ENTREP/FAM189 gene family

Regulation of ubiquitination

Hedgehog signaling

pancreatic cancer

breast cancer

Mar. 2002 - Present
日本病理学会, 学術評議員

Nov. 2015
日本病理学会 学術研究賞
笠井 謙次

Long-term expansion of basal cells and the novel differentiation methods identify mechanisms for switching Claudin expression in normal epithelia
Akihito Inoko; Norihito Soga; Minako Suzuki; Tohru Kiyono; Junichi Ikenouchi; Takahiro Kojima; Yoshikatsu Sato; Daisuke Saito; Tatsuo Miyamoto; Naoki Goshima; Hideaki Ito; Kenji Kasai
Scientific Reports, Apr. 2025, Reviewed
10.1038/s41598-025-95463-3

Use of SATB2 and CDX2 Immunohistochemistry to Characterize and Diagnose Colorectal Cancer.
Shunsuke Kato; Akira Koshino; Jerzy Lasota; Masayuki Komura; Chengbo Wang; Masahide Ebi; Naotaka Ogasawara; Kazuhisa Kojima; Toyonori Tsuzuki; Kenji Kasai; Satoru Takahashi; Markku Miettinen; Kunio Kasugai; Shingo Inaguma
Applied immunohistochemistry & molecular morphology : AIMM, Sep. 2024
32(8), 362, 370, 10.1097/PAI.0000000000001216

染色体不安定性獲得機構解明を目指した、中心小体複製因子STILによる細胞周期チェックポイント抑制機能の解析
伊藤 秀明; 鈴木 佳稔; 大橋 明子; 猪子 誠人; 中村 律子; 陸 美穂; 大西 絋二; 古屋 智子; 都築 豊徳; 笠井 謙次
Cytometry Research, Jul. 2024
34(Suppl.), 75, 75

Characterisation of colorectal cancer by hierarchical clustering analyses for five stroma-related markers.
Sunao Ito; Akira Koshino; Chengbo Wang; Takahiro Otani; Masayuki Komura; Akane Ueki; Shunsuke Kato; Hiroki Takahashi; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kenji Kasai; Kunio Kasugai; Shuji Takiguchi; Satoru Takahashi; Shingo Inaguma
The journal of pathology. Clinical research, Jul. 2024
10(4), e12386, 10.1002/2056-4538.12386

Simultaneous Expression of CD70 and POSTN in Cancer-Associated Fibroblasts Predicts Worse Survival of Colorectal Cancer Patients.
Masayuki Komura; Chengbo Wang; Sunao Ito; Shunsuke Kato; Akane Ueki; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kenji Kasai; Kunio Kasugai; Shuji Takiguchi; Satoru Takahashi; Shingo Inaguma
International journal of molecular sciences, Feb. 2024
25(5), 10.3390/ijms25052537

中心小体複製因子STILによる細胞周期チェックポイント抑制によるアポトーシス回避機構
鈴木 佳稔; 伊藤 秀明; 大橋 明子; 山田 徳香; 猪子 誠人; 中村 律子; 陸 美穂; 大西 紘二; 都築 豊徳; 笠井 謙次
日本病理学会会誌, Feb. 2024
113(1), 476, 476

Characterization of colorectal cancer by hierarchical clustering analyses of five immune cell markers
Sunao Ito; Akira Koshino; Masayuki Komura; Shunsuke Kato; Takahiro Otani; Chengbo Wang; Akane Ueki; Hiroki Takahashi; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kenji Kasai; Kunio Kasugai; Shuji Takiguchi; Satoru Takahashi; Shingo Inaguma
Pathology International, Dec. 2023, Reviewed
10.1111/pin.13391

Stromal POSTN Enhances Motility of Both Cancer and Stromal Cells and Predicts Poor Survival in Colorectal Cancer.
Akane Ueki; Masayuki Komura; Akira Koshino; Chengbo Wang; Kazuhiro Nagao; Mai Homochi; Yuki Tsukada; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kenji Kasai; Kunio Kasugai; Satoru Takahashi; Shingo Inaguma
Cancers, Jan. 2023, Reviewed
15(3), 10.3390/cancers15030606

The Complete Loss of p53 Expression Uniquely Predicts Worse Prognosis in Colorectal Cancer.
Kazuhiro Nagao; Akira Koshino; Akane Sugimura-Nagata; Aya Nagano; Masayuki Komura; Akane Ueki; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kenji Kasai; Satoru Takahashi; Kunio Kasugai; Shingo Inaguma
International journal of molecular sciences, Mar. 2022, Reviewed
23(6), 10.3390/ijms23063252

SPATA18 Expression Predicts Favorable Clinical Outcome in Colorectal Cancer.
Akane Sugimura-Nagata; Akira Koshino; Kazuhiro Nagao; Aya Nagano; Masayuki Komura; Akane Ueki; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kenji Kasai; Satoru Takahashi; Kunio Kasugai; Shingo Inaguma
International journal of molecular sciences, Mar. 2022, Reviewed
23(5), 10.3390/ijms23052753

★ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
Takumi Tsunoda; Miho Riku; Norika Yamada; Hikaru Tsuchiya; Takuya Tomita; Minako Suzuki; Mari Kizuki; Akihito Inoko; Hideaki Ito; Kenta Murotani; Hideki Murakami; Yasushi Saeki; Kenji Kasai
EMBO reports, Feb. 2022, Reviewed
Corresponding, 23(2), e51182, 10.15252/embr.202051182

PBK expression predicts favorable survival in colorectal cancer patients.
Aya Nagano-Matsuo; Satoshi Inoue; Akira Koshino; Akinobu Ota; Kenju Nakao; Masayuki Komura; Hiroyuki Kato; Aya Naiki-Ito; Kawori Watanabe; Yuko Nagayasu; Yoshitaka Hosokawa; Shuji Takiguchi; Kunio Kasugai; Kenji Kasai; Shingo Inaguma; Satoru Takahashi
Virchows Archiv : an international journal of pathology, Aug. 2021, Reviewed
479(2), 277, 284, 10.1007/s00428-021-03062-0

Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer
Akane Sugimura-Nagata; Akira Koshino; Satoshi Inoue; Aya Matsuo-Nagano; Masayuki Komura; Miho Riku; Hideaki Ito; Akihito Inoko; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Satoru Takahashi; Kunio Kasugai; Kenji Kasai; Shingo Inaguma
International Journal of Molecular Sciences, Mar. 2021, Reviewed
22(5), 2690, 2690, 10.3390/ijms22052690

大腸癌細胞におけるPBK発現は大腸癌患者の予後良好因子である
長野 愛矢; 中尾 健寿; 内木 綾; 笠井 謙次; 稲熊 真悟; 高橋 智
日本病理学会会誌, Mar. 2021
110(1), 309, 309

High phospho‐histone H3 expression uniquely predicts favorable survival among four markers of cellular proliferation in colorectal cancer
Akira Koshino; Satoshi Inoue; Akane Sugimura‐Nagata; Takeshi Nishiyama; Hideki Murakami; Hideaki Ito; Miho Riku; Akihito Inoko; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kunio Kasugai; Kenji Kasai; Shingo Inaguma
Pathology International, Feb. 2021, Reviewed
10.1111/pin.13084

PBK Enhances Cellular Proliferation With Histone H3 Phosphorylation and Suppresses Migration and Invasion With CDH1 Stabilization in Colorectal Cancer.
Akira Koshino; Aya Nagano; Akinobu Ota; Toshinori Hyodo; Akane Ueki; Masayuki Komura; Akane Sugimura-Nagata; Masahide Ebi; Naotaka Ogasawara; Kenji Kasai; Yoshitaka Hosokawa; Kunio Kasugai; Satoru Takahashi; Shingo Inaguma
Frontiers in Pharmacology, 2021, Reviewed
12, 772926, 772926, 10.3389/fphar.2021.772926

大腸癌細胞におけるPBK発現は大腸癌患者の予後良好因子である
中尾 健寿; 稲熊 真悟; 内木 綾; 笠井 謙次; 高橋 智
日本病理学会会誌, Mar. 2020
109(1), 428, 428

Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer.
Satoshi Inoue; Takumi Tsunoda; Miho Riku; Hideaki Ito; Akihito Inoko; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Ira Pastan; Kunio Kasugai; Kenji Kasai; Hiroshi Ikeda; Shingo Inaguma
Oncology letters, Mar. 2020, Reviewed, No invitation
19(3), 1741, 1750, 10.3892/ol.2020.11290

★Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
Ito H; Tsunoda T; Riku M; Inaguma S; Inoko A; Murakami H; Ikeda H; Matsuda M; Kasai K
Oncogene, Nov. 2019, Reviewed, No invitation
Corresponding, 39(9), 1931, 1943, 10.1038/s41388-019-1115-9

CD70 expression in tumor-associated fibroblasts predicts worse survival in colorectal cancer patients.
Inoue S; Ito H; Tsunoda T; Murakami H; Ebi M; Ogasawara N; Kasugai K; Kasai K; Ikeda H; Inaguma S
Virchows Archiv : an international journal of pathology, Oct. 2019, Reviewed, No invitation
475(4), 425, 434, 10.1007/s00428-019-02565-1

★CD70 expression correlates with a worse prognosis in malignant pleural mesothelioma patients via immune evasion and enhanced invasiveness.
Inaguma S; Lasota J; Czapiewski P; Langfort R; Rys J; Szpor J; Waloszczyk P; Okoń K; Biernat W; Schrump DS; Hassan R; Kasai K; Miettinen M; Ikeda H
The Journal of Pathology, Oct. 2019, Reviewed, No invitation
10.1002/path.5361

Bicytopenia in Primary Lung Melanoma Treated with Nivolumab.
Ayumu Takahashi; Akihito Kubo; Shohei Mizuno; Kenji Kasai; Nobuhiro Asai; Toshiyuki Yonezawa; Kenshi Kosaka; Masaki Nishimura; Hiroyuki Tanaka; Norihito Yokoe; Toyonori Tsuzuki; Akiyoshi Takami; Etsuro Yamaguchi
Internal medicine (Tokyo, Japan), Mar. 2019, Reviewed
58(6), 827, 831, 10.2169/internalmedicine.1011-18

★GLI1, a master regulator of the hallmark of pancreatic cancer
Kenji Kasai
Pathology International, Dec. 2016, Reviewed, Invited
Lead, 66(12), 653, 660, 10.1111/pin.12476

★Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis
Miho Riku; Shingo Inaguma; Hideaki Ito; Takumi Tsunoda; Hiroshi Ikeda; Kenji Kasai
Oncotarget, Feb. 2016, Reviewed, No invitation
Corresponding, 7(5), 5690, 5701, 10.18632/oncotarget.6788

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells
Shingo Inaguma; Miho Riku; Hideaki Ito; Takumi Tsunoda; Hiroshi Ikeda; Kenji Kasai
Oncotarget, Oct. 2015, Reviewed, No invitation
Corresponding, 6(32), 33648, 33657, 10.18632/oncotarget.5203

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2
Shingo Inaguma; Hideaki Ito; Miho Riku; Hiroshi Ikeda; Kenji Kasai
Oncotarget, Sep. 2015, Reviewed, No invitation
Corresponding, 6(29), 28257, 28268, 10.18632/oncotarget.4960

Pancreatic Neuroendocrine Tumors in Mice Deficient in Proglucagon-Derived Peptides
Yuko Takano; Kenji Kasai; Yoshiko Takagishi; Toyone Kikumori; Tsuneo Imai; Yoshiharu Murata; Yoshitaka Hayashi
PLOS ONE, Jul. 2015, Reviewed, No invitation
10(7), e0133812, 10.1371/journal.pone.0133812

★GLI1 interferes with the DNA mismatch repair system in pancreatic cancer through BHLHE41-mediated suppression of MLH1
Shingo Inaguma; Miho Riku; Mitsuyoshi Hashimoto; Hideki Murakami; Shinsuke Saga; Hiroshi Ikeda; Kenji Kasai
Cancer Research, Dec. 2013, Reviewed, No invitation
Corresponding, 73(24), 7313, 7323, 10.1158/0008-5472.CAN-13-2008

Plasmablastic lymphoma of the stomach in an HIV-negative patient
Mitsuyoshi Hashimoto; Shingo Inaguma; Kenji Kasai; Kyoko Kuwabara; Nobuhiko Noda; Masaya Hayakawa; Masahiko Fujino; Masafumi Ito; Hiroshi Ikeda
Pathology International, Nov. 2012, Reviewed, No invitation
62(11), 763, 770, 10.1111/pin.12005

GLI1 Modulates EMT in Pancreatic Cancer-Letter
Shingo Inaguma; Kenji Kasai; Mitsuyoshi Hashimoto; Hiroshi Ikeda
Cancer Research, Jul. 2012, Reviewed, No invitation
Corresponding, 72(14), 3702, 3703, 10.1158/0008-5472.CAN-12-0379

★GLI1 facilitates the migration and invasion of pancreatic cancer cells through MUC5AC-mediated attenuation of E-cadherin
S. Inaguma; K. Kasai; H. Ikeda
Oncogene, Feb. 2011, Reviewed, No invitation
Corresponding, 30(6), 714, 723, 10.1038/onc.2010.459

★SCL/TAL1 interrupting locus derepresses GLI1 from the negative control of Suppressor-of-Fused in pancreatic cancer cell
Kenji Kasai; Shingo Inaguma; Akiko Yoneyama; Kazuhiro Yoshikawa; Hiroshi Ikeda
Cancer Research, Oct. 2008, Reviewed, No invitation
Lead, 68(19), 7723, 7729, 10.1158/0008-5472.CAN-07-6661

★A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line
H Nishimaki; K Kasai; K Kozaki; T Takeo; H Ikeda; S Saga; M Nitta; G Itoh
Biochemical and Biophysical Research Communications, Feb. 2004, Reviewed, No invitation
Corresponding, 314(2), 313, 320, 10.1016/j.bbrc.2003.12.097

★The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signalling
K Kasai; M Takahashi; N Osumi; S Sinnarajah; T Takeo; H Ikeda; JH Kehrl; G Itoh; H Arnheiter
Genes to Cells, Jan. 2004, Reviewed, No invitation
Lead, 9(1), 49, 58, 10.1111/j.1365-2443.2004.00701.x

★A general method to design dominant negatives to B-HLHZip proteins that abolish DNA binding.
D Krylov; K Kasai; D R Echlin; E J Taparowsky; H Arnheiter; C Vinson
Proceedings of the National Academy of Sciences of the United States of America, Nov. 1997, Not reviewed
94(23), 12274, 9

正常上皮分化には表層アクチンの収縮と細胞内カルシウム流入が必要である
猪子 誠人; 齋藤 大介; 池ノ内 順一; 佐藤 良勝; 伊藤 秀明; 曽我 倫久人; 笠井 謙次
日本細胞生物学会大会講演要旨集, Jun. 2021
73回, WS11, 2

STIL(SCL/TAL1 interrupting locus)による浸潤突起形成機構
伊藤 秀明; 猪子 誠人; 陸 美穂; 村上 秀樹; 笠井 謙次
日本病理学会会誌, Mar. 2021
110(1), 232, 232

CD70分子はMET-ERK経路の活性化、腫瘍細胞の免疫逃避亢進により悪性胸膜中皮腫患者の予後を悪化させる
稲熊 真悟; Lasota Jerzy; 池田 洋; 笠井 謙次; Miettinen Markku; 高橋 智
日本癌学会総会記事, Oct. 2020
79回, OJ12, 6

in vitroでの上皮分化方法に見出した新しい遺伝子と現象
猪子 誠人; 林 裕子; 佐藤 良勝; 齋藤 大介; 池ノ内 順一; 林 良樹; 伊藤 秀明; 曽我 倫久人; 松尾 恵太郎; 笠井 謙次
日本細胞生物学会大会講演要旨集, Jun. 2020
72回, 6, 6

網羅的遺伝子解析から着目した遺伝子産物FAM64Aの乳癌における臨床病理的解析
井戸 美来; 坂野 福奈; 伊藤 由季絵; 後藤 真奈美; 安藤 考人; 毛利 有佳子; 高阪 絢子; 藤井 公人; 笠井 謙次; 中野 正吾
日本乳癌学会総会プログラム抄録集, Jul. 2019
27回, 463, 463

細胞周期・DNA ploidy解析とイメージサイトメトリー
伊藤 秀明; 古屋 智子; 小賀 厚徳; 笠井 謙次; 佐々木 功典
Cytometry Research, May 2018
28(Suppl.), 46, 46

STIL(SCL/TAL-1 Interrupting Locus)による膵臓癌細胞運動能制御機構
伊藤 秀明; 角田 拓実; 陸 美穂; 池田 洋; 笠井 謙次
日本病理学会会誌, Apr. 2016
105(1), 377, 377

Hedgehogシグナル伝達から見た膵臓癌の分子病態
笠井 謙次
日本病理学会会誌, Sep. 2015
104(2), 29, 29

ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる
稲熊 真悟; 笠井 謙次; 伊藤 秀明; 陸 美穂; 池田 洋
日本病理学会会誌, Mar. 2015
104(1), 287, 287

新規転写抑制因子TSHZ2からみた乳癌進展機構
陸 美穂; 笠井 謙次; 稲熊 真悟; 伊藤 秀明; 池田 洋
日本病理学会会誌, Mar. 2015
104(1), 455, 455

ヘッジホッグシグナル系転写因子ZIC2はFGFR3、ANXA8発現誘導を介して膵癌細胞株の増殖を促進する(ZIC2 accelerates the cell proliferation of pancreatic ductal adenocarcinoma through FGFR3 and ANXA8 induction)
稲熊 真悟; 笠井 謙次; 陸 美穂; 池田 洋
日本癌学会総会記事, Sep. 2014
73回, J, 2090

Pancreatic Neuroendocrine Tumors in Mice Deficient in Glucagon Gene
Yoshitaka Hayashi; Yuko Takano; Kenji Kasai; Tsuneo Imai; Yoshiharu Murata
ENDOCRINE REVIEWS, Jun. 2014, Not reviewed, No invitation
35(3)

ZIC2 Is an Indispensable Transcriptional Factor for the Cell Growth of Pancreatic Ductal Adenocarcinoma
S. Inaguma; K. Kasai; M. Hashimoto; M. Riku; H. Ikeda
MODERN PATHOLOGY, Feb. 2014, Not reviewed, No invitation
27, 450A, 450A

膵臓癌細胞において転写因子GLI1はBHLHE41依存性にMLH1発現を抑制し、ミスマッチ修復機構の機能不全を惹起する(GLI1 induces the mismatch repair system insufficiency via BHLHE41-dependent MLH1 reduction in pancreatic cancer cells)
稲熊 真悟; 笠井 謙次; 橋本 光義; 陸 美穂; 池田 洋
日本癌学会総会記事, Oct. 2013
72回, 272, 272

SILによるGLI1のSUFU依存性制御からの離脱機構(SIL de-represses GL11 from the negative control of SUFU in pancreatic cancer cell)
笠井 謙次; 稲熊 真悟; 池田 洋
日本癌学会総会記事, Sep. 2008
67回, 302, 302

形態形成因子Sonic hedgehog (Shh)の新たな細胞内情報伝達機構
笠井謙次; 高橋将文; 西巻春明; 益田健史; 竹尾友宏; 楊朝隆; 池田洋; 大隅典子; 伊藤元
生化学, 25 Nov. 2002, Not reviewed, No invitation
74(11), 1384

腎細胞癌培養細胞によるMN/CA9発現制御の解析
河田 陽一; 植村 天受; 趙 順規; 田中 洋造; 清水 一宏; 平尾 佳彦; 林 毅志; 高須 俊太郎; 村松 秀樹; 笠井 謙次; 小崎 健一; 吉川 和宏; 佐賀 信介
日本癌学会総会記事, Oct. 2002, Not reviewed, No invitation
61回, 250, 250

Hedgehogシグナル伝達から見た膵臓癌の分子病態（A演説）
笠井 謙次
日本病理学会秋期特別総会, Nov. 2015, Invited
Invited oral presentation, Domestic conference

新規ユビキチン化酵素活性化因子ENTREPによるPD-L1修飾と腫瘍免疫制御機構の解明
基盤研究(C)
Apr. 2023 - Mar. 2026
笠井謙次, 笠井謙次, 日本学術振興会, 日本学術振興会, Principal investigator

トリプルネガティブ乳癌における新規核内蛋白ネットワークによる細胞増殖特性
Apr. 2019 - Mar. 2022
笠井 謙次, 笠井 謙次, 日本学術振興会, 日本学術振興会, Principal investigator

新規転写抑制因子標的遺伝子群から見た非浸潤性乳癌進行の分子病理学的機構
Apr. 2015 - Mar. 2018
笠井 謙次, 笠井 謙次, 日本学術振興会, 日本学術振興会, Principal investigator

ヘッジホッグシグナル伝達因子から見た細胞運動性と膵臓癌進展の分子基盤
Apr. 2012 - Mar. 2015
笠井 謙次, 笠井 謙次, 日本学術振興会, 日本学術振興会, Principal investigator

Roles of SIX3 and SIL in the Hedgehog signaling during pancreatic carcinogenesis.
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2009 - Mar. 2012
笠井 謙次, KASAI Kenji; IKEDA Hiroshi; INAGUMA Shingo, 日本学術振興会, Japan Society for the Promotion of Science, Principal investigator

Roles of the Hedgehog signaling in invasion and metastasis of pancreatic cancer
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2007 - Mar. 2009
笠井 謙次, KASAI Kenji; IKEDA Hiroshi; INAGUMA Shingo, 日本学術振興会, Japan Society for the Promotion of Science, Principal investigator

ホジキン病における免疫グロブリン超可変領域の遺伝子的検討
一般研究(C)
名古屋大学
1994 - 1994
森 尚義; 笠井 謙次; 伊藤 雅文, 森 尚義; 笠井 謙次; 伊藤 雅文, 日本学術振興会, 日本学術振興会

non-T ALLにおける免疫グロブリン入鎖高頻度発現の遺伝子的解明
一般研究(C)
名古屋大学
1993 - 1993
森 尚義; 笠井 謙次; 伊藤 雅文, 森 尚義; 笠井 謙次; 伊藤 雅文, 日本学術振興会, 日本学術振興会

Studies on the structure of reticular framework and its micro-environment in the lymphoid
Grant-in-Aid for General Scientific Research (C)
Nagoya University
1992 - 1993
浅井 淳平; 鷲見 幸子; 笠井 謙次; 中山 敦雄; 伊藤 雅文, ASAI Junpei; SUMI Yukiko; KASAI Kenji; NAKAYAMA Atsushi; ITO Masafumi, 日本学術振興会, Japan Society for the Promotion of Science

一般社団法人 全国医学部長病院長会議 理事
organizing_member
May 2022 - May 2024

膵臓がん 広がる仕組みを解明 愛知医大 粘液物質が進行促進
中日新聞, 11 Nov. 2010, Paper

難治性癌治療に期待 細胞増殖の仕組み解明 愛知医大グループ
中日新聞, 28 Oct. 2008, Paper