, 2024年05月
10.1093/mr/roae040

Choice of and response to treatment in patients with early-diagnosed rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J).
Mochihito Suzuki; Shuji Asai; Ryota Hara; Yuji Hirano; Satomi Nagamine; Tetsuya Kaneko; Hideo Sakane; Tadashi Okano; Yutaka Yoshioka; Shigeyoshi Tsuji; Hiroki Wakabayashi; Yuya Takakubo; Toki Takemoto; Takayoshi Fujibayashi; Tatsuo Watanabe; Takefumi Kato; Hajime Ishikawa; Yoshihisa Nasu; Eiji Torikai; Atsushi Kaneko; Hideki Takagi; Toshifumi Fujiwara; Daisuke Kihira; Kyosuke Hattori; Kenji Kishimoto; Yoshifumi Ohashi; Yasumori Sobue; Yutaka Yokota; Tsuyoshi Nishiume; Kenya Terabe; Nobunori Takahashi; Masayo Kojima; Shiro Imagama; Toshihisa Kojima
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2024年05月
29(3), 921, 926, 10.1016/j.jos.2023.03.020

Intervertebral fusion sites in patients with ankylosing spondylitis: A computed tomography study.
Kenji Kishimoto; Shuji Asai; Mochihito Suzuki; Daisuke Kihira; Ryo Sato; Kenya Terabe; Yoshifumi Ohashi; Masataka Maeda; Shiro Imagama
Modern rheumatology, 2024年03月
34(3), 599, 606, 10.1093/mr/road065

Comparison of effectiveness of methotrexate in patients with late-onset versus younger-onset rheumatoid arthritis: Real-world data from an inception cohort in Japan (NICER-J).
Shuji Asai; Mochihito Suzuki; Ryota Hara; Yuji Hirano; Satomi Nagamine; Tetsuya Kaneko; Takahito Suto; Tadashi Okano; Yutaka Yoshioka; Makoto Hirao; Hiroki Wakabayashi; Takayoshi Fujibayashi; Tatsuo Watanabe; Yuya Takakubo; Hajime Ishikawa; Yoshihisa Nasu; Toki Takemoto; Takefumi Kato; Eiji Torikai; Kensuke Koyama; Hideki Takagi; Toshifumi Fujiwara; Yasumori Sobue; Yoshifumi Ohashi; Tsuyoshi Nishiume; Kenya Terabe; Masayo Kojima; Toshihisa Kojima; Shiro Imagama
Modern rheumatology, 2024年03月
10.1093/mr/roae027

Disease activity at baseline is an independent predictor of frailty at one year in pre-frail patients with rheumatoid arthritis; a multicenter retrospective observational study.
Yoshifumi Ohashi; Nobunori Takahashi; Yasumori Sobue; Mochihito Suzuki; Kyosuke Hattori; Kenji Kishimoto; Kenya Terabe; Shuji Asai; Toshihisa Kojima; Masayo Kojima; Shiro Imagama
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2024年01月
29(1), 315, 320, 10.1016/j.jos.2022.10.025

Relationship between locomotive syndrome and large joint symptoms in rheumatoid arthritis patients.
Yasumori Sobue; Mochihito Suzuki; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Koji Funahashi; Hisato Ishikawa; Hidenori Inoue; Shuji Asai; Kenya Terabe; Masataka Maeda; Ryo Sato; Hironobu Kosugiyama; Yusuke Ohno; Shiro Imagama
International journal of rheumatic diseases, 2024年01月
27(1), e14947, 10.1111/1756-185X.14947

Well-controlled disease activity with drug treatment will not improve the frailty status of RA patients to robust state: A multicenter observational study (T-FLAG).
Yoshifumi Ohashi; Nobunori Takahashi; Yasumori Sobue; Mochihito Suzuki; Ryo Sato; Masataka Maeda; Kenya Terabe; Shuji Asai; Shiro Imagama
International journal of rheumatic diseases, 2024年01月
27(1), e14946, 10.1111/1756-185X.14946

Association between laughter, frailty, and depression in rheumatoid arthritis patients.
Mochihito Suzuki; Toshihisa Kojima; Kenya Terabe; Yoshifumi Ohashi; Ryo Sato; Hironobu Kosugiyama; Junya Hasegawa; Yusuke Ohno; Kaoru Nagai; Chinami Ohnishi; Hideshi Sugiura; Hitomi Fujita; Mako Nagayoshi; Masayo Kojima; Shuji Asai; Shiro Imagama
International journal of rheumatic diseases, 2024年01月
27(1), e15034, 10.1111/1756-185X.15034

Associations of frailty with RA-ILD and poor control of disease activity in patients with rheumatoid arthritis: A multi-center retrospective observational study.
Yoshifumi Ohashi; Nobunori Takahashi; Yasumori Sobue; Mochihito Suzuki; Ryo Sato; Masataka Maeda; Daisuke Kihira; Kenji Kishimoto; Kenya Terabe; Shuji Asai; Shiro Imagama
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2023年12月
10.1016/j.jos.2023.11.012

Increased prevalence of Staphylococcus aureus nasal carriage in rheumatoid arthritis patients with moderate/high disease activity.
Shuji Asai; Nobunori Takahashi; Kenji Kishimoto; Mochihito Suzuki; Yoshifumi Ohashi; Kenya Terabe; Toshihisa Kojima; Shiro Imagama
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 2023年11月
28(6), 1400, 1406, 10.1016/j.jos.2022.09.014

Reasons and risk factors for discontinuation of treatment with any biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: A long-term observational study.
Kenya Terabe; Nobunori Takahashi; Shuji Asai; Yuji Hirano; Yasuhide Kanayama; Yuichiro Yabe; Takeshi Oguchi; Takayoshi Fujibayashi; Hisato Ishikawa; Masahiro Hanabayashi; Yosuke Hattori; Mochihito Suzuki; Kenji Kishimoto; Yoshifumi Ohashi; Takahiro Imaizumi; Shiro Imagama; Toshihisa Kojima
Modern rheumatology, 2023年08月
33(5), 891, 898, 10.1093/mr/roac090

Relationship between frailty and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients.
Yasumori Sobue; Mochihito Suzuki; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Koji Funahashi; Hisato Ishikawa; Hidenori Inoue; Shuji Asai; Kenya Terabe; Kenji Kishimoto; Daisuke Kihira; Masataka Maeda; Ryo Sato; Shiro Imagama
Clinical rheumatology, 2023年08月
42(8), 2069, 2077, 10.1007/s10067-023-06639-z

Age and symptoms at onset of ankylosing spondylitis in Japanese patients.
Kenji Kishimoto; Shuji Asai; Mochihito Suzuki; Nobunori Takahashi; Kenya Terabe; Yoshifumi Ohashi; Kyosuke Hattori; Toshihisa Kojima; Shiro Imagama
Modern rheumatology, 2023年07月
33(4), 817, 822, 10.1093/mr/roac081

Periprosthetic humeral fracture revision using a massive allograft in a patient with rheumatoid arthritis: A case report.
Kenji Kishimoto; Toshihisa Kojima; Nobunori Takahashi; Shuji Asai; Kenya Terabe; Mochihito Suzuki; Yoshifumi Ohashi; Daisuke Kihira; Masataka Maeda; Masahiro Tatebe; Shiro Imagama
Modern rheumatology case reports, 2023年06月
7(2), 359, 363, 10.1093/mrcr/rxad001

Effectiveness of tacrolimus concomitant with biological disease-modifying antirheumatic drugs in patients with rheumatoid arthritis.
Kenya Terabe; Nobunori Takahashi; Shuji Asai; Yuji Hirano; Yasuhide Kanayama; Yuichiro Yabe; Takeshi Oguchi; Takayoshi Fujibayashi; Hisato Ishikawa; Masahiro Hanabayashi; Yosuke Hattori; Mochihito Suzuki; Kenji Kishimoto; Yoshifumi Ohashi; Takahiro Imaizumi; Shiro Imagama; Toshihisa Kojima
Modern rheumatology, 2023年03月
33(2), 292, 301, 10.1093/mr/roac025

Factors associated with frailty in rheumatoid arthritis patients with decreased renal function.
Yoshifumi Ohashi; Nobunori Takahashi; Yasumori Sobue; Mochihito Suzuki; Kyosuke Hattori; Kenji Kishimoto; Kenya Terabe; Shuji Asai; Toshihisa Kojima; Masayo Kojima; Shiro Imagama
Modern rheumatology, 2023年03月
33(2), 323, 329, 10.1093/mr/roac018

Validation of grip strength as a measure of frailty in rheumatoid arthritis.
Yasumori Sobue; Mochihito Suzuki; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Koji Funahashi; Hisato Ishikawa; Hidenori Inoue; Masayo Kojima; Shuji Asai; Kenya Terabe; Kenji Kishimoto; Masataka Maeda; Daisuke Kihira; Shiro Imagama; Toshihisa Kojima
Scientific reports, 2022年12月
12(1), 21090, 21090, 10.1038/s41598-022-21533-5

Locomotive syndrome in rheumatoid arthritis patients during the COVID-19 pandemic.
Yasumori Sobue; Mochihito Suzuki; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Koji Funahashi; Hisato Ishikawa; Hidenori Inoue; Masayo Kojima; Shuji Asai; Kenya Terabe; Kyosuke Hattori; Kenji Kishimoto; Nobunori Takahashi; Shiro Imagama; Toshihisa Kojima
Nagoya journal of medical science, 2022年11月
84(4), 799, 812, 10.18999/nagjms.84.4.799

Association between locomotive syndrome and methotrexate discontinuation due to adverse events in rheumatoid arthritis patients: A retrospective observational study.
Yasumori Sobue; Mochihito Suzuki; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Koji Funahashi; Hisato Ishikawa; Hidenori Inoue; Masayo Kojima; Shuji Asai; Kenya Terabe; Kyosuke Hattori; Kenji Kishimoto; Nobunori Takahashi; Shiro Imagama; Toshihisa Kojima
Geriatrics & gerontology international, 2022年10月
22(10), 904, 905, 10.1111/ggi.14475

Influence of frailty on patient global assessment in rheumatoid arthritis.
Mochihito Suzuki; Shuji Asai; Yasumori Sobue; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Hisato Ishikawa; Nobunori Takahashi; Kenya Terabe; Kenji Kishimoto; Kyosuke Hattori; Shiro Imagama; Toshihisa Kojima
Geriatrics & gerontology international, 2022年05月
22(5), 399, 404, 10.1111/ggi.14375

Relationship between locomotive syndrome and frailty in rheumatoid arthritis patients by locomotive syndrome stage.
Yasumori Sobue; Mochihito Suzuki; Yoshifumi Ohashi; Hiroshi Koshima; Nobuyuki Okui; Koji Funahashi; Hisato Ishikawa; Shuji Asai; Kenya Terabe; Yutaka Yokota; Kenji Kishimoto; Nobunori Takahashi; Shiro Imagama; Toshihisa Kojima
Modern rheumatology, 2022年04月
32(3), 546, 553, 10.1093/mr/roab024

Metabolic changes in synovial cells in early inflammation: Involvement of CREB phosphorylation in the anti-inflammatory effect of 2-deoxyglucose.
Kenji Kishimoto; Kenya Terabe; Nobunori Takahashi; Yutaka Yokota; Yoshifumi Ohashi; Kyosuke Hattori; Daisuke Kihira; Masataka Maeda; Toshihisa Kojima; Shiro Imagama
Archives of biochemistry and biophysics, 2021年09月
708, 108962, 108962, 10.1016/j.abb.2021.108962

Activation of transient receptor potential vanilloid 4 protects articular cartilage against inflammatory responses via CaMKK/AMPK/NF-κB signaling pathway.
Kyosuke Hattori; Nobunori Takahashi; Kenya Terabe; Yoshifumi Ohashi; Kenji Kishimoto; Yutaka Yokota; Mochihito Suzuki; Toshihisa Kojima; Shiro Imagama
Scientific reports, 2021年07月
11(1), 15508, 15508, 10.1038/s41598-021-94938-3

Metabolic reprogramming in chondrocytes to promote mitochondrial respiration reduces downstream features of osteoarthritis.
Yoshifumi Ohashi; Nobunori Takahashi; Kenya Terabe; Saho Tsuchiya; Toshihisa Kojima; Cheryl B Knudson; Warren Knudson; Shiro Imagama
Scientific reports, 2021年07月
11(1), 15131, 15131, 10.1038/s41598-021-94611-9

Relationship between disease activity of rheumatoid arthritis and development of locomotive syndrome: A five-year longitudinal cohort study.
Yasumori Sobue; Toshihisa Kojima; Koji Funahashi; Nobuyuki Okui; Nobunori Takahashi; Shuji Asai; Kenya Terabe; Tsuyoshi Nishiume; Mochihito Suzuki; Yutaka Yokota; Yoshifumi Ohashi; Naoki Ishiguro
Modern rheumatology, 2021年01月
31(1), 101, 107, 10.1080/14397595.2020.1744828

Suppression of murine osteoarthritis by 4-methylumbelliferone.
Saho Tsuchiya; Yoshifumi Ohashi; Shinya Ishizuka; Naoki Ishiguro; Dorcas P O'Rourke; Cheryl B Knudson; Warren Knudson
Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2020年05月
38(5), 1122, 1131, 10.1002/jor.24541

Hyaluronan suppresses enhanced cathepsin K expression via activation of NF-κB with mechanical stress loading in a human chondrocytic HCS-2/8 cells.
Mochihito Suzuki; Nobunori Takahashi; Yasumori Sobue; Yoshifumi Ohashi; Kenji Kishimoto; Kyosuke Hattori; Naoki Ishiguro; Toshihisa Kojima
Scientific reports, 2020年01月
10(1), 216, 216, 10.1038/s41598-019-57073-8

Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism.
Kenya Terabe; Yoshifumi Ohashi; Saho Tsuchiya; Shinya Ishizuka; Cheryl B Knudson; Warren Knudson
The Journal of biological chemistry, 2019年11月
294(47), 17799, 17817, 10.1074/jbc.RA119.009556

Inhibition of CD44 intracellular domain production suppresses bovine articular chondrocyte de-differentiation induced by excessive mechanical stress loading.
Yasumori Sobue; Nobunori Takahashi; Yoshifumi Ohashi; Mochihito Suzuki; Tsuyoshi Nishiume; Tomonori Kobayakawa; Kenya Terabe; Warren Knudson; Cheryl Knudson; Naoki Ishiguro; Toshihisa Kojima
Scientific reports, 2019年10月
9(1), 14901, 14901, 10.1038/s41598-019-50166-4

Hyaluronan synthase 2 (HAS2) overexpression diminishes the procatabolic activity of chondrocytes by a mechanism independent of extracellular hyaluronan.
Shinya Ishizuka; Saho Tsuchiya; Yoshifumi Ohashi; Kenya Terabe; Emily B Askew; Naoko Ishizuka; Cheryl B Knudson; Warren Knudson
The Journal of biological chemistry, 2019年09月
294(37), 13562, 13579, 10.1074/jbc.RA119.008567