Effects of pharyngolaryngeal injury on nociceptive swallowing reflexes
Naoyuki Mitarai; Chihiro Nakatomi; Chia-Chien Hsu; Hiroka Yasuda; Mari Fukuzaki; Tomoki Shimada; Ai Orimoto; Chiaki Kitamura; Kentaro Ono
Journal of Oral Biosciences, Feb. 2026
10.1016/j.job.2026.100736

Proliferation and differentiation of human dental pulp stem cells on phosphorylated cellulose nanofiber scaffolds.
Akihiro Iwasaki; Mayumi Hatakeyama; Qimei Liu; Ai Orimoto; Tomokazu Fukuda; Takuya Kitaoka
Carbohydrate polymers, Jul. 2025, Reviewed
359, 123593-123593, 10.1016/j.carbpol.2025.123593

Gene expression profiles in human dental pulp stem cells treated short-term with lipopolysaccharides before and after osteoinduction
Ai Orimoto; Ziyi Wang; Mitsuaki Ono; Chiaki Kitamura; Kentaro Ono
Journal of Oral Biosciences, Mar. 2025, Reviewed
Lead, 10.1016/j.job.2024.100603

Transcriptome-wide profiling for melanocytes derived from newborn and adult human epidermis with enhanced proliferation.
Ai Orimoto; Sayo Kashiwagi; Ayaka Funakoshi; Takashi Shimizu; Tsuyoshi Ishii; Tohru Kiyono; Tomokazu Fukuda
Cell biology international, Jul. 2024, Reviewed
Lead, 10.1002/cbin.12214

The Effects of Short-term Hypoxic on the Differentiation of Human Dental Pulp Stem Cells K4DT
Yuna Kajiwara-Nakagaki; Ai Orimoto; Kaori Kometani-Gunjigake; Chia-Chien Hsu; Chihiro Nakatomi; Michihiko Usui; Wataru Ariyoshi; Takashi Toyono; Kentaro Ono; Tatsuo Kawamoto
The Journal of the Kyushu Dental Society, Jun. 2024, Reviewed
78(1-2), 12-20, 10.2504/kds.78.12

Controlled cell proliferation and immortalization of human dental pulp stem cells with a doxycycline-inducible expression system.
Ai Orimoto; William N Addison; Shinichi Mochizuki; Wataru Ariyoshi; Kentaro Ono; Chiaki Kitamura; Tohru Kiyono; Tomokazu Fukuda
Cell biochemistry and function, Jun. 2024, Reviewed
Lead, 42(4), e4064, 10.1002/cbf.4064

Lipopolysaccharide‐mediated ATP signaling regulates interleukin‐6 mRNA expression via the P2‐purinoceptor in human dental pulp cells
Ai Orimoto; Chiaki Kitamura; Kentaro Ono
Cell Biology International, Mar. 2024
Lead, 10.1002/cbin.12120

PIEZO1 promotes ATP release from periodontal ligament cells following compression force.
Seiwa Horie; Chihiro Nakatomi; Misa Ito-Sago; Aoi Morii; Ai Orimoto; Hiroshi Ikeda; Chia-Chien Hsu; Mako Naniwa; Masahiro Mizuhara; Kaori Gunjigake; Tatsuo Kawamoto; Kentaro Ono
European journal of orthodontics, Sep. 2023
45(5), 565-574, 10.1093/ejo/cjad052

2-hydroxyethyl methacrylate-derived reactive oxygen species stimulate ATP release via TRPA1 in human dental pulp cells.
Ai Orimoto; Chiaki Kitamura; Kentaro Ono
Scientific reports, Jul. 2022
Lead, 12(1), 12343-12343, 10.1038/s41598-022-16559-8

Immortalization of common marmoset-derived fibroblasts via expression of cell cycle regulators using the piggyBac transposon.
Ai Orimoto; Haruka Shinohara; Takahiro Eitsuka; Kiyotaka Nakagawa; Erika Sasaki; Tohru Kiyono; Tomokazu Fukuda
Tissue & cell, Jun. 2022
Lead, 77, 101848-101848, 10.1016/j.tice.2022.101848

Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells.
Kai Furuya; So Fujibayashi; Tao Wu; Kouhei Takahashi; Shin Takase; Ai Orimoto; Eriko Sugano; Hiroshi Tomita; Sayo Kashiwagi; Tohru Kiyono; Tsuyoshi Ishii; Tomokazu Fukuda
BMC genomic data, Jan. 2022
23(1), 2-2, 10.1186/s12863-021-01018-6

Establishment of human airway epithelial cells with doxycycline-inducible cell growth and fluorescence reporters.
Ai Orimoto; Kohei Takahashi; Masaki Imai; Tohru Kiyono; Yoshihiro Kawaoka; Tomokazu Fukuda
Cytotechnology, Aug. 2021
Lead, 73(4), 555-569, 10.1007/s10616-021-00477-0

The transcriptome of wild-type and immortalized corneal epithelial cells.
Kai Furuya; Tao Wu; Ai Orimoto; Eriko Sugano; Hiroshi Tomita; Tohru Kiyono; Takahiro Kurose; Yoshihiro Takai; Tomokazu Fukuda
Scientific data, May 2021
8(1), 126-126, 10.1038/s41597-021-00908-9

Combinatorial expression of cell cycle regulators is more suitable for immortalization than oncogenic methods in dermal papilla cells.
Tomokazu Fukuda; Kai Furuya; Kouhei Takahashi; Ai Orimoto; Eriko Sugano; Hiroshi Tomita; Sayo Kashiwagi; Tohru Kiyono; Tsuyoshi Ishii
iScience, Jan. 2021
24(1), 101929-101929, 10.1016/j.isci.2020.101929

ADAMTSL6β promotes fibrillin-1 microfibril assembly, which is possibly mediated via binding through the third thrombospondin type I domain to fibrillin-1.
Ai Orimoto; Tomokazu Fukuda
Cell biology international, Jul. 2020
Lead, 44(7), 1436-1446, 10.1002/cbin.11337

Primary and immortalized cell lines derived from the Amami rabbit (Pentalagus furnessi) and evolutionally conserved cell cycle control with CDK4 and Cyclin D1.
Ai Orimoto; Masafumi Katayama; Tetsuya Tani; Keiko Ito; Takahiro Eitsuka; Kiyotaka Nakagawa; Miho Inoue-Murayama; Manabu Onuma; Tohru Kiyono; Tomokazu Fukuda
Biochemical and biophysical research communications, May 2020
Lead, 525(4), 1046-1053, 10.1016/j.bbrc.2020.03.036

Efficient immortalization of human dental pulp stem cells with expression of cell cycle regulators with the intact chromosomal condition.
Ai Orimoto; Seiko Kyakumoto; Takahiro Eitsuka; Kiyotaka Nakagawa; Tohru Kiyono; Tomokazu Fukuda
PloS one, 2020
Lead, 15(3), e0229996, 10.1371/journal.pone.0229996

Human Derived Immortalized Dermal Papilla Cells With a Constant Expression of Testosterone Receptor.
Tomokazu Fukuda; Kouhei Takahashi; Shin Takase; Ai Orimoto; Takahiro Eitsuka; Kiyotaka Nakagawa; Tohru Kiyono
Frontiers in cell and developmental biology, 2020
8, 157-157, 10.3389/fcell.2020.00157

Fibrillin-1 insufficiency alters periodontal wound healing failure in a mouse model of Marfan syndrome.
Keisuke Handa; Syouta Abe; V Venkata Suresh; Yoshiyasu Fujieda; Masaki Ishikawa; Ai Orimoto; Yoko Kobayashi; Satoru Yamada; Satoko Yamaba; Shinya Murakami; Masahiro Saito
Archives of oral biology, Jun. 2018
90, 53-60, 10.1016/j.archoralbio.2018.02.017

Metal ions from S-PRG filler have the potential to prevent periodontal disease.
Yoko Iwamatsu-Kobayashi; Syouta Abe; Yoshiyasu Fujieda; Ai Orimoto; Masafumi Kanehira; Keisuke Handa; Venkata Suresh Venkataiah; Wei Zou; Masaki Ishikawa; Masahiro Saito
Clinical and experimental dental research, Aug. 2017
3(4), 126-133, 10.1002/cre2.70

F-spondin negatively regulates dental follicle differentiation through the inhibition of TGF-β activity.
Ai Orimoto; Misaki Kurokawa; Keisuke Handa; Masaki Ishikawa; Eisaku Nishida; Makoto Aino; Akio Mitani; Miho Ogawa; Takashi Tsuji; Masahiro Saito
Archives of oral biology, Jul. 2017
Lead, 79, 7-13, 10.1016/j.archoralbio.2017.02.019

Structure-cytotoxicity relationship of methacrylate-based resin monomers as evaluated by an anti-oxidant responsive element-luciferase reporter assay.
Miki Egashira; Takahiro Suzuki; Ai Orimoto; Tohru Obata; Hiroshi Nakamura; Motohiro Tanaka; Takao Kanamori; Tatsushi Kawai
Dental materials journal, 2016
35(6), 946-951

Isolation and characterization of the human immature osteoblast culture system from the alveolar bones of aged donors for bone regeneration therapy.
Makoto Aino; Eisaku Nishida; Yoshiyasu Fujieda; Ai Orimoto; Akio Mitani; Toshihide Noguchi; Hatsune Makino; Shinya Murakami; Akihiro Umezawa; Toshiyuki Yoneda; Masahiro Saito
Expert opinion on biological therapy, Dec. 2014
14(12), 1731-44, 10.1517/14712598.2014.960387

Effect of 2-hydroxyethyl methacrylate on antioxidant responsive element-mediated transcription: a possible indication of its cytotoxicity.
Ai Orimoto; Takahiro Suzuki; Atsuko Ueno; Tatsushi Kawai; Hiroshi Nakamura; Takao Kanamori
PloS one, 2013
Lead, 8(3), e58907, 10.1371/journal.pone.0058907

細胞外マトリックスを基盤とした疾患生物学 ADAMTS superfamilyを介したMarfan症候群の組織破壊機構の解析
折本 愛; 石河 真幸; 半田 慶介; 齋藤 正寛
Journal of Oral Biosciences Supplement, Sep. 2017, Not reviewed, No invitation
2017, 181-181

結合組織破壊の分子メカニズムの新展開 Pannexin 3は新骨形成制御因子である
石河 真幸; Williams Geneva L; 折本 愛; 半田 慶介; 山田 吉彦; 齋藤 正寛
日本結合組織学会学術大会プログラム・抄録集, Jun. 2017, Not reviewed, No invitation
49回, 52-52

結合組織破壊の分子メカニズムの新展開 ADAMTS superfamilyによるMarfan症候群の解離性大動脈瘤発症機構の解析
折本 愛; 石河 真幸; 半田 慶介; 千々岩 みゆき; 望月 早月; 村澤 祐介; 磯貝 善蔵; 岡田 保典; 齋藤 正寛
日本結合組織学会学術大会プログラム・抄録集, Jun. 2017, Not reviewed, No invitation
49回, 54-54

ADAMTSL6βを介したMarfan症候群の解離性大動脈瘤発症機構の解析
折本 愛; 二木 正晴; 石河 真幸; 半田 慶介; 齋藤 正寛
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, May 2017, Not reviewed, No invitation
146回, 57-57

Pannexin 3によるWnt/β-cateninおよびp21 signalingを介した骨前駆細胞の増殖機構の解析
石河 真幸; 小林 洋子; 折本 愛; 半田 慶介; 齋藤 正寛
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, Oct. 2016, Not reviewed, No invitation
145回, 47-47

未分化骨芽細胞移植を用いた歯周組織再生療法に関する研究
半田 慶介; 二木 正晴; 丸山 顕太郎; 折本 愛; 石河 真幸; 根本 英二; 齋藤 正寛
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, Jun. 2016, Not reviewed, No invitation
144回, 53-53

ADAMTS superfamilyによる新規結合組織破壊機構の解析
折本 愛; 半田 慶介; 齋藤 正寛
日本歯内療法学会学術大会プログラム・抄録集, Jun. 2016, Not reviewed, No invitation
37回, 90-90

ADAMTSL6βを介したマルファン症候群モデルにおける組織破壊機構の解析
折本 愛; 二木 正晴; 石河 真幸; 半田 慶介; 齋藤 正寛
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, Nov. 2015, Not reviewed, No invitation
143回, 40-40

マルファン症候群モデルマウスにおける歯周炎の組織破壊機構に関する研究
半田 慶介; 折本 愛; 小林 洋子; 齋藤 正寛
特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集, Jun. 2015, Not reviewed, No invitation
142回, 62-62

ADAMTSL6βが誘導する微細線維形成によるマルファン症候群モデルマウスの大動脈瘤悪化機構の解析
折本 愛; 半田 慶介; 村澤 裕介; 磯貝 善蔵; 齋藤 正寛
日本結合組織学会学術大会プログラム・抄録集, May 2015, Not reviewed, No invitation
47回, 102-102

無限分裂化歯髄幹細胞を用いた象牙質・歯髄複合体の炎症応答・再生メカニズムの解析
基盤研究(C)
九州歯科大学
01 Apr. 2021 - 31 Mar. 2024
折本 愛, 折本 愛, 日本学術振興会, 日本学術振興会

Novel therapeutic approach from Marfan syndrome for the drug discovery of periodontal diseases
Grant-in-Aid for Young Scientists (B)
東北大学
01 Apr. 2017 - 31 Mar. 2020
折本 愛, Orimoto Ai, 日本学術振興会, Japan Society for the Promotion of Science

Establishing an advanced cell-base assay to evaluate the safety of resin monomers
Grant-in-Aid for Young Scientists (B)
Tohoku University
01 Apr. 2014 - 31 Mar. 2017
折本 愛, Orimoto Ai, 日本学術振興会, Japan Society for the Promotion of Science