shibasundaran karunan
Biochemistry | Senior Assistant Professor |
Paper
- Diffuse Large B-Cell Lymphoma with t(1;22)(q21;q11.2) and t(6;18)(p25;q21): A Case Report
Toshiaki Nagaie; Yasushi Kubota; Ichiro Hanamura; Sivasundaram Karnan; Rika Tomimasu; Michiaki Akashi; Shiho Tsuruda; Akiyoshi Takami; Shinya Kimura; Masaharu Miyahara
Reports, Jan. 2025
10.3390/reports8010005 - Role of versican in extracellular matrix formation: analysis in 3D culture.
Nushrat Jahan; Shamima Islam; Karnan Sivasundaram; Akinobu Ota; Munekazu Naito; Junpei Kuroda; Hideto Watanabe
American journal of physiology. Cell physiology, Dec. 2024
10.1152/ajpcell.00495.2024 - 飽和脂肪酸が悪性中皮腫細胞の増殖に及ぼす影響の解析
太田 明伸; 牧野 帆里; 吉岡 愛唯; 渡邊 由希子; 横谷 楓花; Chowdhury Sajid Iftekhar; Karnan Sivasundaram; 細川 好孝
脂質栄養学, Aug. 2024
33(2), 134, 134 - Targeting fatty acid synthase suppresses tumor development inNF2/CDKN2A-deficient malignant pleural mesothelioma
Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Md Towhid Ahmed Shihan; Nushrat Jahan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Yinzhi Lin; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Jul. 2024
10.1101/2024.07.14.603191 - PDZ-binding kinase inhibitor OTS514 suppresses the proliferation of oral squamous carcinoma cells.
Mikako Kato; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Toshinori Hyodo; Md Lutfur Rahman; Muhammad Nazmul Hasan; Maho Onda; Sayuri Kondo; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Oral diseases, Mar. 2024
30(2), 223, 234, 10.1111/odi.14533 - Leucine zipper protein 1 (LUZP1) regulates the constriction velocity of the contractile ring during cytokinesis.
Toshinori Hyodo; Eri Asano-Inami; Satoko Ito; Mai Sugiyama; Akihiro Nawa; Md Lutfur Rahman; Muhammad Nazmul Hasan; Yuko Mihara; Vu Quang Lam; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Michinari Hamaguchi; Yoshitaka Hosokawa; Hiroyuki Konishi
The FEBS journal, Mar. 2024
291(5), 927, 944, 10.1111/febs.17017 - ARK5 enhances cell survival associated with mitochondrial morphological dynamics from fusion to fission in human multiple myeloma cells.
Sivasundaram Karnan; Ichiro Hanamura; Akinobu Ota; Lam Quang Vu; Kaori Uchino; Tomohiro Horio; Satsuki Murakami; Shohei Mizuno; Md Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Mrityunjoy Biswas; Toshinori Hyodo; Hideaki Ito; Atsushi Suzuki; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Akiyoshi Takami
Cell death discovery, Jan. 2024
10(1), 56, 56, 10.1038/s41420-024-01814-w - Chromosomal Translocations t(1; 22)(q21; q11.2) and t(6; 18)(p25; q21) in a Patient with Diffuse Large B-cell Lymphoma: FISH Analysis
Hiroaki Kitamura; Yasushi Kubota; Ichiro Hanamura; Sivasundaram Karnan; Rika Tomimasu; Michiaki Akashi; Shiho Tsuruda; Akiyoshi Takami; Shinya Kimura; Masaharu Miyahara
Nov. 2023
10.20944/preprints202311.0678.v1 - Inhibition of VEGFR2 and EGFR signaling cooperatively suppresses the proliferation of oral squamous cell carcinoma.
Maho Onda; Akinobu Ota; Kunihiro Ito; Takayuki Ono; Sivasundaram Karnan; Mikako Kato; Sayuri Kondo; Akifumi Furuhashi; Tomio Hayashi; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cancer medicine, Aug. 2023
12(15), 16416, 16430, 10.1002/cam4.6282 - CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma.
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell death discovery, Jul. 2023
9(1), 257, 257, 10.1038/s41420-023-01552-5 - Long noncoding RNA profile of the intracranial artery in patients with moyamoya disease.
Takashi Mamiya; Fumiaki Kanamori; Kinya Yokoyama; Akinobu Ota; Sivasundaram Karnan; Kenji Uda; Yoshio Araki; Satoshi Maesawa; Kazuhiro Yoshikawa; Ryuta Saito
Journal of neurosurgery, Mar. 2023
138(3), 709, 716, 10.3171/2022.5.JNS22579 - BCL6 inhibition ameliorates resistance to ruxolitinib in CRLF2-rearranged acute lymphoblastic leukemia.
Shinobu Tsuzuki; Takahiko Yasuda; Hiroaki Goto; Naoko Maeda; Koshi Akahane; Takeshi Inukai; Hideyuki Yamamoto; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Yoshitaka Hosokawa; Hitoshi Kiyoi; Fumihiko Hayakawa
Haematologica, Feb. 2023
108(2), 394, 408, 10.3324/haematol.2022.280879 - Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens.
Shunpei Yamanaka; Susumu Suzuki; Hideaki Ito; Karnan Sivasundaram; Ichiro Hanamura; Ikuko Okubo; Kazuhiro Yoshikawa; Shoya Ono; Taishi Takahara; Akira Satou; Toyonori Tsuzuki; Ryuzo Ueda; Tetsuya Ogawa; Yasushi Fujimoto
International journal of molecular sciences, Jan. 2023
24(2), 10.3390/ijms24021722 - Flow cytometry-based quantification of genome editing efficiency in human cell lines using the L1CAM gene.
Muhammad Nazmul Hasan; Toshinori Hyodo; Mrityunjoy Biswas; Md Lutfur Rahman; Yuko Mihara; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
PloS one, 2023
18(11), e0294146, 10.1371/journal.pone.0294146 - Cell surface expression of human RP105 depends on N-glycosylation of MD-1.
Mrityunjoy Biswas; Tatsuya Yamazaki; Susumu Tomono; Sivasundaram Karnan; Hidekazu Takagi; Isao Ichimonji; Masanori Inui; Fumiaki Nagaoka; Yoshitaka Hosokawa; Sachiko Akashi-Takamura
FEBS letters, Dec. 2022
596(24), 3211, 3231, 10.1002/1873-3468.14452 - Plumbagin-induced anticancer effects are associated with mitochondrial- encoded respiratory gene downregulation in oral squamous cell carcinoma
Takayuki Ono; Akinobu Ota; Mikako Kato; Sivasundaram Karnan; Toshinori Hyodo; Md Lutfur Rahman; Muhammad Nazmul Hasan; Maho Onda; Yoshitomo Nishio; Remi Matsuyama; Yukako Takigawa; Sayuri Kondo; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Journal of Oral and Maxillofacial Surgery Medicine and Pathology, Nov. 2022
34(6), 805, 812, 10.1016/j.ajoms.2022.04.006 - Correction of a CD55 mutation to quantify the efficiency of targeted knock-in via flow cytometry.
Md Lutfur Rahman; Toshinori Hyodo; Muhammad Nazmul Hasan; Yuko Mihara; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Molecular biology reports, Jul. 2022
49(7), 6241, 6248, 10.1007/s11033-022-07422-0 - Cytotoxicity of Callerya speciosa Fractions against Myeloma and Lymphoma Cell Lines.
Vu Quang Lam; La Hoang Anh; Nguyen Van Quan; Tran Dang Xuan; Ichiro Hanamura; Kaori Uchino; Sivasundaram Karnan; Akiyoshi Takami
Molecules (Basel, Switzerland), Apr. 2022
27(7), 10.3390/molecules27072322 - Accumulation of versican and lack of versikine ameliorate acute colitis.
Shamima Islam; Nushrat Jahan; Arbee Shahida; Sivasundaram Karnan; Hideto Watanabe
Matrix biology : journal of the International Society for Matrix Biology, Mar. 2022
107, 59, 76, 10.1016/j.matbio.2022.02.004 - Flow cytometry-based quantification of targeted knock-in events in human cell lines using a GPI-anchor biosynthesis gene PIGP.
Md Lutfur Rahman; Toshinori Hyodo; Muhammad Nazmul Hasan; Yuko Mihara; Sivasundaram Karnan; Akinobu Ota; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Bioscience reports, Dec. 2021
41(12), 10.1042/BSR20212231 - Experimental strategies to achieve efficient targeted knock-in via tandem paired nicking.
Md Lutfur Rahman; Toshinori Hyodo; Sivasundaram Karnan; Akinobu Ota; Muhammad Nazmul Hasan; Yuko Mihara; Md Wahiduzzaman; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
Scientific reports, Nov. 2021
11(1), 22627, 22627, 10.1038/s41598-021-01978-w - Transcriptome-wide analysis of intracranial artery in patients with moyamoya disease showing upregulation of immune response, and downregulation of oxidative phosphorylation and DNA repair.
Fumiaki Kanamori; Kinya Yokoyama; Akinobu Ota; Kazuhiro Yoshikawa; Sivasundaram Karnan; Mikio Maruwaka; Kenzo Shimizu; Shinji Ota; Kenji Uda; Yoshio Araki; Sho Okamoto; Satoshi Maesawa; Toshihiko Wakabayashi; Atsushi Natsume
Neurosurgical focus, Sep. 2021
51(3), E3, 10.3171/2021.6.FOCUS20870 - ゲノム編集をもちいたFLT3-ITD変異白血病の新規治療標的の探索
花村 一朗; シバスンダラン・カルナン; 太田 明伸; 高杉 壮一; 中村 文乃; 高橋 美裕希; 内野 かおり; 村上 五月; 水野 昌平; 鈴木 進; 上田 龍三; 高見 昭良
MHC: Major Histocompatibility Complex, Aug. 2021
28(2), 123, 123 - The Clinical and Biological Effects of PD-1 Expression on Tumor Cells in Diffuse Large B-Cell Lymphoma
Ichiro Hanamura; Susumu Suzuki; Akinobu Ota; Satsuki Murakami; Akira Satou; Taishi Takahara; Sivasundaram Karnan; Vu Quang Lam; Ayano Nakamura; Souichi Takasugi; Kazuhiro Yoshikawa; Shogo Banno; Masayuki Ejiri; Toyonori Tsuzuki; Yoshitaka Hosokawa; Ryuzo Ueda; Akiyoshi Takami
Hemato, Jun. 2021
2(2), 368, 381, 10.3390/hemato2020023 - CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia.
Sivasundaram Karnan; Ichiro Hanamura; Akinobu Ota; Souichi Takasugi; Ayano Nakamura; Miyuki Takahashi; Kaori Uchino; Satsuki Murakami; Md Wahiduzzaman; Lam Quang Vu; Md Lutfur Rahman; Muhammad Nazmul Hasan; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Kazuhiro Yoshikawa; Susumu Suzuki; Ryuzo Ueda; Masayuki Ejiri; Yoshitaka Hosokawa; Akiyoshi Takami
Cell death discovery, May 2021
7(1), 121, 121, 10.1038/s41420-021-00446-8 - Chromosomal translocation t(11;14) and p53 deletion induced by the CRISPR/Cas9 system in normal B cell-derived iPS cells.
Yusuke Azami; Naohiro Tsuyama; Yu Abe; Misaki Sugai-Takahashi; Ken-Ichi Kudo; Akinobu Ota; Karnan Sivasundaram; Moe Muramatsu; Tomonari Shigemura; Megumi Sasatani; Yuko Hashimoto; Shigehira Saji; Kenji Kamiya; Ichiro Hanamura; Takayuki Ikezoe; Masafumi Onodera; Akira Sakai
Scientific reports, Mar. 2021
11(1), 5216, 5216, 10.1038/s41598-021-84628-5 - Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma.
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md Lutfur Rahman; Muhammad Nazmul Hasan; Md Wahiduzzaman; Ichiro Hanamura; Lam Quang Vu; Akihito Inoko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell death discovery, Nov. 2020
6(1), 127, 127, 10.1038/s41420-020-00364-1 - Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells.
Akinobu Ota; Ichiro Hanamura; Sivasundaram Karnan; Shingo Inaguma; Norio Takei; Vu Quang Lam; Shohei Mizuno; Jo Kanasugi; Md Wahiduzzaman; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Hiroshi Ikeda; Akiyoshi Takami; Yoshitaka Hosokawa
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Aug. 2020
40(8), 389, 405, 10.1089/jir.2020.0111 - Identification of cisplatin-resistant factor by integration of transcriptomic and proteomic data using head and neck carcinoma cell lines.
Daisuke Inukai; Kunihiro Nishimura; Hiroki Okamoto; Rui Sano; Hiromi Ueda; Akinobu Ota; Sivasundaram Karnan; Yoshitaka Hosokawa; Kazuhiro Yoshikawa; Susumu Suzuki; Ryuzo Ueda; Kenta Murotani; Carol R Bradford; Tetsuya Ogawa
Nagoya journal of medical science, Aug. 2020
82(3), 519, 531, 10.18999/nagjms.82.3.519 - Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia.
Shinobu Tsuzuki; Takahiko Yasuda; Shinya Kojima; Masahito Kawazu; Koshi Akahane; Takeshi Inukai; Masue Imaizumi; Takanobu Morishita; Koichi Miyamura; Toshihide Ueno; Sivasundaram Karnan; Akinobu Ota; Toshinori Hyodo; Hiroyuki Konishi; Masashi Sanada; Hirokazu Nagai; Keizo Horibe; Akihiro Tomita; Kyogo Suzuki; Hideki Muramatsu; Yoshiyuki Takahashi; Yasushi Miyazaki; Itaru Matsumura; Hitoshi Kiyoi; Yoshitaka Hosokawa; Hiroyuki Mano; Fumihiko Hayakawa
Blood cancer discovery, Jul. 2020
1(1), 82, 95, 10.1158/2643-3230.BCD-19-0080 - Biallelic loss of FAM46C triggers tumor growth with concomitant activation of Akt signaling in multiple myeloma cells.
Jo Kanasugi; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Vu Quang Lam; Shohei Mizuno; Md Wahiduzzaman; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Akiyoshi Takami
Cancer science, May 2020
111(5), 1663, 1675, 10.1111/cas.14386 - Cover Image
Sayuri Kondo; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Md Wahiduzzaman; Toshinori Hyodo; Md Lutfur Rahman; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cancer Medicine, Apr. 2020
10.1002/cam4.3049 - Discovery of novel molecular characteristics and cellular biological properties in ameloblastoma.
Sayuri Kondo; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Md Wahiduzzaman; Toshinori Hyodo; Md Lutfur Rahman; Kunihiro Ito; Akifumi Furuhashi; Tomio Hayashi; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cancer medicine, Apr. 2020
9(8), 2904, 2917, 10.1002/cam4.2931 - Tandem Paired Nicking Promotes Precise Genome Editing with Scarce Interference by p53.
Toshinori Hyodo; Md Lutfur Rahman; Sivasundaram Karnan; Takuji Ito; Atsushi Toyoda; Akinobu Ota; Md Wahiduzzaman; Shinobu Tsuzuki; Yohei Okada; Yoshitaka Hosokawa; Hiroyuki Konishi
Cell reports, Jan. 2020
30(4), 1195, 1207, 10.1016/j.celrep.2019.12.064 - Establishment and characterization of CRISPR/Cas9-mediated NF2-/- human mesothelial cell line: Molecular insight into fibroblast growth factor receptor 2 in malignant pleural mesothelioma.
Md Wahiduzzaman; Sivasundaram Karnan; Akinobu Ota; Ichiro Hanamura; Hideki Murakami; Akihito Inoko; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cancer science, Jan. 2019
110(1), 180, 193, 10.1111/cas.13871 - The plant alkaloid conophylline inhibits matrix formation of fibroblasts.
Takehiko Tezuka; Akinobu Ota; Sivasundaram Karnan; Katsuhiko Matsuura; Kazuhisa Yokoo; Yoshitaka Hosokawa; Davide Vigetti; Alberto Passi; Sonoko Hatano; Kazuo Umezawa; Hideto Watanabe
The Journal of biological chemistry, Dec. 2018
293(52), 20214, 20226, 10.1074/jbc.RA118.005783 - Establishment and characterization of a novel vincristine-resistant diffuse large B-cell lymphoma cell line containing the 8q24 homogeneously staining region.
Shohei Mizuno; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Jo Kanasugi; Ayano Nakamura; Souichi Takasugi; Kaori Uchino; Tomohiro Horio; Mineaki Goto; Satsuki Murakami; Mayuko Gotou; Hidesuke Yamamoto; Masaya Watarai; Masato Shikami; Yoshitaka Hosokawa; Hiroshi Miwa; Masafumi Taniwaki; Ryuzo Ueda; Masakazu Nitta; Akiyoshi Takami
FEBS open bio, Dec. 2018
8(12), 1977, 1991, 10.1002/2211-5463.12538 - Generation of PTEN‑knockout (‑/‑) murine prostate cancer cells using the CRISPR/Cas9 system and comprehensive gene expression profiling.
Akiko Takao; Kazuhiro Yoshikawa; Sivasundaram Karnan; Akinobu Ota; Hirotsugu Uemura; Marco A De Velasco; Yurie Kura; Susumu Suzuki; Ryuzo Ueda; Tokiko Nishino; Yoshitaka Hosokawa
Oncology reports, Nov. 2018
40(5), 2455, 2466, 10.3892/or.2018.6683 - Novel combined Ato-C treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells in vitro and in vivo.
Md Wahiduzzaman; Akinobu Ota; Sivasundaram Karnan; Ichiro Hanamura; Shohei Mizuno; Jo Kanasugi; Md Lutfur Rahman; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Akiyoshi Takami; Yoshitaka Hosokawa
Cancer letters, Oct. 2018
433, 117, 130, 10.1016/j.canlet.2018.06.027 - Inhibition of NADPH oxidase 2 induces apoptosis in osteosarcoma: The role of reactive oxygen species in cell proliferation.
Kazumasa Kitamoto; Yuji Miura; Sivasundaram Karnan; Akinobu Ota; Hiroyuki Konishi; Yoshitaka Hosokawa; Keiji Sato
Oncology letters, May 2018
15(5), 7955, 7962, 10.3892/ol.2018.8291 - Versican A-subdomain is required for its adequate function in dermal development.
Sonoko Hatano; Naoko Nagai; Nobuo Sugiura; Jun Tsuchimoto; Zenzo Isogai; Koji Kimata; Akinobu Ota; Sivasundaram Karnan; Yoshitaka Hosokawa; Hideto Watanabe
Connective tissue research, Mar. 2018
59(2), 178, 190, 10.1080/03008207.2017.1324432 - Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells.
Masayuki Yamaji; Akinobu Ota; Md Wahiduzzaman; Sivasundaram Karnan; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa; Masayuki Haniuda
Cancer medicine, Nov. 2017
6(11), 2646, 2659, 10.1002/cam4.1179 - 4色蛍光染色を用いたDLBCLにおける免疫抑制環境の解析(Analyzing the immunosuppressive microenvironment of DLBCL using quarto-immunofluorescent staining)
Hanamura Ichiro; Suzuki Susumu; Nishino Tokiko; Kanasugi Jo; Takasugi Soichi; Nakamura Ayano; Uchino Kaori; Horio Tomohiro; Goto Mineaki; Gotou Mayuko; Mizuno Shohei; Takahashi Miyuki; Watarai Masaya; Yamamoto Hidesuke; Mihara Hidetsugu; Imamura Akira; Ota Akinobu; Karnan Sivasundaram; Md Wahiduzzaman; Nakayama Takayuki; Yoshikawa Kazuhiro; Bannno Shogo; Hosokawa Yoshitaka; Ueda Ryuzo; Takami Akiyoshi
臨床血液, Sep. 2017
58(9), 1742, 1742 - SINGLE-NUCLEOTIDE POLYMORPHISM IN THE PBK GENE IS CLOSELY ASSOCIATED WITH MYELOMA CELL PROLIFERATION
I. Hanamura; A. Ota; S. Karnan; M. Wahiduzzaman; S. Mizuno; K. Uchino; J. Kanasugi; T. Horio; S. Murakami; S. Suzuki; R. Ueda; S. Tsuzuki; H. Konishi; Y. Hosokawa; A. Takami
HAEMATOLOGICA, Jun. 2017, Reviewed, No invitation
102(2), 497, 497 - Δ40p53α suppresses tumor cell proliferation and induces cellular senescence in hepatocellular carcinoma cells.
Akinobu Ota; Haruhisa Nakao; Yumi Sawada; Sivasundaram Karnan; Md Wahiduzzaman; Tadahisa Inoue; Yuji Kobayashi; Takaya Yamamoto; Norimitsu Ishii; Tomohiko Ohashi; Yukiomi Nakade; Ken Sato; Kiyoaki Itoh; Hiroyuki Konishi; Yoshitaka Hosokawa; Masashi Yoneda
Journal of cell science, Feb. 2017
130(3), 614, 625, 10.1242/jcs.190736 - Efficient AAV-mediated Gene Targeting Using 2A-based Promoter-trap System
Sivasundaram Karnan; Akinobu Ota; Yuko Konishi; Md Wahiduzzaman; Shinobu Tsuzuki; Yoshitaka Hosokawa; Hiroyuki Konishi
BIO-PROTOCOL, Dec. 2016, Reviewed, No invitation
6(24), e2058, 10.21769/bioprotoc.2058 - Establishment of a Novel DLBCL Cell Line: AMU-ML2, Derived from a Primary Refractory Patient Shows Homogeneous Staining Region of 8q24 Inducing High Expression of Long Non-Coding RNAs Encoded By PVT1 and Resistance to Vincristine
Shohei Mizuno; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Kaori Uchino; Tomohiro Horio; Motonori Mizutani; Mineaki Goto; Miyuki Takahashi; Mayuko Gotou; Yamamoto Hidesuke; Masaya Watarai; Masato Shikami; Yoshitaka Hosokawa; Hiroshi Miwa; Ryuzo Ueda; Masakazu Nitta; Akiyoshi Takami
BLOOD, Dec. 2016, Reviewed, No invitation
128(22), 10.1182/blood.V128.22.2950.2950 - Inhibition of Nox1 induces apoptosis by attenuating the AKT signaling pathway in oral squamous cell carcinoma cell lines.
Kunihiro Ito; Akinobu Ota; Takayuki Ono; Toshiki Nakaoka; Md Wahiduzzaman; Sivasundaram Karnan; Hiroyuki Konishi; Akifumi Furuhashi; Tomio Hayashi; Yoichi Yamada; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Oncology reports, Nov. 2016
36(5), 2991, 2998, 10.3892/or.2016.5068 - Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide.
Sivasundaram Karnan; Akinobu Ota; Yuko Konishi; Md Wahiduzzaman; Yoshitaka Hosokawa; Hiroyuki Konishi
Nucleic acids research, Apr. 2016
44(6), e54, 10.1093/nar/gkv1338 - Overexpression of salivary-type amylase reduces the sensitivity to bortezomib in multiple myeloma cells.
Shohei Mizuno; Ichiro Hanamura; Akinobu Ota; Sivasundaram Karnan; Tomoko Narita; Masaki Ri; Motonori Mizutani; Mineaki Goto; Mayuko Gotou; Norikazu Tsunekawa; Masato Shikami; Shinsuke Iida; Yoshitaka Hosokawa; Hiroshi Miwa; Ryuzo Ueda; Masakazu Nitta; Akiyoshi Takami
International journal of hematology, Nov. 2015
102(5), 569, 78, 10.1007/s12185-015-1859-0 - Inhibition of NADPH oxidase 4 induces apoptosis in malignant mesothelioma: Role of reactive oxygen species.
Motoya Tanaka; Yuji Miura; Hiroki Numanami; Sivasundaram Karnan; Akinobu Ota; Hiroyuki Konishi; Yoshitaka Hosokawa; Masayuki Hanyuda
Oncology reports, Oct. 2015
34(4), 1726, 32, 10.3892/or.2015.4155 - OVEREXPRESSION OF SALIVARY-TYPE AMYLASE REDUCES THE SENSITIVITY TO BORTEZOMIB IN MULTIPLE MYELOMA CELLS
S. Mizuno; I. Hanamura; A. Ota; S. Karnan; T. Narita; M. Ri; M. Goto; M. Gotou; N. Tsunekawa; M. Shikami; S. Iida; Y. Hosokawa; H. Miwa; R. Ueda; N. Masakazu; A. Takami
HAEMATOLOGICA, Jun. 2015, Reviewed, No invitation
100(1), 249, 250, 10.1007/s12185-015-1859-0} - Plumbagin suppresses tumor cell growth in oral squamous cell carcinoma cell lines
T. Ono; A. Ota; K. Ito; T. Nakaoka; S. Karnan; H. Konishi; A. Furuhashi; T. Hayashi; Y. Yamada; Y. Hosokawa; Y. Kazaoka
ORAL DISEASES, May 2015, Reviewed, No invitation
21(4), 501, 511, 10.1111/odi.12310 - High-resolution 400K oligonucleotide array comparative genomic hybridization analysis of neurofibromatosis type 1-associated cutaneous neurofibromas.
Akiko Asai; Sivasundaram Karnan; Akinobu Ota; Miyuki Takahashi; Lhagvasuren Damdindorj; Yuko Konishi; Ekhtear Hossain; Hiroyuki Konishi; Ayako Nagata; Kazuhisa Yokoo; Yoshitaka Hosokawa
Gene, Mar. 2015
558(2), 220, 6, 10.1016/j.gene.2014.12.064 - Lipopolysaccharide augments the uptake of oxidized LDL by up-regulating lectin-like oxidized LDL receptor-1 in macrophages.
Ekhtear Hossain; Akinobu Ota; Sivasundaram Karnan; Miyuki Takahashi; Shahnewaj B Mannan; Hiroyuki Konishi; Yoshitaka Hosokawa
Molecular and cellular biochemistry, Feb. 2015
400(1-2), 29, 40, 10.1007/s11010-014-2259-0 - Amylase-Producing Myeloma Cells Reduced Sensitivity to Dexamethasone and Bortezomib.
Shohei Mizuno; Ichiro Hanamura; Akinobu Ota; Karnan Sivasundaram; Tomoko Narita; Masaki Ri; Motonori Mizutani; Mineaki Goto; Mayuko Gotou; Norikazu Tsunekawa; Masato Shikami; Shinsuke Iida; Yoshitaka Hosokawa; Hiroshi Miwa; Ryuzo Ueda; Masakazu Nitta; Akiyoshi Takami
BLOOD, Dec. 2014, Reviewed, No invitation
124(21) - Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis.
Miyuki Suguro; Noriaki Yoshida; Akira Umino; Harumi Kato; Hiroyuki Tagawa; Masao Nakagawa; Noriko Fukuhara; Sivasundaram Karnan; Ichiro Takeuchi; Toby D Hocking; Kotaro Arita; Kennosuke Karube; Shinobu Tsuzuki; Shigeo Nakamura; Tomohiro Kinoshita; Masao Seto
Cancer science, Jul. 2014
105(7), 897, 904, 10.1111/cas.12442 - Combined arsenic trioxide-cisplatin treatment enhances apoptosis in oral squamous cell carcinoma cells.
Toshiki Nakaoka; Akinobu Ota; Takayuki Ono; Sivasundaram Karnan; Hiroyuki Konishi; Akifumi Furuhashi; Yukinobu Ohmura; Yoichi Yamada; Yoshitaka Hosokawa; Yoshiaki Kazaoka
Cellular oncology (Dordrecht, Netherlands), Apr. 2014
37(2), 119, 29, 10.1007/s13402-014-0167-7 - Array-comparative genomic hybridization profiling of immunohistochemical subgroups of diffuse large B-cell lymphoma shows distinct genomic alterations.
Ying Guo; Ichiro Takeuchi; Sivasundaram Karnan; Tomoko Miyata; Koichi Ohshima; Masao Seto
Cancer science, Apr. 2014
105(4), 481, 9 - A comparative analysis of constitutive promoters located in adeno-associated viral vectors.
Lkhagvasuren Damdindorj; Sivasundaram Karnan; Akinobu Ota; Ekhtear Hossain; Yuko Konishi; Yoshitaka Hosokawa; Hiroyuki Konishi
PloS one, 2014
9(8), e106472, 10.1371/journal.pone.0106472 - Arsenic augments the uptake of oxidized LDL by upregulating the expression of lectin-like oxidized LDL receptor in mouse aortic endothelial cells.
Ekhtear Hossain; Akinobu Ota; Sivasundaram Karnan; Lkhagvasuren Damdindorj; Miyuki Takahashi; Yuko Konishi; Hiroyuki Konishi; Yoshitaka Hosokawa
Toxicology and applied pharmacology, Dec. 2013
273(3), 651, 8, 10.1016/j.taap.2013.10.012 - Arsenic upregulates the expression of angiotensin II Type I receptor in mouse aortic endothelial cells.
Ekhtear Hossain; Akinobu Ota; Miyuki Takahashi; Sivasundaram Karnan; Lkhagvasuren Damdindorj; Yuko Konishi; Hiroyuki Konishi; Yoshitaka Hosokawa
Toxicology letters, Jun. 2013
220(1), 70, 5, 10.1016/j.toxlet.2013.04.006 - Single copies of mutant KRAS and mutant PIK3CA cooperate in immortalized human epithelial cells to induce tumor formation.
Grace M Wang; Hong Yuen Wong; Hiroyuki Konishi; Brian G Blair; Abde M Abukhdeir; John P Gustin; D Marc Rosen; Samuel Ray Denmeade; Zeshaan Rasheed; William Matsui; Joseph P Garay; Morassa Mohseni; Michaela J Higgins; Justin Cidado; Danijela Jelovac; Sarah Croessmann; Rory L Cochran; Sivasundaram Karnan; Yuko Konishi; Akinobu Ota; Yoshitaka Hosokawa; Pedram Argani; Josh Lauring; Ben Ho Park
Cancer research, Jun. 2013
73(11), 3248, 61, 10.1158/0008-5472.CAN-12-1578 - Arsenic trioxide prevents nitric oxide production in lipopolysaccharide -stimulated RAW 264.7 by inhibiting a TRIF-dependent pathway.
Miyuki Takahashi; Akinobu Ota; Sivasundaram Karnan; Ekhtear Hossain; Yuko Konishi; Lkhagvasuren Damdindorj; Hiroyuki Konishi; Takashi Yokochi; Masakazu Nitta; Yoshitaka Hosokawa
Cancer science, Feb. 2013
104(2), 165, 70, 10.1111/cas.12053 - Assessment of the long-term transcriptional activity of a 550-bp-long human β-actin promoter region.
Lkhagvasuren Damdindorj; Sivasundaram Karnan; Akinobu Ota; Miyuki Takahashi; Yuko Konishi; Ekhtear Hossain; Yoshitaka Hosokawa; Hiroyuki Konishi
Plasmid, Nov. 2012
68(3), 195, 200, 10.1016/j.plasmid.2012.07.003 - A system for the measurement of gene targeting efficiency in human cell lines using an antibiotic resistance-GFP fusion gene.
Yuko Konishi; Sivasundaram Karnan; Miyuki Takahashi; Akinobu Ota; Lkhagvasuren Damdindorj; Yoshitaka Hosokawa; Hiroyuki Konishi
BioTechniques, Sep. 2012
53(3), 141, 52, 10.2144/0000113911 - Simple monitoring of gene targeting efficiency in human somatic cell lines using the PIGA gene.
Sivasundaram Karnan; Yuko Konishi; Akinobu Ota; Miyuki Takahashi; Lkhagvasuren Damdindorj; Yoshitaka Hosokawa; Hiroyuki Konishi
PloS one, 2012
7(10), e47389, 10.1371/journal.pone.0047389 - Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells.
Hiroyuki Konishi; Morassa Mohseni; Akina Tamaki; Joseph P Garay; Sarah Croessmann; Sivasundaram Karnan; Akinobu Ota; Hong Yuen Wong; Yuko Konishi; Bedri Karakas; Khola Tahir; Abde M Abukhdeir; John P Gustin; Justin Cidado; Grace M Wang; David Cosgrove; Rory Cochran; Danijela Jelovac; Michaela J Higgins; Sabrina Arena; Lauren Hawkins; Josh Lauring; Amy L Gross; Christopher M Heaphy; Yositaka Hosokawa; Edward Gabrielson; Alan K Meeker; Kala Visvanathan; Pedram Argani; Kurtis E Bachman; Ben Ho Park
Proceedings of the National Academy of Sciences of the United States of America, Oct. 2011
108(43), 17773, 8, 10.1073/pnas.1110969108 - Genomic profiling combined with gene expression profiling in primary central nervous system lymphoma.
Chang Ohk Sung; Sang Cheol Kim; Sivasundaram Karnan; Kennosuke Karube; Hyung Jin Shin; Do-Hyun Nam; Yeon-Lim Suh; Seok-Hyung Kim; Ji Yeon Kim; Seok Jin Kim; Won Seog Kim; Masao Seto; Young-Hyeh Ko
Blood, Jan. 2011
117(4), 1291, 300, 10.1182/blood-2010-07-297861 - Enteropathy-associated T-cell lymphoma--a clinicopathologic and array comparative genomic hybridization study.
Young Hyeh Ko; Sivasundaram Karnan; Kyeong Mee Kim; Cheol Keun Park; Eun Suk Kang; Young Ho Kim; Won Ki Kang; Seok Jin Kim; Won Seog Kim; Woo Yong Lee; Ho Kyung Chun; Masao Seto
Human pathology, Sep. 2010
41(9), 1231, 7, 10.1016/j.humpath.2009.11.020 - Controversial BRCA1 allelotypes in commonly used breast cancer cell lines.
Sivasundaram Karnan; Morassa Mohseni; Yuko Konishi; Akina Tamaki; Yoshitaka Hosokawa; Ben H Park; Hiroyuki Konishi
Breast cancer research and treatment, Jan. 2010
119(1), 249, 51, 10.1007/s10549-009-0465-3 - Array comparative genomic hybridization analysis of PTCL-U reveals a distinct subgroup with genetic alterations similar to lymphoma-type adult T-cell leukemia/lymphoma.
Masao Nakagawa; Aya Nakagawa-Oshiro; Sivasundaram Karnan; Hiroyuki Tagawa; Atae Utsunomiya; Shigeo Nakamura; Ichiro Takeuchi; Koichi Ohshima; Masao Seto
Clinical cancer research : an official journal of the American Association for Cancer Research, Jan. 2009
15(1), 30, 8, 10.1158/1078-0432.CCR-08-1808 - Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer.
Y Tsukamoto; T Uchida; S Karnan; T Noguchi; L T Nguyen; M Tanigawa; I Takeuchi; K Matsuura; N Hijiya; C Nakada; T Kishida; K Kawahara; H Ito; K Murakami; T Fujioka; M Seto; M Moriyama
The Journal of pathology, Dec. 2008
216(4), 471, 82, 10.1002/path.2424 - TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma.
Keiichiro Honma; Shinobu Tsuzuki; Masao Nakagawa; Sivasundaram Karnan; Yoshifusa Aizawa; Won Seog Kim; Yoon-Duk Kim; Young-Hyeh Ko; Masao Seto
Genes, chromosomes & cancer, Jan. 2008
47(1), 1, 7 - Genome-wide array-based comparative genomic hybridization of ocular marginal zone B cell lymphoma: comparison with pulmonary and nodal marginal zone B cell lymphoma.
Won Seog Kim; Keiichiro Honma; Sivasundaram Karnan; Hiroyuki Tagawa; Yoon Duck Kim; Young Lyun Oh; Masao Seto; Young Hyeh Ko
Genes, chromosomes & cancer, Aug. 2007
46(8), 776, 83 - Genetic abnormalities involved in t(12;21) TEL-AML1 acute lymphoblastic leukemia: analysis by means of array-based comparative genomic hybridization.
Shinobu Tsuzuki; Sivasundaram Karnan; Keizo Horibe; Kimikazu Matsumoto; Koji Kato; Takeshi Inukai; Kumiko Goi; Kanji Sugita; Shinpei Nakazawa; Yumiko Kasugai; Ryuzo Ueda; Masao Seto
Cancer science, May 2007
98(5), 698, 706 - Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization shows frequent non-random chromosomal alteration regions including JUN amplification on 1p32.
Tetsuo Taniguchi; Sivasundaram Karnan; Takayuki Fukui; Toshihiko Yokoyama; Hiroyuki Tagawa; Kohei Yokoi; Yuichi Ueda; Tetsuya Mitsudomi; Yoshitsugu Horio; Toyoaki Hida; Yasushi Yatabe; Masao Seto; Yoshitaka Sekido
Cancer science, Mar. 2007
98(3), 438, 46 - [Array CGH analysis for malignant lymphoma].
Masao Seto; Sivasundaram Karnan; Hiroyuki Tagawa
Nihon rinsho. Japanese journal of clinical medicine, Jan. 2007
65 Suppl 1, 182, 8 - Characterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma.
Noriko Fukuhara; Hiroyuki Tagawa; Yoshihiro Kameoka; Yumiko Kasugai; Sivasundaram Karnan; Junichi Kameoka; Takeshi Sasaki; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Cancer science, Jun. 2006
97(6), 499, 504 - Genomewide array-based comparative genomic hybridization analysis of acute promyelocytic leukemia.
Sivasundaram Karnan; Shinobu Tsuzuki; Hitoshi Kiyoi; Hiroyuki Tagawa; Ryozo Ueda; Masao Seto; Tomoki Naoe
Genes, chromosomes & cancer, Apr. 2006
45(4), 420, 5 - Genome-wide array-based comparative genomic hybridization of natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal Nk/T-cell lymphoma, nasal type.
Yasuhiro Nakashima; Hiroyuki Tagawa; Ritsuro Suzuki; Sivasundaram Karnan; Kennosuke Karube; Koichi Ohshima; Koichiro Muta; Hajime Nawata; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Genes, chromosomes & cancer, Nov. 2005
44(3), 247, 55 - Comparison of genome profiles for identification of distinct subgroups of diffuse large B-cell lymphoma.
Hiroyuki Tagawa; Miyuki Suguro; Shinobu Tsuzuki; Keitaro Matsuo; Sivasundaram Karnan; Koichi Ohshima; Masataka Okamoto; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Blood, Sep. 2005
106(5), 1770, 7 - Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.
Hiroyuki Tagawa; Sivasundaram Karnan; Ritsuro Suzuki; Keitaro Matsuo; Xiaohua Zhang; Akinobu Ota; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Oncogene, Feb. 2005
24(8), 1348, 58 - Contig array CGH at 3p14.2 points to the FRA3B/FHIT common fragile region as the target gene in diffuse large B-cell lymphoma.
Yoshihiro Kameoka; Hiroyuki Tagawa; Shinobu Tsuzuki; Sivasundaram Karnan; Akinobu Ota; Miyuki Suguro; Ritsuro Suzuki; Motoko Yamaguchi; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Oncogene, Dec. 2004
23(56), 9148, 54 - Comparison of genetic aberrations in CD10+ diffused large B-cell lymphoma and follicular lymphoma by comparative genomic hybridization and tissue-fluorescence in situ hybridization.
Xiaohua Zhang; Sivasundaram Karnan; Hiroyuki Tagawa; Ritsuro Suzuki; Shinobu Tsuzuki; Yoshitaka Hosokawa; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Cancer science, Oct. 2004
95(10), 809, 14 - Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma: comparison between CD5-positive and CD5-negative cases.
Hiroyuki Tagawa; Shinobu Tsuzuki; Ritsuro Suzuki; Sivasundaram Karnan; Akinobu Ota; Yoshihiro Kameoka; Miyuki Suguro; Keitaro Matsuo; Motoko Yamaguchi; Masataka Okamoto; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Cancer research, Sep. 2004
64(17), 5948, 55 - Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
Akinobu Ota; Hiroyuki Tagawa; Sivasundaram Karnan; Shinobu Tsuzuki; Abraham Karpas; Shigeki Kira; Yasuko Yoshida; Masao Seto
Cancer research, May 2004
64(9), 3087, 95 - Analysis of chromosomal imbalances in de novo CD5-positive diffuse large-B-cell lymphoma detected by comparative genomic hybridization.
Sivasundaram Karnan; Hiroyuki Tagawa; Ritsuro Suzuki; Miyuki Suguro; Motoko Yamaguchi; Masataka Okamoto; Yasuo Morishima; Shigeo Nakamura; Masao Seto
Genes, chromosomes & cancer, Jan. 2004
39(1), 77, 81 - Mutational analysis of the ST7 gene in human myeloid tumor cell lines.
Karnan Sivasundaram; Hiroko Suzuki; Masao Seto; Yoshitaka Hosokawa
Oncology reports, 2003
10(6), 1737, 9
MISC
- Exploration of candidate compounds for KRAS-mutant myeloma using isogenic cell clones with KRAS-G12A
HANAMURA Ichiro; SIVASUNDARAM Karnan; OTA Akinobu; HYODO Yoshinori; HOSOKAWA Yoshitaka; TAKAMI Akiyoshi
日本血液学会学術集会抄録(Web), 2024
86th - Usefulness of gene mutation analysis using NGS in the diagnosis of malignant mesothelioma
MURAKAMI Hideki; SIVASUNDARAM Karnan; MINOSHIMA Makoto; GUNJI Masaharu; KIRIYAMA Ayumi; KOIDE Rio; SHIRAKI Kenta; FUJINO Masahiko; ITO Masafumi
日本病理学会会誌, 2024
113(1) - Differential effect of free fatty acids on the survival of multiple myeloma cells.
SAKAGUCHI Momona; 木村優花; 川村千菜実; 佐伯ななみ; IFTEKHAR Chowdhury Sajid; SIVASUNDARAM Karnan; 細川好孝; 花村一朗; 太田明伸; 太田明伸
International Journal of Myeloma (Web), 2024
14(3) - A novel FIRRM-FIGNL1 interaction enhances the viability of multiple myeloma cells.
太田明伸; 太田明伸; 花村一朗; シバスンダラン カルナン; シバスンダラン カルナン; 武井則雄; IFTEKHAR Chowdhury Sajid; 兵頭寿典; 小西裕之; 都築忍; 高見昭良; 細川好孝
International Journal of Myeloma (Web), 2024
14(3) - LUZP1, a novel CPC colocalizing protein, regulates the constriction velocity of the contractile ring during cytokinesis.
HYODO Toshinori; HASAN Muhammad Nazmul; BISWAS Mrityunjoy; INAMI Eri; KARNAN Sivasundaram; OTA Akinobu; TSUZUKI Shinobu; HOSOKAWA Yoshitaka; KONISHI Hiroyuki
日本分子生物学会年会プログラム・要旨集(Web), 2023
46th - A Rapid and Sensitive FCM-Based Assay for Monitoring CRISPR/Cas9 Genome Editing in L1CAM Gene
HASAN Muhammad Nazmul; HYODO Toshinori; BISWAS Mrityunjoy; RAHMAN MD. Lutfur; MIHARA Yuko; KARNAN Sivasundaram; OTA Akinobu; TSUZUKI Shinobu; HOSOKAWA Yoshitaka; KONISHI Hiroyuki
日本分子生物学会年会プログラム・要旨集(Web), 2023
46th - OTS514 suppresses the tumor growth with concomitant downregulation of E2F target genes in oral squamous carcinoma cells.
太田明伸; 太田明伸; カルナン シバスンダラン; 小西裕之; 都築忍; 細川好孝; 風岡宜暁
日本癌学会学術総会抄録集(Web), 2023
82nd - VEGFR2およびEGFRシグナルの阻害は,口腔扁平上皮癌細胞の生存を低下させる
太田明伸; 太田明伸; 恩田真帆; カルナン シバスンダラン; 加藤三香子; 近藤さゆり; 伊藤邦弘; 風岡宜暁; 細川好孝
日本生化学会大会(Web), 2023
96th - Targeting MEF2D-fusion Oncogenic Transcriptional Circuitries in B-cell Precursor Acute Lymphoblastic Leukemia
Shinobu Tsuzuki; Takahiko Yasuda; Masahito Kawazu; Toshihide Ueno; Sivasundaram Karnan; Akinobu Ota; Masashi Sanada; Hirokazu Nagai; Akihiro Tomita; Yoshiyuki Takahashi; Yasushi Miyazaki; Itaru Matsumura; Hitoshi Kiyoi; Yoshitaka Hosokawa; Hiroyuki Mano; Fumihiko Hayakawa
CANCER SCIENCE, Feb. 2022
113, 1236, 1236 - Study for exploring myeloma-initiating cell using normal B cell-derived iPS cells
阿左見祐介; 津山尚宏; 阿部悠; 高橋美咲; 工藤健一; 深見美和; 太田明伸; SIVASUNDARAM Karnan; 村松萌; 重村倫成; 笹谷めぐみ; 橋本優子; 佐治重衡; 神谷研二; 花村一朗; 池添隆之; 小野寺雅史; 坂井晃
日本血液学会学術集会抄録(Web), 2021
83rd - Pre-B細胞性急性リンパ球性白血病における転写制御ネットワーク
都築忍; 安田貴彦; 河津正人; 上野敏秀; シバスンダラン カルナン; 太田明伸; 真田昌; 永井宏和; 冨田章裕; 高橋義行; 宮崎泰司; 松村到; 清井仁; 細川好孝; 間野博行; 早川文彦
日本癌学会学術総会抄録集(Web), 2021
80th - ヒト大腸がん細胞の腫瘍形成能におけるコノフィリンの分子標的ARL6ip1の関与
林音知; 林音知; シバスンダラン カルナン; 小嶋しおり; 小嶋しおり; 伊藤秀明; 梅澤一夫
日本癌学会学術総会抄録集(Web), 2021
80th - PD-1 expression on lymphoma cells is associated with adverse prognosis in de novo DLBCL
花村一朗; 鈴木進; 太田明伸; 村上五月; カルナン シバスンダラン; クアン ラム; 佐藤啓; 高原大志; 中村文乃; 高杉壮一; 江尻将之; 坂野章吾; 都築豊徳; 細川好孝; 上田龍三; 高見昭良
日本血液学会学術集会抄録(Web), 2021
83rd - Identification of CD24 as a potential diagnostic and therapeutic target for malignant pleural mesothelioma.
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md Lutfur Rahman; Muhammad Nazmul Hasan; Md Wahiduzzaman; Ichiro Hanamura; Lam Quang Vu; Akihito Inoko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell death discovery, 18 Nov. 2020
6(1), 127, 127, 10.1038/s41420-020-00364-1 - CRISPR/CAS9システムによるFAM46Cの欠損は骨髄腫細胞の増殖を促進する
金杉丈; 花村一朗; 太田明伸; カルナン シバスンダラン; 水野昌平; 内野かおり; 鈴木進; 細川好孝; 高見昭良
日本血液学会学術集会抄録(Web), 2020
82nd - Introduction of Chromosomal Translocation t(11;14) and a p53 Deletion into Normal B Cell-Derived iPSCs to Elucidate the Cellular Origin of Myeloma Cells
Aki Yanagi; Naohiro Tsuyama; Misaki Sugai; Yu Abe; Yusuke Azami; Yukari Yanai; Akinobu Ota; Karnan Sivasundaram; Moe Muramatsu; Tomonari Shigemura; Megumi Sasatani; Yuko Hashimoto; Kenji Kamiya; Ichiro Hanamura; Takayuki Ikezoe; Masafumi Onodera; Akira Sakai
BLOOD, Nov. 2019
134, 10.1182/blood-2019-122344 - Attempt to elucidate the mechanism of development of multiple myeloma using iPS cells derived from normal B cells
SAKAI Akira; YANGI Aki; TSUYAMA Naohiro; SUGAI Misaki; ABE Yu; YANAI Yukari; OTA Akinobu; SIVASUNDARAM Karnan; SHIGEMURA Tomonari; SASATANI Megumi; KAMIYA Kenji; HANAMURA Ichiro; IKEZOE Takayuki; ONODERA Masafumi
International Journal of Myeloma (Web), 2019
9(1) - DNA二重鎖切断を介さない変異ノックイン法
兵頭寿典; LUTFUR Rahman Md; 豊田敦; 豊田敦; SIVASUNDARAM Karnan; 太田明伸; 都築忍; 細川好孝; 小西裕之
日本分子生物学会年会プログラム・要旨集(Web), 2019
42nd - Role of PBK in multiple myeloma cell growth: implication of PBK in novel molecular targets for anti-myeloma therapy
OTA Akinobu; HANAMURA Ichiro; SIVASUNDARAM Karnan; TAKAMI Akiyoshi; HOSOKAWA Yoshitaka
International Journal of Myeloma (Web), 2019
9(1) - CRISPR/Cas9を用いたNF2及びCDKN2Aノックアウトヒト中皮腫細胞株の樹立と分子生物学的解析
SIVASUNDARAM Karnan; 太田明伸; 兵頭寿典; 小西裕之; 都築忍; 細川好孝
日本生化学会大会(Web), 2019
92nd - Establishment and characterization of human mesothelial cell lines with CRISPR/Cas9-mediated disruption of NF2 and p16
シバスンダラン カルナン; 太田明伸; 花村一朗; 村上秀樹; 兵頭寿典; 小西裕之; 都築忍; 細川好孝
日本癌学会学術総会抄録集(Web), 2019
78th - 低酸素によるマウス活動期活動量の変化は時計遺伝子によらない波様の反応が決定している
増渕悟; 矢野多佳子; 小松紘司; 中村渉; 太田明伸; シバスンダラン カルナン; 武内恒成; 細川好孝; 藤堂剛; 塩見利明
日本生理学雑誌(Web), 2019
81(1) - Attempt to Prove the Existence of Abnormal B Lymphocyte As Myeloma-Initiating Cells from B Cell-Derived Induced Pluripotent Stem Cells
Aki Yanagi; Naohiro Tsuyama; Yukari Yanai; Yu Abe; Misaki Sugai; Akinobu Ota; Karnan Sivasundaram; Tomonari Shigemura; Megumi Sasatani; Kenji Kamiya; Ichiro Hanamura; Takayuki Ikezoe; Masafumi Onodera; Akira Sakai
BLOOD, Nov. 2018, Reviewed, No invitation
132, 10.1182/blood-2018-99-112759 - 骨髄腫細胞のレナリドマイド耐性に関連する付加的ゲノム異常と遺伝子発現変化の基礎的検討
太田明伸; 花村一朗; KARNAN Sivasundaram; 高見昭良; 細川好孝
International Journal of Myeloma (Web), 2018
8(2) - Bi-allelic loss of FAM46C by CRISPR/CAS9 system enhances myeloma cell growth
KANASUGI Jo; HANAMURA Ichiro; OTA Akinobu; KARNAN Sivasundaram; MIZUNO Shohei; UCHINO Kaori; NAKAMURA Ayano; TAKASUGI Soichi; HORIO Tomohiro; GOTO Mineaki; GOTO Mayuko; TAKAHASHI Miyuki; YAMAMOTO Hidesuke; WATARAI Masaya; MIHARA Hidetsugu; NAKAYAMA Takayuki; KATO Hidehumi; SUZUKI Susumu; KODERA Yoshihisa; HOSOKAWA Yoshitaka; UEDA Ryuzo; TAKAMI Akiyoshi
臨床血液, 2018
59(9) - Attempt to make abnormal B lymphocytes as melomainitiating cells from B-iPSCs
YANAGI Aki; TSUYAMA Naohiro; YANAI Yukari; ABE Yu; SUGAI Misaki; OTA Akinobu; SIVASUNDARAN Karnan; SASATANI Megumi; KAMIYA Kenji; HANAMURA Ichiro; IKEZOE Takayuki; ONODERA Masafumi; SAKAI Akira
臨床血液, 2018
59(9) - Identification of malignant mesothelioma-specific molecule whose expression is induced by deficiency of p16 / NF2 gene
SIVASUNDARAM Karnan; OTA Akinobu; HANAMURA Ichiro; MURAKAMI Hideki; MD Wahiduzzaman; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2018
77th - コノフィリンは,TGFβ媒介経路を介して線維芽細胞におけるヒアルロナン生合成を阻害する
手塚剛彦; 手塚剛彦; 太田明伸; KARNAN S; 横尾和久; 幡野その子; 梅澤一夫; 渡辺秀人
日本結合組織学会学術大会抄録集, 2018
50th - Involvement of PDZ binding kinase in tumor growth in multiple myeloma cells
OTA Akinobu; HANAMURA Ichiro; KARNAN Sivasundaram; KONISHI Hiroyuki; TSUZUKI Sinobu; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2018
77th - CRISPR/cas9系によるFAM46Cの対立遺伝子喪失は骨髄腫細胞の増殖を促進する。
金杉丈; 太田明伸; 花村一朗; シバスンダラン カルナン; 村上五月; 水野昌平; 内野かおり; 堀尾知弘; 細川好孝; 高見昭良
日本リンパ網内系学会会誌, 2018
58 - 悪性中皮腫細胞の増殖を特異的に抑制するAkt阻害剤の探索と同定
太田明伸; 山地雅之; ワヒドッジャマン ムハマド; カルナン シバスンダラン; 兵頭寿典; 小西裕之; 都築忍; 羽生田正行; 細川好孝
日本生化学会大会(Web), 2018
91st - Establishment and molecular characterization of leukemia cells producing FLT3-ITD by CRISPR/Cas9
HANAMURA Ichiro; KARNAN Sivasundaram; OTA Akinobu; MD Wahiduzzaman; GOTO Mineaki; TAKAHASHI Miyuki; MIZUNO Shohei; UCHINO Kaori; SUZUKI Susumu; TSUZUKI Shinobu; KONISHI Hiroyuki; UEDA Ryuzo; HOSOKAWA Yoshitaka; TAKAMI Akiyoshi
臨床血液, 2017
58(9) - The rs3779620 in the PBK gene is closely associated with myeloma cell growth
HANAMURA Ichiro; OTA Akinobu; KARNAN Sivasundaram; MD Wahiduzzaman; MIZUNO Shohei; UCHINO Kaori; KANASUGI Jo; HORIO Tomohiro; MURAKAMI Satsuki; SUZUKI Susumu; TSUZUKI Shinobu; KONISHI Hiroyuki; UEDA Ryuzo; HOSOKAWA Yoshitaka; TAKAMI Akiyoshi
臨床血液, 2017
58(9) - Combined arsenic trioxide-cisplatin treatment synergistically suppresses proliferation of Bcr-Abl-positive leukemic cells
WAHIDUZZAMAN Md; OTA Akinobu; KARNAN Sivasundaram; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th - 新規Interleukin-6誘導因子PDZ binding kinaseは骨髄腫細胞の増殖と進展に関与する
OTA Akinobu; HANAMURA Ichiro; KARNAN Sivasundaram; WAHIDUZZAMAN Md.; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th - PBK遺伝子多型rs3779620は骨髄腫細胞の増殖と密接に関連する
花村一朗; 太田明伸; KARNAN Sivasundaram; 水野昌平; 内野かおり; 金杉丈; 堀尾知弘; 村上五月; 鈴木進; 上田龍三; 細川好孝; 高見昭良
International Journal of Myeloma (Web), 2017
7(1) - Establishment and molecular characterization of human mesothelial cells disrupting NF2 using the CRISPR/Cas9 system
SIVASUNDARAM Karnan; OTA Akinobu; HANAMURA Ichiro; MURAKAMI Hideki; HYODO Toshinori; MD Wahiduzzaman; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2017
76th - Synergistic antiproliferative effect of combined arsenic trioxide-cisplatin treatment in Bcr-Abl positive leukemic cells
OTA Akinobu; WAHIDUZZAMAN Md; KARNAN Sivasundaram; HYODO Toshinori; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2017
76th - 悪性胸膜中皮腫の早期診断腫瘍マーカーの検討
シバスンダラン カルナン; OTA Akinobu; HANAMURA Ichiro; MURAKAMI Hideki; HYODO Toshinori; MD Wahiduzzaman; KONISHI Hiroyuki; TSUZUKI Shinobu; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2017
90th - protein phosphatase2Aの調節サブユニットPPP2R5Eは微小管架橋因子MTCL1の発現量を制御する。
兵頭寿典; 稲見恵理; 太田明伸; シバスンダラン カルナン; 小西裕之; 細川好孝
日本生化学会大会(Web), 2017
90th - NOX1はAKTシグナルを介して口腔扁平上皮癌細胞の生存に寄与する
太田 明伸; カルナン・シバスンダラン; 小西 裕之; 風岡 宜暁; 細川 好孝
日本癌学会総会記事, Oct. 2016, Not reviewed, No invitation
75回, P, 2290 - Arsenic trioxide prevents SOCS3 expression by inhibiting JAK-STAT signaling pathway
TAKAHASHI Miyuki; OTA Akinobu; KARNAN Sivasundaram; TAKASUGI Soichi; NAKAMURA Ayano; UCHINO Kaori; NAKAYAMA Takayuki; KATO Hidefumi; HANAMURA Ichiro; HOSOKAWA Yoshitaka; TAKAMI Akiyoshi
臨床血液, 2016
57(9) - Combined arsenic trioxide-cisplatin treatment enhances apoptosis in leukemic cell lines
WAHIDUZZAMAN Md; OTA Akinobu; KARNAN Sivasundaram; KONISHI Hiroyuki; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2016
89th - 遺伝子改変・ゲノム編集効率を測定するアッセイ系としてのPIGA遺伝子の利用
小西裕之; シバスンダラン カルナン; 太田明伸; 都築忍; 細川好孝
日本分子生物学会年会プログラム・要旨集(Web), 2016
39th - 肝がん細胞株におけるp53アイソフォームdelta40p53の性状解析
太田明伸; ワヒドゥザマン ムハマド; カルナン シバスンダラン; 小西裕之; 細川好孝
日本生化学会大会(Web), 2016
89th - Establishment of a novel DLBCL cell line, AMU-ML-2, carrying HSR on 8q24 containing MYC and PVT1
MIZUNO Shohei; HANAMURA Ichiro; OTA Akinobu; SIVASUNDARAM Karnan; UTINO Kaori; HORIO Tomohiro; MIZUTANI Motonori; GOTO Mineaki; TAKAHASHI Miyuki; GOTOU Mayuko; YAMAMOTO Hidesuke; WATARAI Masaya; SHIKAMI Masato; TANIWAKI Masafumi; HOSOKAWA Yoshitaka; NITTA Masakazu; MIWA Hiroshi; UEDA Ryuzo; TAKAMI Akiyoshi
臨床血液, 2015
56(9) - Oncogenic properties of a human bronchial epithelial cell line undergoing targeted knock-in of a KRAS mutation
KONISHI Hiroyuki; SIVASUNDARAM Karnan; OTA Akinobu; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2015
74th - Delta40p53 suppresses tumor cell proliferation in HepG2 cells
OTA Akinobu; SIVASUNDARAM Karnan; KONISHI Hiroyuki; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2015
74th - The versican A-subdomain is essential for regulating cell behavior
HATANO Sonoko; SIVASUNDARAM Karnan; OTA Akinobu; HOSOKAWA Yoshitaka; KIMATA Koji; WATANABE Hideto
日本癌学会学術総会抄録集(Web), 2015
74th - 口腔がん細胞株に対するプランバギンのプロオキシダント作用とアポトーシス誘導にはミトコンドリア遺伝子発現系が関与する
太田明伸; カルナン シバスンダラン; 小西裕之; 細川好孝
日本生化学会大会(Web), 2015
88th - Establishment and characterization of myeloma cell lines transfected with amylase
MIZUNO Shohei; HANAMURA Ichiro; OTA Akinobu; SIVASUNDARAM Karnan; NARITA Tomoko; RI Masaki; GOTO Mineaki; GOTOU Mayuko; TSUNEKAWA Norikazu; SHIKAMI Masato; IIDA Shinsuke; HOSOKAWA Yoshitaka; MIWA Hiroshi; UEDA Ryuzou; NITTA Masakazu; TAKAMI Akiyoshi
臨床血液, 2014
55(9) - MM細胞株を用いた異所性アミラーゼ安定的発現株の樹立とその性状解析
水野昌平; 花村一朗; 太田明伸; SIVASUNDARAM Karnan; 成田朋子; 李政樹; 後藤峰明; 後藤麻友子; 恒川敬和; 爾見雅人; 飯田真介; 細川好孝; 上田龍三; 仁田正和; 三輪啓志
International Journal of Myeloma (Web), 2014
4(2) - Plumbagin suppresses cellular growth through generation of reactive oxygen species in oral squamous cell carcinoma cells
AKINOBU Ota; KARNAN Sivasundaram; KONISHI Hiroyuki; KAZAOKA Yoshiaki; HOSOKAWA Yoshitaka
日本癌学会学術総会抄録集(Web), 2014
73rd - リポポリサッカライドはErk1/2シグナルを介したLOX-1の発現増加によってマクロファージの酸化LDLの取り込みを増強する
太田明伸; ホセイン イックティアル; シバスンダラン カルナン; マンナン シャンナワジ; 小西裕之; 細川好孝
日本生化学会大会(Web), 2014
87th - アデノ随伴ウイルスに基づく遺伝子改変ベクター内で薬剤耐性遺伝子の発現を制御するプロモーターの選択と遺伝子改変効率の関係
小西裕之; カルナン シバスンダラン; 太田明伸; 細川好孝
日本分子生物学会年会プログラム・要旨集(Web), 2014
37th - 400KオリゴアレイCGHを用いたNF1患者の皮膚神経線維腫の解析
浅井晶子; 永田亜矢子; シバスンダラン カルナン; 太田明伸; 細川好孝; 横尾和久
日本形成外科学会基礎学術集会プログラム・抄録集, 2014
23rd - KRAS変異およびPIK3CA変異のノックインを施したヒト上皮細胞株の生化学的解析
SIVASUNDARAM Karnan; 太田明伸; 細川好孝; 小西裕之
日本生化学会大会(Web), 2013
86th - Genome-wide analysis of secondary plasma cell leukemia in a relapsed myeloma patient
MIZUNO Shohei; HANAMURA Ichiro; MIZUTANI Motonori; GOTO Mineaki; TSUNEKAWA Norikazu; WAKABAYASHI Motohiro; OTA Akinobu; SIVASUNDARAM Karnan; SHIKAMI Masato; HOSOKAWA Yoshitaka; NITTA Masakazu; MIWA Hiroshi
臨床血液, 2013
54(9) - Arsenic trioxide inhibits interferon-gamma-mediated nitric oxide production in mouse vascular endothelial cells
HOSSAIN Ekhtear; OTA Akinobu; KARNAN Sivasundaram; DAMDINDORJ Lkhagvasuren; KONISHI Yuko; KONISHI Hiroyuki; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2013
86th - 三酸化砒素はTRIF依存性経路を抑制しLPS刺激後のRAW264.7細胞からの一酸化窒素の産生を阻害する(Arsenic trioxide inhibited the NO production in LPS-stimulated RAW 264.7 cells by preventing the TRIF dependent pathway)
高橋 美裕希; 太田 明伸; Sivasundaram Karnan; 小西 裕之; 花村 一朗; 三輪 啓志; 仁田 正和; 細川 好孝
日本癌学会総会記事, Aug. 2012
71回, 153, 153 - Identification of a 1.4Mb-amplicon in HSR on 8q24 containing c-MYC and PVT1 in DLBCL: A case report
MIZUNO Shohei; HAMAMURA Ichiro; HORIO Tomohiro; GOTO Mineaki; GOTOU Mayuko; HIRAMATSU Akihito; WATARAI Masaya; TAKAHASHI Emiko; OTA Akinobu; KARNAN Sivasundaram; HOSOKAWA Yoshitaka; SHIKAMI Masato; TAIWAKI Masafumi; MIWA Hiroshi; NITTA Masakazu
臨床血液, 2012
53(9) - Arsenic Exposure Accelerates Angiotensin II-Mediated Ca2+ Signaling in Mouse Aortic Endothelial Cells by Upregulation of AT1 Receptor
HOSSAIN Ekhtear; OTA Akinobu; TAKAHASHI Miyuki; KARNAN Sivasundaram; DAMDINDORJ Lkhagvasuren; KONISHI Yuko; KONISHI Hiroyuki; HOSOKAWA Yoshitaka
日本生化学会大会(Web), 2012
85th - 三酸化ヒ素はSTAT1の活性化を阻害しRAW264.7細胞からの二重鎖RNA刺激によるNO産生を抑制する
太田明伸; 高橋美裕希; 高橋美裕希; KARNAN Sivasundaram; HOSSAIN Ekhtear; DAMDINDORJ Lkhagvasuren; 小西裕子; 小西裕之; 細川好孝
日本生化学会大会(Web), 2012
85th - PIGA遺伝子を利用したヒト体細胞株の遺伝子ターゲッティング効率の測定
SIVASUNDARAM Karnan; 小西裕子; 太田明伸; 高橋美裕希; DAMDINDORJ Lkhagvasuren; 細川好孝; 小西裕之
日本生化学会大会(Web), 2012
85th - A comparative investigation of the long-term transcriptional activity of constitutive promoters placed in plasmids and adeno-associated viral vectors
DAMDINDORJ Lkhagvasuren; SIVASUNDARAM Karnan; OTA Akinobu; TAKAHASHI Miyuki; KONISHI Yuko; HOSSAIN Ekhtear; HOSOKAWA Yoshitaka; KONISHI Hiroyuki
日本生化学会大会(Web), 2012
85th - 抗生剤耐性遺伝子-EGFP融合遺伝子を用いたヒト体細胞株の遺伝子ターゲッティング効率の定量
小西裕之; 小西裕子; KARNAN Sivasundaram; 高橋美裕希; 太田明伸; DAMDINDORJ Lkhagvasuren; 細川好孝
日本生化学会大会(Web), 2012
85th - 染色体8q24領域のHSR様増幅により,c-MYCおよびPVT1の同時増幅を認めたDLBCLの一例
水野昌平; 花村一朗; 堀尾知弘; 後藤峰明; 菅沼和人; 後藤麻友子; 平松明人; 若林基弘; 渡会雅也; 清水宏伸; 高橋恵美子; 太田明伸; シバスンダランカルナン; 細川好孝; 爾見雅人; 谷脇雅史; 三輪啓志; 仁田正和
日本リンパ網内系学会会誌, 2012
52 - ヒト体細胞株におけるPIGA遺伝子を利用した遺伝子ターゲッティング効率定量系の作成
SIVASUNDARAM Karnan; 小西裕子; 高橋美裕希; DAMDINDORJ Lkhagvasuren; 細川好孝; 小西裕之
生化学, 2011 - Functional analyses of cancer genes using a novel technology of human somatic cell gene targeting
KONISHI Hiroyuki; KONISHI Hiroyuki; SIVASUNDARAM Karnan; HOSOKAWA Yoshitaka
日本癌学会学術総会記事, 2010
69th - ヒト培養細胞遺伝子改変の新しい技術を用いた癌関連遺伝子の機能解析
小西裕之; 小西裕之; KARNAN Sivasundaram; 高橋美裕希; LKHAGVASUREN Damdindorj; 小西裕子; 細川好孝
生化学, 2010 - IL-4/CD40 ligand co-stimulation induces long-term proliferation for CD10+ GCB-like DLBCL in vitro
KATO Harumi; KATO Harumi; KAGAMI Yoshitoyo; NAKAGAWA Masao; SIVASUNDARAM Karnan; YATABE Yasushi; NAKAMURA Shigeo; MORISHIMA Yasuo; SETO Masao
臨床血液, 2010
51(9) - Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer
TSUKAMOTO Yoshiyuki; UCHIDA Tomohisa; KARNAN Sivasundaram; NOGUCHI Tsuyoshi; TANIGAWA Masato; TAKEUCHI Ichiro; MATSUURA Keiko; NAKADA Chisato; TUNG Nguyen; HIJIYA Naoki; ITO Hisao; SETO Masao; MORIYAMA Masatsugu
日本癌学会学術総会記事, 2008
67th(4), 471, 82, 10.1002/path.2424 - Genomic profiling of malignant pleural mesothelioma with array-based comparative genomic hybridization
Tetsuo Taniguchi; Sivasundaram Karnan; Takayuki Fukui; Toshihiko Yokoyama; Hiroyuki Tagawa; Kohei Yokoi; Yuichi Ueda; Tetsuya Mitsudomi; Yoshitsugu Horio; Toyoaki Hisa; Yasushi Yatabe; Masao Seto; Yoshitaka Sekido
JOURNAL OF THORACIC ONCOLOGY, Aug. 2007, Not reviewed, No invitation
2(8), S428, S428 - High-resolution analysis of DNA copy number alterations and the gene expression in renal clear cell carcinoma
MATSUURA Keiko; YOSHIMOTO Taichiro; KARNAN Sivasundaram; TAGAWA Hiroyuki; NAKADA Chisato; TANIGAWA Masato; TSUKAMOTO Yoshiyuki; UCHIDA Tomohisa; TAKEUCHI Ichiro; SATO Fuminori; MIMATA Hiromitsu; SETO Masao; MORIYAMA Masatsugu
日本癌学会学術総会記事, 2007
66th(4), 392, 401 - Ocular adnexal marginal zone B cell lymphoma showed distinct genomic profile.
HONMA Keiichiro; SIVASUNDARAM Karnan; TAGAWA Hiroyuki; SETO Masao
日本癌学会学術総会記事, 2007
66th - Comparison of PTCL-U and lymphoma-type ATLL in terms of genomic imbalance by using array CGH analysis
NAKAGAWA Masao; NAKAGAWA Aya; SIVASUNDARAM Karnan; TAGAWA Hiroyuki; NAKAMURA Shigeo; OHSHIMA Koichi; SETO Masao
日本癌学会学術総会記事, 2007
66th - Analysis of advanced gastric carcinoma with array-based comparative genomic hybridization.
UCHIDA Tomohisa; KARNAN Sivasundaram; TSUKAMOTO Yoshiyuki; NOGUCHI Tsuyoshi; TAGAWA Hiroyuki; HIJIYA Naoki; MATSUURA Keiko; SETO Masao; MORIYAMA Masatsugu
日本癌学会学術総会記事, 2007
66th - Array CGH analysis for PTCL-U revealed two genetically distinct subgroups.
Masao Nakagawa; Aya Oshiro; Hiroyuki Tagawa; Sivasundaram Karnan; Shinobu Tsuzuki; Koichi Ohshima; Shigeo Nakamura; Masao Seto
BLOOD, Nov. 2006, Not reviewed, No invitation
108(11), 582A, 582A - Array CGH法を用いた悪性胸膜中皮腫の網羅的ゲノム解析
谷口哲郎; SIVASUNDARAM Karnan; 福井高幸; 福井高幸; 横山俊彦; 田川博之; 光冨徹哉; 堀尾芳嗣; 樋田豊明; 谷田部恭; 瀬戸加大; 関戸好孝
日本癌学会学術総会記事, 2006
65th - アレイCGHを用いた腎細胞癌ゲノム異常の網羅的遺伝子解析
吉本多一郎; 吉本多一郎; SIVASUNDARAM Karnan; 松浦恵子; 田川博之; 塚本善之; 内田智久; 佐藤文憲; 三股浩光; 瀬戸加大; 守山正胤
日本癌学会学術総会記事, 2006
65th - Array-based comparative genomic hybridization(array-CGH)法を用いた胃癌における網羅的な染色体構造異常と解析
内田智久; SIVASUNDARAM Karnan; 塚本善之; 野口剛; 田川博之; 瀬戸加大; 守山正胤
日本癌学会学術総会記事, 2006
65th - Phenomics of Escherichia coli K-12; analysis by Phenotype Microarray and its database.
MATSUI Hiroko; TANISHIMA Shigeki; GOBARA Hiroki; BABA Tomoya; SUHARNAN Sivasundaram; AFUSO Hitoshi; NAMIHIRA Koyo; OKAZAKI Takeo; NAKAMURA Morikazu; NAKAJIMA Yumiko; WANNER Barry L.; MORI Hirotada
生化学, 2006 - Defining second-hit genetic abnormalities involved in the t(12;21) TEL-AML1 acute lymphoblastic leukemia by array-based comparative genomic hybridization
S Tsuzuki; S Karnan; K Horibe; K Matsumoto; K Kato; K Sugita; S Nakazawa; M Seto
BLOOD, Nov. 2005, Not reviewed, No invitation
106(11), 798A, 798A - ゲノムワイドアレイCGH法によるNK細胞リンパ腫/白血病のゲノム異常の解析:aggressive NK-cell leukemiaとextranodal NK/T-cell lymphoma,nasal typeでは,ゲノム異常のパターンが異なる
中嶋康博; 中嶋康博; 田川博之; 鈴木律朗; KARNAN Sivasundaram; 加留部謙之輔; 大島孝一; 牟田耕一郎; 名和田新; 森島泰雄; 中村栄男; 瀬戸加大
月刊血液・腫よう科, 2005
51(6) - Array CGH法によるびまん性大細胞型B細胞性リンパ腫70症例の6p21増幅領域解析とその標的遺伝子の同定
春日井由美子; 田川博之; 亀岡吉弘; SIVASUNDARAM Karnan; 鈴木律朗; 都築忍; 細川好孝; 森島泰雄; 中村栄男; 瀬戸加大
日本癌学会学術総会記事, 2005
64th - アレイCGHによるNK細胞リンパ腫/白血病の解析:aggressive NK-cell leukemiaとextranodal NK/T lymphomaではゲノム異常が異なる
中嶋康博; 中嶋康博; 田川博之; 鈴木律朗; SIVASUNDARAM Karnan; 大島孝一; 牟田耕一郎; 名和田新; 森島泰雄; 中村栄男; 瀬戸加大
日本癌学会学術総会記事, 2005
64th - Array CGH analysis for target genes at 6p21 amplification region in diffuse large B-cell lymphoma
Y Kasugai; H Tagawa; Y Kameoka; S Karnan; R Suzuki; S Tsuzuki; Y Hosokawa; M Seto
BLOOD, Nov. 2004, Not reviewed, No invitation
104(11), 316A, 317A - Genome-wide array-based CGH for mantle cell lymphoma: Precise mapping of genomic aberrations and identification of novel candidate genes.
H Tagawa; S Karnan; R Suzuki; A Ota; S Tsuzuki; Y Morishima; S Nakamura; M Seto
BLOOD, Nov. 2004, Not reviewed, No invitation
104(11), 790A, 790A - MASL1, a candidate oncogene found in amplification at 8p23.1, is translocated in immunoblastic B-cell lymphoma cell line OCI-LY8
H Tagawa; S Karnan; Y Kasugai; S Tuzuki; R Suzuki; Y Hosokawa; M Seto
ONCOGENE, Apr. 2004, Not reviewed, No invitation
23(14), 2576, 2581, 10.1038/sj.onc.1207352 - Diffuse Large B-Cell LymphomaのゲノムワイドなアレイCGH解析
田川博之; 都築忍; 鈴木律朗; KARNAN S; 太田明伸; 松尾恵太郎; 吉田安子; 森島泰夫; 中村栄男
臨床血液, 2004
45(8) - Genome-wide screening of diffuse large B-cell lymphomas by array-based comparative genomic hybridization.
H Tagawa; S Karnan; A Ota; Y Kasugai; Y Yoshida; M Kawase; R Suzuki; Y Hosokawa; Y Morishima; S Nakamura; M Seto
BLOOD, Nov. 2003, Not reviewed, No invitation
102(11), 266B, 266B - 造血器腫よう発症機構の分子生物学的研究および診断への応用 Array CGHによるリンパ腫のゲノム1次構造異常の探索
田川博之; シバスンダランカルナン; 亀岡吉弘; 春日井由美子; 中村栄男; 森島泰雄; 瀬戸加大
愛知県がんセンター年報(Web), 2003
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Research Themes
- The development of molecular-targeted drugs targeting lipid metabolism in NF2/CDKN2A-deficient malignant mesothelioma
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2022 - Mar. 2025
シバスンダラン カルナン; 村上 秀樹, シバスンダラン カルナン; 村上 秀樹, 日本学術振興会, Japan Society for the Promotion of Science - Development of novel cancer immunotheray by combining regulatory T-cell elimination and TGF-b inhibitors
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2021 - Mar. 2024
鈴木 進; シバスンダラン カルナン; 小川 徹也; 土本 純, 鈴木 進; シバスンダラン カルナン; 小川 徹也; 土本 純, 日本学術振興会, Japan Society for the Promotion of Science - Elucidation of the pathogenesis of malignant mesothelioma based on genetic abnormalities and therapeutic targets for genomic medicine
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2019 - Mar. 2023
シバスンダラン カルナン; 村上 秀樹, Sivasundaram Karnan, 日本学術振興会, Japan Society for the Promotion of Science - Defining the KRAS signaling cascade using a genome-edited human bronchial epithelial cell line
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2013 - Mar. 2017
シバスンダラン カルナン; 小西 裕之; 細川 好孝, Sivasundaram Karnan, 日本学術振興会, Japan Society for the Promotion of Science - Understanding the molecular mechanisms of breast cancer by targeting mutant BRCA1 in hereditary breast cancer cells
Grant-in-Aid for Young Scientists (B)
Aichi Medical University
2010 - 2011
シバスンダラン カルナン, SIVASUNDARAM Karnan, 日本学術振興会, Japan Society for the Promotion of Science
Industrial Property Rights
- 特開2024-061699, 特願2022-169541, RAS遺伝子変異体癌治療薬
シバスンダラン カルナン, 太田 明伸, 花村 一朗, 細川 好孝 - 特開2023-059508, 特願2021-169563, 悪性中皮腫の治療薬
シバスンダラン カルナン, 太田明伸, 細川 好孝
