TSUZUKI Shinobu
Biochemistry | Professor |
Profile
Research area
腫瘍学
血液学
生化学Main lectures
分子病態学Graduating school
名古屋大学医学部医学科（1987年）Previous workplace
名古屋第一赤十字病院（1987年4月～1992年3月）
名古屋大学医学部附属病院（1995年8月～1998年10月）
愛知県がんセンター研究所（2001年9月～2016年6月）Study abroad experience
Institute of Cancer Research（英国）（1998年11月～2001年8月）Main academic activities
日本癌学会
日本血液学会
米国血液学会Main research topic
白血病の発症機構解析・治療法の探索
悪性リンパ腫の発症機構解析・治療法の探索
悪性中皮腫の発症機構解析・治療法の探索Self-introduction
臨床医として10年以上，研究者として15年以上の経験をもとに，臨床医の視点を取り入れた研究を行います。
学生講義では，典型例を取り上げて，分子や遺伝子の異常と疾患の成り立ちを中心にお話します。ともに考え，ともに学んでいきたいと考えています。Hobby
散歩
Paper
- Targeting fatty acid synthase suppresses tumor development inNF2/CDKN2A-deficient malignant pleural mesothelioma
Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Md Towhid Ahmed Shihan; Nushrat Jahan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Yinzhi Lin; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Jul. 2024
10.1101/2024.07.14.603191 - NUP98-BPTF promotes oncogenic transformation through PIM1 upregulation.
Mina Noura; Sakura Tomita; Takahiko Yasuda; Shinobu Tsuzuki; Hitoshi Kiyoi; Fumihiko Hayakawa
Cancer medicine, Jul. 2024
13(13), e7445, 10.1002/cam4.7445 - RGS1 and CREB5 are direct and common transcriptional targets of ZNF384-fusion proteins.
Chiharu Yamada; Kentaro Okada; Koya Odaira; Mahiru Tokoro; Eisuke Iwamoto; Masashi Sanada; Mina Noura; Syuichi Okamoto; Takahiko Yasuda; Shinobu Tsuzuki; Hitoshi Kiyoi; Fumihiko Hayakawa
Cancer medicine, Jul. 2024
13(14), e7471, 10.1002/cam4.7471 - ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells.
Sivasundaram Karnan; Ichiro Hanamura; Akinobu Ota; Lam Quang Vu; Kaori Uchino; Tomohiro Horio; Satsuki Murakami; Shohei Mizuno; Md Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Mrityunjoy Biswas; Toshinori Hyodo; Hideaki Ito; Atsushi Suzuki; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Akiyoshi Takami
Cell death discovery, Jan. 2024
10(1), 56, 56, 10.1038/s41420-024-01814-w - ★Suppression of super-enhancer-driven TAL1 expression by KLF4 in T-cell acute lymphoblastic leukemia.
Mina Noura; Hidemasa Matsuo; Takahiko Yasuda; Shinobu Tsuzuki; Hitoshi Kiyoi; Fumihiko Hayakawa
Oncogene, Dec. 2023
10.1038/s41388-023-02913-1 - Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis
Toshinori Hyodo; Eri Asano‐Inami; Satoko Ito; Mai Sugiyama; Akihiro Nawa; Md Lutfur Rahman; Muhammad Nazmul Hasan; Yuko Mihara; Vu Quang Lam; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Michinari Hamaguchi; Yoshitaka Hosokawa; Hiroyuki Konishi
The FEBS Journal, Nov. 2023
10.1111/febs.17017 - CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell Death Discovery, Jul. 2023
10.1038/s41420-023-01552-5 - EBF1-JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity.
Yukino Kojima; Fumika Kawashima; Takahiko Yasuda; Koya Odaira; Yuichiro Inagaki; Chiharu Yamada; Ami Muraki; Mina Noura; Shuichi Okamoto; Shogo Tamura; Eisuke Iwamoto; Masashi Sanada; Itaru Matsumura; Yasushi Miyazaki; Tetsuhito Kojima; Hitoshi Kiyoi; Shinobu Tsuzuki; Fumihiko Hayakawa
International journal of hematology, May 2023
118(1), 65, 74, 10.1007/s12185-023-03585-z - Functional inhibition of MEF2 by C/EBP is a possible mechanism of leukemia development by CEBP-IGH fusion gene.
Koya Odaira; Takahiko Yasuda; Kentaro Okada; Takuya Shimooka; Yukino Kojima; Mina Noura; Shogo Tamura; Shingo Kurahashi; Eisuke Iwamoto; Masashi Sanada; Itaru Matsumura; Yasushi Miyazaki; Tetsuhito Kojima; Hitoshi Kiyoi; Shinobu Tsuzuki; Fumihiko Hayakawa
Cancer science, Nov. 2022
114(3), 781, 792, 10.1111/cas.15641 - ★Oncogenic lesions and molecular subtypes in adults with B-cell acute lymphoblastic leukemia.
Takahiko Yasuda; Masashi Sanada; Shinobu Tsuzuki; Fumihiko Hayakawa
Cancer science, Sep. 2022
10.1111/cas.15583 - ★BCL6 inhibition ameliorates ruxolitinib resistance in CRLF2-rearranged acute lymphoblastic leukemia.
Shinobu Tsuzuki; Takahiko Yasuda; Hiroaki Goto; Naoko Maeda; Koshi Akahane; Takeshi Inukai; Hideyuki Yamamoto; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Yoshitaka Hosokawa; Hitoshi Kiyoi; Fumihiko Hayakawa
Haematologica, Aug. 2022
10.3324/haematol.2022.280879 - ★Two novel high-risk adult B-cell acute lymphoblastic leukemia subtypes with high expression of CDX2 and IDH1/2 mutations.
Takahiko Yasuda; Masashi Sanada; Masahito Kawazu; Shinya Kojima; Shinobu Tsuzuki; Hiroo Ueno; Eisuke Iwamoto; Yuka Iijima-Yamashita; Tomomi Yamada; Takashi Kanamori; Rieko Nishimura; Yachiyo Kuwatsuka; Satoru Takada; Masatsugu Tanaka; Shuichi Ota; Nobuaki Dobashi; Etsuko Yamazaki; Asao Hirose; Tohru Murayama; Masahiko Sumi; Shinya Sato; Naoyuki Tange; Yukinori Nakamura; Yuna Katsuoka; Emiko Sakaida; Toyotaka Kawamata; Hiroatsu Iida; Yuichi Shiraishi; Yasuhito Nannya; Seishi Ogawa; Masafumi Taniwaki; Norio Asou; Yoshihiro Hatta; Hitoshi Kiyoi; Itaru Matsumura; Keizo Horibe; Hiroyuki Mano; Tomoki Naoe; Yasushi Miyazaki; Fumihiko Hayakawa
Blood, Mar. 2022
139(12), 1850, 1862, 10.1182/blood.2021011921 - Experimental strategies to achieve efficient targeted knock-in via tandem paired nicking.
Md Lutfur Rahman; Toshinori Hyodo; Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Yuko Mihara; Md Wahiduzzaman; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Scientific reports, Nov. 2021
11(1), 22627, 22627, 10.1038/s41598-021-01978-w - CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia.
Sivasundaram Karnan; Ichiro Hanamura; Akinobu Ota; Souichi Takasugi; Ayano Nakamura; Miyuki Takahashi; Kaori Uchino; Satsuki Murakami; Md Wahiduzzaman; Lam Quang Vu; Md Lutfur Rahman; Muhammad Nazmul Hasan; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Kazuhiro Yoshikawa; Susumu Suzuki; Ryuzo Ueda; Masayuki Ejiri; Yoshitaka Hosokawa; Akiyoshi Takami
Cell death discovery, May 2021
7(1), 121, 121, 10.1038/s41420-021-00446-8 - Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma.
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md Lutfur Rahman; Muhammad Nazmul Hasan; Md Wahiduzzaman; Ichiro Hanamura; Lam Quang Vu; Akihito Inoko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell death discovery, Nov. 2020
6(1), 127, 127, 10.1038/s41420-020-00364-1 - Staurosporine and venetoclax induce the caspase-dependent proteolysis of MEF2D-fusion proteins and apoptosis in MEF2D-fusion (+) ALL cells
Naoyuki Tange; Fumihiko Hayakawa; Takahiko Yasuda; Koya Odaira; Hideyuki Yamamoto; Daiki Hirano; Toshiyasu Sakai; Seitaro Terakura; Shinobu Tsuzuki; Hitoshi Kiyoi
Biomedicine and Pharmacotherapy, Aug. 2020
128, 10.1016/j.biopha.2020.110330 - Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells.
Akinobu Ota; Ichiro Hanamura; Sivasundaram Karnan; Shingo Inaguma; Norio Takei; Vu Quang Lam; Shohei Mizuno; Jo Kanasugi; Md Wahiduzzaman; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Hiroshi Ikeda; Akiyoshi Takami; Yoshitaka Hosokawa
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Aug. 2020, Reviewed, No invitation
40(8), 389, 405, 10.1089/jir.2020.0111 - ★Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia
Shinobu Tsuzuki; Takahiko Yasuda; Shinya Kojima; Masahito Kawazu; Koshi Akahane; Takeshi Inukai; Masue Imaizumi; Takanobu Morishita; Koichi Miyamura; Toshihide Ueno; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Masashi Sanada; Hirokazu Nagai; Keizo Horibe; Akihiro Tomita; Kyogo Suzuki; Hideki Muramatsu; Yoshiyuki Takahashi; Yasushi Miyazaki; Itaru Matsumura; Hitoshi Kiyoi; Yoshitaka Hosokawa; Hiroyuki Mano; Fumihiko Hayakawa
Blood Cancer Discovery, Jul. 2020, Reviewed, No invitation
Lead, 1(1), 82, 95, 10.1158/2643-3230.bcd-19-0080 - ★High prevalence of MEF2D fusion in human B-cell precursor acute lymphoblastic leukemia cell lines.
Koshi Akahane; Takahiko Yasuda; Shinobu Tsuzuki; Fumihiko Hayakawa; Nobutaka Kiyokawa; Shinpei Somazu; Atsushi Watanabe; Keiko Kagami; Masako Abe; Daisuke Harama; Kumiko Goi; Masahito Kawazu; Shinya Kojima; Toshihiko Imamura; Hiroaki Goto; Shotaro Iwamoto; Masayoshi Minegishi; Masafumi Abe; Hiroshi Hojo; Toshiya Inaba; Hiroyuki Mano; Kanji Sugita; Takeshi Inukai
Hematological oncology, Jun. 2020, Reviewed, No invitation
38(4), 614, 617, 10.1002/hon.2762 - Cover Image
Sayuri Kondo; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Md Wahiduzzaman; Toshinori Hyodo; Md Lutfur Rahman; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cancer Medicine, Apr. 2020
10.1002/cam4.3049 - Bi‐allelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells
Jo Kanasugi; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Lam Quang Vu; Shohei Mizuno; Md Wahiduzzaman; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Akiyoshi Takami
Cancer Science, Mar. 2020, Reviewed, No invitation
10.1111/cas.14386 - Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53.
Toshinori Hyodo; Md Lutfur Rahman; Sivasundaram Karnan; Takuji Ito; Atsushi Toyoda; Akinobu Ota; Md Wahiduzzaman; Shinobu Tsuzuki; Yohei Okada; Yoshitaka Hosokawa; Hiroyuki Konishi
Cell reports, Jan. 2020, Reviewed, No invitation
30(4), 1195, 1207, 10.1016/j.celrep.2019.12.064 - ★ZNF384-fusion proteins have high affinity for the transcriptional coactivator EP300 and aberrant transcriptional activities.
Yamamoto H; Hayakawa F; Yasuda T; Odaira K; Minamikawa Y; Tange N; Hirano D; Kojima Y; Morishita T; Tsuzuki S; Naoe T; Kiyoi H
FEBS letters, Aug. 2019, Reviewed, No invitation
593(16), 2151-2161, 10.1002/1873-3468.13506 - ★Chromosomal translocation-mediated evasion from miRNA induces strong MEF2D fusion protein expression, causing inhibition of PAX5 transcriptional activity.
Hirano D; Hayakawa F; Yasuda T; Tange N; Yamamoto H; Kojima Y; Morishita T; Imoto N; Tsuzuki S; Mano H; Naoe T; Kiyoi H
Oncogene, Mar. 2019, Reviewed, No invitation
38(13), 2263, 2274, 10.1038/s41388-018-0573-9 - Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma.
Wahiduzzaman M; Karnan S; Ota A; Hanamura I; Murakami H; Inoko A; Rahman ML; Hyodo T; Konishi H; Tsuzuki S; Hosokawa Y
Cancer science, Jan. 2019, Reviewed, No invitation
110(1), 180, 193, 10.1111/cas.13871 - ★Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo.
Wahiduzzaman M; Ota A; Karnan S; Hanamura I; Mizuno S; Kanasugi J; Rahman ML; Hyodo T; Konishi H; Tsuzuki S; Takami A; Hosokawa Y
Cancer letters, Oct. 2018, Reviewed, No invitation
433, 117, 130, 10.1016/j.canlet.2018.06.027 - ★Synergistic antiproliferative effect of combined arsenic trioxide-cisplatin treatment in Bcr-Abl positive leukemic cells
Ota Akinobu; Wahiduzzaman Md; Karnan Sivasundaram; Hyodo Toshinori; Konishi Hiroyuki; Tsuzuki Shinobu; Hosokawa Yoshitaka
CANCER SCIENCE, Jan. 2018, Reviewed, No invitation
109, 685 - Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells
Masayuki Yamaji; Akinobu Ota; Md Wahiduzzaman; Sivasundaram Karnan; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Masayuki Haniuda
CANCER MEDICINE, Nov. 2017, Reviewed, No invitation
6(11), 2646, 2659, 10.1002/cam4.1179 - SINGLE-NUCLEOTIDE POLYMORPHISM IN THE PBK GENE IS CLOSELY ASSOCIATED WITH MYELOMA CELL PROLIFERATION
I. Hanamura; A. Ota; S. Karnan; M. Wahiduzzaman; S. Mizuno; K. Uchino; J. Kanasugi; T. Horio; S. Murakami; S. Suzuki; R. Ueda; S. Tsuzuki; H. Konishi; Y. Hosokawa; A. Takami
HAEMATOLOGICA, Jun. 2017, Reviewed, No invitation
102(2), 497, 497 - Efficient AAV-mediated gene targeting using 2A-based promoter-trap system
Karnan S; Ota A; Konishi Y; Wahiduzzaman M; Tsuzuki S; Hosokawa Y; Konishi H
Bio-protocol, Dec. 2016, Reviewed, No invitation
6, e2058, 10.21769/BioProtoc.2058 - Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation
Tatsuo Kakiuchi; Taishi Takahara; Yumiko Kasugai; Kotaro Arita; Noriaki Yoshida; Kennosuke Karube; Miyuki Suguro; Keitaro Matsuo; Hayao Nakanishi; Tohru Kiyono; Shigeo Nakamura; Hirotaka Osada; Yoshitaka Sekido; Masao Seto; Shinobu Tsuzuki
CARCINOGENESIS, Nov. 2016, Reviewed, No invitation
37(11), 1098, 1109, 10.1093/carcin/bgw084 - Synergistic activity of Card11 mutant and Bcl6 in the development of diffuse large B-cell lymphoma in a mouse model
Taishi Takahara; Keitaro Matsuo; Masao Seto; Shigeo Nakamura; Shinobu Tsuzuki
CANCER SCIENCE, Nov. 2016, Reviewed, No invitation
107(11), 1572, 1580, 10.1111/cas.13057 - New mouse model of acute adult T-cell leukemia generated by transplantation of AKT, BCLxL, and HBZ-transduced T cells
Yumiko Kasugai; Noriaki Yoshida; Koichi Ohshima; Keitaro Matsuo; Masao Seto; Shinobu Tsuzuki
CANCER SCIENCE, Aug. 2016, Reviewed, No invitation
107(8), 1072, 1078, 10.1111/cas.12974 - ★Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults
Takahiko Yasuda; Shinobu Tsuzuki; Masahito Kawazu; Fumihiko Hayakawa; Shinya Kojima; Toshihide Ueno; Naoto Imoto; Shinji Kohsaka; Akiko Kunita; Koichiro Doi; Toru Sakura; Toshiaki Yujiri; Eisei Kondo; Katsumichi Fujimaki; Yasunori Ueda; Yasutaka Aoyama; Shigeki Ohtake; Junko Takita; Eirin Sai; Masafumi Taniwaki; Mineo Kurokawa; Shinichi Morishita; Masashi Fukayama; Hitoshi Kiyoi; Yasushi Miyazaki; Tomoki Naoe; Hiroyuki Mano
NATURE GENETICS, May 2016, Reviewed, No invitation
48(5), 569, +, 10.1038/ng.3535 - ★B Cell Linker Protein (BLNK) Is a Selective Target of Repression by PAX5-PML Protein in the Differentiation Block That Leads to the Development of Acute Lymphoblastic Leukemia
Naoto Imoto; Fumihiko Hayakawa; Shingo Kurahashi; Takanobu Morishita; Yuki Kojima; Takahiko Yasuda; Keiki Sugimoto; Shinobu Tsuzuki; Tomoki Naoe; Hitoshi Kiyoi
JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2016, Reviewed, No invitation
291(9), 4723, 4731, 10.1074/jbc.M115.637835 - STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas
Noriaki Yoshida; Shinobu Tsuzuki; Kennosuke Karube; Taishi Takahara; Miyuki Suguro; Hiroaki Miyoshi; Momoko Nishikori; Masanori Shimoyama; Kunihiro Tsukasaki; Koichi Ohshima; Masao Seto
CANCER SCIENCE, Oct. 2015, Reviewed, No invitation
106(10), 1455, 1462, 10.1111/cas.12742 - Generation of Mouse Pluripotent Stem Cell-Derived Proliferating Myeloid Cells as an Unlimited Source of Functional Antigen-Presenting Cells
Rong Zhang; Tian-Yi Liu; Satoru Senju; Miwa Haruta; Narumi Hirosawa; Motoharu Suzuki; Minako Tatsumi; Norihiro Ueda; Hiroyuki Maki; Ryusuke Nakatsuka; Yoshikazu Matsuoka; Yutaka Sasaki; Shinobu Tsuzuki; Hayao Nakanishi; Ryoko Araki; Masumi Abe; Yoshiki Akatsuka; Yasushi Sakamoto; Yoshiaki Sonoda; Yasuharu Nishimura; Kiyotaka Kuzushima; Yasushi Uemura
CANCER IMMUNOLOGY RESEARCH, Jun. 2015, Reviewed, No invitation
3(6), 668, 677, 10.1158/2326-6066.CIR-14-0117 - ★Synergy of Myc, cell cycle regulators and the Akt pathway in the development of aggressive B-cell lymphoma in a mouse model
K. Arita; S. Tsuzuki; K. Ohshima; T. Sugiyama; M. Seto
LEUKEMIA, Nov. 2014, Reviewed, No invitation
28(11), 2270, 2272, 10.1038/leu.2014.224 - ★Molecular Characterization of Chronic-type Adult T-cell Leukemia/Lymphoma
Noriaki Yoshida; Kennosuke Karube; Atae Utsunomiya; Kunihiro Tsukasaki; Yoshitaka Imaizumi; Naoya Taira; Naokuni Uike; Akira Umino; Kotaro Arita; Miyuki Suguro; Shinobu Tsuzuki; Tomohiro Kinoshita; Koichi Ohshima; Masao Seto
CANCER RESEARCH, Nov. 2014, Reviewed, No invitation
74(21), 6129, 6138, 10.1158/0008-5472.CAN-14-0643 - Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
Miyuki Suguro; Noriaki Yoshida; Akira Umino; Harumi Kato; Hiroyuki Tagawa; Masao Nakagawa; Noriko Fukuhara; Sivasundaram Karnan; Ichiro Takeuchi; Toby D Hocking; Kotaro Arita; Kennosuke Karube; Shinobu Tsuzuki; Shigeo Nakamura; Tomohiro Kinoshita; Masao Seto
Cancer science, Jul. 2014
105(7), 897, 904, 10.1111/cas.12442 - 血液・造血器腫瘍 最新の話題 レトロウイルスによる正常B細胞への遺伝子導入を用いた成熟B細胞腫瘍マウスモデル
在田 幸太郎; 都築 忍; 大島 孝一; 杉山 敏郎; 瀬戸 加大
Cytometry Research, Jun. 2014
24(Suppl.), 38, 38 - リンパ球系 Burkitt lymphomaの遺伝子変異
都築 忍; 在田 幸太郎; 瀬戸 加大
Annual Review血液, Jan. 2014
2014, 136, 140 - Gene expression profiling of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways
Harumi Kato; Kennosuke Karube; Kazuhito Yamamoto; Jun Takizawa; Shinobu Tsuzuki; Yasushi Yatabe; Teru Kanda; Miyuki Katayama; Yukiyasu Ozawa; Kenji Ishitsuka; Masataka Okamoto; Tomohiro Kinoshita; Koichi Ohshima; Shigeo Nakamura; Yasuo Morishima; Masao Seto
Cancer Science, 2014, Reviewed, No invitation
105(5), 537, 544, 10.1111/cas.12389 - ★Functionally Deregulated AML1/RUNX1 Cooperates with BCR-ABL to Induce a Blastic Phase-Like Phenotype of Chronic Myelogenous Leukemia in Mice
Kiyoko Yamamoto; Shinobu Tsuzuki; Yosuke Minami; Yukiya Yamamoto; Akihiro Abe; Koichi Ohshima; Masao Seto; Tomoki Naoe
PLoS ONE, Sep. 2013, Reviewed, No invitation
8(9), e74864, 10.1371/journal.pone.0074864 - ★Generation of mouse models of lymphoid neoplasm using retroviral gene transduction of in vitro-induced germinal center B and T cells
Kotaro Arita; Yumiko Maeda-Kasugai; Koichi Ohshima; Shinobu Tsuzuki; Miyuki Suguro-Katayama; Kennosuke Karube; Noriaki Yoshida; Toshiro Sugiyama; Masao Seto
EXPERIMENTAL HEMATOLOGY, Aug. 2013, Reviewed, No invitation
41(8), 731, 741, 10.1016/j.exphem.2013.04.001 - Comprehensive gene expression profiles of NK cell neoplasms identify vorinostat as an effective drug candidate
Kennosuke Karube; Shinobu Tsuzuki; Noriaki Yoshida; Kotaro Arita; Harumi Kato; Miyuki Katayama; Young-Hyeh Ko; Koichi Ohshima; Shigeo Nakamura; Tomohiro Kinoshita; Masao Seto
CANCER LETTERS, Jun. 2013, Reviewed, No invitation
333(1), 47, 55, 10.1016/j.canlet.2012.12.022 - ★TEL (ETV6)-AML1 (RUNX1) Initiates Self-Renewing Fetal Pro-B Cells in Association with a Transcriptional Program Shared with Embryonic Stem Cells in Mice
Shinobu Tsuzuki; Masao Seto
STEM CELLS, Feb. 2013, Reviewed, No invitation
31(2), 236, 247, 10.1002/stem.1277 - Clonal heterogeneity of mantle cell lymphoma revealed by array comparative genomic hybridization
Fang Liu; Noriaki Yoshida; Miyuki Suguro; Harumi Kato; Kennosuke Karube; Kotaro Arita; Kiyoko Yamamoto; Shinobu Tsuzuki; Koichi Oshima; Masao Seto
European Journal of Haematology, Jan. 2013, Reviewed, No invitation
90(1), 51, 58, 10.1111/ejh.12030 - Lineage-specific growth inhibition of NK cell lines by FOXO3 in association with Akt activation status.
Kennosuke Karube; Shinobu Tsuzuki; Noriaki Yoshida; Kotaro Arita; Fang Liu; Eisaku Kondo; Young-Hyeh Ko; Koichi Ohshima; Shigeo Nakamura; Tomohiro Kinoshita; Masao Seto
Experimental hematology, Dec. 2012, Reviewed, No invitation
40(12), 1005, 1015, 10.1016/j.exphem.2012.08.005 - Identification of multiple subclones in peripheral T-cell lymphoma, not otherwise specified with genomic aberrations
Noriaki Yoshida; Akira Umino; Fang Liu; Kotaro Arita; Kennosuke Karube; Shinobu Tsuzuki; Koichi Ohshima; Masao Seto
CANCER MEDICINE, Dec. 2012, Reviewed, No invitation
1(3), 289, 294, 10.1002/cam4.34 - ★Expansion of functionally defined mouse hematopoietic stem and progenitor cells by a short isoform of RUNX1/AML1
Shinobu Tsuzuki; Masao Seto
BLOOD, Jan. 2012, Reviewed, No invitation
119(3), 727, 735, 10.1182/blood-2011-06-362277 - Mutation analysis of NF-kappa B signal pathway-related genes in ocular MALT lymphoma
Fang Liu; Kennosuke Karube; Harumi Kato; Kotaro Arita; Noriaki Yoshida; Kiyoko Yamamoto; Shinobu Tsuzuki; Wonseog Kim; Young-Hyeh Ko; Masao Seto
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2012, Reviewed, No invitation
5(5), 436, 441 - ★Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells
Masao Nakagawa; Shinobu Tsuzuki; Keiichiro Honma; Osamu Taguchi; Masao Seto
HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, Sep. 2011, Reviewed, No invitation
96(9), 1318, 1326, 10.3324/haematol.2011.041053 - ★Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses
Kennosuke Karube; Masao Nakagawa; Shinobu Tsuzuki; Ichiro Takeuchi; Keiichiro Honma; Yasuhiro Nakashima; Norio Shimizu; Young-Hyeh Ko; Yasuo Morishima; Koichi Ohshima; Shigeo Nakamura; Masao Seto
BLOOD, Sep. 2011, Reviewed, No invitation
118(12), 3195, 3204, 10.1182/blood-2011-04-346890 - The LRF transcription factor regulates mature B cell development and the germinal center response in mice
Nagisa Sakurai; Manami Maeda; Sung-Uk Lee; Yuichi Ishikawa; Min Li; John C. Williams; Lisheng Wang; Leila Su; Mai Suzuki; Toshiki I. Saito; Shigeru Chiba; Stefano Casola; Hideo Yagita; Julie Teruya-Feldstein; Shinobu Tsuzuki; Ravi Bhatia; Takahiro Maeda
JOURNAL OF CLINICAL INVESTIGATION, Jul. 2011, Reviewed, No invitation
121(7), 2583, 2598, 10.1172/JCI45682 - ★Promotion and maintenance of leukemia by ERG
Shinobu Tsuzuki; Osamu Taguchi; Masao Seto
BLOOD, Apr. 2011, Reviewed, No invitation
117(14), 3858, 3868, 10.1182/blood-2010-11-320515 - ★PAX5-PML acts as a dual dominant-negative form of both PAX5 and PML.
Kurahashi S; Hayakawa F; Miyata Y; Yasuda T; Minami Y; Tsuzuki S; Abe A; Naoe T
Oncogene, 2011, Reviewed, No invitation
30(14), 1822-30 - Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center type
Tomomi Sakai; Momoko Nishikori; Masaharu Tashima; Ryo Yamamoto; Toshio Kitawaki; Akifumi Takaori-Kondo; Takayo Suzuki; Shinobu Tsuzuki; Takashi Uchiyama
CANCER SCIENCE, Dec. 2009, Reviewed, No invitation
100(12), 2361, 2367, 10.1111/j.1349-7006.2009.01344.x - ★TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
Keiichiro Honma; Shinobu Tsuzuki; Masao Nakagawa; Hiroyuki Tagawa; Shigeo Nakamura; Yasuo Morishima; Masao Seto
BLOOD, Sep. 2009, Reviewed, No invitation
114(12), 2467, 2475, 10.1182/blood-2008-12-194852 - TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma
Keiichiro Honma; Shinobu Tsuzuki; Masao Nakagawa; Sivasundaram Karnan; Yoshifusa Aizawa; Won Seog Kim; Yoon-Duk Kim; Young-Hyeh Ko; Masao Seto
GENES CHROMOSOMES & CANCER, Jan. 2008, Reviewed, No invitation
47(1), 1, 7, 10.1002/gcc.20499 - ★Initiating and cancer-propagating cells in TEL-AML1-associated childhood leukemia
Dengli Hong; Rajeev Gupta; Philip Ancliff; Ann Atzberger; John Brown; Shamit Soneji; Joanne Green; Sue Colman; Wanda Piacibello; Veronica Buckle; Shinobu Tsuzuki; Mel Greaves; Tariq Enver
SCIENCE, Jan. 2008, Reviewed, No invitation
319(5861), 336, 339, 10.1126/science.1150648 - Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development
Hiroyuki Tagawa; Kennosuke Karube; Shinobu Tsuzuki; Kouich Ohshima; Masao Seto
CANCER SCIENCE, Sep. 2007, Reviewed, No invitation
98(9), 1482, 1490, 10.1111/j.1349-7006.2007.00531.x - ★Isoform-specific potentiation of stem and progenitor cell engraftment by AML1/RUNX1
Shinobu Tsuzuki; Dengli Hong; Rajeev Gupta; Keitaro Matsuo; Masao Seto; Tariq Enver
PLOS MEDICINE, May 2007, Reviewed, No invitation
4(5), 880, 896, 10.1371/journal.pmed.0040172 - Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia: Analysis by means of array-based comparative genomic hybridization
Shinobu Tsuzuki; Sivasundaram Karnan; Keizo Horibe; Kimikazu Matsumoto; Koji Kato; Takeshi Inukai; Kumiko Goi; Kanji Sugita; Shinpei Nakazawa; Yumiko Kasugai; Ryuzo Ueda; Masao Seto
CANCER SCIENCE, May 2007, Reviewed, No invitation
98(5), 698, 706, 10.1111/j.1349-7006.2007.00443.x - Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia
S Karnan; S Tsuzuki; H Kiyoi; H Tagawa; R Ueda; M Seto; T Naoe
GENES CHROMOSOMES & CANCER, Apr. 2006, Reviewed, No invitation
45(4), 420, 425, 10.1002/gec.20309 - MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10
M Nakagawa; Y Hosokawa; M Yonezumi; K Izumiyama; R Suzuki; S Tsuzuki; M Asaka; M Seto
BLOOD, Dec. 2005, Reviewed, No invitation
106(13), 4210, 4216, 10.1182/blood-2004-12-4785 - Array CGH法によるびまん性大細胞型B細胞性リンパ腫72症例の6p21増幅領域解析とその標的遺伝子の同定
春日井 由美子; 田川 博之; 亀岡 吉弘; シバスンダラム・カルナン; 鈴木 律朗; 都築 忍; 細川 好孝; 森島 泰雄; 中村 栄男; 瀬戸 加大
日本癌学会総会記事, Sep. 2005
64回, 258, 258 - ★Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma
H Tagawa; M Suguro; S Tsuzuki; K Matsuo; S Karnan; K Ohshima; M Okamoto; Y Morishima; S Nakamura; M Seto
BLOOD, Sep. 2005, Reviewed, No invitation
106(5), 1770, 1777, 10.1182/blood-2005-02-0542 - [Antiapoptotic functions of the retrovirally transferred API2-MALT1 gene].
Mayama K; Tsuzuki S; Seto M
[Rinsho ketsueki] The Japanese journal of clinical hematology, Jul. 2005, Reviewed, No invitation
46(7), 479, 485, 10.11406/rinketsu.46.479 - Developmental impact of leukemic fusion genes on stem cell fate
T Enver; S Tsuzuki; J Brown; DL Hong; R Gupta; T Ford; MI Egucchi; M Egucchi; M Greaves
HEMATOPOIETIC STEM CELLS V, 2005, Reviewed, No invitation
1044, 16, 23, 10.1196/annals.1349.003 - Molecular evaluation of endothelial progenitor cells in patients with ischemic limbs - Therapeutic effect by stem cell transplantation
K Yamamoto; T Kondo; S Suzuki; H Izawa; M Kobayashi; N Emi; K Komori; T Naoe; J Takamatsu; T Murohara
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Dec. 2004, Reviewed, No invitation
24(12), E192, E196, 10.1161/01.ATV.0000147730.78953.60 - Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma
Y Kameoka; H Tagawa; S Tsuzuki; S Karnan; A Ota; M Suguro; R Suzuki; M Yamaguchi; Y Morishima; S Nakamura; M Seto
ONCOGENE, Dec. 2004, Reviewed, No invitation
23(56), 9148, 9154, 10.1038/sj.onc.1208136 - Comparison of genetic aberrations in CD10(+) diffused large B-cell lymphoma and follicular lymphoma by comparative genomic hybridization and tissue-fluorescence in situ hybridization
XH Zhang; S Karnan; H Tagawa; R Suzuki; S Tsuzuki; Y Hosokawa; Y Morishima; S Nakamura; M Seto
CANCER SCIENCE, Oct. 2004, Reviewed, No invitation
95(10), 809, 814, 10.1111/j.1349-7006.2004.tb02186.x - Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma: Comparison between CD5-positive and CD5-negative cases
H Tagawa; S Tsuzuki; R Suzuki; S Karnan; A Ota; Y Kameoka; M Suguro; K Matsuo; M Yamaguchi; M Okamoto; Y Morishima; S Nakamura; M Seto
CANCER RESEARCH, Sep. 2004, Reviewed, No invitation
64(17), 5948, 5955, 10.1158/0008-5472.CAN-03-4056 - ★Cross talk between retinoic acid signaling and transcription factor GATA-2.
Shinobu Tsuzuki; Kenji Kitajima; Toru Nakano; Annegret Glasow; Arthur Zelent; Tariq Enver
Molecular and cellular biology, Aug. 2004, Reviewed, No invitation
24(15), 6824, 36, 10.1128/mcb.24.15.6824-6836.2004 - ★Modeling first-hit functions of the t(12;21) TEL-AML1 translocation in mice
S Tsuzuki; M Seto; M Greaves; T Enver
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2004, Reviewed, No invitation
101(22), 8443, 8448, 10.1073/pnas.0402063101 - Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma
A Ota; H Tagawa; S Karnan; S Tsuzuki; A Karpas; S Kira; Y Yoshida; M Seto
CANCER RESEARCH, May 2004, Reviewed, No invitation
64(9), 3087, 3095, 10.1158/0008-5472.CAN-03-3773 - Involvement of mitogen-activated protein kinase in the cytokineregulated phosphorylation of transcription factor GATA-1
M Towatari; M Ciro; S Ottolenghi; S Tsuzuki; T Enver
HEMATOLOGY JOURNAL, 2004, Reviewed, No invitation
5(3), 262, 272, 10.1038/sj.thj.6200345 - Stability and subcellular localization of API2-MALT1 chimeric protein involved in t(11;18) (q21;q21) MALT lymphoma
K Izumiyama; M Nakagawa; M Yonezumi; Y Kasugai; R Suzuki; H Suzuki; S Tsuzuki; Y Hosokawa; M Asaka; M Seto
ONCOGENE, Nov. 2003, Reviewed, No invitation
22(50), 8085, 8092, 10.1038/sj.onc.1207002 - ★Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and the t(11;17)-generated PLZF-retinoic acid receptor alpha oncoprotein
S Tsuzuki; T Enver
BLOOD, May 2002, Reviewed, No invitation
99(9), 3404, 3410, 10.1182/blood.V99.9.3404 - Acute promyelocytic leukemia with apparently normal karyotype: Molecular findings and response to all-trans retinoic acid
A. Kohno; S. Tsuzuki; M. Kasai; K. Miyamura; N. Emi; M. Tanimoto; H. Saito
Leukemia and Lymphoma, 2001, Reviewed, No invitation
42(1-2), 151, 161, 10.3109/10428190109097687 - Histone deacetylase 3 associates with and represses the transcription factor GATA-2.
Ozawa Y; Towatari M; Tsuzuki S; Hayakawa F; Maeda T; Miyata Y; Tanimoto M; Saito H
Blood, 2001, Reviewed, No invitation
98(7), 2116-23, 2123, 10.1182/blood.V98.7.2116 - ★Potentiation of GATA-2 activity through interactions with the promyelocytic leukemia protein(PML)and the t(15:17)-generated PML-retinoic acid receptor alpha oncoprotein.
S Tsuzuki; M Towatari; H Saito; T Enver
MOLECULAR AND CELLULAR BIOLOGY, Sep. 2000, Reviewed, No invitation
Lead, 20(17), 6276, 6286, 10.1128/MCB.20.17.6276-6286.2000 - Syndecan-4 deficiency impairs focal adhesion formation only under restricted conditions
Kazuhiro Ishiguro; Kenji Kadomatsu; Tetsuhito Kojima; Hisako Muramatsu; Shinobu Tsuzuki; Eishin Nakamura; Kazuo Kusugami; Hidehiko Saito; Takashi Muramatsu
Journal of Biological Chemistry, Feb. 2000, Reviewed, No invitation
275(8), 5249, 5252, 10.1074/jbc.275.8.5249 - c-Myb acetylation at the carboxyl-terminal conserved domain by transcriptional co-activator p300
Akihiro Tomita; Masayuki Towatari; Shinobu Tsuzuki; Fumihiko Hayakawa; Hiroshi Kosugi; Katsuyuki Tamai; Toshiaki Miyazaki; Tomohiro Kinoshita; Hidehiko Saito
Oncogene, Jan. 2000, Reviewed, No invitation
19(3), 444, 451, 10.1038/sj.onc.1203329 - FK506 (tacrolimus) inhibits extravasation of lymphoid cells by abrogating VLA-4/VCAM-1 mediated transendothelial migration
Shinobu Tsuzuki; Noriko Toyama-Sorimachi; Fujiko Kitamura; Yoshimi Tobita; Masayuki Miyasaka
FEBS Letters, Jul. 1998, Reviewed, No invitation
430(3), 414, 418, 10.1016/S0014-5793(98)00703-0 - Utility and Safety of Hickman Catheters for Venous Access after Bone Marrow Transplantation
Takashi Kumagai; Hisashi Sakamaki; Syuu Tanikawa; Hideki Akiyama; Yoshiharu Maeda; Tsuneo Sasaki; Shinobu Tsuzuki; Shigeru Takamoto; Keiichi Takahashi; Yasusuke Onozawa
Internal Medicine, 1998, Reviewed, No invitation
37(3), 286, 291, 10.2169/internalmedicine.37.286 - Intracellular signal-transducing elements involved in transendothelial migration of lymphoma cells
Shinobu Tsuzuki; Noriko Toyama-Sorimachi; Fujiko Kitamura; Hiroko Tsuboi; Joji Ando; Takashi Sakurai; Narito Morii; Shuh Narumiya; Masayuki Miyasaka
Japanese Journal of Cancer Research, 1998, Reviewed, No invitation
89(5), 571, 577, 10.1111/j.1349-7006.1998.tb03299.x - Molecular cloning, genomic organization, promoter activity, and tissue-specific expression of the mouse ryudocan gene
S Tsuzuki; T Kojima; A Katsumi; T Yamazaki; Sugiura, I; H Saito
JOURNAL OF BIOCHEMISTRY, Jul. 1997, Reviewed, No invitation
122(1), 17, 24 - Two distinct novel splice site mutations in a compound heterozygous patient with protein S deficiency
T Yamazaki; A Katsumi; Y Okamoto; T Takafuta; S Tsuzuki; K Kagami; Sugiura, I; T Kojima; K Fujimura; H Saito
THROMBOSIS AND HAEMOSTASIS, Jan. 1997, Reviewed, No invitation
77(1), 14, 20 - Analysis for antithrombin gene polymorphisms in Japanese subjects and cosegregation studies in families with hereditary antithrombin deficiency
Tomio Yamazaki; Akira Katsumi; Shinobu Tsuzuki; Isamu Sugiura; Tetsuhito Kojima; Junki Takamatsu; Hidehiko Saito
Thrombosis Research, May 1996, Reviewed, No invitation
82(3), 275, 280, 10.1016/0049-3848(96)00074-6 - Structural organization and promoter activity of the human ryudocan gene
A Takagi; T Kojima; S Tsuzuki; A Katsumi; T Yamazaki; Sugiura, I; M Hamaguchi; H Saito
JOURNAL OF BIOCHEMISTRY, May 1996, Reviewed, No invitation
119(5), 979, 984 - Enrichment of human hematopoietic progenitor cells using the AIS microcellector.
Akatsuka Yoshiki; Mukaiyama Taketo; Horikoshi Noboru; Tsuzuki Shinobu; Kodera Yoshihisa; Katoh Hidefumi; Emi Nobuhiko
Japanese Journal of Transfusion and Cell Therapy, 1994, Reviewed, No invitation
40(1), 68, 75, 10.3925/jjtc1958.40.68 - Allogeneic cryopreserved marrow transplantation in a patient with chronic myelogenous leukemia
Akatsuka Y; Takeshita T; Tsuzuki S; Suzuki R; Sugihara T; Minami S; Kodera Y
[Rinshō ketsueki] The Japanese journal of clinical hematology, 1994, Reviewed, No invitation
35(3), 304, 308 - [Analysis of chronic graft-versus-host disease in patients after bone marrow transplantation from HLA-identical siblings].
Akatsuka Y; Tsuzuki S; Sugihara T; Minami S; Kodera Y; Hirabayashi N
[Rinsho ketsueki] The Japanese journal of clinical hematology, Dec. 1993, Reviewed, No invitation
34, 1517, 1524, 10.11406/rinketsu.34.1517 - Long persistent bcr-abl positive transcript detected by polymerase chain reaction after marrow transplant for chronic myelogenous leukemia without clinical relapse: A study of 64 patients
K. Miyamura; T. Tahara; M. Tanimoto; Y. Morishita; K. Kawashima; Y. Morishima; H. Saito; S. Tsuzuki; K. Takeyama; Y. Kodera; K. Matsuyama; N. Hirabayashi; H. Yamada; K. Naito; K. Imai; H. Sakamaki; O. Asai; S. Mizutani
Blood, 1993, Reviewed, No invitation
81(4), 1089, 1093 - Autologous BMT in high risk patients with CALLA-positive ALL: Possible efficacy of ex vivo marrow leukemia cell purging with monoclonal antibodies and complement
Y. Morishima; K. Miyamura; S. Kosjima; R. Ueda; Y. Morishita; H. Sao; M. Tanimoto; R. Ohno; R. Sobue; M. Hirano; H. Sakamaki; S. Takamoto; K. Imai; Y. Onozawa; S. Yokomaku; Y. Kato; S. Tsuzuki; Y. Akatsuka; S. Minami
Bone Marrow Transplantation, 1993, Reviewed, No invitation
11(4), 255, 259 - [A case report of multiple-transfused aplastic anemia complicated by hemolysis and delayed neutrophil recovery after bone marrow transplantation].
Akatsuka Y; Maeda H; Tsuzuki S; Sugihara T; Minami S; Kodera Y; Koike K
[Rinsho ketsueki] The Japanese journal of clinical hematology, Mar. 1992, Reviewed, No invitation
33, 322, 327, 10.11406/rinketsu.33.322 - [Treatment of aplastic anemia with antilymphocyte globulin, high-dose methylprednisolone and androgen].
Kojima S; Miyajima Y; Fukuda M; Matsuyama T; Maeda H; Yamamoto K; Tsuzuki S; Akatsuka M; Sugihara T; Minami S
[Rinsho ketsueki] The Japanese journal of clinical hematology, Jan. 1992, Reviewed, No invitation
33, 11, 16, 10.11406/rinketsu.33.11 - [Delay in red blood cell recovery after major ABO incompatible bone marrow transplantation].
Fukuda M; Matsumoto K; Kojima S; Matsuyama T; Maeda H; Akatsuka Y; Tsuzuki S; Sughara T; Minami S; Kodera Y
[Rinsho ketsueki] The Japanese journal of clinical hematology, Jan. 1991, Reviewed, No invitation
32, 24, 28, 10.11406/rinketsu.32.24
MISC
- A novel FIRRM-FIGNL1 interaction enhances the viability of multiple myeloma cells.
太田明伸; 太田明伸; 花村一朗; シバスンダラン カルナン; シバスンダラン カルナン; 武井則雄; IFTEKHAR Chowdhury Sajid; 兵頭寿典; 小西裕之; 都築忍; 高見昭良; 細川好孝
International Journal of Myeloma (Web), 2024
14(3) - LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis.
HYODO Toshinori; HASAN Muhammad Nazmul; BISWAS Mrityunjoy; INAMI Eri; KARNAN Sivasundaram; OTA Akinobu; TSUZUKI Shinobu; HOSOKAWA Yoshitaka; KONISHI Hiroyuki
日本分子生物学会年会プログラム・要旨集(Web), 2023
46th - A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene
HASAN Muhammad Nazmul; HYODO Toshinori; BISWAS Mrityunjoy; RAHMAN MD. Lutfur; MIHARA Yuko; KARNAN Sivasundaram; OTA Akinobu; TSUZUKI Shinobu; HOSOKAWA Yoshitaka; KONISHI Hiroyuki
日本分子生物学会年会プログラム・要旨集(Web), 2023
46th - OTS514 suppresses the tumor growth with concomitant downregulation of E2F target genes in oral squamous carcinoma cells.
太田明伸; 太田明伸; カルナン シバスンダラン; 小西裕之; 都築忍; 細川好孝; 風岡宜暁
日本癌学会学術総会抄録集(Web), 2023
82nd - Pre-B細胞性急性リンパ球性白血病における転写制御ネットワーク
都築忍; 安田貴彦; 河津正人; 上野敏秀; シバスンダラン カルナン; 太田明伸; 真田昌; 永井宏和; 冨田章裕; 高橋義行; 宮崎泰司; 松村到; 清井仁; 細川好孝; 間野博行; 早川文彦
日本癌学会学術総会抄録集(Web), 2021
80th - p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Establishment and characterization of human mesothelial cell lines with CRISPR/Cas9-mediated disruption of NF2 and p16)
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2019, Not reviewed, No invitation
78回, P, 1221 - CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析
Sivasundaram Karnan; 太田 明伸; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本生化学会大会プログラム・講演要旨集, Sep. 2019, Not reviewed, No invitation
92回, [3P, 277] - DNA二重鎖切断を介さない変異ノックイン法
兵頭寿典; LUTFUR Rahman Md; 豊田敦; 豊田敦; SIVASUNDARAM Karnan; 太田明伸; 都築忍; 細川好孝; 小西裕之
日本分子生物学会年会プログラム・要旨集(Web), 2019
42nd - 多発性骨髄腫の腫瘍増殖におけるPDZ binding kinaseの関与(Involvement of PDZ binding kinase in tumor growth in multiple myeloma cells)
太田 明伸; 花村 一朗; カルナン・シバスンダラン; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation
77回, 764, 764 - p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Identification of malignant mesothelioma-specific molecule whose expression is induced by deficiency of p16 / NF2 gene)
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; ムハマド・ワヒドゥーズマン; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation
77回, 1541, 1541 - ZNF384融合遺伝子による急性リンパ性白血病発症機構の解明(Molecular mechanisms of B acute lymphoblastic leukemia development by ZNF384-fusion proteins)
山本 秀行; 早川 文彦; 安田 貴彦; 南川 友香; 丹下 直幸; 平野 大希; 小島 勇貴; 森下 喬允; 都築 忍; 間野 博行; 直江 知樹; 清井 仁
臨床血液, Sep. 2018, Not reviewed, No invitation
59(9), 1535, 1535 - 成人B細胞性急性リンパ性白血病のゲノム学的・臨床的な特徴(Genomic and clinical characterization of adult B-cell acute lymphoblastic leukemia)
安田 貴彦; 西島 大; 小島 進也; 河津 正人; 上野 敏秀; 都築 忍; 清井 仁; 松村 到; 宮崎 泰司; 堀部 敬三; 間野 博行; 直江 知樹; 眞田 昌; 早川 文彦
臨床血液, Sep. 2018, Not reviewed, No invitation
59(9), 1535, 1535 - p16/NF2遺伝子の欠損により発現の誘導される悪性中皮腫特異的分子の同定(Identification of malignant mesothelioma-specific molecule whose expression is induced by deficiency of p16 / NF2 gene)
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; ムハマド・ワヒドゥーズマン; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation
77回, 1541, 1541 - 多発性骨髄腫の腫瘍増殖におけるPDZ binding kinaseの関与(Involvement of PDZ binding kinase in tumor growth in multiple myeloma cells)
太田 明伸; 花村 一朗; カルナン・シバスンダラン; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2018, Not reviewed, No invitation
77回, 764, 764 - 悪性中皮腫細胞の増殖を特異的に抑制するAkt阻害剤の探索と同定
太田明伸; 山地雅之; ワヒドッジャマン ムハマド; カルナン シバスンダラン; 兵頭寿典; 小西裕之; 都築忍; 羽生田正行; 細川好孝
日本生化学会大会(Web), Sep. 2018, Not reviewed, No invitation
91回, [1P, 293] - 新規Interleukin-6誘導因子PDZ binding kinaseは骨髄腫細胞の増殖と進展に関与する
太田 明伸; 花村 一朗; カルナン・シバスンダラン; ワヒドゥザマン・ムハマド; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
生命科学系学会合同年次大会, Dec. 2017, Not reviewed, No invitation
2017年度, [1P, 0949] - CRISPR/Cas9を用いたNF2ノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析
シバスンダラン・カルナン; 太田 明伸; 花村 一朗; 村上 秀樹; 兵頭 寿典; ムハマド・ワヒドゥ-ズマン; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2017, Not reviewed, No invitation
76回, P, 1075 - 亜ヒ酸とシスプラチンによる併用療法はBcr-Abl陽性白血病細胞に対して相乗的な増殖抑制効果を示す
太田 明伸; ワヒドゥージャマン・ムハマド; カルナン・シバスンダラン; 兵頭 寿典; 小西 裕之; 都築 忍; 細川 好孝
日本癌学会総会記事, Sep. 2017, Not reviewed, No invitation
76回, P, 2235 - Establishment and molecular characterization of leukemia cells producing FLT3-ITD by CRISPR/Cas9
HANAMURA Ichiro; KARNAN Sivasundaram; OTA Akinobu; MD Wahiduzzaman; GOTO Mineaki; TAKAHASHI Miyuki; MIZUNO Shohei; UCHINO Kaori; SUZUKI Susumu; TSUZUKI Shinobu; KONISHI Hiroyuki; UEDA Ryuzo; HOSOKAWA Yoshitaka; TAKAMI Akiyoshi
臨床血液, 2017
58(9) - The rs3779620 in the PBK gene is closely associated with myeloma cell growth
HANAMURA Ichiro; OTA Akinobu; KARNAN Sivasundaram; MD Wahiduzzaman; MIZUNO Shohei; UCHINO Kaori; KANASUGI Jo; HORIO Tomohiro; MURAKAMI Satsuki; SUZUKI Susumu; TSUZUKI Shinobu; KONISHI Hiroyuki; UEDA Ryuzo; HOSOKAWA Yoshitaka; TAKAMI Akiyoshi
臨床血液, 2017
58(9) - Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells
WAHIDUZZAMAN Md; OTA Akinobu; KARNAN Sivasundaram; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th - 悪性胸膜中皮腫の早期診断腫瘍マーカーの検討
シバスンダラン カルナン; OTA Akinobu; HANAMURA Ichiro; MURAKAMI Hideki; HYODO Toshinori; MD Wahiduzzaman; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th - Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults (vol 48, pg 569, 2016)
Takahiko Yasuda; Shinobu Tsuzuki; Masahito Kawazu; Fumihiko Hayakawa; Shinya Kojima; Toshihide Ueno; Naoto Imoto; Shinji Kohsaka; Akiko Kunita; Koichiro Doi; Toru Sakura; Toshiaki Yujiri; Eisei Kondo; Katsumichi Fujimaki; Yasunori Ueda; Yasutaka Aoyama; Shigeki Ohtake; Junko Takita; Eirin Sai; Masafumi Taniwaki; Mineo Kurokawa; Shinichi Morishita; Masashi Fukayama; Hitoshi Kiyoi; Yasushi Miyazaki; Tomoki Naoe; Hiroyuki Mano
NATURE GENETICS, Dec. 2016
48(12), 1591, 1591, 10.1038/ng1216-1587a - 小児がんおよび思春期・若年成人がんのゲノム研究による統合的理解と臨床展開 AYA世代急性リンパ性白血病における網羅的融合遺伝子解析
安田 貴彦; 都築 忍; 河津 正人; 早川 文彦; 小島 進也; 上野 敏秀; 清井 仁; 直江 知樹; 間野 博行
日本癌学会総会記事, Oct. 2016, Not reviewed, No invitation
75回, SST6, 3 - 遺伝子改変・ゲノム編集効率を測定するアッセイ系としてのPIGA遺伝子の利用
小西裕之; シバスンダラン カルナン; 太田明伸; 都築忍; 細川好孝
日本分子生物学会年会プログラム・要旨集(Web), 2016, Not reviewed, No invitation
39th, ROMBUNNO.1P‐0781 (WEB ONLY) - 【リンパ腫学-最新の研究動向-】リンパ腫研究の動向 悪性リンパ腫モデル細胞の作成とその薬剤スクリーニングへの応用
都築 忍
日本臨床, Oct. 2015, Not reviewed, No invitation
73(増刊8 リンパ腫学), 196, 200 - レトロウイルスによる遺伝子導入を用いた成熟B細胞リンパ腫マウスモデル
在田 幸太郎; 都築 忍; 大島 孝一; 杉山 敏郎; 瀬戸 加大
Cytometry Research, Oct. 2015, Not reviewed, No invitation
25(2), 15, 19 - 急性型成人T細胞性白血病/リンパ腫(ATL)の新規マウスモデル
春日井 由美子; 都築 忍; 吉田 稚明; 片山 幸; 高原 大志; 加留部 謙之輔; 大島 孝一; 瀬戸 加大
日本癌学会総会記事, Oct. 2015, Not reviewed, No invitation
74回, J, 1116 - マウスモデルを用いたDiffuse large B cell lymphoma(DLBCL)関連遺伝子の機能解析
高原 大志; 都築 忍
日本癌学会総会記事, Oct. 2015, Not reviewed, No invitation
74回, P, 2266 - STX11 Acts As a Novel Tumor Suppressor Gene in Peripheral T-Cell Lymphomas
Noriaki Yoshida; Shinobu Tsuzuki; Kennosuke Karube; Miyuki Katayama; Taishi Takahara; Shigeo Nakamura; Momoko Nishikori; Masanori Shimoyama; Koichi Ohshima; Kunihiro Tsukasaki; Masao Seto
BLOOD, Dec. 2014, Not reviewed, No invitation
124(21) - PAX5-PML Induces Pro B Acute Lymphoblastic Leukemia in Mice
Naoto Imoto; Shingo Kurahashi; Fumihiko Hayakawa; Takahiko Yasuda; Keiki Sugimoto; Yuki Kojima; Takanobu Morishita; Yuichiro Inagaki; Shinobu Tsuzuki; Tomoki Naoe; Hitoshi Kiyoi
BLOOD, Dec. 2014, Not reviewed, No invitation
124(21) - Myc、細胞周期関連遺伝子、Aktパスウエイの協調によるマウスリンパ腫モデル(Synergy of Myc, cell cycle regulators and the Akt pathway in a mouse model of B-cell lymphoma)
都築 忍; 在田 幸太郎; 大島 孝一; 杉山 敏郎; 瀬戸 加大
日本癌学会総会記事, Sep. 2014, Not reviewed, No invitation
73回, P, 3049 - マントル細胞リンパ腫における、染色体1番短腕に存在する腫瘍抑制遺伝子CDC14Aの同定(Identification of CDC14A as tumor-suppressor candidate of chromosome 1p in mantle cell lymphom)
高原 大志; 吉田 稚明; 在田 幸太郎; 垣内 辰雄; 片山 幸; 春日井 由美子; 都築 忍; 瀬戸 加大
日本癌学会総会記事, Sep. 2014, Not reviewed, No invitation
73回, P, 2118 - Hippo経路の不活性化による中皮細胞の形質転換への寄与(Inactivation of Hippo-pathway contributes to the transformation of mesothelial cells)
垣内 辰雄; 高原 大志; 吉田 稚明; 在田 幸太郎; 春日井 由美子; 片山 幸; 中西 速夫; 長田 啓隆; 関戸 好孝; 都築 忍; 瀬戸 加大
日本癌学会総会記事, Sep. 2014, Not reviewed, No invitation
73回, J, 3106 - STX11はT細胞性腫瘍特異的ながん抑制遺伝子である
YOSHIDA CHIAKI; TSUZUKI SHINOBU; KARUBE KENNOSUKE; TAKAHARA TAISHI; TAKAHARA TAISHI; NISHIKORI MOMOKO; SHIMOYAMA MASANORI; OSHIMA KOICHI; TSUKASAKI KUNIHIRO; SETO MASAO
日本リンパ網内系学会会誌, 06 Jun. 2014, Not reviewed, No invitation
54, 118 - Cell Cycle Deregulation Determines Acute Transformation In Chronic Type Adult T-Cell Leukemia/Lymphoma
Noriaki Yoshida; Kennosuke Karube; Atae Utsunomiya; Kunihiro Tsukasaki; Yoshitaka Imaizumi; Naoya Taira; Naokuni Uike; Akira Umino; Kotaro Arita; Miyuki Suguro; Shinobu Tsuzuki; Tomohiro Kinoshita; Koichi Ohshima; Masao Seto
BLOOD, Nov. 2013, Not reviewed, No invitation
122(21) - TRAILを発現する多能性幹細胞由来ミエロイド細胞を用いた細胞医薬の開発(Pluripotent stem cell-derived myeloid cells engineered to express TRAIL as a possible cell medicine for cancer)
牧 寛之; 植村 靖史; 張 エイ; 竹田 和由; 劉 天懿; 鈴木 元晴; 都築 忍; 岡村 文子; 赤塚 美樹; 西村 泰治; 千住 覚; 葛島 清隆
日本癌学会総会記事, Oct. 2013, Not reviewed, No invitation
72回, 371, 371 - Deregulation of CCND1 or BCL2 in the Immature B-Cell Stage Determines the Resulting Lymphoma Histology
Masaharu Tashima; Momoko Nishikori; Wataru Kishimoto; Ryo Yamamoto; Tomomi Sakai; Katsuyuki Ohmori; Shinobu Tsuzuki; Masao Seto; Akifumi Takaori-Kondo
BLOOD, Nov. 2012, Not reviewed, No invitation
120(21) - Identification of Multiple Subclones in Peripheral T-Cell Lymphoma, Not Otherwise Specified with Genomic Aberrations
Noriaki Yoshida; Akira Umino; Fang Liu; Kotaro Arita; Kennosuke Karube; Shinobu Tsuzuki; Koichi Ohshima; Masao Seto
BLOOD, Nov. 2012, Not reviewed, No invitation
120(21) - 加齢関連EBLPDの発現解析から明らかとなった特徴的な発癌経路における変化(Expression analysis of age-related EBLPD uncovers alterations in characteristic oncogenetic pathways)
Kato Harumi; Karube Kennosuke; Yamamoto Kazuhito; Takizawa Jun; Tsuzuki Shinobu; Katayama Miyuki; Kanda Teru; Yatabe Yasushi; Ozawa Yukiyasu; Ishitsuka Kenji; Okamoto Masataka; Kinoshita Tomohiro; Oshima Koichi; Nakamura Shigeo; Morishima Yasuo; Seto Masao
臨床血液, Sep. 2012, Not reviewed, No invitation
53(9), 1098, 1098 - 慢性型ATLのゲノム異常解析
吉田稚明; 吉田稚明; 加留部謙之輔; 片山幸; 在田幸太郎; 在田幸太郎; 海野啓; 海野啓; 宇都宮與; 塚崎邦弘; 今泉芳孝; 平良直也; 大島孝一; 都築忍; 瀬戸加大; 瀬戸加大
ATLシンポジウム/HTLV-1国際シンポジウム/HTLV-1研究会プログラム・抄録集, 2012
1st-2nd-5th - Deregulated Activity of AML1/RUNX1 Cooperates with BCR-ABL to Immortalize Hematopoietic Progenitor Cells and Induces Blast Crisis-Like Disease of Chronic Myelogenous Leukemia in Mice
Kiyoko Yamamoto; Shinobu Tsuzuki; Tomoki Naoe; Masao Seto
BLOOD, Nov. 2011, Not reviewed, No invitation
118(21), 1600, 1601 - Gene Expression Profiling of Age-Related Epstein-Barr Virus (EBV)-Associated B-Cell Lymphoproliferative Disorder Uncovers Alterations in Immune and Inflammatory Genes: Possible Implications for Pathogenesis
Harumi Kato; Kazuhito Yamamoto; Kennosuke Karube; Miyuki Katayama; Shinobu Tsuzuki; Yasushi Yatabe; Jun Takizawa; Koichi Ohshima; Shigeo Nakamura; Yasuo Morishima; Masao Seto
BLOOD, Nov. 2011, Not reviewed, No invitation
118(21), 1474, 1474 - 加齢性EBV関連リンパ増殖性疾患の遺伝子発現解析
加藤 春美; 山本 一仁; 加留部 謙之輔; 都築 忍; 谷田部 恭; 瀧澤 淳; 大島 孝一; 中村 栄男; 森島 泰雄; 瀬戸 加大
臨床血液, Sep. 2011, Not reviewed, No invitation
52(9), 1120, 1120 - 加齢性EBV関連B細胞性リンパ増殖性疾患の発現プロファイル(Gene expression profiling of EBV-positive diffuse large B-cell lymphoma (DLBCL) of the elderly)
加藤 春美; 山本 一仁; 加留部 謙之輔; 都築 忍; 谷田部 恭; 瀧澤 淳; 大島 孝一; 中村 栄男; 森島 泰雄; 瀬戸 加大
日本癌学会総会記事, Sep. 2011, Not reviewed, No invitation
70回, 443, 443 - IDENTIFICATION OF FOXO3 AND PRDM1 AS TUMOR SUPPRESSOR GENE CANDIDATES IN NK CELL NEOPLASMS BY THE COMBINATION OF GENOMIC AND FUNCTIONAL ANALYSES
K. Karube; M. Nakagawa; S. Tsuzuki; Y. Ko; S. Nakamura; M. Seto
ANNALS OF ONCOLOGY, Jun. 2011, Not reviewed, No invitation
22, 100, 101 - B Cells with BCL2/IGH Translocation Compose a Distinctive Cell Population That May Serve as a Reservoir of Lymphoma of Germinal Center B-Cell Type
Tomomi Sakai; Momoko Nishikori; Masaharu Tashima; Ryo Yamamoto; Toshio Kitawaki; Akifumi Takaori-Kondo; Shinobu Tsuzuki; Takashi Uchiyama
BLOOD, Nov. 2008, Not reviewed, No invitation
112(11), 714, 714 - Synergistic action of the microRNA-17 polycistron and Myc in aggressive cancer development (vol 98, pg 1482, 2007)
Tagawa H; Karube K; Tsuzuki S; Ohshima K; Seto M.
CANCER SCIENCE, Jan. 2008, Not reviewed, No invitation
99(1), 186, 186 - Ocular adnexal marginal zone B cell lymphoma has characteristic deletion at chromosome band 6q23.3-24.1 whose target is TNFAIP3
Keiichiro Honma; Shinobu Tsuzuki; Masao Nakagawa; Sivasundaram Kaman; Won-Seog Kim; Yoon-Duk Kim; Young-Hyeh Ko; Masao Seto
BLOOD, Nov. 2007, Not reviewed, No invitation
110(11), 777A, 778A - Array CGH analysis for PTCL-U revealed two genetically distinct subgroups.
Masao Nakagawa; Aya Oshiro; Hiroyuki Tagawa; Sivasundaram Karnan; Shinobu Tsuzuki; Koichi Ohshima; Shigeo Nakamura; Masao Seto
BLOOD, Nov. 2006, Not reviewed, No invitation
108(11), 582A, 582A - The synergistic action of the microRNA-17 cluster with c-MYC in aggressive cancer development.
Hiroyuki Tagawa; Kennoske Karube; Shinobu Tsuzuki; Kouichi Ohshima; Masao Seto
BLOOD, Nov. 2006, Not reviewed, No invitation
108(11), 411A, 411A - Defining second-hit genetic abnormalities involved in the t(12;21) TEL-AML1 acute lymphoblastic leukemia by array-based comparative genomic hybridization
S Tsuzuki; S Karnan; K Horibe; K Matsumoto; K Kato; K Sugita; S Nakazawa; M Seto
BLOOD, Nov. 2005, Not reviewed, No invitation
106(11), 798A, 798A - MALT1 contains nuclear export signals and regulates cytoplasmic localization of BCL10
M Nakagawa; Y Hosokawa; R Suzuki; S Tsuzuki; M Seto
ANNALS OF ONCOLOGY, Jun. 2005, Not reviewed, No invitation
16, 92, 93 - Developmental impact of leukaemia associated fusion genes on stem cell fate.
S Tsuzuki; DL Hong; M Eguchi; M Eguchi; M Greaves; J Brown; R Gupta; T Enver
BLOOD CELLS MOLECULES AND DISEASES, Mar. 2005, Not reviewed, No invitation
34(2), 85, 85 - Array CGH法によるびまん性大細胞型B細胞性リンパ腫70症例の6p21増幅領域解析とその標的遺伝子の同定
春日井由美子; 田川博之; 亀岡吉弘; SIVASUNDARAM Karnan; 鈴木律朗; 都築忍; 細川好孝; 森島泰雄; 中村栄男; 瀬戸加大
日本癌学会学術総会記事, 2005
64th - Array CGH analysis for target genes at 6p21 amplification region in diffuse large B-cell lymphoma
Y Kasugai; H Tagawa; Y Kameoka; S Karnan; R Suzuki; S Tsuzuki; Y Hosokawa; M Seto
BLOOD, Nov. 2004, Not reviewed, No invitation
104(11), 316A, 317A - Contig array CGH at 3p14.2 points to the FHIT gene as the deleted gene in diffuse large B cell lymphoma
Y Kameoka; H Tagawa; S Tsuzuki; A Ota; R Suzuki; M Seto
BLOOD, Nov. 2004, Not reviewed, No invitation
104(11), 431A, 432A - Genome-wide array-based CGH for mantle cell lymphoma: Precise mapping of genomic aberrations and identification of novel candidate genes.
H Tagawa; S Karnan; R Suzuki; A Ota; S Tsuzuki; Y Morishima; S Nakamura; M Seto
BLOOD, Nov. 2004, Not reviewed, No invitation
104(11), 790A, 790A - Diffuse Large B‐Cell LymphomaのゲノムワイドなアレイCGH解析
田川博之; 都築忍; 鈴木律朗; KARNAN S; 太田明伸; 松尾恵太郎; 吉田安子; 森島泰夫; 中村栄男
臨床血液, 30 Aug. 2004, Not reviewed, No invitation
45(8), 740 - 悪性リンパ腫における13q31領域の増幅責任遺伝子C13orf25の同定
太田明伸; 田川博之; SIVASUNDARAM K; 都築忍; 清藤勉; 森島泰雄; 中村栄男; 瀬戸加大
日本癌学会総会記事, 25 Aug. 2004, Not reviewed, No invitation
63rd, 161 - Subcellular localization of AP12, MALT1, and AP12-MALT1 chimeric proteins involved in t(11;18)(q21;q21) MALT lymphoma.
M Nakagawa; K Izumiyama; M Yonezumi; Y Kasugai; R Suzuki; H Suzuki; S Tsuzuki; Y Hosokawa; M Seto
BLOOD, Nov. 2003, Not reviewed, No invitation
102(11), 182B, 182B - Ligand dependent potentiation of GATA-2 activity through interaction with retinoic acid receptors.
S Tsuzuki; T Enver; A Zelent
BLOOD, Nov. 2002, Not reviewed, No invitation
100(11), 718A, 718A - PLZF proteins can function as co-repressors of GATA-family transcription factors.
S Tsuzuki; S Ivins; F Guidez; A Zelent; T Enver
BLOOD, Nov. 2001, Not reviewed, No invitation
98(11), 553A, 553A - NF-IL6 modulates the transcriptional activity of p5 promotor of adeno-associated virus type 2.
T Itou; H Iida; M Towatari; S Tsuzuki; N Iijima; M Tanimoto; K Miyamura; H Saito
BLOOD, Nov. 1996, Not reviewed, No invitation
88(10), 546, 546
Research Themes
- 隠れドライバーから見た、難治性リンパ性白血病の成立・維持機構の解明
基盤研究(B)
愛知医科大学
01 Apr. 2022 - 31 Mar. 2026
都築 忍; 安田 貴彦, 都築 忍; 安田 貴彦, 日本学術振興会, 日本学術振興会 - 脂肪組織由来間葉系幹細胞-造血幹細胞における代謝経路解析：抗加齢作用に注目して
基盤研究(C)
愛知医科大学
01 Apr. 2020 - 31 Mar. 2023
中山 享之; 都築 忍, 中山 享之; 都築 忍, 日本学術振興会, 日本学術振興会 - Deciphering leukemia development and maintenance from the perspective of functions of fusion genes
Grant-in-Aid for Scientific Research (B)
Aichi Medical University
01 Apr. 2018 - 31 Mar. 2021
都築 忍; 安田 貴彦, Tsuzuki Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Investigation of mechanisms underlying the development of lymphoma and myeloma using a high-throughput mouse model system
Grant-in-Aid for Scientific Research (C)
01 Apr. 2015 - 31 Mar. 2018
都築 忍, Tsuzuki Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Investigation for molecular mechanisms underlying the establishment of "pre"-leukemic stem cells aiming for therapy and prevention of leukemia
Grant-in-Aid for Scientific Research (C)
Aichi Cancer Center Research Institute
2010 - 2012
都築 忍, TSUZUKI Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Molecular mechanisms of lymphomagenesis
Grant-in-Aid for Scientific Research on Priority Areas
Aichi Cancer Center Research Institute
2005 - 2009
瀬戸 加大; 都筑 忍, SETO Masao, 日本学術振興会, Japan Society for the Promotion of Science - Modeling human leukemia/lymphoma, and ex vivo expansion of hematopoietic stem cells and granulocytes
Grant-in-Aid for Scientific Research (C)
Aichi Cancer Center Research Institute
2007 - 2008
都築 忍, TSUZUKI Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Analysis of multi-step processes of leukemia-genesis in childhood leukemia.
Grant-in-Aid for Scientific Research (C)
Aichi Cancer Center Research Institute
2005 - 2006
都築 忍, TSUZUKI Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Roles of GATA-2/retinoic acid receptor pathways and TEL-AML1 translocation in leukemia
Grant-in-Aid for Scientific Research (C)
Aichi Cancer Center
2003 - 2004
都築 忍, TSUZUKI Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Roles of translocation junction genes for proliferation and differentiation of hemotolymphoid cell
Grant-in-Aid for Scientific Research (B)
Aichi Cancer Center
2002 - 2003
瀬戸 加大; 都築 忍, SETO Masao; TSUZUKI Shinobu, 日本学術振興会, Japan Society for the Promotion of Science - Establishment of Ryudocan Null Mouse and ELISA for Blood Levels of Ryudocan
Grant-in-Aid for Scientific Research (B)
Nagoya University
1998 - 1999
小嶋 哲人; 山本 晃士; 門松 健治; 都築 忍, KOJIMA Tetsuhito; YAMAMOTO Koji; KADOMATSU Kenji, 日本学術振興会, Japan Society for the Promotion of Science - Ryudocan expression and its regulation
Grant-in-Aid for Scientific Research (C)
Nagoya University
1998 - 1999
小嶋 哲人; 安部 明弘; 山本 晃士; 都築 忍; 唐渡 雅行, KOJIMA Tetsuhito; ABE Akihiro; YAMAMOTO Koji, 日本学術振興会, Japan Society for the Promotion of Science - 老化と血栓症:老化モデルマウスでは血液凝固線溶因子の組織内発現異常が存在するか?
萌芽的研究
名古屋大学
1998 - 1999
齋藤 英彦; 安部 明弘; 山本 晃士; 都築 忍, 齋藤 英彦; 安部 明弘; 山本 晃士; 都築 忍, 日本学術振興会, 日本学術振興会 - 動脈硬化の発症病態に関わるHSPG・Ryudocanの機能解析
特定領域研究(A)
名古屋大学
1998 - 1998
小嶋 哲人; 都築 忍; 門松 健治, 小嶋 哲人; 都築 忍; 門松 健治, 日本学術振興会, 日本学術振興会 - 転写因子とcofactorによる造血幹細胞分化モデル:GATA-2とPMLの結合
特定領域研究(A)
名古屋大学
1998 - 1998
齋藤 英彦; 都築 忍; 唐渡 雅行; 谷本 光音, 齋藤 英彦; 都築 忍; 唐渡 雅行; 谷本 光音, 日本学術振興会, 日本学術振興会 - Development of Immunogene Therapy for B-cell malignancy
Grant-in-Aid for Scientific Research (B)
NAGOYA UNIVERSITY
1997 - 1998
齋藤 英彦; 安部 明弘; 都築 忍; 恵美 宣彦, SAITO Hidehiko; ABE Akihiro; TUZUKI Sinobu; EMI Nobuhiko, 日本学術振興会, Japan Society for the Promotion of Science - がん遺伝子
1998 - 血液の増殖、分化
1998 - 造血器腫瘍の発生機構
1998 - Oncogenes
1998 - Proliferation and differentiation of hematopoietic cells
1998 - Mechanisms of Malignant hematopoiesis
1998 - 造血幹細胞においてGATA-2遺伝子産物と機能的に結合する蛋白の分離同定
重点領域研究
名古屋大学
1997 - 1997
齋藤 英彦; 都築 忍; 唐渡 雅行; 谷本 光音, 齋藤 英彦; 都築 忍; 唐渡 雅行; 谷本 光音, 日本学術振興会, 日本学術振興会 - Molecular and Functional Analysis of Heparan sulfate Proteoglycan-Ryudocan.
Grant-in-Aid for Scientific Research (C)
Nagoya University
1996 - 1997
小嶋 哲人; 都築 忍; 唐渡 雅行, KOJIMA Tetsuhito; TUZUKI Shinobu; TOWATARI Masayuki, 日本学術振興会, Japan Society for the Promotion of Science - 造血器腫瘍の分子病態
Industrial Property Rights
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