KOMATSU Koji
Physiology | Senior Assistant Professor |
Profile
Research area
生殖生理
生殖医学Main lectures
生理学Ⅰ
生理学実習Graduating school
京都大学農学部生物生産科学科（2001年）Final Education
京都大学大学院医学研究科（2007年）Previous workplace
京都大学大学院医学研究科 産学連携研究員（2007年4月～2008年9月）
自然科学研究機構 基礎生物学研究所 リサーチフェロー（2008年10月～2011年3月）
医療法人 葵鐘会 研究開発課 課長（2011年4月～2015年6月）Main academic activities
繁殖生物学会
日本生理学会Main research topic
卵巣内動態のライブイメージング解析
Award
Paper
- Tamoxifen Activates Dormant Primordial Follicles in Mouse Ovaries.
Wei Wei; Kouji Komatsu; Satoko Osuka; Tomohiko Murase; Bayasula Bayasula; Natsuki Nakanishi; Tomoko Nakamura; Maki Goto; Akira Iwase; Satoru Masubuchi; Hiroaki Kajiyama
Reproductive sciences (Thousand Oaks, Calif.), Feb. 2022
10.1007/s43032-022-00896-0 - 17β-Estradiol and cathepsins control primordial follicle growth in mouse ovaries.
Kouji Komatsu; Wei Wei; Tomohiko Murase; Satoru Masubuchi
Reproduction (Cambridge, England), Sep. 2021
162(4), 277, 287, 10.1530/REP-20-0599 - Increased supply from blood vessels promotes the activation of dormant primordial follicles in mouse ovaries.
Kouji Komatsu; Satoru Masubuchi
The Journal of reproduction and development, Apr. 2020, Reviewed, No invitation
66(2), 105, 113, 10.1262/jrd.2019-091 - Mouse oocytes connect with granulosa cells by fusing with cell membranes and form a large complex during follicle development.
Komatsu K; Masubuchi S
Biology of reproduction, Sep. 2018, Reviewed, No invitation
99(3), 527, 535, 10.1093/biolre/ioy072 - Ovarian Tissue Culture to Visualize Phenomena in Mouse Ovary.
Kouji Komatsu; Akira Iwase; Tomohiko Murase; Satoru Masubuchi
Journal of visualized experiments : JoVE, Jun. 2018, Reviewed, No invitation
(136), 10.3791/57794 - Exogenous GDF-9 Treatment Induces Follicular Development through Downregulation of Anti-Mullerian Hormone Receptor as Visualized in the Sliced Ovarian Tissue Culture System.
Murase Tomohiko; Iwase Akira; Komatsu Kouji; Wei Wei; Ganieva Umida; Bayasula Bayasula; Nguyen Phuoc X; Yoshita Sayako; Qin Ying; Muraoka Ayako; Hayashi Shotaro; Kasahara Yukiyo; Nakanishi Natsuki; Nagai Takashi; Shimizu Ken; Ishida Chiharu; Nakamura Tomoko; Osuka Satoko; Goto Maki; Kikkawa Fumitaka
REPRODUCTIVE SCIENCES, Mar. 2018, Reviewed, No invitation
25, 177A - Follicle dynamics: visualization and analysis of follicle growth and maturation using murine ovarian tissue culture.
Tomohiko Murase; Akira Iwase; Kouji Komatsu; Bayasula; Tomoko Nakamura; Satoko Osuka; Sachiko Takikawa; Maki Goto; Tomomi Kotani; Fumitaka Kikkawa
Journal of assisted reproduction and genetics, Feb. 2018, Reviewed, No invitation
35(2), 339, 343, 10.1007/s10815-017-1073-5 - The concentration-dependent effect of progesterone on follicle growth in the mouse ovary
Kouji Komatsu; Satoru Masubuchi
JOURNAL OF REPRODUCTION AND DEVELOPMENT, Jun. 2017, Reviewed, No invitation
63(3), 271, 277, 10.1262/jrd.2016-154 - Observation of the dynamics of follicular development in the ovary
Kouji Komatsu; Satoru Masubuchi
Reproductive Medicine and Biology, Jan. 2017, Reviewed, No invitation
16(1), 21, 27, 10.1002/rmb2.12010 - Dynamics of planar cell polarity protein Vangl2 in the mouse oviduct epithelium
Dongbo Shi; Fumiko Usami; Kouji Komatsu; Sanae Oka; Takaya Abe; Tadashi Uemura; Toshihiko Fujimori
MECHANISMS OF DEVELOPMENT, Aug. 2016, Reviewed, No invitation
141, 78, 89, 10.1016/j.mod.2016.05.002 - Multiple phases in regulation of Nanog expression during pre-implantation development
Kouji Komatsu; Toshihiko Fujimori
DEVELOPMENT GROWTH & DIFFERENTIATION, Dec. 2015, Reviewed, No invitation
57(9), 648, 656, 10.1111/dgd.12244 - Is the serum L-arginine level during early pregnancy a predictor of pregnancy-induced hypertension?
Jingwen Wang; Tomomi Kotani; Hiroyuki Tsuda; Yukio Mano; Seiji Sumigama; Hua Li; Koji Komatsu; Rika Miki; Ei Maruta; Yoshimitsu Niwa; Takashi Mitsui; Shigeru Yoshida; Mamoru Yamashita; Koji Tamakoshi; Fumitaka Kikkawa
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, Jul. 2015, Reviewed, No invitation
57(1), 74, 81, 10.3164/jcbn.14-104 - Analysis of the Effect of Leukemia Inhibitory Factor on Follicular Growth in Cultured Murine Ovarian Tissue
Kouji Komatsu; Tomoko Koya; Jingwen Wang; Mamoru Yamashita; Fumitaka Kikkawa; Akira Iwase
BIOLOGY OF REPRODUCTION, Jul. 2015, Reviewed, No invitation
93(1), 18, 18, 10.1095/biolreprod.115.128421 - Regulation of secondary follicle growth by theca cells and insulin-like growth factor 1
Noriko Shiomi-Sugaya; Kouji Komatsu; Jingwen Wang; Mamoru Yamashita; Fumitaka Kikkawa; Akira Iwase
JOURNAL OF REPRODUCTION AND DEVELOPMENT, Jun. 2015, Reviewed, No invitation
61(3), 161, 168, 10.1262/jrd.2014-107 - Celsr1 is required for the generation of polarity at multiple levels of the mouse oviduct
Dongbo Shi; Kouji Komatsu; Mayumi Hirao; Yayoi Toyooka; Hiroshi Koyama; Fadel Tissir; Andre M. Goffinet; Tadashi Uemura; Toshihiko Fujimori
DEVELOPMENT, Dec. 2014, Reviewed, No invitation
141(23), 4558, 4568, 10.1242/dev.115659 - Mitochondrial membrane potential in 2-cell stage embryos correlates with the success of preimplantation development
Kouji Komatsu; Akira Iwase; Miki Mawatari; Jingwen Wang; Mamoru Yamashita; Fumitaka Kikkawa
REPRODUCTION, May 2014, Reviewed, No invitation
147(5), 627, 638, 10.1530/REP-13-0288 - マウス体外受精胚におけるミトコンドリア膜電位，活性酸素種濃度と胚発生の関連性
小松 紘司; 岩瀬 明; 馬渡 未来; 山下 守; 吉川 史隆
日本繁殖生物学会 講演要旨集, 2013
106, OR1, 17-OR1-17, 10.14882/jrds.106.0.OR1-17.0 - Automatic Extraction of Nuclei Centroids of Mouse Embryonic Cells from Fluorescence Microscopy Images
Md Khayrul Bashar; Koji Komatsu; Toshihiko Fujimori; Tetsuya J. Kobayashi
PLOS ONE, May 2012, Reviewed, No invitation
7(5), e35550, 10.1371/journal.pone.0035550 - Improving the detection of cell centroids from fluorescence images by adaptive filtering
M. K. Bashar; K. Komatsu; T. Fujimori; T. J. Kobayashi
2012 7th International Conference on Electrical and Computer Engineering, ICECE 2012, 2012, Reviewed, No invitation
256, 259, 10.1109/ICECE.2012.6471534 - Adaptive Cell Nuclei Detection From Fluorescence Images by Optimizing Object Sizes Nuclei Detection by Size Optimization
Md. Khayrul Bashar; Toshihiko Fujimori; Koji Komatsu; Tetsuya J. Kobayashi
2012 IEEE EMBS CONFERENCE ON BIOMEDICAL ENGINEERING AND SCIENCES (IECBES), 2012, Reviewed, No invitation - Analysis of ciliary beat frequency and ovum transport ability in the mouse oviduct
Dongbo Shi; Kouji Komatsu; Tadashi Uemura; Toshihiko Fujimori
GENES TO CELLS, Mar. 2011, Reviewed, No invitation
16(3), 282, 290, 10.1111/j.1365-2443.2011.01484.x - Lack of cadherins Celsr2 and Celsr3 impairs ependymal ciliogenesis, leading to fatal hydrocephalus
Fadel Tissir; Yibo Qu; Mireille Montcouquiol; Libing Zhou; Kouji Komatsu; Dongbo Shi; Toshihiko Fujimori; Jason Labeau; Donatienne Tyteca; Pierre Courtoy; Yves Poumay; Tadashi Uemura; Andre M. Goffinet
NATURE NEUROSCIENCE, Jun. 2010, Reviewed, No invitation
13(6), 700, U71, 10.1038/nn.2555 - Morphological organization of the mouse preimplantation embryo.
Toshihiko Fujimori; Yoko Kurotaki; Kouji Komatsu; Yo-ichi Nabeshima
Reproductive sciences (Thousand Oaks, Calif.), Feb. 2009, Reviewed, No invitation
16(2), 171, 7, 10.1177/1933719108331120 - Roles of ADAM protease Meltrin β \n（ADAM19）in the circuatory organ development.
Atsuo Iida; Hidetoshi Sakurai; Kouji Komatsu; Atsuko Sehara-Fujisawa
International Society for Stem Cell Research 7th Annual Meeting （2009.7.8 Barcelona, Spain）, 2009, Reviewed, No invitation - Roles of Meltrin-beta/ADAM19 in Progression of Schwann Cell Differentiation and Myelination during Sciatic Nerve Regeneration
Shuji Wakatsuki; Norihiro Yumoto; Koji Komatsu; Toshiyuki Araki; Atsuko Sehara-Fujisawa
JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2009, Reviewed, No invitation
284(5), 2957, 2966, 10.1074/jbc.M803191200 - Meltrin beta expressed in cardiac neural crest cells is required for ventricular septum formation of the heart
Kouji Komatsu; Shuji Wakatsuki; Shu-ichi Yamada; Ken-ichi Yamamura; Jun-ichi Miyazaki; Atsuko Sehara-Fujisawa
DEVELOPMENTAL BIOLOGY, Mar. 2007, Reviewed, No invitation
303(1), 82, 92, 10.1016/j.ydbio.2006.10.037 - Essential roles of Meltrin beta (ADAM19) in heart development
K Kurohara; K Komatsu; T Kurisaki; A Masuda; N Irie; M Asano; K Sudo; Y Nabeshima; Y Iwakura; A Sehara-Fujisawa
DEVELOPMENTAL BIOLOGY, Mar. 2004, Reviewed, No invitation
267(1), 14, 28, 10.1016/j.ydbio.2003.10.021 - Expression of prolactin receptor mRNAs in ovaries of senescence accelerated mice
M Kiso; N Manabe; M Shimabe; K Komatsu; H Miyamoto
SENESCENCE-ACCELERATED MOUSE (SAM): AN ANIMAL MODEL OF SENESCENCE, 2004, Reviewed, No invitation
1260, 233, 236, 10.1016/S0531-5131(03)01427-4 - Expression of matrix metalloproteinases and their tissue inhibitors in ovaries of senescence accelerated mice
M Shimabe; N Manabe; M Kiso; K Komatsu; H Miyamoto
SENESCENCE-ACCELERATED MOUSE (SAM): AN ANIMAL MODEL OF SENESCENCE, 2004, Reviewed, No invitation
1260, 229, 232, 10.1016/S0531-5131(03)01426-2 - Abnormal structural luteolysis in ovaries of the senescence accelerated mouse (SAM): Expression of fas Ligand/Fas-mediated apoptosis signaling molecules in luteal cells
M Kiso; N Manabe; K Komatsu; M Shimabe; H Miyamoto
JOURNAL OF REPRODUCTION AND DEVELOPMENT, Dec. 2003, Reviewed, No invitation
49(6), 457, 463, 10.1262/jrd.49.457 - Soluble Fas (FasB) regulates luteal cell apoptosis during luteolysis in murine ovaries
K Komatsu; N Manabe; M Kiso; M Shimabe; H Miyamoto
MOLECULAR REPRODUCTION AND DEVELOPMENT, Aug. 2003, Reviewed, No invitation
65(4), 345, 352, 10.1002/mrd.10312 - Changes in localization of immune cells and cytokines in corpora lutea during luteolysis in murine ovaries
K Komatsu; N Manabe; M Kiso; M Shimabe; H Miyamoto
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-COMPARATIVE EXPERIMENTAL BIOLOGY, Apr. 2003, Reviewed, No invitation
296A(2), 152, 159, 10.1002/jez.a.10246 - Abnormal Accumulation of Luteal Bodies in Ovaries of the Senescence Accelerated Mouse (SAM).
KISO Minako; MANABE Noboru; KOMATSU Kohji; NISIOKA Noriyuki; NAKAI-SUGIMOTO Nami; MIYAMOTO Hajime
The Japanese journal of animal reproduction, 2001
47(3), 153, 164, 10.1262/jrd.47.153
MISC
- Activity rhythms in caffeine treated molecular clock deficient mice
増渕悟; 矢野多佳子; 小松紘司; 池上啓介; 藤堂剛; 中村渉
時間生物学, 2022
28(2) - 目で見る卵胞、卵子、胚と生殖医学 卵胞の動的観察
邨瀬 智彦; 小松 紘司; 岩瀬 明
HORMONE FRONTIER IN GYNECOLOGY, Jun. 2019, Not reviewed, No invitation
26(2), 76, 78 - 低酸素によるマウス活動期活動量の変化は時計遺伝子によらない波様の反応が決定している
増渕悟; 矢野多佳子; 小松紘司; 中村渉; 太田明伸; シバスンダラン カルナン; 武内恒成; 細川好孝; 藤堂剛; 塩見利明
日本生理学雑誌(Web), Feb. 2019, Not reviewed, No invitation
81(1), 18, 19 - 卵管は脇役か?その生理と病態 卵管の生理 卵の取り込みと受精卵の輸送
石東博; 石東博; 小松紘司; 藤森俊彦
臨床婦人科産科, 10 Sep. 2016, Not reviewed, No invitation
70(9), 810‐816, 816, 10.11477/mf.1409208853 - ニューテクノロジー―明日の生殖医学研究に向けて―ライブセルイメージングによる着床前胚発生研究
小松紘司; 藤森俊彦
Horm Front Gynecol, 01 Mar. 2011, Not reviewed, No invitation
18(1), 13-18,8 - クローズアップ実験法 Series176 ImageJを用いた組織切片画像の三次元データ化
入江直樹; 小松紘司; 瀬原淳子
実験医学, 01 Mar. 2008, Not reviewed, No invitation
26(4), 555, 560 - 心臓の発生と先天性心疾患,そして再生医療への展望 Meltrin βと心内膜床形成
小松紘司; 瀬原淳子
分子心血管病, 01 Apr. 2006, Not reviewed, No invitation
7(2), 178, 183 - Apoptosis is regulated by soluble Fas during luteolysis in luteal cells of mouse ovaries.
N Manabe; K Komatsu; M Kiso; Y Goto; S Anan; JY Li
BIOLOGY OF REPRODUCTION, 2005, Not reviewed, No invitation
223, 223 - Luteal cell apoptosis is regulated by soluble Fas during luteolysis in the mouse
N Manabe; K Komatsu; M Kiso; Y Goto; M Sugimoto
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Jul. 2004, Not reviewed, No invitation
52, S30, S30
Books and other publications
Lectures, oral presentations, etc.
- 卵母細胞が卵胞発育期に発揮する体内栄養環境への適応能力の解明
小松紘司; 増渕悟
第117回日本繁殖生物学会大会, Sep. 2024, No invitation
202409, 202409, Poster presentation - オレイン酸の摂取量が卵子に及ぼす影響の解析
小松紘司; 増渕悟
第116回日本繁殖生物学会大会, Sep. 2023, No invitation
202309, 202309, Oral presentation - 卵胞発育期の栄養環境が卵母細胞のミトコンドリア機能に及ぼす影響の解析
小松紘司; 増渕悟
第67回日本生殖医学会学術講演会, Nov. 2022, No invitation
202211, 202211, Poster presentation - 卵胞発育期においてオレイン酸は卵母細胞におけるOXPHOS複合体の発現を制御する
小松紘司; 増渕悟
第115回日本繁殖生物学会大会, Sep. 2022
202209, 202209, Poster presentation - 17β-エストラジオールはcathepsin阻害因子stefin Aの発現を制御する事 によって原始卵胞の発育をコントロールしている
小松紘司; 増渕悟
第113回日本繁殖生物学会大会, Sep. 2020, No invitation
202009, 202009, Poster presentation - 卵巣内で起こる血管新生は休眠状態の原始卵胞を活性化する
小松紘司; 増渕悟
第64回日本生殖医学会学術講演会, Nov. 2019, No invitation
201911, 201911, Oral presentation - 卵巣内における原始卵胞～一次卵胞の発育過程にはマルチステップな卵胞 発育制御機構が存在する
小松紘司; 増渕悟
第112回日本繁殖生物学会大会, Sep. 2019, No invitation
201909, 201909, Poster presentation - Promoting follicle development by inducing ovarian angiogenesis
Kouji Komatsu; Satoru Masubuchi
第 9 回アジア・オセアニア生理学会連合大会, Mar. 2019, No invitation
201903, 201903, Poster presentation - 卵母細胞－顆粒層細胞間の細胞膜融合による新規結合構造の解析
小松紘司; 増渕悟
第19回日本生殖工学会学術講演会, Feb. 2019, Invited
201902, 201902, Invited oral presentation - 生理活性物質徐放剤を用いた原始卵胞のin vivo activation
小松紘司; 増渕悟
第111回日本繁殖生物学会大会, Sep. 2018, No invitation
201809, 201809, Poster presentation - ライブイメージング解析によって発見された新しい卵子－顆粒層細胞間結合
小松紘司; 増渕悟
第62回日本生殖医学会学術講演会, Nov. 2017, No invitation
201711, 201711, Oral presentation - Mouse o ocyte connect s with cumulus cells thro ug h cell membrane fusion during follicle development
Kouji Komatsu; Satoru Masubuchi
4th World Congress of Reproductive Biology, Sep. 2017, No invitation
201709, 201709, Poster presentation - 組織切片の三次元構築とライブイメージングによる原始卵胞発育制御機構の解析
小松紘司; 増渕悟
第109回日本繁殖生物学会大会, Sep. 2016, No invitation
201609, 201609, Poster presentation - Time-lapse analysis of the follicular growth in the cultured ovarian tissue
小松紘司; 増渕悟
第93回日本生理学会大会, Mar. 2016, Invited
201603, 201603, Invited oral presentation - Progesteroneの卵胞発育に対する効果
小松紘司; 増渕悟
第108回日本繁殖生物学会大会, Sep. 2015, No invitation
201509, 201509, Poster presentation - マウス卵巣組織片培養による卵胞発育制御メカニズムの解析ーLIFはpreantral follicleの発育を制御するー
小松紘司; 岩瀬明; 小屋朋子; 山下守; 今井伸二郎、吉川史隆
第106回日本繁殖生物学会大会, Aug. 2014, No invitation
201408, 201408, Oral presentation - マウス体外受精胚におけるミトコンドリア膜電位、活性酸素種濃度と胚発生の関連性
小松紘司; 岩瀬明; 馬渡未来; 山下守; 史隆史隆
第106回日本繁殖生物学会大会, Sep. 2013, No invitation
201309, 201309, Oral presentation - The analysis of cell movement and expression of OCT4, Nanog and Cdx2 during mouse blastocyst formation
Koji Komatsu; Yoichi Nabeshima; Toshihiko Fujimori
Join meeting of the French and Japanese Developmental Biology, Sep. 2008, No invitation
200809, 200809, Poster presentation - マウス黄体退行における可溶性Fasの関与
小松紘司; 木曽美奈子; 島辺宋健; 中山瑞穂; 眞鍋昇; 宮本元
第95回日本繁殖生物学会大会, Sep. 2002, No invitation
200209, 200209, Oral presentation
Research Themes
- Inflammaging－細胞老化を標的とした卵巣機能長寿化への挑戦
基盤研究(B)
群馬大学
01 Apr. 2024 - 31 Mar. 2028
岩瀬 明; 北原 慈和; 大須賀 智子; 小松 紘司; 中村 智子; 小林 未央, 岩瀬 明; 北原 慈和; 大須賀 智子; 小松 紘司; 中村 智子; 小林 未央, 日本学術振興会, 日本学術振興会 - オレイン酸が卵母細胞のミトコンドリア機能に及ぼす影響とその作用メカニズムの解明
基盤研究(C)
愛知医科大学
01 Apr. 2024 - 31 Mar. 2027
小松 紘司, 小松 紘司, 日本学術振興会, 日本学術振興会 - 卵子の質を向上させる栄養因子の探索とその作用メカニズムの解明
愛知医科大学
Dec. 2023 - Dec. 2025
小松紘司, 小松紘司, 公益財団法人 日東学術振興財団, 公益財団法人 日東学術振興財団, Principal investigator - オレイン酸摂取が卵子のミトコンドリア機能に及ぼす影響の解明
Jul. 2023 - Jul. 2024
小松紘司, 小松紘司, 公益財団法人 三島海雲記念財団, 公益財団法人 三島海雲記念財団, Principal investigator - 新規自己抗体標的抗原に着目した自己免疫関連生殖機能障害の病態解明と早期診断法確立
Grant-in-Aid for Scientific Research (B)
Gunma University
Apr. 2020 - Mar. 2024
岩瀬 明; 北原 慈和; 大須賀 智子; 小松 紘司; 小谷 友美, 岩瀬 明; 北原 慈和; 大須賀 智子; 小松 紘司; 小谷 友美, 日本学術振興会, Japan Society for the Promotion of Science - 卵胞発育制御機構の解明と原始卵胞のin vivo activation法の開発
Apr. 2018 - Mar. 2021
小松紘司, 小松紘司, 日本学術振興会, 日本学術振興会, Principal investigator - 卵巣組織動態のライブイメージング解析による血清の原始卵胞発育誘導
Dec. 2016 - Dec. 2018
小松紘司, 小松紘司, 公益財団法人 日東学術振興財団, 公益財団法人 日東学術振興財団, Principal investigator - Elucidation of folliculogenesis by spatio-temporal investigation
Grant-in-Aid for Scientific Research (B)
Nagoya University
Apr. 2015 - Mar. 2018
岩瀬 明; 後藤 真紀; 滝川 幸子; 中村 智子; 中原 辰夫; 邨瀬 智彦; 魏 威; Nguyen Phuoc Xuan; 小松 紘司, Iwase Akira; MURASE Tomohiko; WEI wei; NGUYEN Phuoc Xuan; KOMATSU Kouji, 日本学術振興会, Japan Society for the Promotion of Science - 卵巣内における卵胞発育動態のライブイメージング解析
Aug. 2015 - Mar. 2016
小松紘司, 小松紘司, 日本学術振興会, 日本学術振興会, Principal investigator - The imaging analysis of the mechanism of cell differentiation during mouse blastocyst formation
Grant-in-Aid for Young Scientists (B)
National Institute for Basic Biology
Apr. 2008 - Mar. 2010
小松紘司, KOMATSU Kouji, 日本学術振興会, Japan Society for the Promotion of Science, Principal investigator
