Chromosomal instability

cell migration

invasion

Pathology

Cytometry

Sonic hedgehog

cell cycle

Onclogy

May 2020 - Present
Japan Human Cell Society, Human cell, editor

2020 - Present
公益法人 柔道整復研修財団, 柔道整復師国家試験委員

Oct. 2019 - Present
日本サイトメトリー技術者認定協議会, カリキュラム委員

Apr. 2019 - Present
日本病理学会, 学術評議員

Apr. 2017 - Present
日本ヒト細胞学会, 評議員

Apr. 2014 - Present
日本サイトメトリー学会, 代議員・庶務委員

Apr. 2020
学術奨励賞, 日本病理学会
伊藤秀明

2014
The 22th encouragement Award of the pancrea research foundation of Japan, 膵臓癌進展における SCL/TAL-1 interrupting locus(STIL)の機能解析 -細胞運動制御を標的とする治療戦略開発のための基盤的研究-, Pancreas research foundation of Japan
Ito Hideaki

Mar. 2013
Encouragement prize of Yamaguchi University Graduate school of Medicin, 山口大学
Ito Hideaki

2012
Student Travel Award for attendance of CYTO 2012, Detection of tetrasomic cells with proliferative capability arising from disomic cells by image cytometry and FISH, International society of advanced cytometry
International society
Ito Hideaki

Mar. 2011
Encouragement prize of Yamaguchi University Graduate school of Medicine, Yamaguchi University
Ito Hideaki

染色体不安定性獲得機構解明を目指した、中心小体複製因子STILによる細胞周期チェックポイント抑制機能の解析
伊藤 秀明; 鈴木 佳稔; 大橋 明子; 猪子 誠人; 中村 律子; 陸 美穂; 大西 絋二; 古屋 智子; 都築 豊徳; 笠井 謙次
Cytometry Research, Jul. 2024
34(Suppl.), 75, 75

中心小体複製因子STILによる細胞周期チェックポイント抑制によるアポトーシス回避機構
鈴木 佳稔; 伊藤 秀明; 大橋 明子; 山田 徳香; 猪子 誠人; 中村 律子; 陸 美穂; 大西 紘二; 都築 豊徳; 笠井 謙次
日本病理学会会誌, Feb. 2024
113(1), 476, 476

CAMK2D: a novel molecular target for BAP1-deficient malignant mesothelioma
Sivasundaram Karnan; Akinobu Ota; Hideki Murakami; Md. Lutfur Rahman; Md Wahiduzzaman; Muhammad Nazmul Hasan; Lam Quang Vu; Ichiro Hanamura; Akihito Inoko; Miho Riku; Hideaki Ito; Yoshifumi Kaneko; Toshinori Hyodo; Hiroyuki Konishi; Shinobu Tsuzuki; Yoshitaka Hosokawa
Cell Death Discovery, Jul. 2023
10.1038/s41420-023-01552-5

Establishment of Mucoepidermoid Carcinoma Cell Lines from Surgical and Recurrence Biopsy Specimens.
Shunpei Yamanaka; Susumu Suzuki; Hideaki Ito; Karnan Sivasundaram; Ichiro Hanamura; Ikuko Okubo; Kazuhiro Yoshikawa; Shoya Ono; Taishi Takahara; Akira Satou; Toyonori Tsuzuki; Ryuzo Ueda; Tetsuya Ogawa; Yasushi Fujimoto
International journal of molecular sciences, Jan. 2023
24(2), 10.3390/ijms24021722

Multiple cerebral infarctions due to calcified amorphous tumor growing rapidly from an antecedent infection and decreasing rapidly by detachment of fibrin and antithrombotic drugs: a case report
Motoya Kimura; Jun-Ichi Niwa; Hideaki Ito; Katsuhiko Matsuyama; Manabu Doyu
BMC Neurology, Oct. 2022
22(1), 10.1186/s12883-022-02918-5

In Situ PD-L1 Expression in Oral Squamous Cell Carcinoma Is Induced by Heterogeneous Mechanisms among Patients
Yutaro Kondo; Susumu Suzuki; Shoya Ono; Mitsuo Goto; Satoru Miyabe; Tetsuya Ogawa; Hiromi Tsuchida; Hideaki Ito; Taishi Takahara; Akira Satou; Toyonori Tsuzuki; Kazuhiro Yoshikawa; Ryuzo Ueda; Toru Nagao
International Journal of Molecular Sciences, Apr. 2022
23(8), 4077, 4077, 10.3390/ijms23084077

ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer.
Takumi Tsunoda; Miho Riku; Norika Yamada; Hikaru Tsuchiya; Takuya Tomita; Minako Suzuki; Mari Kizuki; Akihito Inoko; Hideaki Ito; Kenta Murotani; Hideki Murakami; Yasushi Saeki; Kenji Kasai
EMBO reports, Feb. 2022
23(2), e51182, 10.15252/embr.202051182

Improving function of cytotoxic T‐lymphocytes by transforming growth factor‐β inhibitor in oral squamous cell carcinoma
Yutaro Kondo; Susumu Suzuki; Taishi Takahara; Shoya Ono; Mitsuo Goto; Satoru Miyabe; Yoshihiko Sugita; Tetsuya Ogawa; Hideaki Ito; Akira Satou; Toyonori Tsuzuki; Kazuhiro Yoshikawa; Ryuzo Ueda; Toru Nagao
Cancer Science, Oct. 2021
112(10), 4037, 4049, 10.1111/cas.15081

口腔扁平上皮癌の免疫療法におけるTGF-β阻害剤の有用性
近藤 祐太朗; 高原 大志; 小野 翔矢; 後藤 満雄; 小川 徹也; 伊藤 秀明; 佐藤 啓; 都築 豊徳; 吉川 和宏; 上田 龍三; 鈴木 進
日本癌学会総会記事, Sep. 2021
80回, [J12, 5]

頭頸部粘表皮癌由来の継代細胞株樹立とその特徴について
山中 俊平; 鈴木 進; 伊藤 秀明; 小野 翔矢; 近藤 祐太朗; 犬飼 大輔; 岡本 啓希; 高原 大志; 都築 豊徳; 吉川 和宏; 上田 龍三; 小川 徹也
日本癌学会総会記事, Sep. 2021
80回, [P14, 2]

正常上皮分化には表層アクチンの収縮と細胞内カルシウム流入が必要である
猪子 誠人; 齋藤 大介; 池ノ内 順一; 佐藤 良勝; 伊藤 秀明; 曽我 倫久人; 笠井 謙次
日本細胞生物学会大会講演要旨集, Jun. 2021
73回, WS11, 2

Expression and Prognostic Significance of CD47–SIRPA Macrophage Checkpoint Molecules in Colorectal Cancer
Akane Sugimura-Nagata; Akira Koshino; Satoshi Inoue; Aya Matsuo-Nagano; Masayuki Komura; Miho Riku; Hideaki Ito; Akihito Inoko; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Satoru Takahashi; Kunio Kasugai; Kenji Kasai; Shingo Inaguma
International Journal of Molecular Sciences, Mar. 2021
22(5), 2690, 2690, 10.3390/ijms22052690

High phospho‐histone H3 expression uniquely predicts favorable survival among four markers of cellular proliferation in colorectal cancer
Akira Koshino; Satoshi Inoue; Akane Sugimura‐Nagata; Takeshi Nishiyama; Hideki Murakami; Hideaki Ito; Miho Riku; Akihito Inoko; Masahide Ebi; Naotaka Ogasawara; Toyonori Tsuzuki; Kunio Kasugai; Kenji Kasai; Shingo Inaguma
Pathology International, Feb. 2021
71(5), 316, 324, 10.1111/pin.13084

Gastric Adenocarcinoma with Enteroblastic and Neuroendocrine Differentiation Arising near the Heterotopic Gastric Glands and Ectopic Pancreas
Kenta Ishii, Manabu Takano, Akifumi Nakagawa, Atsushi Ogawa, Kenzo Ono, Hideaki Ito
日本消化器外科学会雑誌, Apr. 2020, Reviewed, No invitation
53(4), 321, 328

★Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.
Hideaki Ito; Takumi Tsunoda; Miho Riku; Shingo Inaguma; Akihito Inoko; Hideki Murakami; Hiroshi Ikeda; Michiyuki Matsuda; Kenji Kasai
Oncogene, Feb. 2020, Reviewed, No invitation
39(9), 1931, 1943, 10.1038/s41388-019-1115-9.

Image cytometric detection and elucidation of proliferative capability of chromosome doubling cells
Hideaki Ito; Tomoko Furuya; Kohsuke Sasaki; Kenzo Ikemoto; Atsunori Oga
CYTOMETRY RESEARCH, Nov. 2019, Reviewed, Invited
Lead, 29(2), 29, 34, 10.18947/cytometryresearch.29.2_29

CD70 expression in tumor-associated fibroblasts predicts worse survival in colorectal cancer patients.
Satoshi Inoue; Hideaki Ito; Takumi Tsunoda; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Kunio Kasugai; Kenji Kasai; Hiroshi Ikeda; Shingo Inaguma
Virchows Arch., Oct. 2019, Reviewed, No invitation
475(4), 425, 434, 10.1007/s00428-019-02565-1

Diffuse mesothelin expression leads to worse prognosis through enhanced cellular proliferation in colorectal cancer.
Satoshi Inoue; Takumi Tsunoda; Miho Riku; Hideaki Ito; Akihito Inoko; Hideki Murakami; Masahide Ebi; Naotaka Ogasawara; Ira Pastan; Kunio Kasugai; Kenji Kasai; Hiroshi Ikeda; Shingo Inaguma
Oncology Letters (in press), 2019, Reviewed, No invitation

Familial Mediterranean fever type 2 with heterozygous mutations of E148Q and M694I in a Japanese patient with progressive systemic AA amyloidosis
Mayumi Ito; Hironobu Nobata; Hirokazu Imai; Masabumi Yoshino; Shogo Banno; Yasuhiko Ito; Hideaki Ito; Dai Kishida
Modern Rheumatology Case Reports, Jan. 2018, Reviewed, No invitation
3(1), 79, 85

STIL(SCL/TAL-1 Interrupting Locus)による膵臓癌細胞運動能制御機構
伊藤 秀明; 角田 拓実; 陸 美穂; 池田 洋; 笠井 謙次
日本病理学会会誌, Apr. 2016
105(1), 377, 377

Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis
Miho Riku; Shingo Inaguma; Hideaki Ito; Takumi Tsunoda; Hiroshi Ikeda; Kenji Kasai
Oncotarget, Feb. 2016, Reviewed, No invitation
7(5), 5690, 5701, 10.18632/oncotarget.6788

GLI1 orchestrates CXCR4/CXCR7 signaling to enhance migration and metastasis of breast cancer cells
Shingo Inaguma; Miho Riku; Hideaki Ito; Takumi Tsunoda; Hiroshi Ikeda; Kenji Kasai
ONCOTARGET, Oct. 2015, Reviewed, No invitation
6(32), 33648, 33657, 10.18632/oncotarget.5203

Addiction of pancreatic cancer cells to zinc-finger transcription factor ZIC2
Shingo Inaguma; Hideaki Ito; Miho Riku; Hiroshi Ikeda; Kenji Kasai
ONCOTARGET, Sep. 2015, Reviewed, No invitation
6(29), 28257, 28268, 10.18632/oncotarget.4960

ヘッジホッグ系転写因子GLI1はCXCL12/CXCR4経路の活性化により乳癌細胞の遊走能を亢進させる
稲熊 真悟; 笠井 謙次; 伊藤 秀明; 陸 美穂; 池田 洋
日本病理学会会誌, Mar. 2015
104(1), 287, 287

新規転写抑制因子TSHZ2からみた乳癌進展機構
陸 美穂; 笠井 謙次; 稲熊 真悟; 伊藤 秀明; 池田 洋
日本病理学会会誌, Mar. 2015
104(1), 455, 455

Combination Immunotherapy with 4-1BB Activation and PD-1 Blockade Enhances Antitumor Efficacy in a Mouse Model of Subcutaneous Tumor
Yoshitaro Shindo; Kiyoshi Yoshimura; Atsuo Kuramasu; Yusaku Watanabe; Hideaki Ito; Tomoko Kondo; Atsunori Oga; Hiroshi Ito; Shigefumi Yoshino; Shoichi Hazama; Koji Tamada; Hideo Yagita; Masaaki Oka
ANTICANCER RESEARCH, Jan. 2015, Reviewed, No invitation
35(1), 129, 136

マウス大腸癌皮下腫瘍モデルに対する抗4-1BB抗体/抗PD-1抗体を用いた癌免疫療法(Combination immunotherapy with 4-1BB mAb and PD-1 mAb enhances antitumor efficacy in mouse subcutaneous model)
新藤 芳太郎; 吉村 清; 倉増 敦朗; 伊藤 秀明; 小賀 厚徳; 前田 訓子; 吉野 茂文; 硲 彰一; 玉田 耕治; 八木田 秀雄; 岡 正朗
日本癌学会総会記事, Sep. 2014
73回, J, 3045

Analysis of Centromere Signal Patterns in Breast Cancer Cells with Chromosomal Instability Using Image Cytometry Combined with Centromere Fluorescence In Situ Hybridization
Hideaki Ito; Atsunori Oga; Kenzo Ikemoto; Tomoko Furuya; Noriko Maeda; Shigeru Yamamoto; Shigeto Kawauchi; Hiroshi Itoh; Masaaki Oka; Kohsuke Sasaki
CYTOMETRY PART A, Sep. 2014, Reviewed, No invitation
85A(9), 809, 816, 10.1002/cyto.a.22502

Quantitative Analysis of Centromeric FISH Spots during the Cell Cycle by Image Cytometry
Genta Amakawa; Kenzo Ikemoto; Hideaki Ito; Tomoko Furuya; Kohsuke Sasaki
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Oct. 2013, Reviewed, No invitation
61(10), 699, 705, 10.1369/0022155413498754

A case of gastric adenocarcinoma with conspicuous binuclear cytologic features
Hideaki Ito; Chiemi Furuya; Tsuyoshi Yamanouchi; Kenzo Ikemoto; Tomoe Katoh; Masahiko Onoda; Tomoko Kondo; Atsunori Oga
CANCER GENETICS, Jul. 2013, Reviewed, No invitation
206(7-8), 304, 307, 10.1016/j.cancergen.2013.08.001

Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization
Hideaki Ito; Atsunori Oga; Tomoko Furuya; Kenzo Ikemoto; Genta Amakawa; Yasuyo Chochi; Shigeto Kawauchi; Kohsuke Sasaki
CELL PROLIFERATION, Jun. 2013, Reviewed, No invitation
46(3), 356, 363, 10.1111/cpr.12032

The possibility of cell cycle analysis with image cytometry
Genta Amakawa; Kenzo Ikemoto; Hideaki Ito; Kohsuke Sasaki
CYTOMETRY RESEARCH, Sep. 2012, Not reviewed, No invitation
22(2), 1, 6, 10.18947/cytometryresearch.22.2_1

DNA copy number aberrations associated with the clinicopathological features of colorectal cancers: Identification of genomic biomarkers by array-based comparative genomic hybridization
Motonao Nakao; Shigeto Kawauchi; Tetsuji Uchiyama; Jun Adachi; Hideaki Ito; Yasuyo Chochi; Tomoko Furuya; Atsunori Oga; Kohsuke Sasaki
ONCOLOGY REPORTS, Jun. 2011, Reviewed, No invitation
25(6), 1603, 1611, 10.3892/or.2011.1246

持続収縮後にみられる骨格筋の弛緩特性変化
石井 禎基; 伊藤 秀明; 和足 孝之; 土屋 禎三
理学療法の医学的基礎, May 2006, Reviewed, No invitation
10(1), 21, 21

Sliding movements of molluscan and algal myosin attached to a magnetizable bead under a load controlled by electromagnet
Takashi Watari; Koki Kumakiri; Akira Ono; Yoshiki Ishii; Hideaki Itoh; Zhenli Huang; Teizo Tsuchiya
JOURNAL OF PHYSIOLOGICAL SCIENCES, Feb. 2006, Reviewed, No invitation
56(1), 13, 20, 10.2170/physiolsci.R2134

カエル前脚筋と後脚筋の収縮特性の比較
石井 禎基; 伊藤 秀明; 和足 孝之; 土屋 禎三
理学療法の医学的基礎, May 2005, Reviewed, No invitation
9(1), 13, 13

Transforming growth factor-beta inhibitor is a candidate drug for immunotherapy of oral squamous cell carcinoma
Yutaro Kondo; Taishi Takahara; Shoya Ono; Mitsuo Goto; Tetsuya Ogawa; Hideaki Ito; Akira Sato; Toyonori Tsuzuki; Kazuhiro Yoshikawa; Ryuzo Ueda; Susumu Suzuki
CANCER SCIENCE, Feb. 2022
113

細胞周期・DNA ploidy解析とイメージサイトメトリー
伊藤 秀明; 古屋 智子; 小賀 厚徳; 笠井 謙次; 佐々木 功典
Cytometry Research, May 2018
28(Suppl.), 46, 46

マウス大腸癌皮下腫瘍モデルに対する抗4-1BB抗体/抗PD-1抗体を用いた癌免疫療法
新藤 芳太郎; 吉村 清; 倉増 敦朗; 伊藤 秀明; 渡邊 裕策; 前田 訓子; 小賀 厚徳; 吉野 茂文; 硲 彰一; 玉田 耕治; 八木田 秀雄; 岡 正朗
山口医学, Aug. 2014, Not reviewed, No invitation
63(3), 233, 233

Recordings of shell movements and tension changes in vivo in adductor of bivalve
Hideaki Itoh; Yoshiki Ishii; Takashi Watari; Nobuko Tokuda; Teizo Tsuchiya
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, Nov. 2007, Not reviewed, No invitation
148(3), 351, 352, 10.1016/j.cbpb.2007.07.076

スタンダートフローサイトメトリー 第2版
伊藤秀明, Contributor, V章データ解析と結果の評価 細胞核（DNA量）
医歯薬出版社, Jun. 2017, Not reviewed

病理と臨床 31巻臨時創刊号 『細胞診の基本から実践へ』
伊藤秀明, Contributor, イメージサイトメトリーの細胞診への応用
文光堂, 2013, Not reviewed

STIL(SCL/TAL1 interrupting locus)膵臓癌細胞遊走における機能解析
伊藤秀明
第36回ヒト細胞学会学術集会, Aug. 2018, No invitation
Domestic conference

細胞周期・DNA ploidy解析とイメージサイトメトリー
伊藤秀明
第28回日本サイトメトリー学会学術集会, May 2018, No invitation
Public discourse, Domestic conference

膵臓癌細胞遊走STIL(SCL/TAL1 interrupting locus)の細胞骨格制御機構
伊藤秀明
第106回日本病理学会総会, Apr. 2017, No invitation
Oral presentation, Domestic conference

STIL(SCL/TAL1 interrupting locus)による膵臓癌細胞運動能制御機構
伊藤秀明
第105回日本病理学会総会, May 2016, No invitation
Oral presentation, Domestic conference

Nuclear morphology, DNA content, and chromosome number.
Ito Hideaki
The 105th annual meeting of the japanease society of pathology, May 2016, No invitation
Nominated symposium, Domestic conference

Analysis of chromosomal instability using image cytometry
Ito Hideaki
33th Annual Meeting of the Japan human cell society, Aug. 2015, Invited
Nominated symposium, Domestic conference

Detection of tetrasomic cells with proliferative capability arising from disomic cells by image cytometry and FISH
Ito Hideaki
CYTO 2012, 2012, No invitation
Poster presentation, International conference

膵臓癌における中心小体複製関連因子STIL(SCL/TAL1 interrup ting locus)による細胞遊走亢進機構の解明
伊藤秀明
第30回日本サイトメトリー学会学術集会, No invitation
Public symposium

STILによるタイトジャンクション減弱機構の解明と非浸潤性乳管癌病理診断への応用
Grant-in-Aid for Early-Career Scientists
Aichi Medical University
Apr. 2020 - Mar. 2023
伊藤 秀明, 伊藤 秀明, 日本学術振興会, Japan Society for the Promotion of Science

ヘッジホッグ関連因子STILによる浸潤突起を介した膵臓癌浸潤機構の解明
Apr. 2016 - Mar. 2020
伊藤秀明, 伊藤秀明, 日本学術振興会, 日本学術振興会, Principal investigator

Downstream of newly identified transcriptional repressor and its role in the progression of non-invasive breast cancer.
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2015 - 31 Mar. 2018
笠井 謙次; 池田 洋; 稲熊 真悟; 伊藤 秀明, KASAI KENJI; IKEDA HIROSHI; INAGUMA SHINGO; ITO HIDEAKI, 日本学術振興会, Japan Society for the Promotion of Science

Hedgehog signaling molecule SIL regulates the migration and progression of pancreatic ductal adenocarcinoma.
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
01 Apr. 2012 - 31 Mar. 2015
笠井 謙次; 稲熊 真悟; 池田 洋; 伊藤 秀明, KASAI Kenji; INAGUMA Shingo; IKEDA Hiroshi; ITO Hideaki, 日本学術振興会, Japan Society for the Promotion of Science

特許5935201, 特表2013-153704, 特開2013-153704, 特願2012-017988, イメージサイトメーターを利用した染色体多倍性を示し、かつ、細胞増殖能を有する細胞の有無を判定する方法
伊藤秀明

日本サイトメトリー技術者認定協議会 技術講習会
lecturer
日本サイトメトリー技術者認定協議会, 09 Nov. 2019

日本サイトメトリー技術者認定協議会 技術講習会
lecturer
日本サイトメトリー技術者認定協議会, Nov. 2018

日本サイトメトリー技術者認定協議会 技術講習会
lecturer
日本サイトメトリー技術者認定協議会, Nov. 2017