critical care medicine

sepsis

brain injury post cardiac arrest

cardiac arrest

acute respiratory distress syndrome

Resuscitation

post cardiac arrest

Apr. 2026
Travel Award, Dose-response relationship by minutes-level between initial norepinephrine dose and time to achieve target MAP, Korean Society of Critical Care Medicine 46th Annual Congress
Mitsuaki Nishikimi

Nov. 2025
President's Award (Phoenix Outstanding Researcher Award), Hiroshima University
Mitsuaki Nishikimi

2024
Journal of Intensive Care Award, Japanese Society of Intensive Care Medicine

2023
Wolf Creek Innovator Award finalist, Wolf Creek

Jun. 2022
Awards of Excellence in Research, Feinstein Institute for Medical Research

Nov. 2021
Best of Best Oral Presentation Award, American Heart Association

Nov. 2020
Young Investigator Award, American Heart Association

Mar. 2019
Encouragement award, Japanese Society of Intensive Care Medicine

Nov. 2017
Young Investigator Award, , American Heart Association

Optimizing the Timing and Integration of MRI-Based Prognostication After Pediatric Cardiac Arrest.
Sumiko Sasaki; Takeshi Namba; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, May 2026
10.1097/PCC.0000000000003947

Rhythm-specific association of epinephrine with outcomes in non-shockable cardiac arrest: A nationwide propensity-matched study.
Ryo Emoto; Mitsuaki Nishikimi; Kazuya Kikutani; Junki Ishii; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime; Taku Iwami
Resuscitation, Apr. 2026
111116-111116, 10.1016/j.resuscitation.2026.111116

Exploratory Study of Selective Brain Hypothermia Using Transnasal Evaporative Cooling Under Controlled Normothermia with an Endovascular Device.
Mitsuaki Nishikimi; Kazuya Kikutani; Mayumi Higashi; Shinichiro Ohshimo; Tatsuhiko Anzai; Nobuaki Shime
Journal of cardiovascular development and disease, Mar. 2026
13(3), 10.3390/jcdd13030120

★Association between initial norepinephrine dose and minute by minute mean arterial pressure.
Mitsuaki Nishikimi; Shinichiro Ohshimo; Kiyono Nobayashi; Takahiro Kinoshita; Nobuaki Shime
Critical care (London, England), Feb. 2026
30(1), 10.1186/s13054-026-05920-2

Association of Serum KL-6 With Mortality in Patients With Acute Respiratory Distress Syndrome (ARDS) Requiring Extracorporeal Membrane Oxygenation (ECMO): A Multicenter Retrospective Cohort Study.
Kenshiro Wada; Naofumi Bunya; Hirofumi Ohnishi; Ryuichi Nakayama; Yoshihiro Hagiwara; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime; Eichi Narimatsu
ASAIO journal (American Society for Artificial Internal Organs : 1992), Feb. 2026
10.1097/MAT.0000000000002679

Impact of post-decannulation high fever on mortality in patients with severe ARDS treated with veno-venous ECMO: a multicenter retrospective study.
Kenji Fujizuka; Mitsuaki Nishikimi; Kazuya Kikutani; Ryo Emoto; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime; Hiroyuki Suzuki
Journal of intensive care, Feb. 2026
14(1), 10.1186/s40560-026-00865-8

Association between hospital arrival time/day and mortality in pediatric patients with severe trauma: a nationwide retrospective observational study in Japan.
Shingo Ohki; Ryu Matsuo; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Injury, Feb. 2026
57(2), 112946-112946, 10.1016/j.injury.2025.112946

Association Between Positive End-Expiratory Pressure at Venovenous Extracorporeal Membrane Oxygenation Initiation and Liberation Outcomes in Acute Respiratory Distress Syndrome: A Multicenter Retrospective Study.
Takashi Hongo; Yoshinori Kosaki; Tetsuya Yumoto; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime; Atsunori Nakao; Hiromichi Naito
Critical care explorations, Feb. 2026
8(2), e1375, 10.1097/CCE.0000000000001375

Subphenotype-Specific Risk of Intracranial Hemorrhage During Extracorporeal Membrane Oxygenation in Acute Respiratory Distress Syndrome.
Mitsuaki Nishikimi; Shinichiro Ohshimo; Wataru Fukumoto; Ryo Emoto; Kazuo Awai; Shigeyuki Matsui; Nobuaki Shime
ASAIO journal (American Society for Artificial Internal Organs : 1992), Jan. 2026
10.1097/MAT.0000000000002629

Pulmonary Alveolar Proteinosis Complicated by Invasive Streptococcus pneumoniae Infection Requiring Extracorporeal Membrane Oxygenation: A Case Report.
Utaho Mizusawa; Shinichiro Ohshimo; Kazuya Kikutani; Momoko Nakamura; Mitsuaki Nishikimi; Takeshi Namba; Yuki Masuka; Takahiro Inagawa; Nobuaki Shime
Acute medicine & surgery, 2026
13(1), e70110, 10.1002/ams2.70110

Discrepancy in perceived appropriate and desired resuscitation durations between physicians and laypersons in cardiac arrest patients.
Yuko Tanabe; Takeshi Namba; Shoichi Maeda; Mitsuaki Nishikimi; Eri Ishikawa; Shinichiro Ohshimo; Nobuaki Shime
Journal of intensive care, Dec. 2025
14(1), 5-5, 10.1186/s40560-025-00841-8

Development and validation of the STeP score for predicting tracheostomy in patients with sepsis using a nationwide ICU database: a retrospective observational study.
Kazuya Kikutani; Mitsuaki Nishikimi; Michihito Kyo; Satoshi Yamaga; Tatsutoshi Shimatani; Kohei Ota; Shinichiro Ohshimo; Nobuaki Shime
Journal of intensive care, Nov. 2025
13(1), 64-64, 10.1186/s40560-025-00833-8

Impact of staff turnover on extracorporeal cardiopulmonary resuscitation in out-of-hospital cardiac arrest patients: a nationwide registry-based analysis in Japan.
Kazuya Kikutani; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Resuscitation plus, Nov. 2025
26, 101107-101107, 10.1016/j.resplu.2025.101107

Neurological outcomes with hypothermia versus normothermia in patients with moderate initial illness severity following resuscitation from out-of-hospital cardiac arrest: protocol for a multicentre randomised controlled trial (R-CAST OHCA).
Hiromichi Naito; Mitsuaki Nishikimi; Yohei Okada; Hiroki Maeyama; Takeyuki Kiguchi; Takashi Yorifuji; Kazuki Nishida; Shigeyuki Matsui; Yasuhiro Kuroda; Kei Nishiyama; Taku Iwami; Atsunori Nakao
BMJ open, Aug. 2025
15(8), e101809, 10.1136/bmjopen-2025-101809

Pulse Steroid Therapy for Severe Acute Respiratory Distress Syndrome: A Propensity Score-Matched Analysis.
Yasumasa Kawano; Junichi Maruyama; Mitsuaki Nishikimi; Hisatomi Arima; Yuhei Irie; Shinichi Morimoto; Kentaro Muranishi; Maiko Nakashio; Yoshihiko Nakamura
Journal of clinical medicine, Aug. 2025
14(15), 10.3390/jcm14155547

Association between increasing institutional experience with ECPR and outcomes in patients with out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM-OHCA registry).
Kazuya Kikutani; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Resuscitation, Apr. 2025
209, 110487-110487, 10.1016/j.resuscitation.2024.110487

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.
Nobuaki Shime; Taka-Aki Nakada; Tomoaki Yatabe; Kazuma Yamakawa; Yoshitaka Aoki; Shigeaki Inoue; Toshiaki Iba; Hiroshi Ogura; Yusuke Kawai; Atsushi Kawaguchi; Tatsuya Kawasaki; Yutaka Kondo; Masaaki Sakuraya; Shunsuke Taito; Kent Doi; Hideki Hashimoto; Yoshitaka Hara; Tatsuma Fukuda; Asako Matsushima; Moritoki Egi; Shigeki Kushimoto; Takehiko Oami; Kazuya Kikutani; Yuki Kotani; Gen Aikawa; Makoto Aoki; Masayuki Akatsuka; Hideki Asai; Toshikazu Abe; Yu Amemiya; Ryo Ishizawa; Tadashi Ishihara; Tadayoshi Ishimaru; Yusuke Itosu; Hiroyasu Inoue; Hisashi Imahase; Haruki Imura; Naoya Iwasaki; Noritaka Ushio; Masatoshi Uchida; Michiko Uchi; Takeshi Umegaki; Yutaka Umemura; Akira Endo; Marina Oi; Akira Ouchi; Itsuki Osawa; Yoshiyasu Oshima; Kohei Ota; Takanori Ohno; Yohei Okada; Hiromu Okano; Yoshihito Ogawa; Masahiro Kashiura; Daisuke Kasugai; Ken-Ichi Kano; Ryo Kamidani; Akira Kawauchi; Sadatoshi Kawakami; Daisuke Kawakami; Yusuke Kawamura; Kenji Kandori; Yuki Kishihara; Sho Kimura; Kenji Kubo; Tomoki Kuribara; Hiroyuki Koami; Shigeru Koba; Takehito Sato; Ren Sato; Yusuke Sawada; Haruka Shida; Tadanaga Shimada; Motohiro Shimizu; Kazushige Shimizu; Takuto Shiraishi; Toru Shinkai; Akihito Tampo; Gaku Sugiura; Kensuke Sugimoto; Hiroshi Sugimoto; Tomohiro Suhara; Motohiro Sekino; Kenji Sonota; Mahoko Taito; Nozomi Takahashi; Jun Takeshita; Chikashi Takeda; Junko Tatsuno; Aiko Tanaka; Masanori Tani; Atsushi Tanikawa; Hao Chen; Takumi Tsuchida; Yusuke Tsutsumi; Takefumi Tsunemitsu; Ryo Deguchi; Kenichi Tetsuhara; Takero Terayama; Yuki Togami; Takaaki Totoki; Yoshinori Tomoda; Shunichiro Nakao; Hiroki Nagasawa; Yasuhisa Nakatani; Nobuto Nakanishi; Norihiro Nishioka; Mitsuaki Nishikimi; Satoko Noguchi; Suguru Nonami; Osamu Nomura; Katsuhiko Hashimoto; Junji Hatakeyama; Yasutaka Hamai; Mayu Hikone; Ryo Hisamune; Tomoya Hirose; Ryota Fuke; Ryo Fujii; Naoki Fujie; Jun Fujinaga; Yoshihisa Fujinami; Sho Fujiwara; Hiraku Funakoshi; Koichiro Homma; Yuto Makino; Hiroshi Matsuura; Ayaka Matsuoka; Tadashi Matsuoka; Yosuke Matsumura; Akito Mizuno; Sohma Miyamoto; Yukari Miyoshi; Satoshi Murata; Teppei Murata; Hiromasa Yakushiji; Shunsuke Yasuo; Kohei Yamada; Hiroyuki Yamada; Ryo Yamamoto; Ryohei Yamamoto; Tetsuya Yumoto; Yuji Yoshida; Shodai Yoshihiro; Satoshi Yoshimura; Jumpei Yoshimura; Hiroshi Yonekura; Yuki Wakabayashi; Takeshi Wada; Shinichi Watanabe; Atsuhiro Ijiri; Kei Ugata; Shuji Uda; Ryuta Onodera; Masaki Takahashi; Satoshi Nakajima; Junta Honda; Tsuguhiro Matsumoto
Journal of intensive care, Mar. 2025
13(1), 15-15, 10.1186/s40560-025-00776-0

Changes in the neurological status from 30 to 90 days post-cardiac arrest by age: A nationwide retrospective observational study.
Hiromi Miyoshi; Mitsuaki Nishikimi; Kazuya Kikutani; Shinichiro Ohshimo; Nobuaki Shime
Resuscitation plus, Mar. 2025
22, 100917-100917, 10.1016/j.resplu.2025.100917

Improved survival and neurological outcomes with lysophosphatidylcholine supplementation in severe cardiac arrest model.
Muhammad Shoaib; Mitsuaki Nishikimi; Rishabh C Choudhary; Tsukasa Yagi; Kei Hayashida; Tai Yin; Blanca B Espin; Lance B Becker; Junhwan Kim
Frontiers in pharmacology, 2025
16, 1587776-1587776, 10.3389/fphar.2025.1587776

Effect Size of Targeted Temperature Management in Pediatric Patients with Post-Cardiac Arrest Syndrome According to the Severity.
Takeshi Namba; Mitsuaki Nishikimi; Ryo Emoto; Kazuya Kikutani; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime
Life (Basel, Switzerland), Dec. 2024
15(1), 10.3390/life15010026

Sequential Use of Romiplostim after Eltrombopag for Refractory Thrombocytopenia in Hydrocarbon-Induced Myelodysplasia.
Luis F Morales; Santiago J Miyara; Sara Guevara; Christine N Metz; Muhammad Shoaib; Stacey Watt; Stefanos Zafeiropoulos; Alexia McCann-Molmenti; Kei Hayashida; Ryosuke Takegawa; Koichiro Shinozaki; Rishabh C Choudhary; Elena C Brindley; Mitsuaki Nishikimi; Adam M Kressel; Yaser M Alsalmay; Elvio A Mazzotta; Young Min Cho; Gabriel I Aranalde; Daniel A Grande; Stavros Zanos; Linda Shore-Lesserson; Lance B Becker; Ernesto P Molmenti
The International journal of angiology : official publication of the International College of Angiology, Inc, Dec. 2024
33(4), 318-321, 10.1055/s-0041-1726366

Resuscitation Attempt and Outcomes in Patients With Asystole Out-of-Hospital Cardiac Arrest
Junki Ishii; Mitsuaki Nishikimi; Kazuya Kikutani; Shingo Ohki; Kohei Ota; Tatsuhiko Anzai; Kunihiko Takahashi; Masashi Okubo; Shinichiro Ohshimo; Taku Iwami; Nobuaki Shime
JAMA Network Open, Nov. 2024
7(11), e2445543-e2445543, 10.1001/jamanetworkopen.2024.45543

Increased national critical care demands were associated with a higher mortality of intubated COVID-19 patients in Japan: a retrospective observational study
Kazuya Kikutani; Mitsuaki Nishikimi; Ryo Emoto; Shigeyuki Matsui; Hiroyuki Ohbe; Takayuki Ogura; Satoru Hashimoto; Shigeki Kushimoto; Shinhiro Takeda; Shinichiro Ohshimo; Nobuaki Shime
Journal of Intensive Care, Nov. 2024
12(1), 46-46, 10.1186/s40560-024-00758-8

Diagnostic utility of plasma translocator protein 18 kDa (TSPO) in sepsis: A case-control study.
Miyuki Hattori; Kazuya Kikutani; Koji Hosokawa; Michihito Kyo; Mitsuaki Nishikimi; Kohei Ota; Shinichiro Ohshimo; Hidenori Aizawa; Nobuaki Shime
Medicine, Nov. 2024
103(44), e40396, 10.1097/MD.0000000000040396

★Identification of novel sub-phenotypes of severe ARDS requiring ECMO using latent class analysis
Mitsuaki Nishikimi; Shinichiro Ohshimo; Giacomo Bellani; Wataru Fukumoto; Tatsuhiko Anzai; Keibun Liu; Junki Ishii; Michihito Kyo; Kazuo Awai; Kunihiko Takahashi; Nobuaki Shime; Jun Hamaguchi; Kazuki Matsumura; Kenji Fujizuka; Yoshihiro Hagiwara; Ryuichi Nakayama; Naofumi Bunya; Junichi Maruyama; Takayuki Ogura; Mitsunobu Nakamura; Keiki Shimizu; Mamoru Masuda
Critical Care, Oct. 2024
28(1), 343-343, 10.1186/s13054-024-05143-3

Complex interaction of infusion volumes and confounding factors with lactate clearance in septic shock.
Junki Ishii; Shinichiro Ohshimo; Mitsuaki Nishikimi; Michihito Kyo; Nobuaki Shime
Intensive care medicine, Sep. 2024
50(9), 1545-1546, 10.1007/s00134-024-07530-4

Reply to Sethuraman et al. Comment on "Utsumi et al. Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest. Medicina 2024, 60, 510".
Shu Utsumi; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Medicina (Kaunas, Lithuania), Aug. 2024
60(8), 10.3390/medicina60081289

No improvement in mortality among critically ill patients with carbapenems as initial empirical therapy and more detection of multi-drug resistant pathogens associated with longer use: a post hoc analysis of a prospective cohort study.
Junki Ishii; Mitsuaki Nishikimi; Liesbet De Bus; Jan De Waele; Akihiro Takaba; Akira Kuriyama; Atsuko Kobayashi; Chie Tanaka; Hideki Hashi; Hideki Hashimoto; Hiroshi Nashiki; Mami Shibata; Masafumi Kanamoto; Masashi Inoue; Satoru Hashimoto; Shinshu Katayama; Shinsuke Fujiwara; Shinya Kameda; Shunsuke Shindo; Tetsuya Komuro; Toshiomi Kawagishi; Yasumasa Kawano; Yoshihito Fujita; Yoshiko Kida; Yuya Hara; Hideki Yoshida; Shigeki Fujitani; Nobuaki Shime
Microbiology spectrum, Jul. 2024
12(7), e0034224, 10.1128/spectrum.00342-24

Should Transport Ventilators Be Used in Times of Crisis? The Use of Emergency Authorized Nonconventional Ventilators Is Associated With Mortality Among Patients With COVID-19 Acute Respiratory Distress Syndrome.
Vikram B Gondhalekar; Amir Gandomi; Sarah L Gilman; Negin Hajizadeh; Zubair M Hasan; Matthew A Bank; Daniel M Rolston; Allison Cohen; Timmy Li; Mitsuaki Nishikimi; Mangala Narasimhan; Lance Becker; Daniel Jafari
Critical care medicine, Jul. 2024
52(7), 1021-1031, 10.1097/CCM.0000000000006252

Identifying Subgroups with Differential Responses to Amiodarone among Cardiac Arrest Patients with a Shockable Rhythm at Hospital Arrival using the Machine Learning Approach.
Ryo Emoto; Mitsuaki Nishikimi; Kazuya Kikutani; Junki Ishii; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime
Reviews in cardiovascular medicine, Jul. 2024
25(7), 268-268, 10.31083/j.rcm2507268

The Role of Phospholipid Alterations in Mitochondrial and Brain Dysfunction after Cardiac Arrest.
Rishabh C Choudhary; Cyrus E Kuschner; Jacob Kazmi; Liam Mcdevitt; Blanca B Espin; Mohammed Essaihi; Mitsuaki Nishikimi; Lance B Becker; Junhwan Kim
International journal of molecular sciences, Apr. 2024
25(9), 10.3390/ijms25094645

The Current Discussion Regarding End-of-Life Care for Patients with Out-of-Hospital Cardiac Arrest with Initial Non-Shockable Rhythm: A Narrative Review.
Junki Ishii; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Medicina (Kaunas, Lithuania), Mar. 2024
60(4), 10.3390/medicina60040533

Differences in Pathophysiology and Treatment Efficacy Based on Heterogeneous Out-of-Hospital Cardiac Arrest.
Shu Utsumi; Mitsuaki Nishikimi; Shinichiro Ohshimo; Nobuaki Shime
Medicina (Kaunas, Lithuania), Mar. 2024
60(3), 10.3390/medicina60030510

★Wolf Creek XVII part 9: Wolf Creek Innovator in Cardiac Arrest and Resuscitation Science Award.
Adam L Gottula; Carolina B Maciel; Mitsuaki Nishikimi; Rajat Kalra; Jacob Sunshine; Ryan W Morgan
Resuscitation plus, Mar. 2024
17, 100519-100519, 10.1016/j.resplu.2023.100519

External validation of the rCAST for patients after in-hospital cardiac arrest: a multicenter retrospective observational study
Junki Ishii; Mitsuaki Nishikimi; Kazuya Kikutani; Michihito Kyo; Shingo Ohki; Kohei Ota; Mitsuhiro Fujino; Masaaki Sakuraya; Shinichiro Ohshimo; Nobuaki Shime
Scientific Reports, Feb. 2024
14(1), 4284-4284, 10.1038/s41598-024-54851-x

Association between hospital volume and in-hospital mortality in pediatric severe traumatic brain injury: a nationwide retrospective observational study in Japan.
Shu Utsumi; Shingo Ohki; Takeshi Ueda; Shunsuke Amagasa; Mitsuaki Nishikimi; Nobuaki Shime
Journal of neurosurgery. Pediatrics, Feb. 2024
33(2), 137-141, 10.3171/2023.10.PEDS23425

Association between regional critical care capacity and the incidence of invasive mechanical ventilation for coronavirus disease 2019: a population-based cohort study.
Hiroyuki Ohbe; Satoru Hashimoto; Takayuki Ogura; Mitsuaki Nishikimi; Daisuke Kudo; Nobuaki Shime; Shigeki Kushimoto
Journal of intensive care, Jan. 2024
12(1), 6-6, 10.1186/s40560-024-00718-2

Chest CT findings in severe acute respiratory distress syndrome requiring V-V ECMO: J-CARVE registry.
Mitsuaki Nishikimi; Shinichiro Ohshimo; Wataru Fukumoto; Jun Hamaguchi; Kazuki Matsumura; Kenji Fujizuka; Yoshihiro Hagiwara; Ryuichi Nakayama; Naofumi Bunya; Junichi Maruyama; Toshikazu Abe; Tatsuhiko Anzai; Yoshitaka Ogata; Hiromichi Naito; Yu Amemiya; Tokuji Ikeda; Masayuki Yagi; Yutaro Furukawa; Hayato Taniguchi; Tsukasa Yagi; Ken Katsuta; Daisuke Konno; Ginga Suzuki; Yuki Kawasaki; Noriyuki Hattori; Tomoyuki Nakamura; Natsuki Kondo; Hitoshi Kikuchi; Shinichi Kai; Saaya Ichiyama; Kazuo Awai; Kunihiko Takahashi; Nobuaki Shime
Journal of intensive care, Jan. 2024
12(1), 5-5, 10.1186/s40560-023-00715-x

External validation of the sICOP score for early mortality in mechanically ventilated patients with COVID-19.
Mitsuaki Nishikimi; Kei Hayashida; Takashi Tagami; Shinichiro Ohshimo; Nobuaki Shime; Kazuma Yamakawa
Acute medicine & surgery, 2024
11(1), e978, 10.1002/ams2.978

Prediction of the neurological outcomes post-cardiac arrest: A prospective validation of the CAST and rCAST.
Kazuya Kikutani; Mitsuaki Nishikimi; Kota Matsui; Atsushi Sakurai; Kei Hayashida; Nobuya Kitamura; Takashi Tagami; Taka-Aki Nakada; Shigeyuki Matsui; Shinichiro Ohshimo; Nobuaki Shime
The American journal of emergency medicine, Jan. 2024
75, 46-52, 10.1016/j.ajem.2023.10.028

Neurological Improvement via Lysophosphatidic Acid Administration in a Rodent Model of Cardiac Arrest-Induced Brain Injury.
Mitsuaki Nishikimi; Rishabh C Choudhary; Muhammad Shoaib; Tsukasa Yagi; Lance B Becker; Junhwan Kim
International journal of molecular sciences, Dec. 2023
24(24), 10.3390/ijms242417451

Instruments to assess post-intensive care syndrome assessment: a scoping review and modified Delphi method study.
Nobuto Nakanishi; Keibun Liu; Akira Kawauchi; Masatsugu Okamura; Kohei Tanaka; Sho Katayama; Yuki Mitani; Kohei Ota; Shunsuke Taito; Kenichi Fudeyasu; Yuki Masuka; Shodai Yoshihiro; Shu Utsumi; Mitsuaki Nishikimi; Mamoru Masuda; Yuki Iida; Yusuke Kawai; Junji Hatakeyama; Toru Hifumi; Takeshi Unoki; Daisuke Kawakami; Kengo Obata; Hajime Katsukawa; Hidenori Sumita; Tomoyuki Morisawa; Masahiro Takahashi; Norihiko Tsuboi; Ryo Kozu; Shunsuke Takaki; Junpei Haruna; Yoshihisa Fujinami; Nobuyuki Nosaka; Kyohei Miyamoto; Kensuke Nakamura; Yutaka Kondo; Shigeaki Inoue; Osamu Nishida
Critical care (London, England), Nov. 2023
27(1), 430-430, 10.1186/s13054-023-04681-6

High versus low positive end-expiratory pressure setting in patients receiving veno-venous extracorporeal membrane oxygenation support for severe acute respiratory distress syndrome: study protocol for the multicentre, randomised ExPress SAVER Trial
Mitsuaki Nishikimi; Shinichiro Ohshimo; Jun Hamaguchi; Kenji Fujizuka; Yoshihiro Hagiwara; Tatsuhiko Anzai; Junki Ishii; Yoshitaka Ogata; Toshiyuki Aokage; Tokuji Ikeda; Tsukasa Yagi; Ginga Suzuki; Ken Ishikura; Ken Katsuta; Daisuke Konno; Noriyuki Hattori; Tomoyuki Nakamura; Yosuke Matsumura; Daisuke Kasugai; Hitoshi Kikuchi; Tatsuhiko Iino; Shinichi Kai; Haruka Hashimoto; Takeshi Yoshida; Yumi Igarashi; Takayuki Ogura; Kazuki Matsumura; Keiki Shimizu; Mitsunobu Nakamura; Shingo Ichiba; Kunihiko Takahashi; Nobuaki Shime
BMJ Open, Oct. 2023
13(10), e072680-e072680, 10.1136/bmjopen-2023-072680

Predictive Accuracy of the ROX Index for Re-Intubation in Mechanically Ventilated Patients With COVID-19.
Yusuke Okazaki; Mitsuaki Nishikimi; Junki Ishii; Kohei Ota; Shinichiro Ohshimo; Nobuaki Shime
Respiratory care, Aug. 2023
68(8), 1067-1074, 10.4187/respcare.10549

Multi-Drug Cocktail Therapy Improves Survival and Neurological Function after Asphyxial Cardiac Arrest in Rodents.
Rishabh C Choudhary; Muhammad Shoaib; Kei Hayashida; Tai Yin; Santiago J Miyara; Cristina d'Abramo; William G Heuser; Koichiro Shinozaki; Nancy Kim; Ryosuke Takegawa; Mitsuaki Nishikimi; Timmy Li; Casey Owens; Ernesto P Molmenti; Mingzhu He; Sonya Vanpatten; Yousef Al-Abed; Junhwan Kim; Lance B Becker
Cells, Jun. 2023
12(11), 10.3390/cells12111548

Characteristics of the pulmonary opacities on chest CT associated with difficulty in short-term liberation from veno-venous ECMO in patients with severe ARDS.
Mitsuaki Nishikimi; Shinichiro Ohshimo; Wataru Fukumoto; Tatsuhiko Anzai; Kazuo Awai; Takayuki Ogura; Toshikazu Abe; Mamoru Masuda; Kenji Fujizuka; Mitsunobu Nakamura; Michihito Kyo; Kunihiko Takahashi; Nobuaki Shime
Respiratory research, May 2023
24(1), 128-128, 10.1186/s12931-023-02425-2

Lung Abscess and Pyothorax in Critically Ill COVID-19 Patients: A Single-Center Retrospective Study.
Shu Utsumi; Shinichiro Ohshimo; Junki Ishii; Mitsuaki Nishikimi; Nobuaki Shime
Critical care explorations, May 2023
5(5), e0919, 10.1097/CCE.0000000000000919

Continuously increased generation of ROS in human plasma after cardiac arrest as determined by Amplex Red oxidation.
Muhammad Shoaib; Nancy Kim; Rishabh C Choudhary; Blanca Espin; Mitsuaki Nishikimi; Ann Iverson; Tsukasa Yagi; Seyedeh Shadafarin Marashi Shoshtari; Koichiro Shinozaki; Lance B Becker; Junhwan Kim
Free radical research, May 2023
57(5), 384-394, 10.1080/10715762.2023.2250547

Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest.
Kei Hayashida; Ryosuke Takegawa; Yusuke Endo; Tai Yin; Rishabh C Choudhary; Tomoaki Aoki; Mitsuaki Nishikimi; Atsushi Murao; Eriko Nakamura; Muhammad Shoaib; Cyrus Kuschner; Santiago J Miyara; Junhwan Kim; Koichiro Shinozaki; Ping Wang; Lance B Becker
BMC medicine, Mar. 2023
21(1), 56-56, 10.1186/s12916-023-02759-0

Quantification of respiratory sounds by a continuous monitoring system can be used to predict complications after extubation: a pilot study.
Kazuya Kikutani; Shinichiro Ohshimo; Takuma Sadamori; Shingo Ohki; Hiroshi Giga; Junki Ishii; Hiromi Miyoshi; Kohei Ota; Mitsuaki Nishikimi; Nobuaki Shime
Journal of clinical monitoring and computing, Feb. 2023
37(1), 237-248, 10.1007/s10877-022-00884-4

院外心停止例での体温管理療法に関する無作為化比較試験
内藤 宏道; 錦見 満暁; 岡田 遥平; 前山 博輝; 木口 雄之; 西田 一貴; 松井 茂之; 黒田 泰弘; 西山 慶; 石見 拓; 中尾 篤典
日本脳低温療法・体温管理学会誌, Sep. 2022
25(1), 12-13

院外心停止例での体温管理療法に関する無作為化比較試験
内藤 宏道; 錦見 満暁; 岡田 遥平; 前山 博輝; 木口 雄之; 西田 一貴; 松井 茂之; 黒田 泰弘; 西山 慶; 石見 拓; 中尾 篤典
日本脳低温療法・体温管理学会誌, Sep. 2022
25(1), 12-13

Reply: COVID-19 Mortality Differences: Patient-related Data and Intensive Care Unit Load Are Prerequisites.
Mitsuaki Nishikimi; Daniel Jafari; Muhammad Shoaib; Lance B Becker
Annals of the American Thoracic Society, Sep. 2022
19(9), 1624-1625, 10.1513/AnnalsATS.202204-313LE

Mortality of Mechanically Ventilated COVID-19 Patients in Traditional versus Expanded Intensive Care Units in New York.
Mitsuaki Nishikimi; Daniel Jafari; Neha Singh; Koichiro Shinozaki; Cristina P Sison; Muhammad Shoaib; Jonathan Gong; Rehana Rasul; Timmy Li; Kei Hayashida; Daniel M Rolston; Santiago J Miyara; Jamie S Hirsch; Amir Gandomi; Maureen T White; Mark P Jarrett; Martin L Lesser; Lance B Becker
Annals of the American Thoracic Society, Aug. 2022
19(8), 1346-1354, 10.1513/AnnalsATS.202106-705OC

The finger-to-nose test improved diagnosis of cerebrovascular events in patients presenting with isolated dizziness in the emergency department.
Kazuki Nishida; Takuya Usami; Nana Matsumoto; Mitsuaki Nishikimi; Kunihiko Takahashi; Shigeyuki Matsui
Nagoya journal of medical science, Aug. 2022
84(3), 621-629, 10.18999/nagjms.84.3.621

Alarming of Severe Respiratory Failure Requiring ECMO Caused by the SARS-CoV-2 Omicron Variant.
Shinichiro Ohshimo; Nobuaki Shime; Tatsutoshi Shimatani; Yusuke Okazaki; Mitsuaki Nishikimi; Momoko Asada; Kohei Ota; Yuji Fujino; Shinhiro Takeda
JMA journal, Jul. 2022
5(3), 370-371, 10.31662/jmaj.2022-0049

Prediction of Prehospital Change of the Cardiac Rhythm From Nonshockable to Shockable in Out-of-Hospital Patients With Cardiac Arrest: A Post Hoc Analysis of a Nationwide, Multicenter, Prospective Registry.
Ryo Emoto; Mitsuaki Nishikimi; Muhammad Shoaib; Kei Hayashida; Kazuki Nishida; Kazuya Kikutani; Shinichiro Ohshimo; Shigeyuki Matsui; Nobuaki Shime; Taku Iwami
Journal of the American Heart Association, Jun. 2022
11(12), e025048, 10.1161/JAHA.121.025048

広島大学病院での重症COVID-19患者の診療 第1～3波と第4～5波の比較
菊谷 知也; 錦見 満暁; 山賀 聡之; 大下 慎一郎; 志馬 伸朗
広島医学, Jun. 2022, Reviewed
75(6), 239-243

COVID-19-Associated Portal Vein Thrombosis Post-Cholecystitis
Sara Guevara; Santiago J. Miyara; Judith Aronsohn; Joseph T. Homsi; Alexia McCann-Molmenti; James M. Mumford; Barbara Keber; Linda Shore-Lesserson; Luis Morales; Christine N. Metz; Young Min Cho; Christine L. Sardo Molmenti; Rodrigo Loto; Martin M. Pesce; Stefanos Zafeiropoulos; Dimitrios Giannis; Derek O. Pipolo; Francky Jacque; Lisandro Montorfano; Koichiro Shinozaki; Muhammad Shoaib; Rishabh C. Choudhary; Mitsuaki Nishikimi; Ryosuke Takegawa; Yusuke Endo; Kei Hayashida; Fermin M. Fontan; Lance B. Becker; Ernesto P. Molmenti
International Journal of Angiology, May 2022, Reviewed, No invitation
32(4), 262-268, 10.1055/s-0042-1743409

★Preserving Brain LPC-DHA by Plasma Supplementation Attenuates Brain Injury after Cardiac Arrest.
Mitsuaki Nishikimi; Muhammad Shoaib; Rishabh C Choudhary; Tomoaki Aoki; Santiago J Miyara; Tsukasa Yagi; Kei Hayashida; Ryosuke Takegawa; Tai Yin; Lance B Becker; Junhwan Kim
Annals of neurology, Mar. 2022
91(3), 389-403, 10.1002/ana.26296

★Phospholipid Screening Postcardiac Arrest Detects Decreased Plasma Lysophosphatidylcholine: Supplementation as a New Therapeutic Approach.
Mitsuaki Nishikimi; Tsukasa Yagi; Muhammad Shoaib; Ryosuke Takegawa; Rehana Rasul; Kei Hayashida; Yu Okuma; Tai Yin; Rishabh C Choudhary; Lance B Becker; Junhwan Kim
Critical care medicine, Feb. 2022
50(2), e199-e208, 10.1097/CCM.0000000000005180

Differential Effectiveness of Hypothermic Targeted Temperature Management According to the Severity of Post-Cardiac Arrest Syndrome.
Kazuya Kikutani; Mitsuaki Nishikimi; Tatsutoshi Shimatani; Michihito Kyo; Shinichiro Ohshimo; Nobuaki Shime
Journal of clinical medicine, Nov. 2021
10(23), 10.3390/jcm10235643

Hydrogen gas with extracorporeal cardiopulmonary resuscitation improves survival after prolonged cardiac arrest in rats.
Tai Yin; Lance B Becker; Rishabh C Choudhary; Ryosuke Takegawa; Muhammad Shoaib; Koichiro Shinozaki; Yusuke Endo; Koichiro Homma; Daniel M Rolston; Shuhei Eguchi; Tadashi Ariyoshi; Asami Matsumoto; Kentaro Oka; Motomichi Takahashi; Tomoaki Aoki; Santiago J Miyara; Mitsuaki Nishikimi; Junichi Sasaki; Junhwan Kim; Ernesto P Molmenti; Kei Hayashida
Journal of translational medicine, Nov. 2021
19(1), 462-462, 10.1186/s12967-021-03129-1

The rCAST score is useful for estimating the neurological prognosis in pediatric patients with post-cardiac arrest syndrome before ICU admission: External validation study using a nationwide prospective registry.
Yuma Yasuda; Mitsuaki Nishikimi; Kota Matsui; Atsushi Numaguchi; Kazuki Nishida; Ryo Emoto; Shigeyuki Matsui; Naoyuki Matsuda
Resuscitation, Nov. 2021
168, 103-109, 10.1016/j.resuscitation.2021.09.025

Intubated COVID-19 predictive (ICOP) score for early mortality after intubation in patients with COVID-19.
Mitsuaki Nishikimi; Rehana Rasul; Cristina P Sison; Daniel Jafari; Muhammad Shoaib; Koichiro Shinozaki; Timmy Li; Kei Hayashida; Daniel M Rolston; Jamie S Hirsch; Lance B Becker
Scientific reports, Oct. 2021
11(1), 21124-21124, 10.1038/s41598-021-00591-1

ホスホリピドミクスにより明らかとなった脳損傷の主な原因である血漿LPCの減少(Phospholipidomics revealed identification of decreased plasma LPC as a major cause of brain damage)
Nishikimi Mitsuaki; Yagi Tsukasa; Takegawa Ryosuke; Hayashida Kei; Lance Becker; Kim Junhwan
日本集中治療医学会雑誌, Sep. 2021
28(Suppl.2), 331-331

Understanding physiologic phospholipid maintenance in the context of brain mitochondrial phospholipid alterations after cardiac arrest.
Cyrus E Kuschner; Nancy Kim; Muhammad Shoaib; Rishabh C Choudhary; Mitsuaki Nishikimi; Tai Yin; Lance B Becker; Charles L Hoppel; Junhwan Kim
Mitochondrion, Sep. 2021
60, 112-120, 10.1016/j.mito.2021.08.009

Outcome Related to Level of Targeted Temperature Management in Postcardiac Arrest Syndrome of Low, Moderate, and High Severities: A Nationwide Multicenter Prospective Registry.
Mitsuaki Nishikimi; Takayuki Ogura; Kazuki Nishida; Kei Hayashida; Ryo Emoto; Shigeyuki Matsui; Naoyuki Matsuda; Taku Iwami
Critical care medicine, Aug. 2021
49(8), e741-e750, 10.1097/CCM.0000000000005025

Right Ventricle Embolization of IVC Filter Fragments: An Incidental Finding
Santiago J. Miyara; Sara Guevara; Linda Shore-Lesserson; Muhammad Shoaib; Claudia Kirsch; Christine N. Metz; Vinay Nair; Lawrence Lau; Rishabh C. Choudhary; Alexia McCann-Molmenti; Anthony M. Baez; Kei Hayashida; Ryosuke Takegawa; Koichiro Shinozaki; Tomoaki Aoki; Mitsuaki Nishikimi; Young Min Cho; Alexis Morell; Stefanos Zafeiropoulos; Stavros Zanos; Stacey Watt; Lisandro Montorfano; Cristian D. Bartoc; Claudio M. Lumermann; Judith Aronsohn; Lance B. Becker; Ernesto P. Molmenti
International Journal of Angiology, Jul. 2021, Reviewed, No invitation
34(2), 100-104, 10.1055/s-0041-1730451

The interplay between bystander cardiopulmonary resuscitation and ambient temperature on neurological outcome after cardiac arrest: A nationwide observational cohort study.
Kei Hayashida; Ryosuke Takegawa; Mitsuaki Nishikimi; Tomoaki Aoki; Ryo Emoto; Koichiro Shinozaki; Santiago J Miyara; Daniel M Rolston; Timmy Li; Muhammad Shoaib; Tatsuma Fukuda; Ernesto P Molmenti; Masaru Suzuki; Junichi Sasaki; Shigeyuki Matsui; Lance B Becker
Resuscitation, Jul. 2021
164, 46-53, 10.1016/j.resuscitation.2021.05.008

Mitochondrial transplantation therapy for ischemia reperfusion injury: a systematic review of animal and human studies.
Kei Hayashida; Ryosuke Takegawa; Muhammad Shoaib; Tomoaki Aoki; Rishabh C Choudhary; Cyrus E Kuschner; Mitsuaki Nishikimi; Santiago J Miyara; Daniel M Rolston; Sara Guevara; Junhwan Kim; Koichiro Shinozaki; Ernesto P Molmenti; Lance B Becker
Journal of translational medicine, May 2021
19(1), 214-214, 10.1186/s12967-021-02878-3

Effects of Post-Resuscitation Normoxic Therapy on Oxygen-Sensitive Oxidative Stress in a Rat Model of Cardiac Arrest.
Yu Okuma; Lance B Becker; Kei Hayashida; Tomoaki Aoki; Kota Saeki; Mitsuaki Nishikimi; Muhammad Shoaib; Santiago J Miyara; Tai Yin; Koichiro Shinozaki
Journal of the American Heart Association, Apr. 2021
10(7), e018773, 10.1161/JAHA.120.018773

The evaluation of pituitary damage associated with cardiac arrest: An experimental rodent model.
Yu Okuma; Tomoaki Aoki; Santiago J Miyara; Kei Hayashida; Mitsuaki Nishikimi; Ryosuke Takegawa; Tai Yin; Junhwan Kim; Lance B Becker; Koichiro Shinozaki
Scientific reports, Jan. 2021
11(1), 629-629, 10.1038/s41598-020-79780-3

Failure of non-invasive respiratory support after 6 hours from initiation is associated with ICU mortality.
Mitsuaki Nishikimi; Kazuki Nishida; Yuichiro Shindo; Muhammad Shoaib; Daisuke Kasugai; Yuma Yasuda; Michiko Higashi; Atsushi Numaguchi; Takanori Yamamoto; Shigeyuki Matsui; Naoyuki Matsuda
PloS one, 2021
16(4), e0251030, 10.1371/journal.pone.0251030

Assessment of Cerebral Blood Oxygenation by Near-Infrared Spectroscopy before and after Resuscitation in a Rat Asphyxia Cardiac Arrest Model.
Tsukasa Yagi; Koichiro Shinozaki; Yu Okuma; Tai Yin; Mitsuaki Nishikimi; Takeyuki Kiguchi; Taku Iwami; Lance B Becker
Advances in experimental medicine and biology, 2021
1269, 311-315, 10.1007/978-3-030-48238-1_49

Pneumatosis Intestinalis in the Setting of COVID-19: A Single Center Case Series From New York.
Santiago J Miyara; Lance B Becker; Sara Guevara; Claudia Kirsch; Christine N Metz; Muhammad Shoaib; Elliot Grodstein; Vinay V Nair; Nicholas Jandovitz; Alexia McCann-Molmenti; Kei Hayashida; Ryosuke Takegawa; Koichiro Shinozaki; Tsukasa Yagi; Tomoaki Aoki; Mitsuaki Nishikimi; Rishabh C Choudhary; Young Min Cho; Stavros Zanos; Stefanos Zafeiropoulos; Hannah B Hoffman; Stacey Watt; Claudio M Lumermann; Judith Aronsohn; Linda Shore-Lesserson; Ernesto P Molmenti
Frontiers in medicine, 2021
8, 638075-638075, 10.3389/fmed.2021.638075

Plasma metabolomics supports the use of long-duration cardiac arrest rodent model to study human disease by demonstrating similar metabolic alterations.
Muhammad Shoaib; Rishabh C Choudhary; Jaewoo Choi; Nancy Kim; Kei Hayashida; Tsukasa Yagi; Tai Yin; Mitsuaki Nishikimi; Jan F Stevens; Lance B Becker; Junhwan Kim
Scientific reports, Nov. 2020
10(1), 19707-19707, 10.1038/s41598-020-76401-x

心肺蘇生時のモニタリングとしての近赤外線分光法の有用性
八木 司; 篠崎 広一郎; 大熊 佑; 錦見 満暁; 林田 敬; 木口 雄之; 石見 拓; Becker Lance
日本集中治療医学会雑誌, Sep. 2020
27(Suppl.), 502-502

High-flow nasal cannula therapy for acute respiratory failure in patients with interstitial pneumonia: a retrospective observational study.
Norihito Omote; Naoyuki Matsuda; Naozumi Hashimoto; Kazuki Nishida; Koji Sakamoto; Akira Ando; Yoshio Nakahara; Mitsuaki Nishikimi; Michiko Higashi; Shigeyuki Matsui; Yoshinori Hasegawa
Nagoya journal of medical science, May 2020
82(2), 301-313, 10.18999/nagjms.82.2.301

Relationship Between Serum Norepinephrine Levels at ICU Admission and the Risk of ICU-Acquired Delirium: Secondary Analysis of the Melatonin Evaluation of Lowered Inflammation of ICU Trial.
Yuma Yasuda; Mitsuaki Nishikimi; Kazuki Nishida; Kunihiko Takahashi; Atsushi Numaguchi; Michiko Higashi; Shigeyuki Matsui; Naoyuki Matsuda
Critical care explorations, Feb. 2020
2(2), e0082, 10.1097/CCE.0000000000000082

Clinical Frailty Scale Score Before ICU Admission Is Associated With Mobility Disability in Septic Patients Receiving Early Rehabilitation.
Hiroki Nakajima; Mitsuaki Nishikimi; Miho Shimizu; Kazuhiro Hayashi; Takayuki Inoue; Kazuki Nishida; Kunihiko Takahashi; Shigeyuki Matsui; Yoshihiro Nishida; Naoyuki Matsuda
Critical care explorations, Dec. 2019
1(12), e0066, 10.1097/CCE.0000000000000066

A Progressive Early Mobilization Program Is Significantly Associated With Clinical and Economic Improvement: A Single-Center Quality Comparison Study.
Keibun Liu; Takayuki Ogura; Kunihiko Takahashi; Mitsunobu Nakamura; Hiroaki Ohtake; Kenji Fujiduka; Emi Abe; Hitoshi Oosaki; Dai Miyazaki; Hiroyuki Suzuki; Mitsuaki Nishikimi; Mamoru Komatsu; Alan Kawarai Lefor; Takashi Mato
Critical care medicine, Sep. 2019
47(9), e744-e752, 10.1097/CCM.0000000000003850

Variable Selection for Nonparametric Learning with Power Series Kernels.
Kota Matsui; Wataru Kumagai; Kenta Kanamori; Mitsuaki Nishikimi; Takafumi Kanamori
Neural computation, Aug. 2019
31(8), 1718-1750, 10.1162/neco_a_01212

External validation of a risk classification at the emergency department of post-cardiac arrest syndrome patients undergoing targeted temperature management.
Mitsuaki Nishikimi; Takayuki Ogura; Kazuki Nishida; Kunihiko Takahashi; Mitsunobu Nakamura; Shigeyuki Matsui; Naoyuki Matsuda; Taku Iwami
Resuscitation, Jul. 2019
140, 135-141, 10.1016/j.resuscitation.2019.05.028

Challenges and Inconsistencies in Using Lysophosphatidic Acid as a Biomarker for Ovarian Cancer.
Tsukasa Yagi; Muhammad Shoaib; Cyrus Kuschner; Mitsuaki Nishikimi; Lance B Becker; Annette T Lee; Junhwan Kim
Cancers, Apr. 2019
11(4), 10.3390/cancers11040520

Differential Effects of Mild Therapeutic Hypothermia Against Normothermia for Post-Cardiac Arrest Syndrome According to the Severity Scale
Nishikimi, Mitsuaki; Ogura, Takayuki; Nishida, Kazuki; Iwami, Taku
Circulation, 2019

Timing of administration of epinephrine predicts the responsiveness to epinephrine in norepinephrine-refractory septic shock: a retrospective study.
Daisuke Kasugai; Mitsuaki Nishikimi; Kazuki Nishida; Michiko Higashi; Takanori Yamamoto; Atsushi Numaguchi; Kunihiko Takahashi; Shigeyuki Matsui; Naoyuki Matsuda
Journal of intensive care, 2019
7, 20-20, 10.1186/s40560-019-0377-1

Sleep, the Missing Link? Reply
Nishikimi Mitsuaki; Numaguchi Atsushi; Takahashi Kunihiko; Matsui Shigeyuki; Matsuda Naoyuki
CRITICAL CARE MEDICINE, Dec. 2018, Reviewed, No invitation
46(12), E1225-E1226, 10.1097/CCM.0000000000003452

The authors reply.
Mitsuaki Nishikimi; Atsushi Numaguchi; Kunihiko Takahashi; Shigeyuki Matsui; Naoyuki Matsuda
Critical care medicine, Dec. 2018
46(12), e1225-e1226, 10.1097/CCM.0000000000003452

Early Administration of Ramelteon in the ICU: Effects Deserve Further Study Reply
Nishikimi Mitsuaki; Numaguchi Atsushi; Takahashi Kunihiko; Matsui Shigeyuki; Matsuda Naoyuki
CRITICAL CARE MEDICINE, Oct. 2018, Not reviewed, No invitation
46(10), E1010-E1011, 10.1097/CCM.0000000000003315

The authors reply.
Mitsuaki Nishikimi; Atsushi Numaguchi; Kunihiko Takahashi; Shigeyuki Matsui; Naoyuki Matsuda
Critical care medicine, Oct. 2018
46(10), e1010-e1011, 10.1097/CCM.0000000000003315

Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial.
Mitsuaki Nishikimi; Atsushi Numaguchi; Kunihiko Takahashi; Yasuhiro Miyagawa; Kota Matsui; Michiko Higashi; Go Makishi; Shigeyuki Matsui; Naoyuki Matsuda
Critical care medicine, Jul. 2018
46(7), 1099-1105, 10.1097/CCM.0000000000003132

Differential effect of mild therapeutic hypothermia depending on the findings of hypoxic encephalopathy on early CT images in patients with post-cardiac arrest syndrome.
Mitsuaki Nishikimi; Takayuki Ogura; Kazuki Nishida; Kunihiko Takahashi; Kenji Fukaya; Keibun Liu; Mitsunobu Nakamura; Shigeyuki Matsui; Naoyuki Matsuda
Resuscitation, Jul. 2018
128, 11-15, 10.1016/j.resuscitation.2018.04.029

The safety of a novel early mobilization protocol conducted by ICU physicians: a prospective observational study.
Keibun Liu; Takayuki Ogura; Kunihiko Takahashi; Mitsunobu Nakamura; Hiroaki Ohtake; Kenji Fujiduka; Emi Abe; Hitoshi Oosaki; Dai Miyazaki; Hiroyuki Suzuki; Mitsuaki Nishikimi; Alan Kawarai Lefor; Takashi Mato
Journal of intensive care, 2018
6, 10-10, 10.1186/s40560-018-0281-0

Accuracy of the first interpretation of early brain CT images for predicting the prognosis of post-cardiac arrest syndrome patients at the emergency department.
Mitsuaki Nishikimi; Takayuki Ogura; Kota Matsui; Kunihiko Takahashi; Kenji Fukaya; Keibun Liu; Hideo Morita; Mitsunobu Nakamura; Shigeyuki Matsui; Naoyuki Matsuda
Journal of intensive care, 2018
6, 26-26, 10.1186/s40560-018-0296-6

A novel scoring system for predicting the neurologic prognosis prior to the initiation of induced hypothermia in cases of post-cardiac arrest syndrome: the CAST score.
Mitsuaki Nishikimi; Naoyuki Matsuda; Kota Matsui; Kunihiko Takahashi; Tadashi Ejima; Keibun Liu; Takayuki Ogura; Michiko Higashi; Hitoshi Umino; Go Makishi; Atsushi Numaguchi; Satoru Matsushima; Hideki Tokuyama; Mitsunobu Nakamura; Shigeyuki Matsui
Scandinavian journal of trauma, resuscitation and emergency medicine, May 2017
25(1), 49-49, 10.1186/s13049-017-0392-y

CAST: a new score for early prediction of neurological outcomes after cardiac arrest before therapeutic hypothermia with high accuracy.
Mitsuaki Nishikimi; Naoyuki Matsuda; Kota Matsui; Kunihiko Takahashi; Tadashi Ejima; Keibun Liu; Takayuki Ogura; Michiko Higashi; Hitoshi Umino; Go Makishi; Atsushi Numaguchi; Satoru Matsushima; Hideki Tokuyama; Mitsunobu Nakamura; Shigeyuki Matsui
Intensive care medicine, Dec. 2016
42(12), 2106-2107, 10.1007/s00134-016-4492-3

Axon guidance mechanisms for establishment of callosal connections.
Mitsuaki Nishikimi; Koji Oishi; Kazunori Nakajima
Neural plasticity, 2013
2013, 149060-149060, 10.1155/2013/149060

Segregation and pathfinding of callosal axons through EphA3 signaling.
Mitsuaki Nishikimi; Koji Oishi; Hidenori Tabata; Kenichi Torii; Kazunori Nakajima
The Journal of neuroscience : the official journal of the Society for Neuroscience, Nov. 2011
31(45), 16251-60, 10.1523/JNEUROSCI.3303-11.2011

集中治療領域における抗MRSA薬の経験的投与に関する適切性の検討
檜山洋子; 錦見満暁; 冨田隆志; 松尾裕彰; 志馬伸朗
日本集中治療医学会中国・四国支部学術集会プログラム・抄録集(Web), 2024
8th

短期間での急変を繰り返しV-A ECMO管理を要した特発性冠動脈解離の一例
三善冴子; 錦見満暁; 安部倉萌; 難波剛史; 菊谷知也; 上田猛; 太田浩平; 大下慎一郎; 志馬伸朗
日本集中治療医学会中国・四国支部学術集会プログラム・抄録集(Web), 2024
8th

都道府県の集中治療提供体制とCOVID-19による人工呼吸あるいはECMO管理を要する患者発生率との関連
大邉寛幸; 大邉寛幸; 橋本悟; 小倉崇以; 錦見満曉; 工藤大介; 志馬伸朗; 久志本成樹
日本集中治療医学会学術集会(Web), 2024
51st

ECMOを要するARDSにおける血清KL-6値は退院時生存を予測する-J-CARVEレジストリ解析-
文屋尚史; 和田健志郎; 中山龍一; 錦見満曉; 大下慎一郎; 成松英智; 志馬伸明
日本呼吸療法医学会学術集会プログラム・抄録集, 2024
46th (Web)

徹底ガイド 脳神経疾患管理-研修医からの質問306-II.脳神経疾患の管理と治療に必要な知識 19 心肺停止後体温管理療法
錦見満曉
救急・集中治療, 2022
34(3)

心肺停止後におけるリゾリン脂質であるLPCの血中濃度の減少の重要性
錦見満暁; 八木司; 竹川良介; 林田敬; ベッカー ランス; キム ジュワン
日本集中治療医学会学術集会(Web), 2021
48th

蘇生後脳症に対する軽度低体温療法のCT像による有効性の検討
錦見 満暁; 小倉 崇以; 西田 一貴; 中村 光伸; 劉 啓文; 徳山 秀樹; 松田 直之
日本救急医学会雑誌, Sep. 2017
28(9), 622-622

DHA含有リゾリン脂質を基軸とした蘇生後脳障害の病態メカニズム解明と創薬基盤構築
基盤研究(B)
広島大学
01 Apr. 2026 - 31 Mar. 2030
錦見 満曉, 錦見 満曉, 日本学術振興会, 日本学術振興会

Development of novel treatments for acute exacerbations of interstitial lung disease: an integrated strategy of ECMO and GDF-15 inhibition therapy.
Grant-in-Aid for Scientific Research (C)
Hiroshima University
01 Apr. 2025 - 31 Mar. 2028
大下 慎一郎; 錦見 満曉; 島谷 竜俊, 大下 慎一郎; 錦見 満曉; 島谷 竜俊, 日本学術振興会, Japan Society for the Promotion of Science

Regulatory Mechanisms of Translocator Protein and Lysophospholipids in Sepsis
Grant-in-Aid for Scientific Research (C)
Hiroshima University
01 Apr. 2025 - 31 Mar. 2028
菊谷 知也; 錦見 満曉; 相澤 秀紀, 菊谷 知也; 錦見 満曉; 相澤 秀紀, 日本学術振興会, Japan Society for the Promotion of Science

Identifying Novel Sepsis Endotypes
Grant-in-Aid for Scientific Research (B)
Tohoku University
01 Apr. 2024 - 31 Mar. 2026
工藤 大介; 田宮 元; 早川 峰司; 菱沼 英史; 久志本 成樹; 成田 暁; 山川 一馬; 佐藤 哲哉; 小柴 生造; 湯本 哲也; 後藤 匡啓; 近藤 豊; 石原 唯史; 佐藤 幸男; 錦見 満曉; 堤 悠介; 高山 渉; 鈴木 浩大; 春日井 大介, 工藤 大介; 田宮 元; 早川 峰司; 菱沼 英史; 久志本 成樹; 成田 暁; 山川 一馬; 佐藤 哲哉; 小柴 生造; 湯本 哲也; 後藤 匡啓; 近藤 豊; 石原 唯史; 佐藤 幸男; 錦見 満曉; 堤 悠介; 高山 渉; 鈴木 浩大; 春日井 大介, 日本学術振興会, Japan Society for the Promotion of Science

心停止後症候群に対する33℃と35℃の目標温度管理の神経学的予後に関する比較
基盤研究(C)
岡山大学
01 Apr. 2021 - 31 Mar. 2026
内藤 宏道; 頼藤 貴志; 中尾 篤典; 西田 一貴; 錦見 満曉, 内藤 宏道; 頼藤 貴志; 中尾 篤典; 西田 一貴; 錦見 満曉, 日本学術振興会, 日本学術振興会

Selective Brain Hypothermia Combined with Core Warming with Endovascular Devices
Hiroshima Univeristy
Jun. 2023 - Dec. 2025
錦見 満暁; 大下 慎一郎, Mitsuaki Nishikimi; Shinichiro Ohshimo, ZOLL FOUNDATION, INC., ZOLL FOUNDATION, INC., Principal investigator

Establishment of CT phenotyping for severe ARDS requiring V-V ECMO
Grant-in-Aid for Scientific Research (C)
Hiroshima University
01 Apr. 2022 - 31 Mar. 2025
錦見 満曉; 志馬 伸朗; 高橋 邦彦; 大下 慎一郎, Nishikimi Mitsuaki, 日本学術振興会, Japan Society for the Promotion of Science

心肺停止後症候群の早期神経学的予後予測: CAST scoreの確立に向けて
若手研究
名古屋大学
01 Apr. 2018 - 31 Mar. 2019
錦見 満曉, 錦見 満曉, 日本学術振興会, 日本学術振興会

Weil Institute celebrates the future of resuscitation science through legendary Wolf Creek Conference
https://weilinstitute.med.umich.edu/latest-news/weil-wolf-creek, Jun. 2023, Internet

命の砦(とりで)〜集中治療室 密着40日の記録〜
NHK, 命の砦(とりで)〜集中治療室 密着40日の記録〜, https://www.nhk.jp/p/etv21c/ts/M2ZWLQ6RQP/episode/te/P8LZKWG8NM/, 04 Feb. 2023, Media report

こうして僕らは医師になる～沖縄県立中部病院 研修医たちの10年～
NHKBS1, こうして僕らは医師になる～沖縄県立中部病院 研修医たちの10年～, https://www.facebook.com/NHKonline/posts/6484597051566905/?locale2=es_LA&paipv=0&eav=AfZpqBiLKAWj9_Rp9kD6xb2-_FapUQqjZidK0VaVl3qE-Z16-8vjoBeDmM3Tm0ClwWQ&_rdr, 03 Dec. 2022, Media report