The TDP-43I383V heterozygous mutation results in increased TDP-43 expression and altered neuronal activity in ALS patient-derived iPSC motor neurons
Ryo Chikuchi; Yuta Kato; Aya Tomatsu; Shuto Nishisaki; Yu Kawakami; Takashi Yoshimura; Jiayi Li; Yohei Iguchi; Kazunari Onodera; Rina Hashimoto; Ikuko Aiba; Ryoichi Nakamura; Genki Tohnai; Naoki Atsuta; Gen Sobue; Yohei Okada; Masahisa Katsuno; Satoshi Yokoi
NEUROSCIENCE RESEARCH, Jan. 2026
222, 10.1016/j.neures.2025.105003

A genome-wide association study identifies the GPM6A locus associated with age at onset in ALS.
Ryoichi Nakamura; Genki Tohnai; Naoki Atsuta; Yumi Matsuda; Satoru Morimoto; Daisuke Ito; Masahisa Katsuno; Yuishin Izumi; Mitsuya Morita; Ikuko Iwata; Ichiro Yabe; Tomoko Nakazato; Nobutaka Hattori; Takehisa Hirayama; Osamu Kano; Asako Tamura; Naoki Suzuki; Masashi Aoki; Kazumoto Shibuya; Satoshi Kuwabara; Masaya Oda; Rina Hashimoto; Ikuko Aiba; Tomohiko Ishihara; Osamu Onodera; Toru Yamashita; Hiroyuki Ishiura; Kota Bokuda; Toshio Shimizu; Yoshio Ikeda; Kazuko Hasegawa; Fumiaki Tanaka; Takanori Yokota; Kazuaki Kanai; Yu-Ichi Noto; Ryuji Kaji; Hirohisa Watanabe; Tomoko Konishi; Mikiko Hasegawa; Hozuki Fukaya; Jun-Ichi Niwa; Manabu Doyu; Yohei Okada; Shiho Nakamura; Fumiko Ozawa; Hideyuki Okano; Masahiro Nakatochi; Gen Sobue
Communications biology, Dec. 2025
8(1), 1720-1720, 10.1038/s42003-025-09168-4

SMN2 gene copy number affects the incidence and prognosis of motor neuron diseases in Japan.
Tomohiko Ishihara; Akihide Koyama; Naoki Atsuta; Mari Tada; Saori Toyoda; Kenta Kashiwagi; Sachiko Hirokawa; Yuya Hatano; Akio Yokoseki; Ryoichi Nakamura; Genki Tohnai; Yuishin Izumi; Ryuji Kaji; Mitsuya Morita; Asako Tamura; Osamu Kano; Masashi Aoki; Satoshi Kuwabara; Akiyoshi Kakita; Gen Sobue; Osamu Onodera
BMC medical genomics, Nov. 2024
17(1), 263-263, 10.1186/s12920-024-02026-y

CHCHD2 P14L, found in amyotrophic lateral sclerosis, exhibits cytoplasmic mislocalization and alters Ca2+ homeostasis
Aya Ikeda; Hongrui Meng; Daisuke Taniguchi; Muneyo Mio; Manabu Funayama; Kenya Nishioka; Mari Yoshida; Yuanzhe Li; Hiroyo Yoshino; Tsuyoshi Inoshita; Kahori Shiba-Fukushima; Yohei Okubo; Takashi Sakurai; Taku Amo; Ikuko Aiba; Yufuko Saito; Yuko Saito; Shigeo Murayama; Naoki Atsuta; Ryoichi Nakamura; Genki Tohnai; Yuishin Izumi; Mitsuya Morita; Asako Tamura; Osamu Kano; Masaya Oda; Satoshi Kuwabara; Toru Yamashita; Jun Sone; Ryuji Kaji; Gen Sobue; Yuzuru Imai; Nobutaka Hattori
PNAS Nexus, Jul. 2024
3(8), 10.1093/pnasnexus/pgae319

Exercise attenuates polyglutamine-mediated neuromuscular degeneration in a mouse model of spinal and bulbar muscular atrophy.
Tomoki Hirunagi; Hideaki Nakatsuji; Kentaro Sahashi; Mikiyasu Yamamoto; Madoka Iida; Genki Tohnai; Naohide Kondo; Shinichiro Yamada; Ayuka Murakami; Seiya Noda; Hiroaki Adachi; Gen Sobue; Masahisa Katsuno
Journal of cachexia, sarcopenia and muscle, Nov. 2023
10.1002/jcsm.13344

Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.
Ryoichi Nakamura; Genki Tohnai; Masahiro Nakatochi; Naoki Atsuta; Hirohisa Watanabe; Daisuke Ito; Masahisa Katsuno; Akihiro Hirakawa; Yuishin Izumi; Mitsuya Morita; Takehisa Hirayama; Osamu Kano; Kazuaki Kanai; Nobutaka Hattori; Akira Taniguchi; Naoki Suzuki; Masashi Aoki; Ikuko Iwata; Ichiro Yabe; Kazumoto Shibuya; Satoshi Kuwabara; Masaya Oda; Rina Hashimoto; Ikuko Aiba; Tomohiko Ishihara; Osamu Onodera; Toru Yamashita; Koji Abe; Kouichi Mizoguchi; Toshio Shimizu; Yoshio Ikeda; Takanori Yokota; Kazuko Hasegawa; Fumiaki Tanaka; Kenji Nakashima; Ryuji Kaji; Jun-Ichi Niwa; Manabu Doyu; Chikashi Terao; Shiro Ikegawa; Koki Fujimori; Shiho Nakamura; Fumiko Ozawa; Satoru Morimoto; Kazunari Onodera; Takuji Ito; Yohei Okada; Hideyuki Okano; Gen Sobue
Journal of neurology, neurosurgery, and psychiatry, May 2023
94(10), 816-824, 10.1136/jnnp-2022-330851

The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK.
Satoshi Yokoi; Takuji Ito; Kentaro Sahashi; Masahiro Nakatochi; Ryoichi Nakamura; Genki Tohnai; Yusuke Fujioka; Shinsuke Ishigaki; Tsuyoshi Udagawa; Yuishin Izumi; Mitsuya Morita; Osamu Kano; Masaya Oda; Takefumi Sone; Hideyuki Okano; Naoki Atsuta; Masahisa Katsuno; Yohei Okada; Gen Sobue
The Journal of neuroscience : the official journal of the Society for Neuroscience, Oct. 2022
42(47), 8881-8896, 10.1523/JNEUROSCI.0455-22.2022

Mutation screening of the DNAJC7 gene in Japanese patients with sporadic amyotrophic lateral sclerosis.
Genki Tohnai; Ryoichi Nakamura; Naoki Atsuta; Masahiro Nakatochi; Naoki Hayashi; Daisuke Ito; Hazuki Watanabe; Hirohisa Watanabe; Masahisa Katsuno; Yuishin Izumi; Akira Taniguchi; Kazuaki Kanai; Mitsuya Morita; Osamu Kano; Satoshi Kuwabara; Masaya Oda; Koji Abe; Masashi Aoki; Ikuko Aiba; Koichi Okamoto; Kouichi Mizoguchi; Tomohiko Ishihara; Akihiro Kawata; Takanori Yokota; Kazuko Hasegawa; Isao Nagano; Ichiro Yabe; Fumiaki Tanaka; Satoshi Kuru; Nobutaka Hattori; Kenji Nakashima; Ryuji Kaji; Gen Sobue
Neurobiology of aging, May 2022
113, 131-136, 10.1016/j.neurobiolaging.2021.12.002

Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.
Tomoki Hirunagi; Kentaro Sahashi; Kiyoshi Tachikawa; Angel I Leu; Michelle Nguyen; Rajesh Mukthavaram; Priya P Karmali; Padmanabh Chivukula; Genki Tohnai; Madoka Iida; Kazunari Onodera; Manabu Ohyama; Yohei Okada; Hideyuki Okano; Masahisa Katsuno
Molecular therapy. Nucleic acids, Jun. 2021
24, 1-10, 10.1016/j.omtn.2021.02.007

A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.
Ryoichi Nakamura; Kazuharu Misawa; Genki Tohnai; Masahiro Nakatochi; Sho Furuhashi; Naoki Atsuta; Naoki Hayashi; Daichi Yokoi; Hazuki Watanabe; Hirohisa Watanabe; Masahisa Katsuno; Yuishin Izumi; Kazuaki Kanai; Nobutaka Hattori; Mitsuya Morita; Akira Taniguchi; Osamu Kano; Masaya Oda; Kazumoto Shibuya; Satoshi Kuwabara; Naoki Suzuki; Masashi Aoki; Yasuyuki Ohta; Toru Yamashita; Koji Abe; Rina Hashimoto; Ikuko Aiba; Koichi Okamoto; Kouichi Mizoguchi; Kazuko Hasegawa; Yohei Okada; Tomohiko Ishihara; Osamu Onodera; Kenji Nakashima; Ryuji Kaji; Yoichiro Kamatani; Shiro Ikegawa; Yukihide Momozawa; Michiaki Kubo; Noriko Ishida; Naoko Minegishi; Masao Nagasaki; Gen Sobue
Communications biology, Sep. 2020, Reviewed, No invitation
3(1), 526-526, 10.1038/s42003-020-01251-2

Genetic and functional analysis of KIF5A variants in Japanese patients with sporadic amyotrophic lateral sclerosis.
Ryoichi Nakamura; Genki Tohnai; Naoki Atsuta; Masahiro Nakatochi; Naoki Hayashi; Hazuki Watanabe; Daichi Yokoi; Hirohisa Watanabe; Masahisa Katsuno; Yuishin Izumi; Akira Taniguchi; Kazuaki Kanai; Mitsuya Morita; Osamu Kano; Satoshi Kuwabara; Masaya Oda; Koji Abe; Masashi Aoki; Ikuko Aiba; Koichi Okamoto; Kouichi Mizoguchi; Nobutaka Hattori; Kenji Nakashima; Ryuji Kaji; Gen Sobue
Neurobiology of aging, Jul. 2020, Reviewed, No invitation
97, 147.e11-147.e17, 10.1016/j.neurobiolaging.2020.07.010

Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy.
Madoka Iida; Kentaro Sahashi; Naohide Kondo; Hideaki Nakatsuji; Genki Tohnai; Yutaka Tsutsumi; Seiya Noda; Ayuka Murakami; Kazunari Onodera; Yohei Okada; Masahiro Nakatochi; Yuka Tsukagoshi Okabe; Shinobu Shimizu; Masaaki Mizuno; Hiroaki Adachi; Hideyuki Okano; Gen Sobue; Masahisa Katsuno
Nature communications, Sep. 2019, Reviewed, No invitation
10(1), 4262-4262, 10.1038/s41467-019-12282-7

DNA methylation inhibitor attenuates polyglutamine-induced neurodegeneration by regulating Hes5.
Kondo N; Tohnai G; Sahashi K; Iida M; Kataoka M; Nakatsuji H; Tsutsumi Y; Hashizume A; Adachi H; Koike H; Shinjo K; Kondo Y; Sobue G; Katsuno M
EMBO molecular medicine, May 2019, Reviewed, No invitation
11(5), 10.15252/emmm.201708547

Frequency and characteristics of the TBK1 gene variants in Japanese patients with sporadic amyotrophic lateral sclerosis.
Genki Tohnai; Ryoichi Nakamura; Jun Sone; Masahiro Nakatochi; Daichi Yokoi; Masahisa Katsuno; Hazuki Watanabe; Hirohisa Watanabe; Mizuki Ito; Yuanzhe Li; Yuishin Izumi; Mitsuya Morita; Akira Taniguchi; Osamu Kano; Masaya Oda; Satoshi Kuwabara; Koji Abe; Ikuko Aiba; Koichi Okamoto; Kouichi Mizoguchi; Kazuko Hasegawa; Masashi Aoki; Nobutaka Hattori; Osamu Onodera; Hiroya Naruse; Jun Mitsui; Yuji Takahashi; Jun Goto; Hiroyuki Ishiura; Shinichi Morishita; Jun Yoshimura; Koichiro Doi; Shoji Tsuji; Kenji Nakashima; Ryuji Kaji; Naoki Atsuta; Gen Sobue
Neurobiology of aging, Apr. 2018, Reviewed, No invitation
64, 158.e15-158.e19-158.e19, 10.1016/j.neurobiolaging.2017.12.005

Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility.
Chizu Tanikawa; Koji Ueda; Akari Suzuki; Aritoshi Iida; Ryoichi Nakamura; Naoki Atsuta; Genki Tohnai; Gen Sobue; Naomi Saichi; Yukihide Momozawa; Yoichiro Kamatani; Michiaki Kubo; Kazuhiko Yamamoto; Yusuke Nakamura; Koichi Matsuda
Cell reports, Feb. 2018, Reviewed, No invitation
22(6), 1473-1483, 10.1016/j.celrep.2018.01.031

The SMN gene copy number states in Japanese ALS patients
Ishihara T; Toyoda S; Koyama A; Tada M; Atsuta N; Nakamura R; Tohnai G; Sone J; Izumi Y; Kaji R; Morita M; Taniguchi A; Kakita A; Sobue G; Nishizawa M; Onodera O
JOURNAL OF THE NEUROLOGICAL SCIENCES, Oct. 2017, Not reviewed, No invitation
381, 211-211, 10.1016/j.jns.2017.08.604

BIIB021, A SYNTHETIC Hsp90 INHIBITOR, INDUCES MUTANT ATAXIN-1 DEGRADATION THROUGH THE ACTIVATION OF HEAT SHOCK FACTOR 1
Ying Ding; Hiroaki Adachi; Masahisa Katsuno; Kentaro Sahashi; Naohide Kondo; Madoka Iida; Genki Tohnai; Hideaki Nakatsuji; Gen Sobue
NEUROSCIENCE, Jul. 2016, Reviewed, No invitation
327, 20-31, 10.1016/j.neuroscience.2016.03.064

Next-generation sequencing of 28 ALS-related genes in a Japanese ALS cohort
Ryoichi Nakamura; Jun Sone; Naoki Atsuta; Genki Tohnai; Hazuki Watanabe; Daichi Yokoi; Masahiro Nakatochi; Hirohisa Watanabe; Mizuki Ito; Jo Senda; Masahisa Katsuno; Fumiaki Tanaka; Yuanzhe Li; Yuishin Izumi; Mitsuya Morita; Akira Taniguchi; Osamu Kano; Masaya Oda; Satoshi Kuwabara; Koji Abe; Ikuko Aiba; Koichi Okamoto; Kouichi Mizoguchi; Kazuko Hasegawa; Masashi Aoki; Nobutaka Hattori; Shoji Tsuji; Kenji Nakashima; Ryuji Kaji; Gen Sobue
NEUROBIOLOGY OF AGING, Mar. 2016, Reviewed, No invitation
39, 219.e1-8, 10.1016/j.neurobiolaging.2015.11.030

Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration
Ying Ding; Hiroaki Adachi; Masahisa Katsuno; Zhe Huang; Yue-Mei Jiang; Naohide Kondo; Madoka Iida; Genki Tohnai; Hideaki Nakatsuji; Hiroshi Funakoshi; Toshikazu Nakamura; Gen Sobue
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2015, Reviewed, No invitation
468(4), 677-683, 10.1016/j.bbrc.2015.11.015

Silencing neuronal mutant androgen receptor in a mouse model of spinal and bulbar muscular atrophy
Kentaro Sahashi; Masahisa Katsuno; Gene Hung; Hiroaki Adachi; Naohide Kondo; Hideaki Nakatsuji; Genki Tohnai; Madoka Iida; C. Frank Bennett; Gen Sobue
HUMAN MOLECULAR GENETICS, Nov. 2015, Reviewed, No invitation
24(21), 5985-5994, 10.1093/hmg/ddv300

Pioglitazone suppresses neuronal and muscular degeneration caused by polyglutamine-expanded androgen receptors
Madoka Iida; Masahisa Katsuno; Hideaki Nakatsuji; Hiroaki Adachi; Naohide Kondo; Yu Miyazaki; Genki Tohnai; Kensuke Ikenaka; Hirohisa Watanabe; Masahiko Yamamoto; Ken Kishida; Gen Sobue
HUMAN MOLECULAR GENETICS, Jan. 2015, Reviewed, No invitation
24(2), 314-329, 10.1093/hmg/ddu445

Paeoniflorin eliminates a mutant AR via NF-YA-dependent proteolysis in spinal and bulbar muscular atrophy
Genki Tohnai; Hiroaki Adachi; Masahisa Katsuno; Hideki Doi; Shinjiro Matsumoto; Naohide Kondo; Yu Miyazaki; Madoka Iida; Hideaki Nakatsuji; Qiang Qiang; Ying Ding; Hirohisa Watanabe; Masahiko Yamamoto; Kenzo Ohtsuka; Gen Sobue
HUMAN MOLECULAR GENETICS, Jul. 2014, Reviewed, No invitation
23(13), 3552-3565, 10.1093/hmg/ddu066

Genistein, a natural product derived from soybeans, ameliorates polyglutamine-mediated motor neuron disease
Qiang Qiang; Hiroaki Adachi; Zhe Huang; Yue-Mei Jiang; Masahisa Katsuno; Makoto Minamiyama; Hideki Doi; Shinjiro Matsumoto; Naohide Kondo; Yu Miyazaki; Madoka Iida; Genki Tohnai; Gen Sobue
JOURNAL OF NEUROCHEMISTRY, Jul. 2013, Reviewed, No invitation
126(1), 122-130, 10.1111/jnc.12172

p62/SQSTM1 Differentially Removes the Toxic Mutant Androgen Receptor via Autophagy and Inclusion Formation in a Spinal and Bulbar Muscular Atrophy Mouse Model
Hideki Doi; Hiroaki Adachi; Masahisa Katsuno; Makoto Minamiyama; Shinjiro Matsumoto; Naohide Kondo; Yu Miyazaki; Madoka Iida; Genki Tohnai; Qiang Qiang; Fumiaki Tanaka; Toru Yanagawa; Eiji Warabi; Tetsuro Ishii; Gen Sobue
JOURNAL OF NEUROSCIENCE, May 2013, Reviewed, No invitation
33(18), 7710-7727, 10.1523/JNEUROSCI.3021-12.2013

Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration
Naohide Kondo; Masahisa Katsuno; Hiroaki Adachi; Makoto Minamiyama; Hideki Doi; Shinjiro Matsumoto; Yu Miyazaki; Madoka Iida; Genki Tohnai; Hideaki Nakatsuji; Shinsuke Ishigaki; Yusuke Fujioka; Hirohisa Watanabe; Fumiaki Tanaka; Akira Nakai; Gen Sobue
NATURE COMMUNICATIONS, Jan. 2013, Reviewed, No invitation
4, 1405, 10.1038/ncomms2417

Viral delivery of miR-196a ameliorates the SBMA phenotype via the silencing of CELF2
Yu Miyazaki; Hiroaki Adachi; Masahisa Katsuno; Makoto Minamiyama; Yue-Mei Jiang; Zhe Huang; Hideki Doi; Shinjiro Matsumoto; Naohide Kondo; Madoka Iida; Genki Tohnai; Fumiaki Tanaka; Shin-ichi Muramatsu; Gen Sobue
NATURE MEDICINE, Jul. 2012, Reviewed, No invitation
18(7), 1136-+, 10.1038/nm.2791

Protective effect of a molecular chaperone inducer, paeoniflorin, on the HCl- and ethanol-triggered gastric mucosal injury
Midori Asai; Daisuke Kawashima; Kiyoe Katagiri; Rika Takeuchi; Genki Tohnai; Kenzo Ohtsuka
LIFE SCIENCES, Feb. 2011, Reviewed, No invitation
88(7-8), 350-357, 10.1016/j.lfs.2010.12.014

CoVA(深層学習による新規のヒト全変異解析)によるALSの解析
小林尚輝; 小林尚輝; 小林尚輝; 小林尚輝; 森本悟; 中村亮一; 中村亮一; 藤内玄規; 藤内玄規; 熱田直樹; 熱田直樹; 祖父江元; 祖父江元; 中澤仁; 岡野栄之
脳循環代謝(Web), 2024
36(1)

SOD1遺伝子変異による筋萎縮性側索硬化症の臨床的特徴
中村亮一; 藤内玄規; 熱田直樹; 伊藤大輔; 勝野雅央; 和泉唯信; 平山剛久; 狩野修; 中里朋子; 服部信孝; 橋本里奈; 饗場郁子; 澁谷和幹; 桑原聡; 鈴木直輝; 青木正志; 織田雅也; 森田光哉; 道勇学; 祖父江元
日本神経学会学術大会プログラム・抄録集, 2024
65th

SOD1-G93S変異陽性筋萎縮性側索硬化症患者の臨床遺伝学的特徴
中村亮一; 中杤昌弘; 熱田直樹; 藤内玄規; 伊藤大輔; 和泉唯信; 橋本里奈; 饗場郁子; 溝口功一; 金井数明; 青木正志; 柴田俊; 伊藤千弘; 湯淺知子; 徳井啓介; 川頭祐一; 丹羽淳一; 道勇学; 勝野雅央; 祖父江元
日本神経学会学術大会プログラム・抄録集, 2022
63rd

【ALS 2019】ALSにおける患者レジストリの役割 JaCALSなど
熱田 直樹; 中村 亮一; 林 直毅; 藤内 玄規; 勝野 雅央; 祖父江 元
BRAIN and NERVE: 神経研究の進歩, Nov. 2019, Not reviewed, No invitation
71(11), 1215-1225

Clinical characteristics of familial and sporadic amyotrophic lateral sclerosis patients with G93S mutation in the SOD1 gene
Nakamura R; Atsuta N; Tohnai G; Yokoi D; Watanabe H; Hayashi N; Sone J; Ito M; Watanabe H; Katsuno M; Izumi Y; Hashimoto R; Aiba I; Mizoguchi K; Kaji R; Sobue G
JOURNAL OF THE NEUROLOGICAL SCIENCES, 15 Oct. 2017, Not reviewed, No invitation
381, 568-568, 10.1016/j.jns.2017.08.1599

Understanding of the role of proteinaceous inclusions in spinal and bulbar muscular atrophy
Sahashi K; Kondo N; Iida M; Nakatsuji H; Tohnai G; Iguchi Y; Sobue G; Katsuno M
JOURNAL OF THE NEUROLOGICAL SCIENCES, 15 Oct. 2017, Not reviewed, No invitation
381, 709-709, 10.1016/j.jns.2017.08.1997

Akt signaling pathway is dysregulated in polyglutamine diseases
Iida M; Sahashi K; Kondo N; Nakatsuji H; Tohnai G; Tsutsumi Y; Adachi H; Sobue G; Katsuno M
JOURNAL OF THE NEUROLOGICAL SCIENCES, 15 Oct. 2017, Not reviewed, No invitation
381, 209-209, 10.1016/j.jns.2017.08.597

DNA methylation inhibitor mitigates spinal and bulbar muscular atrophy model mouse
Kondo N; Sahashi K; Iida M; Nakatsuji H; Tohnai G; Adachi H; Sobue G; Katsuno M
JOURNAL OF THE NEUROLOGICAL SCIENCES, 15 Oct. 2017, Not reviewed, No invitation
381, 476-477, 10.1016/j.jns.2017.08.3551

【神経疾患のゲノム医療】 筋萎縮性側索硬化症のゲノム医療
中村 亮一; 藤内 玄規; 熱田 直樹; 勝野 雅央; 祖父江 元
神経内科, Jun. 2017, Not reviewed, No invitation
86(6), 678-685

Therapeutic strategies for spinal and bulbar muscular atrophy
Kondo Naohide; Sahashi Kentaro; Iida Madoka; Tohnai Genki; Sobue Gen; Katsuno Masahisa
Neurological Therapeutics, 2017
34(2), 101-106, 10.15082/jsnt.34.2_101

球脊髄性筋萎縮症の病態におけるp62/SQSTM1の役割
足立弘明; 土井英樹; 勝野雅央; 南山誠; 松本慎二郎; 近藤直英; 宮崎雄; 藤内玄規; 飯田円; 田中章景; 祖父江元
臨床ストレス応答学会大会抄録集, 2011
6th

球脊髄性筋萎縮症モデルにおけるシャクヤク抽出物の治療効果
藤内玄規; 足立弘明; 勝野雅央; 南山誠; 土井英樹; 松本慎二郎; 近藤直英; 宮崎雄; 飯田円; 田中章景; 大塚健三; 祖父江元
臨床ストレス応答学会大会抄録集, 2011
6th

SBMAモデルにおけるシャクヤク抽出物の治療効果
藤内玄規; 足立弘明; 勝野雅央; 南山誠; 和座雅浩; 土井英樹; 田中章景; 大塚健三; 祖父江元
日本Cell Death学会学術集会プログラム抄録集, 2010
19th

SBMAモデルにおけるシャクヤク抽出物の治療効果
藤内玄規; 足立弘明; 勝野雅央; 南山誠; 土井英樹; 松本慎二郎; 近藤直英; 田中章景; 大塚健三; 祖父江元
臨床ストレス応答学会大会抄録集, 2010
5th

ゲノム情報を基盤としたALSの治療薬探索と患者iPS細胞由来運動ニューロンを用いた検証
Apr. 2025 - Mar. 2027
藤内 玄規, 藤内 玄規, 一般社団法人日本ALS協会, 一般社団法人日本ALS協会, Principal investigator

ALSにおける老化によるタンパク質品質管理機構の発現変化と病態への影響
基盤研究(C)
愛知医科大学
Apr. 2023 - Mar. 2026
藤内 玄規, 藤内 玄規, 日本学術振興会, 日本学術振興会

患者iPS細胞由来運動ニューロンを用いた筋萎縮性側索硬化症の病態解明と治療薬候補の検証
2023 - 2026
藤内 玄規, 藤内 玄規, Principal investigator

Elucidating the heterogeneity of amyotrophic lateral sclerosis by neuropathological analysis linked to clinical genomic information
Grant-in-Aid for Scientific Research (C)
Aichi Medical University
Apr. 2022 - Mar. 2025
熱田 直樹; 中村 亮一; 道勇 学; 祖父江 元; 藤内 玄規; 陸 雄一, 熱田 直樹; 中村 亮一; 道勇 学; 祖父江 元; 藤内 玄規; 陸 雄一, 日本学術振興会, Japan Society for the Promotion of Science

筋萎縮性側索硬化症のmissing heritabilityに関わる遺伝子の探索
基盤研究(C)
愛知医科大学
Apr. 2022 - Mar. 2025
中村 亮一; 藤内 玄規; 熱田 直樹; 道勇 学; 祖父江 元, 中村 亮一; 藤内 玄規; 熱田 直樹; 道勇 学; 祖父江 元, 日本学術振興会, 日本学術振興会, Coinvestigator

ゲノムワイド関連解析から予測したオートファジーを標的とするALS治療薬候補の検証
Apr. 2023 - Mar. 2024
藤内 玄規, 藤内 玄規, 堀科学芸術振興財団, 堀科学芸術振興財団, Principal investigator

タンパク質品質管理機構を標的としたALSの病態解明と治療法開発
Jan. 2023 - Dec. 2023
藤内 玄規, 藤内 玄規, 一般社団法人せりか基金, 一般社団法人せりか基金, Principal investigator

候補遺伝子アプローチによる筋萎縮性側索硬化症病態関連遺伝子の探索
基盤研究(C)
名古屋大学
Apr. 2019 - Mar. 2022
中村 亮一; 藤内 玄規; 勝野 雅央; 熱田 直樹, 中村 亮一; 藤内 玄規; 勝野 雅央; 熱田 直樹, 日本学術振興会, 日本学術振興会, Coinvestigator

異常タンパク分解系を標的とした運動ニューロン疾患治療薬の開発
基盤研究(C)
名古屋大学
Apr. 2019 - Mar. 2022
藤内 玄規, 藤内 玄規, 日本学術振興会, 日本学術振興会, Principal investigator

Therapeutic development based on factors affecting progression and prognosis of amyotrophic lateral sclerosis
Grant-in-Aid for Scientific Research (C)
Nagoya University
Apr. 2017 - Mar. 2020
熱田 直樹; 中村 亮一; 藤内 玄規; 勝野 雅央; 祖父江 元, Atsuta Naoki, 日本学術振興会, Japan Society for the Promotion of Science, Coinvestigator

Expression and role of autophagy-related molecules in motor neuron disease
Grant-in-Aid for Young Scientists (B)
Nagoya University
01 Apr. 2017 - 31 Mar. 2019
藤内 玄規, Tohnai Genki, 日本学術振興会, Japan Society for the Promotion of Science, Principal investigator

Analysis of genes affecting cognitive function in sporadic ALS
Grant-in-Aid for Young Scientists (B)
Nagoya University
Apr. 2017 - Mar. 2019
中村 亮一; 勝野 雅央; 熱田 直樹; 藤内 玄規, Nakamura Ryoichi; KATSUNO Masahisa; ATSUTA Naoki; TOHNAI Genki, 日本学術振興会, Japan Society for the Promotion of Science, Coinvestigator

Development of a novel therapy for neurodegenerative disease using tacrolimus derivative
Grant-in-Aid for Young Scientists (B)
Nagoya University
01 Apr. 2015 - 31 Mar. 2017
藤内 玄規, TOHNAI Genki, 日本学術振興会, Japan Society for the Promotion of Science, Principal investigator