上田 昌史
<基礎医学部門>薬理学講座 | 助教 |
論文
- The MCPH7 Gene Product STIL Is Essential for Dendritic Spine Formation
Tohru Matsuki; Hidenori Tabata; Masashi Ueda; Hideaki Ito; Koh-ichi Nagata; Yumi Tsuneura; Shima Eda; Kenji Kasai; Atsuo Nakayama
Cells, 2025年01月, 査読有り
10.3390/cells14020062 - The distribution of neuroligin4, an autism-related postsynaptic molecule, in the human brain.
Akie Toya; Masahide Fukada; Eiko Aoki; Tohru Matsuki; Masashi Ueda; Shima Eda; Yoshio Hashizume; Akio Iio; Shigeo Masaki; Atsuo Nakayama
Molecular brain, 2023年02月, 査読有り
16(1), 20, 20, 10.1186/s13041-023-00999-y - Endoplasmic reticulum stress contributes to the decline in doublecortin expression in the immature neurons of mice with long-term obesity.
Kiyomi Nakagawa; Saiful Islam; Masashi Ueda; Toshiyuki Nakagawa
Scientific reports, 2022年01月, 査読有り
12(1), 1022, 1022, 10.1038/s41598-022-05012-5 - STK25 and MST3 have overlapping roles to regulate Rho GTPases during cortical development.
Tohru Matsuki; Akio Iio; Masashi Ueda; Yumi Tsuneura; Brian W Howell; Atsuo Nakayama
The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021年09月, 査読有り
41(43), 8887, 8903, 10.1523/JNEUROSCI.0523-21.2021 - Knockdown of Son, a mouse homologue of the ZTTK syndrome gene, causes neuronal migration defects and dendritic spine abnormalities.
Masashi Ueda; Tohru Matsuki; Masahide Fukada; Shima Eda; Akie Toya; Akio Iio; Hidenori Tabata; Atsuo Nakayama
Molecular brain, 2020年05月, 査読有り, 招待無し
筆頭著者, 13(1), 80, 80, 10.1186/s13041-020-00622-4 - Cullin-4B E3 ubiquitin ligase mediates Apaf-1 ubiquitination to regulate caspase-9 activity.
Eri Ohta; Masanori Itoh; Masashi Ueda; Yoko Hida; Miao-Xing Wang; Miki Hayakawa-Ogura; Shimo Li; Emika Nishida; Kazunori Ohta; Tana; Saiful Islam; Kiyomi Nakagawa; Tomomi Sunayama; Huayue Chen; So Hirata; Masashi Endo; Yoya Ohno; Toshiyuki Nakagawa
PloS one, 2019年, 査読有り, 招待無し
14(7), e0219782, 10.1371/journal.pone.0219782 - Odor preference and olfactory memory are impaired in Olfaxin-deficient mice.
Saiful Islam; Masashi Ueda; Emika Nishida; Miao-Xing Wang; Masatake Osawa; Dongsoo Lee; Masanori Itoh; Kiyomi Nakagawa; Tana; Toshiyuki Nakagawa
Brain research, 2018年06月, 査読有り, 招待無し
筆頭著者, 1688, 81, 90, 10.1016/j.brainres.2018.03.025 - Dietary Quercetin Ameliorates Memory Impairment in a Murine Model of Alzheimer’s Disease with Obesity and Diabetes, Suppressing ATF4 Expression
Kiyomi Nakagawa; Masashi Ueda; Masanori Itoh; Saiful Islam; Tana; Toshiyuki Nakagawa
Journal of Neurology and Neuroscience, 2017年, 査読有り
08(06), 10.21767/2171-6625.1000234 - Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients.
Toshiyuki Nakagawa; Masanori Itoh; Kazunori Ohta; Yuichi Hayashi; Miki Hayakawa; Yasushi Yamada; Hiroshi Akanabe; Tokio Chikaishi; Kiyomi Nakagawa; Yoshinori Itoh; Takato Muro; Daisuke Yanagida; Ryo Nakabayashi; Tetsuya Mori; Kazuki Saito; Kaori Ohzawa; Chihiro Suzuki; Shimo Li; Masashi Ueda; Miao-Xing Wang; Emika Nishida; Saiful Islam; Tana; Masuko Kobori; Takashi Inuzuka
Neuroreport, 2016年06月, 査読有り, 招待無し
27(9), 671, 6, 10.1097/WNR.0000000000000594 - Expanded polyglutamine embedded in the endoplasmic reticulum causes membrane distortion and coincides with Bax insertion.
Masashi Ueda; Shimo Li; Masanori Itoh; Miao-Xing Wang; Miki Hayakawa; Saiful Islam; Tana; Kiyomi Nakagawa; Huayue Chen; Toshiyuki Nakagawa
Biochemical and biophysical research communications, 2016年05月, 査読有り, 招待無し
474(2), 259, 263, 10.1016/j.bbrc.2016.04.034 - CED-4 is an mRNA-binding protein that delivers ced-3 mRNA to ribosomes.
Miao-Xing Wang; Masanori Itoh; Shimo Li; Yoko Hida; Kazunori Ohta; Miki Hayakawa; Emika Nishida; Masashi Ueda; Saiful Islam; Tana; Toshiyuki Nakagawa
Biochemical and biophysical research communications, 2016年01月, 査読有り, 招待無し
470(1), 48, 53, 10.1016/j.bbrc.2015.12.102 - Quercetin reduces eIF2α phosphorylation by GADD34 induction.
Miki Hayakawa; Masanori Itoh; Kazunori Ohta; Shimo Li; Masashi Ueda; Miao-xing Wang; Emika Nishida; Saiful Islam; Chihiro Suzuki; Kaori Ohzawa; Masuko Kobori; Takashi Inuzuka; Toshiyuki Nakagawa
Neurobiology of aging, 2015年09月, 査読有り, 招待無し
36(9), 2509, 18, 10.1016/j.neurobiolaging.2015.05.006 - Polyglutamine expansion disturbs the endoplasmic reticulum formation, leading to caspase-7 activation through Bax.
Masashi Ueda; Shimo Li; Masanori Itoh; Yoshika Hayakawa-Yano; Miao-xing Wang; Miki Hayakawa; Ryoko Hasebe-Matsubara; Kazunori Ohta; Eri Ohta; Akihito Mizuno; Yoko Hida; Munekazu Matsumoto; Huayue Chen; Toshiyuki Nakagawa
Biochemical and biophysical research communications, 2014年01月, 査読有り, 招待無し
443(4), 1232, 8, 10.1016/j.bbrc.2013.12.114 - Olfaxin as a novel Prune2 isoform predominantly expressed in olfactory system.
Shimo Li; Yoshika Hayakawa-Yano; Masanori Itoh; Masashi Ueda; Kazunori Ohta; Yoshihiro Suzuki; Akihito Mizuno; Eri Ohta; Yoko Hida; Miao-Xing Wang; Toshiyuki Nakagawa
Brain research, 2012年12月, 査読有り, 招待無し
1488, 1, 13, 10.1016/j.brainres.2012.10.001 - Endoplasmic reticulum stress enhances γ-secretase activity.
Kazunori Ohta; Akihito Mizuno; Shimo Li; Masanori Itoh; Masashi Ueda; Eri Ohta; Yoko Hida; Miao-xing Wang; Manabu Furoi; Yukihiro Tsuzuki; Mitsuaki Sobajima; Yoshimasa Bohmoto; Tatsuya Fukushima; Masuko Kobori; Takashi Inuzuka; Toshiyuki Nakagawa
Biochemical and biophysical research communications, 2011年12月, 査読有り, 招待無し
416(3-4), 362, 6, 10.1016/j.bbrc.2011.11.042 - The expression and localization of Prune2 mRNA in the central nervous system.
Shimo Li; Masanori Itoh; Kazunori Ohta; Masashi Ueda; Akihito Mizuno; Eri Ohta; Yoko Hida; Miao-Xing Wang; Kazunori Takeuchi; Toshiyuki Nakagawa
Neuroscience letters, 2011年10月, 査読有り, 招待無し
503(3), 208, 14, 10.1016/j.neulet.2011.08.037 - Cayman Ataxia-Related Protein is a Presynapse-Specific Caspase-3 Substrate
Masanori Itoh; Shimo Li; Kazunori Ohta; Aiko Yamada; Yoshika Hayakawa-Yano; Masashi Ueda; Yoko Hida; Yoshihiro Suzuki; Eri Ohta; Akihito Mizuno; Yoshiko Banno; Toshiyuki Nakagawa
Neurochemical Research, 2011年07月, 査読有り
36(7), 1304, 1313, 10.1007/s11064-011-0430-5 - Autophagy impairment stimulates PS1 expression and gamma-secretase activity.
Kazunori Ohta; Akihito Mizuno; Masashi Ueda; Shimo Li; Yoshihiro Suzuki; Yoko Hida; Yoshika Hayakawa-Yano; Masanori Itoh; Eri Ohta; Masuko Kobori; Toshiyuki Nakagawa
Autophagy, 2010年04月, 査読有り, 招待無し
6(3), 345, 52 - Dysfunction of autophagy lead to activation of gamma-secretase through GCN2
Kazunori Ohta; Akihito Mizuno; Masashi Ueda; Shimo Li; Yoshihiro Suzuki; Yoko Hida; Yoshika Hayakawa-Yano; Masanori Itoh; Eri Ohta; Masuko Kobori; Toshiyuki Nakagawa
NEUROSCIENCE RESEARCH, 2010年, 査読有り, 招待無し
68, E188, E188, 10.1016/j.neures.2010.07.2404 - γ-セクレターゼの活性を制御する新規プレセニリン2アイソフォームの解析
鈴木 欣宏; 太田 和徳; 伊藤 正徳; 上田 昌史; 李 詩沫; 樋田 陽子; 酒向 ゆかり; 光田 輝彦; 矢野 佳芳; 犬塚 貴; 中川 敏幸
臨床神経学, 2009年12月, 査読有り
49(12), 1078, 1078 - An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor.
Yoshihiro Suzuki; Kazunori Ohta; Masanori Itoh; Yukari Sakoh-Sumitomo; Teruhiko Mitsuda; Masashi Ueda; Yoshika Hayakawa-Yano; Shimo Li; Yoko Hida; Takashi Inuzuka; Yong-Keun Jung; Toshiyuki Nakagawa
FEBS letters, 2009年05月, 査読有り, 招待無し
583(9), 1403, 8, 10.1016/j.febslet.2009.04.014 - Implication of phospholipase D2 in oxidant-induced phosphoinositide 3-kinase signaling via Pyk2 activation in PC12 cells.
Yoshiko Banno; Kenji Ohguchi; Naoki Matsumoto; Masahiro Koda; Masashi Ueda; Akira Hara; Ivan Dikic; Yoshinori Nozawa
The Journal of biological chemistry, 2005年04月, 査読有り, 招待無し
280(16), 16319, 24
MISC
- STK25が関与する大脳皮質形成機構
松木亨; 飯尾明生; 上田昌史; 上田昌史; 常浦祐未; BRIAN Howell; 中山敦雄
日本臨床分子形態学会総会・学術集会講演プログラム・要旨集, 2021年
53rd - γ-セクレターゼ活性を制御する新規プレセニリン2アイソフォームの解析
鈴木 欣宏; 酒向 ゆかり; 光田 輝彦; 矢野 佳芳; 伊藤 正徳; 上田 昌史; 太田 和徳; 李 詩沫; 犬塚 貴; 中川 敏幸
臨床神経学, 2007年12月, 査読無し, 招待無し
47(12), 995, 995
講演・口頭発表等
- SON haploinsufficiency, a cause of human intellectual disabilities, affects the neuronal migrations and dendritic spine formations in the developing mouse brain
Ueda M; Matsuki T; Eda S; Nakayama A
Society for Neuroscience (49th Annual Meeting), 招待無し
201910, 201910, ポスター発表 - SON haploinsufficiency, which is causing an intellectual disability, dysregulates neuronal migration in developing mouse brain
Ueda_M; Matsuki T; Eda S; Nakayama A
The 11th NAGOYA Global Retreat, 2019年02月, 招待無し
201902, 201902, 口頭発表（一般） - Insertion of polyglutamine to the endoplasmic reticulum membrane with the morphological disruption initiates the cell death through Bax
Ueda_M; Li S; Itoh M; Wang M; Hayakawa M; Islam S, Tana; Nakagawa K; Chen H; Nakagawa T
The 9th NAGOYA Global Retreat, 2017年02月, 招待無し
201702, 201702, 口頭発表（一般） - Polyglutamine expansion affects morphology of the endoplasmic reticulum-mitochondria contact sites, initiating cell death
Ueda M; Li S; Itoh M; Ohta K; Wang M; Chen H; Yamaguchi K; Kuwata K; Hayakawa M; Hida Y; Nakagawa T
Society for Neuroscience (43nd Annual Meeting), 招待無し
201311, 201311, ポスター発表 - Disruption of the endoplasmic reticulum by polyglutamine expansion induces Apaf-1-dependent, activation of caspase-7
M.Ueda; S.Li; M.Itoh; Y.Hida; Hayakawa-Yano; Y.Suzuki; K.Ohta; E.Ohta; A.Mizuno; T.Nakagawa
Society for Neuroscience (39th Annual Meeting), 招待無し
200910, 200910, ポスター発表
共同研究・競争的資金等の研究課題
- ZTTK症候群の知的障害発症機構解明を目指した核内蛋白質SONの機能解析
若手研究
愛知県医療療育総合センター発達障害研究所
2020年04月 - 2024年03月
上田 昌史, 上田 昌史, 日本学術振興会, 日本学術振興会, 研究代表者 - 自閉症原因遺伝子NLGN4Xの発現変化に起因する分子病態の解析
基盤研究(C)
愛知県医療療育総合センター発達障害研究所
2017年04月 - 2023年03月
飯尾 明生; 松木 亨; 上田 昌史, 飯尾 明生; 松木 亨; 上田 昌史, 日本学術振興会, 日本学術振興会, 研究分担者 - 知的障害の原因となるSONハプロ不全の分子機構解明
若手研究(B)
愛知県心身障害者コロニー発達障害研究所
2017年04月01日 - 2020年03月31日
上田 昌史, Ueda Masashi, 日本学術振興会, Japan Society for the Promotion of Science
