WADA Iori
Ophthalmology | Assistant Professor |
Paper
- RPE With ROCK-Mediated Epithelial-Mesenchymal Transition as a Key Contributor of Subretinal Fibrosis in AMD
Iori Wada; Keijiro Ishikawa; Muneo Yamaguchi; Shotaro Shimokawa; Ji Rui; Kenichiro Mori; Yoshihiro Kaizu; Mitsuru Arima; Shoji Notomi; Yusuke Murakami; Shigenori Inagaki; Yuta Kohro; Makoto Tsuda; Kensuke Shibata; Ryo Terao; Takeshi Terabayashi; Toshimasa Ishizaki; Shigeo Yoshida; Tatsuro Ishibashi; Susumu Ishida; Rajendra S Apte; Koh-Hei Sonoda; Shintaro Nakao
Investigative Ophthalmology & Visual Science, May 2026
67(5), 33-33, 10.1167/iovs.67.5.33 - En-face quantitative evaluation using ultra-high-resolution OCT of hyperreflective foci in neovascular age-related macular degeneration.
Iori Wada; Shintaro Nakao; Satomi Shiose; Yoshihiro Kaizu; Muneo Yamaguchi; Keijiro Ishikawa; Kohei Kiyohara; Tatsuro Ishibashi; Koh-Hei Sonoda
Japanese journal of ophthalmology, Jun. 2025
10.1007/s10384-025-01219-x - Liposome Encapsulation Enhances Ripasudil Therapeutic Efficacy Against Proliferative Vitreoretinal Diseases: Implications in Advanced Ocular Treatment.
Rui Ji; Keijiro Ishikawa; Wei Tan; Kenichiro Mori; Ryotaro Tsukamoto; Naoya Matsunaga; Kohei Kiyohara; Yosuke Fukuda; Iori Wada; Tomoyuki Isobe; Tomohito Tanihara; Yuya Yoshida; Kouta Mayanagi; Kosuke Oyama; Yuma Terada; Kaita Otsuki; Kengo Hamamura; Hiroshi Kikuchi; Shintaro Nakao; Shigeo Yoshida; Ram Kannan; Shigehiro Ohdo; Koh-Hei Sonoda
Investigative ophthalmology & visual science, Jun. 2025
66(6), 56-56, 10.1167/iovs.66.6.56 - Five-year Outcome of Aflibercept Administration with "Treat and Extend" for Neovascular Age-Related Macular Degeneration.
Iori Wada; Yuji Oshima; Yosuke Fukuda; Satomi Shiose; Kumiko Kano; Keijiro Ishikawa; Shintaro Nakao; Yoshihiro Kaizu; Eiichi Hasegawa; Ram Kannan; Tatsuro Ishibashi; Koh-Hei Sonoda
Clinical ophthalmology (Auckland, N.Z.), 2025
19, 835-845, 10.2147/OPTH.S501953 - Heterotypic macrophages/microglia differentially contribute to retinal ischaemia and neovascularisation.
Muneo Yamaguchi; Shintaro Nakao; Mitsuru Arima; Karis Little; Aditi Singh; Iori Wada; Yoshihiro Kaizu; Souska Zandi; Justus G Garweg; Tetsuya Matoba; Wataru Shiraishi; Ryo Yamasaki; Kensuke Shibata; Yasuhiro Go; Tatsuro Ishibashi; Akiyoshi Uemura; Alan W Stitt; Koh-Hei Sonoda
Diabetologia, Oct. 2024
67(10), 2329-2345, 10.1007/s00125-024-06215-3 - Correction to: Persistence of vascular empty sleeves in choroidal neovascularization after anti-VEGF therapy in both animal models and humans.
Iori Wada; Shintaro Nakao; Yosuke Fukuda; Satomi Shiose; Atsunobu Takeda; Ram Kannan; Koh-Hei Sonoda
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Oct. 2023
261(10), 3047-3047, 10.1007/s00417-023-06214-x - Characterization and contribution of RPE senescence to Age-related macular degeneration in Tnfrsf10 knock out mice.
Iori Wada; Kenichiro Mori; Parameswaran G Sreekumar; Rui Ji; Christine Spee; Elise Hong; Keijiro Ishikawa; Koh-Hei Sonoda; Ram Kannan
bioRxiv : the preprint server for biology, Aug. 2023
10.1101/2023.08.04.552052 - Persistence of vascular empty sleeves in choroidal neovascularization after VEGF therapy in both animal models and humans.
Iori Wada; Shintaro Nakao; Yosuke Fukuda; Satomi Shiose; Atsunobu Takeda; Ram Kannan; Koh-Hei Sonoda
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Aug. 2023
261(8), 2189-2197, 10.1007/s00417-023-06018-z - VOLUMETRIC THREE-DIMENSIONAL OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY OF RETINAL NEOVASCULARIZATION IN PROLIFERATIVE DIABETIC RETINOPATHY.
Shintaro Nakao; Yoshihiro Kaizu; Juun Horie; Iori Wada; Mitsuru Arima; Yosuke Fukuda; Keijiro Ishikawa; Koh-Hei Sonoda
Retinal cases & brief reports, May 2023
17(3), 315-320, 10.1097/ICB.0000000000001183 - Animal model of subretinal fibrosis without active choroidal neovascularization.
Souska Zandi; Yuebing Li; Laura Jahnke; Anelia Schweri-Olac; Keijiro Ishikawa; Iori Wada; Shintaro Nakao; Martin S Zinkernagel; Volker Enzmann
Experimental eye research, Apr. 2023
229, 109428-109428, 10.1016/j.exer.2023.109428 - Identifying Hyperreflective Foci in Diabetic Retinopathy via VEGF-Induced Local Self-Renewal of CX3CR1+ Vitreous Resident Macrophages.
Muneo Yamaguchi; Shintaro Nakao; Iori Wada; Tetsuya Matoba; Mitsuru Arima; Yoshihiro Kaizu; Mariko Shirane; Keijiro Ishikawa; Takahito Nakama; Yusuke Murakami; Masaharu Mizuochi; Wataru Shiraishi; Ryo Yamasaki; Toshio Hisatomi; Tatsuro Ishibashi; Masabumi Shibuya; Alan W Stitt; Koh-Hei Sonoda
Diabetes, Dec. 2022
71(12), 2685-2701, 10.2337/db21-0247 - Morphology and fluorescein leakage in diabetic retinal microaneurysms: a study using multiple en face OCT angiography image averaging.
Yosuke Fukuda; Shintaro Nakao; Yoshihiro Kaizu; Mitsuru Arima; Sakurako Shimokawa; Iori Wada; Muneo Yamaguchi; Atsunobu Takeda; Koh-Hei Sonoda
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Nov. 2022
260(11), 3517-3523, 10.1007/s00417-022-05713-7 - Mechanisms of Epithelial-Mesenchymal Transition and Prevention of Dispase-Induced PVR by Delivery of an Antioxidant αB Crystallin Peptide.
Iori Wada; Parameswaran G Sreekumar; Christine Spee; Andrew J MacKay; Michael Ip; Ram Kannan
Antioxidants (Basel, Switzerland), Oct. 2022
11(10), 10.3390/antiox11102080 - Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography.
Iori Wada; Shintaro Nakao; Mitsuru Arima; Keijiro Ishikawa; Muneo Yamaguchi; Yoshihiro Kaizu; Haruka Sekiryu; Kenichiro Mori; Kohei Kiyohara; Atsunobu Takeda; Tatsuro Ishibashi; SriniVas R Sadda; Koh-Hei Sonoda
Translational vision science & technology, Sep. 2022
11(9), 21-21, 10.1167/tvst.11.9.21 - Longer Interscan Times in OCT Angiography Detect Slower Capillary Flow in Diabetic Retinopathy.
Yoshihiro Kaizu; Shintaro Nakao; Tomomi Soda; Juun Horie; Iori Wada; Muneo Yamaguchi; Atsunobu Takeda; Koh-Hei Sonoda
Ophthalmology science, Sep. 2022
2(3), 100181-100181, 10.1016/j.xops.2022.100181 - TNFRSF10A downregulation induces retinal pigment epithelium degeneration during the pathogenesis of age-related macular degeneration and central serous chorioretinopathy.
Kenichiro Mori; Keijiro Ishikawa; Yosuke Fukuda; Rui Ji; Iori Wada; Yuki Kubo; Masato Akiyama; Shoji Notomi; Yusuke Murakami; Shintaro Nakao; Satoshi Arakawa; Satomi Shiose; Toshio Hisatomi; Shigeo Yoshida; Ram Kannan; Koh-Hei Sonoda
Human molecular genetics, Jul. 2022
31(13), 2194-2206, 10.1093/hmg/ddac020 - One-year efficacy of "rescue photodynamic therapy" for patients with typical age-related macular degeneration, polypoidal choroidal vasculopathy, and pachychoroid neovasculopathy refractory to anti-vascular endothelial growth factor therapy.
Iori Wada; Satomi Shiose; Keijiro Ishikawa; Kumiko Kano; Shoji Notomi; Kenichiro Mori; Masato Akiyama; Shintaro Nakao; Koh-Hei Sonoda
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, Jun. 2022
260(6), 2029-2036, 10.1007/s00417-022-05553-5 - A Case of Bullous Central Serous Chorioretinopathy Treated with Surgical Removal of Submacular Fibrin and Subsequent Photodynamic Therapy under Silicone Oil.
Shoji Notomi; Satomi Shiose; Ri-Ichiro Kohno; Sakurako Shimokawa; Keijiro Ishikawa; Kumiko Kano; Kenichiro Mori; Iori Wada; Yosuke Fukuda; Shunji Nakatake; Muneo Yamaguchi; Koh-Hei Sonoda
Case reports in ophthalmology, 2022
13(2), 385-392, 10.1159/000524515 - Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1+ Macrophage Infiltration.
Iori Wada; Shintaro Nakao; Muneo Yamaguchi; Yoshihiro Kaizu; Mitsuru Arima; Shinichiro Sawa; Koh-Hei Sonoda
Investigative ophthalmology & visual science, Oct. 2021
62(13), 17-17, 10.1167/iovs.62.13.17 - Publisher Correction: Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes.
Mitsuru Arima; Shintaro Nakao; Yoshihiro Kaizu; Iori Wada; Muneo Yamaguchi; Kohta Fujiwara; Masato Akiyama; Alan W Stitt; Koh-Hei Sonoda
Scientific reports, Jun. 2021
11(1), 12344-12344, 10.1038/s41598-021-91789-w - Diabetic vascular hyperpermeability: optical coherence tomography angiography and functional loss assessments of relationships among retinal vasculature changes.
Mitsuru Arima; Shintaro Nakao; Yoshihiro Kaizu; Iori Wada; Muneo Yamaguchi; Kohta Fujiwara; Masato Akiyama; Alan W Stitt; Koh-Hei Sonoda
Scientific reports, Feb. 2021
11(1), 4185-4185, 10.1038/s41598-021-83334-6 - Drusen and pigment abnormality predict the development of neovascular age-related macular degeneration in Japanese patients.
Shoji Notomi; Satomi Shiose; Keijiro Ishikawa; Yosuke Fukuda; Kumiko Kano; Kenichiro Mori; Iori Wada; Yoshihiro Kaizu; Hidetaka Matsumoto; Masato Akiyama; Koh-Hei Sonoda
PloS one, 2021
16(7), e0255213, 10.1371/journal.pone.0255213 - 特集 第73回日本臨床眼科学会講演集[8] 原著 ポリープ状脈絡膜血管症に対する光線力学的療法併用抗血管内皮増殖因子治療後短期における治療成績と再発予測因子
永吉 美月; 塩瀬 聡美; 和田 伊織; 狩野 久美子; 石川 桂二郎; 秋山 雅人; 森 賢一郎; 納富 昭司; 中尾 新太郎; 久冨 智朗; 園田 康平
臨床眼科, Oct. 2020
74(10), 1241-1249, 10.11477/mf.1410213701 - Capillary dropout is dominant in deep capillary plexus in early diabetic retinopathy in optical coherence tomography angiography.
Yoshihiro Kaizu; Shintaro Nakao; Mitsuru Arima; Iori Wada; Muneo Yamaguchi; Haruka Sekiryu; Takehito Hayami; Keijiro Ishikawa; Yasuhiro Ikeda; Koh-Hei Sonoda
Acta ophthalmologica, Aug. 2019
97(5), e811-e812, 10.1111/aos.14041 - Flow Density in Optical Coherence Tomography Angiography is Useful for Retinopathy Diagnosis in Diabetic Patients.
Yoshihiro Kaizu; Shintaro Nakao; Mitsuru Arima; Takehito Hayami; Iori Wada; Muneo Yamaguchi; Haruka Sekiryu; Keijiro Ishikawa; Yasuhiro Ikeda; Koh-Hei Sonoda
Scientific reports, Jun. 2019
9(1), 8668-8668, 10.1038/s41598-019-45194-z
MISC
- Liposome encapsulation enhance the efficacy of Ripasudil on subretinal fibrosis
季鋭; 石川桂二郎; 森賢一郎; 和田伊織; 松永直哉; 福田洋輔; 大戸茂弘; 園田康平
日本眼科学会雑誌, 2022
126 - Decreased TNFRSF10A expression promotes RPE cell death via PKC activation
森賢一郎; 石川桂二郎; 和田伊織; 久保夕樹; 中間崇仁; 秋山雅人; 有馬充; 納富昭司; 村上祐介; 中尾新太郎; 久冨智朗; 吉田茂生; 園田康平
日本眼科学会雑誌, 2021
125 - Short-term treatment outcome of photodynamic therapy for patients with pachychoroid neovasculopathy
福山文里; 塩瀬聡美; 石川桂二郎; 狩野久美子; 和田伊織; 森賢一郎; 海津嘉弘; 秋山雅人; 中間崇仁; 納富昭司; 園田康平
臨床眼科, 2021
75(9) - 治療抵抗性糖尿病黄斑浮腫に対する硝子体手術前後の黄斑形態変化
吉村茉莉花; 石川桂二郎; 森賢一郎; 福田洋輔; 和田伊織; 山口宗男; 納富昭司; 中尾新太郎; 武田篤信; 園田康平
糖尿病合併症, 2021
35(Supplement-1) - ポリープ状脈絡膜血管症に対する光線力学的療法併用抗血管内皮増殖因子治療後短期における治療成績と再発予測因子—Short-term efficacy and predictors of recurrence of initial photodynamic therapy with anti-vascular endothelial growth factor injections for polypoidal choroidal vasculopathy—第73回日本臨床眼科学会講演集(8)
永吉 美月; 塩瀬 聡美; 和田 伊織; 狩野 久美子; 石川 桂二郎; 秋山 雅人; 森 賢一郎; 納富 昭司; 中尾 新太郎; 久冨 智朗; 園田 康平
臨床眼科, Oct. 2020
74(10), 1241-1249 - Short-term efficacy and predictors of recurrence of initial photodynamic therapy with anti-vascular endothelial growth factor injections for polypoidal choroidal vasculopathy
永吉美月; 永吉美月; 塩瀬聡美; 和田伊織; 狩野久美子; 石川桂二郎; 秋山雅人; 森賢一郎; 納富昭司; 中尾新太郎; 久冨智朗; 久冨智朗; 園田康平
臨床眼科, 2020
74(10) - ボリューメトリック3次元OCT angiographyを用いたPDRにおける網膜新生血管評価
福田洋輔; 中尾新太郎; 海津嘉弘; 和田伊織; 有馬充; 石川桂二郎; 園田康平
糖尿病合併症, 2020
34(Supplement 1) - 超広角走査型レーザー検眼鏡を用いた,網膜剥離術後の増殖硝子体網膜症の観察
浅原健一郎; 石川桂二郎; 森賢一郎; 和田伊織; 海津嘉弘; 中間崇仁; 納富昭司; 向野利一郎; 武田篤信; 園田康平
日本網膜硝子体学会総会プログラム・講演抄録集, 2020
59th - 加齢黄斑変性僚眼における前駆病変の滲出型への移行に関する検討
納富昭司; 塩瀬聡美; 石川桂二郎; 狩野久美子; 森賢一郎; 和田伊織; 海津嘉弘; 秋山雅人; 園田康平
日本網膜硝子体学会総会プログラム・講演抄録集, 2020
59th - 滲出型加齢黄斑変性に伴う網膜色素上皮裂孔の発生パターン
福井卓磨; 石川桂二郎; 塩瀬聡美; 狩野久美子; 森賢一郎; 和田伊織; 海津嘉弘; 中間崇仁; 納富昭司; 園田康平
日本網膜硝子体学会総会プログラム・講演抄録集, 2020
59th - Denoise処理OCT angiography画像における網膜毛細血管瘤の検出および形態分類能評価
海津嘉弘; 中尾新太郎; 福田洋輔; 下川桜子; 和田伊織; 山口宗男; 森賢一郎; 石川桂二郎; 園田康平
日本眼科学会雑誌, 2020
124 - 滲出型加齢黄斑変性に対するアフリベルセプト治療後の黄斑萎縮に関連する因子の検討
福田洋輔; 大島裕司; 大島裕司; 塩瀬聡美; 和田伊織; 狩野久美子; 石川桂二郎; 秋山雅人; 森賢一郎; 海津嘉弘; 納富昭司; 中尾新太郎; 園田康平
日本網膜硝子体学会総会プログラム・講演抄録集, 2019
58th - OCT angiographyにおけるinterscan time変更による網膜血管検出能の検討
海津嘉弘; 中尾新太郎; 有馬充; 和田伊織; 森賢一郎; 山口宗男; 石川桂二郎; 園田康平
日本網膜硝子体学会総会プログラム・講演抄録集, 2019
58th - 加算平均OCT angiographyを用いた糖尿病網膜症における毛細血管瘤の形態解析
福田洋輔; 中尾新太郎; 海津嘉弘; 有馬充; 和田伊織; 山口宗男; 秋山雅人; 石川桂二郎; 下川桜子; 園田康平
日本眼循環学会講演抄録集, 2019
36th - 滲出型加齢黄斑変性におけるrescue-PDT半年間の治療成績について
和田伊織; 塩瀬聡美; 狩野久美子; 海津嘉弘; 石川桂二郎; 中尾新太郎; 園田康平
日本眼循環学会講演抄録集, 2019
36th - 加齢黄斑変性に対するアフリベルセプトtreat and extend法の5年成績
大島裕司; 大島裕司; 塩瀬聡美; 狩野久美子; 石川桂二郎; 中尾新太郎; 和田伊織; 海津嘉弘; 長谷川英一; 園田康平
日本眼循環学会講演抄録集, 2019
36th - 加齢黄斑変性の網膜色素上皮層の障害範囲とアフリベルセプト治療後の線維化の関連
石川桂二郎; 塩瀬聡美; 秋山雅人; 狩野久美子; 海津嘉弘; 和田伊織; 中尾新太郎; 大島裕司; 大島裕司; 園田康平
日本眼科学会雑誌, 2019
123 - 糖尿病網膜症におけるCD206+CX3CR1+硝子体界面マクロファージ局所増殖
山口宗男; 山口宗男; 中尾新太郎; 和田伊織; 海津嘉弘; 有馬充; 石川桂二郎; 中間崇仁; 中間崇仁; 白石渉; 山崎亮; 吉良潤一; 石橋達朗; 園田康平
日本眼科学会雑誌, 2019
123 - 加齢黄斑変性に対するアフリベルセプト投与後に網膜下線維化をきたす症例の特徴
石川桂二郎; 塩瀬聡美; 秋山雅人; 狩野久美子; 森賢一郎; 久保夕樹; 海津嘉弘; 和田伊織; 長谷川英一; 中尾新太郎; 大島祐司; 大島祐司; 園田康平
日本網膜硝子体学会総会プログラム・講演抄録集, 2018
57th - 糖尿病網膜症におけるOCT angiographyの網膜血管描出再現性は病期により異なる
海津嘉弘; 中尾新太郎; 和田伊織; 山口宗男; 有馬充; 石川桂二郎; 園田康平
日本眼循環学会講演抄録集, 2018
35th - AMDの活動性マーカーとしてのEn Face OCTによるhyperreflective foci
和田伊織; 中尾新太郎; 大島裕司; 大島裕司; 海津嘉弘; 山口宗男; 有馬充; 石川桂二郎; 狩野久美子; 塩瀬聡美; 石橋達朗; 園田康平
日本眼循環学会講演抄録集, 2018
35th - 糖尿病黄斑浮腫における中心窩無血管野面積とアフリベルセプト治療効果との相関
小林義行; 吉田茂生; 久保夕樹; 中間崇仁; 石川桂二郎; 和田伊織; 海津嘉弘; 山口宗男; 中尾新太郎; 久冨智朗; 池田康博; 石橋達朗; 園田康平
糖尿病合併症, 2017
31(Supplement 1) - ROCK阻害剤を用いた加齢黄斑変性の長期治療に伴う線維化の予防
和田伊織; 中尾新太郎; 山口宗男; 石川桂二郎; 吉田茂生; 有馬充; 磯部友之; 金児佳生; 石橋達朗; 園田康平
日本心血管内分泌代謝学会学術総会プログラム及び抄録集, 2017
21st - アフリベルセプト硝子体注射前後における糖尿病黄斑浮腫患者中心窩無血管野のOCTA解析
小林義行; 吉田茂生; 岡本美里; 久保夕樹; 周也荻; 中間崇仁; 石川桂二郎; 和田伊織; 海津嘉弘; 山口宗男; 中尾新太郎; 石橋達朗; 園田康平
糖尿病合併症, 2016
30(Supplement 1)
Research Themes
- Creation of RPE function markers for visual function preservation: Development of new diagnostic indicators using polarized OCT
Grant-in-Aid for Research Activity Start-up
Aichi Medical University
31 Jul. 2025 - 31 Mar. 2027
和田 伊織, 和田 伊織, 日本学術振興会, Japan Society for the Promotion of Science
