Targeting fatty acid synthase suppresses tumor development inNF2/CDKN2A-deficient malignant pleural mesothelioma
Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Md Towhid Ahmed Shihan; Nushrat Jahan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Yinzhi Lin; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Jul. 2024
10.1101/2024.07.14.603191

染色体不安定性獲得機構解明を目指した、中心小体複製因子STILによる細胞周期チェックポイント抑制機能の解析
伊藤 秀明; 鈴木 佳稔; 大橋 明子; 猪子 誠人; 中村 律子; 陸 美穂; 大西 絋二; 古屋 智子; 都築 豊徳; 笠井 謙次
Cytometry Research, Jul. 2024
34(Suppl.), 75, 75

中心小体複製因子STILによる細胞周期チェックポイント抑制によるアポトーシス回避機構
鈴木 佳稔; 伊藤 秀明; 大橋 明子; 山田 徳香; 猪子 誠人; 中村 律子; 陸 美穂; 大西 紘二; 都築 豊徳; 笠井 謙次
日本病理学会会誌, Feb. 2024
113(1), 476, 476

CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell Death Discovery, Jul. 2023
10.1038/s41420-023-01552-5

Motor neuron TDP-43 proteinopathy in progressive supranuclear palsy and corticobasal degeneration.
Yuichi Riku; Yasushi Iwasaki; Shinsuke Ishigaki; Akio Akagi; Masato Hasegawa; Kenya Nishioka; Yuanzhe Li; Miho Riku; Takeshi Ikeuchi; Yusuke Fujioka; Hiroaki Miyahara; Jun Sone; Nobutaka Hattori; Mari Yoshida; Masahisa Katsuno; Gen Sobue
Brain : a journal of neurology, Mar. 2022
145(8), 2769, 2784, 10.1093/brain/awac091

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
Takumi Tsunoda; Miho Riku; Norika Yamada; Hikaru Tsuchiya; Takuya Tomita; Minako Suzuki; Mari Kizuki; Akihito Inoko; Hideaki Ito; Kenta Murotani; Hideki Murakami; Yasushi Saeki; Kenji Kasai
EMBO reports, Feb. 2022
23(2), e51182, 10.15252/embr.202051182

ラブドイド形質を伴う肉腫型悪性中皮腫の一剖検例
陸 美穂; 村上 秀樹; 小野 謙三; 横山 多佳子; 加藤 宗博; 笠井 謙次
現代医学, Jun. 2021
68(1), 123, 128

Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer
Akane Sugimura-Nagata; Akira Koshino; Satoshi Inoue; Aya Matsuo-Nagano; Masayuki Komura; Miho Riku; Hideaki Ito; Akihito Inoko; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Satoru Takahashi; Kunio Kasugai; Kenji Kasai; Shingo Inaguma
International Journal of Molecular Sciences, Mar. 2021
22(5), 2690, 2690, 10.3390/ijms22052690

STIL(SCL/TAL1 interrupting locus)による浸潤突起形成機構
伊藤 秀明; 猪子 誠人; 陸 美穂; 村上 秀樹; 笠井 謙次
日本病理学会会誌, Mar. 2021
110(1), 232, 232

High phospho‐histone H3 expression uniquely predicts favorable survival among four markers of cellular proliferation in colorectal cancer
Akira Koshino; Satoshi Inoue; Akane Sugimura‐Nagata; Takeshi Nishiyama; Hideki Murakami; Hideaki Ito; Miho Riku; Akihito Inoko; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kunio Kasugai; Kenji Kasai; Shingo Inaguma
Pathology International, Feb. 2021
10.1111/pin.13084

Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer.
Satoshi Inoue; Takumi Tsunoda; Miho Riku; Hideaki Ito; Akihito Inoko; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Ira Pastan; Kunio Kasugai; Kenji Kasai; Hiroshi Ikeda; Shingo Inaguma
Oncology letters, Mar. 2020, Reviewed, No invitation
19(3), 1741, 1750, 10.3892/ol.2020.11290

Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
Ito H; Tsunoda T; Riku M; Inaguma S; Inoko A; Murakami H; Ikeda H; Matsuda M; Kasai K
Oncogene, Nov. 2019, Reviewed, No invitation
10.1038/s41388-019-1115-9

Phase I study of concurrent vinorelbine and radiation therapy in high-risk postmastectomy breast cancer patients
Kazunori Honda; Miho Riku; Madoka Iwase; Naoki Hirasawa; Tetsuya Yamada; Yasutomo Goto; Kenji Kawada
BREAST CANCER, Sep. 2016, Reviewed, No invitation
23(5), 701, 705, 10.1007/s12282-015-0627-6

STIL(SCL/TAL-1 Interrupting Locus)による膵臓癌細胞運動能制御機構
伊藤 秀明; 角田 拓実; 陸 美穂; 池田 洋; 笠井 謙次
日本病理学会会誌, Apr. 2016
105(1), 377, 377

Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis
Miho Riku; Shingo Inaguma; Hideaki Ito; Takumi Tsunoda; Hiroshi Ikeda; Kenji Kasai
ONCOTARGET, Feb. 2016, Reviewed, No invitation
7(5), 5690, 5701, 10.18632/oncotarget.6788

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells
Shingo Inaguma; Miho Riku; Hideaki Ito; Takumi Tsunoda; Hiroshi Ikeda; Kenji Kasai
ONCOTARGET, Oct. 2015, Reviewed, No invitation
6(32), 33648, 33657, 10.18632/oncotarget.5203

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2
Shingo Inaguma; Hideaki Ito; Miho Riku; Hiroshi Ikeda; Kenji Kasai
ONCOTARGET, Sep. 2015, Reviewed, No invitation
6(29), 28257, 28268, 10.18632/oncotarget.4960

ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる
稲熊 真悟; 笠井 謙次; 伊藤 秀明; 陸 美穂; 池田 洋
日本病理学会会誌, Mar. 2015
104(1), 287, 287

新規転写抑制因子TSHZ2からみた乳癌進展機構
陸 美穂; 笠井 謙次; 稲熊 真悟; 伊藤 秀明; 池田 洋
日本病理学会会誌, Mar. 2015
104(1), 455, 455

ヘッジホッグシグナル系転写因子ZIC2はFGFR3、ANXA8発現誘導を介して膵癌細胞株の増殖を促進する(ZIC2 accelerates the cell proliferation of pancreatic ductal adenocarcinoma through FGFR3 and ANXA8 induction)
稲熊 真悟; 笠井 謙次; 陸 美穂; 池田 洋
日本癌学会総会記事, Sep. 2014
73回, J, 2090

GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through bhlhe41-mediated suppression of MLH1
Shingo Inaguma; Miho Riku; Mitsuyoshi Hashimoto; Hideki Murakami; Shinsuke Saga; Hiroshi Ikeda; Kenji Kasai
Cancer Research, Dec. 2013, Reviewed, No invitation
73(24), 7313, 7323, 10.1158/0008-5472.CAN-13-2008

膵臓癌細胞において転写因子GLI1はBHLHE41依存性にMLH1発現を抑制し、ミスマッチ修復機構の機能不全を惹起する(GLI1 induces the mismatch repair system insufficiency via BHLHE41-dependent MLH1 reduction in pancreatic cancer cells)
稲熊 真悟; 笠井 謙次; 橋本 光義; 陸 美穂; 池田 洋
日本癌学会総会記事, Oct. 2013
72回, 272, 272

乳癌の新規予後規定因子TSHZ2によるクロマチン制御と上皮間葉転換調節機構の解明
若手研究
愛知医科大学
01 Apr. 2020 - 31 Mar. 2023
陸 美穂, 陸 美穂, 日本学術振興会, 日本学術振興会

新規転写抑制因子TSHZ2によるクロマチン制御を介した乳癌進展機構の解明
若手研究(B)
愛知医科大学
01 Apr. 2016 - 31 Mar. 2018
陸 美穂, 陸 美穂, 日本学術振興会, 日本学術振興会