IEZAKI Takashi
Physiology | Assistant Professor |
Profile
Research area
骨代謝
薬理学Main lectures
生理学2Graduating school
金沢大学薬学部創薬科学科（2011年）Final Education
金沢大学大学院医薬保健学総合研究科（2016年）Previous workplace
金沢大学（2016年4月～2019年3月）
岐阜薬科大学（2020年8月～2022年4月）Study abroad experience
Salk研究所（米国）（2019年4月～2020年7月）Main academic activities
日本薬理学会
日本骨代謝学会
日本生理学会Main research topic
遺伝性疾患に対する核酸医薬開発研究Self-introduction
2022年5月から愛知医科大学へ着任いたしました。骨代謝の生理学的役割や，骨代謝疾患の研究を主に行っています。Hobby
サイクリング
Paper
- L-type amino acid transporter 1 in hypothalamic neurons in mice maintains energy and bone homeostasis.
Gyujin Park; Kazuya Fukasawa; Tetsuhiro Horie; Yusuke Masuo; Yuka Inaba; Takanori Tatsuno; Takanori Yamada; Kazuya Tokumura; Sayuki Iwahashi; Takashi Iezaki; Katsuyuki Kaneda; Yukio Kato; Yasuhito Ishigaki; Michihiro Mieda; Tomohiro Tanaka; Kazuma Ogawa; Hiroki Ochi; Shingo Sato; Yun-Bo Shi; Hiroshi Inoue; Hojoon Lee; Eiichi Hinoi
JCI insight, Mar. 2023
10.1172/jci.insight.154925 - Conditional inactivation of the L-type amino acid transporter LAT1 in chondrocytes models idiopathic scoliosis in mice.
Sayuki Iwahashi; Jiajun Lyu; Kazuya Tokumura; Ryoma Osumi; Manami Hiraiwa; Takuya Kubo; Tetsuhiro Horie; Satoru Demura; Noriaki Kawakami; Taku Saito; Gyujin Park; Kazuya Fukasawa; Takashi Iezaki; Akane Suzuki; Akane Tomizawa; Hiroki Ochi; Hironori Hojo; Shinsuke Ohba; Eiichi Hinoi
Journal of cellular physiology, Sep. 2022
237(11), 4292, 4302, 10.1002/jcp.30883 - The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
Takanori Yamada; Kazuya Fukasawa; Tetsuhiro Horie; Takuya Kadota; Jiajun Lyu; Kazuya Tokumura; Shinsuke Ochiai; Sayuki Iwahashi; Akane Suzuki; Gyujin Park; Rie Ueda; Megumi Yamamoto; Tatsuya Kitao; Hiroaki Shirahase; Hiroki Ochi; Shingo Sato; Takashi Iezaki; Eiichi Hinoi
Stem cell reports, Jun. 2022
17(7), 1576, 1588, 10.1016/j.stemcr.2022.06.001 - Erk5 in Bone Marrow Mesenchymal Stem Cells Regulates Bone Homeostasis by Preventing Osteogenesis in Adulthood.
Tetsuhiro Horie; Kazuya Fukasawa; Takanori Yamada; Seiya Mizuno; Takashi Iezaki; Kazuya Tokumura; Sayuki Iwahashi; Shiho Sakai; Akane Suzuki; Takuya Kubo; Ryoma Osumi; Akane Tomizawa; Hiroki Ochi; Shingo Sato; Katsuyuki Kaneda; Satoru Takahashi; Eiichi Hinoi
Stem cells (Dayton, Ohio), Apr. 2022
40(4), 411, 422, 10.1093/stmcls/sxac011 - SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability.
Manami Hiraiwa; Kazuya Fukasawa; Takashi Iezaki; Hemragul Sabit; Tetsuhiro Horie; Kazuya Tokumura; Sayuki Iwahashi; Misato Murata; Masaki Kobayashi; Akane Suzuki; Gyujin Park; Katsuyuki Kaneda; Tomoki Todo; Atsushi Hirao; Mitsutoshi Nakada; Eiichi Hinoi
Communications biology, Jan. 2022
5(1), 22, 22, 10.1038/s42003-021-02950-0 - CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway.
Kazuya Fukasawa; Takuya Kadota; Tetsuhiro Horie; Kazuya Tokumura; Ryuichi Terada; Yuka Kitaguchi; Gyujin Park; Shinsuke Ochiai; Sayuki Iwahashi; Yasuka Okayama; Manami Hiraiwa; Takanori Yamada; Takashi Iezaki; Katsuyuki Kaneda; Megumi Yamamoto; Tatsuya Kitao; Hiroaki Shirahase; Masaharu Hazawa; Richard W Wong; Tomoki Todo; Atsushi Hirao; Eiichi Hinoi
Oncogene, Mar. 2021
40(15), 2803, 2815, 10.1038/s41388-021-01745-1 - mTOR regulates skeletogenesis through complex-dependent and complex-independent pathways
Tokumura Kazuya; Iwahashi Sayuki; Fukasawa Kazuya; Iezaki Takashi; Hinoi Eiichi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021, Not reviewed
94, 1-O-G3-3, 10.1254/jpssuppl.94.0_1-o-g3-3 - CDK8 maintains stemness and tumorigenicity of glioma stem cells by controlling the c-MYC pathway
Fukasawa Kazuya; Tokumura Kazuya; Iwahashi Sayuki; Iezaki Takashi; Hinoi Eiichi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021, Not reviewed
94, 2-O-D2-1, 10.1254/jpssuppl.94.0_2-o-d2-1 - mTORC1 hyperactivation causes skeletal defects during embryogenesis
Iwahashi Sayuki; Tokumura Kazuya; Fukasawa Kazuya; Iezaki Takashi; Hinoi Eiichi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2021, Not reviewed
94, 1-O-G3-4, 10.1254/jpssuppl.94.0_1-o-g3-4 - [Phosphorylation of Smurf2 at Thr249 by Erk5 regulates TGF-β signaling].
Takashi Iezaki; Eiichi Hinoi
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2021
156(5), 271, 274, 10.1254/fpj.21029 - Daily oral supplementation of Hochu-Ekki-To prevents osteoclastic activation and bone loss in ovariectomized mice.
Shinsuke Ochiai; Kazuya Tokumura; Gyujin Park; Kakeru Ozaki; Tetsuhiro Horie; Takanori Yamada; Sayuki Iwahashi; Kaname Ohta; Hiroki Fusawa; Yasuka Okayama; Katsuyuki Kaneda; Takashi Iezaki; Eiichi Hinoi
Journal of pharmacological sciences, Jan. 2021
145(1), 1, 5, 10.1016/j.jphs.2020.09.007 - mTOR regulates skeletogenesis through canonical and noncanonical pathways.
Kazuya Tokumura; Sayuki Iwahashi; Gyujin Park; Shinsuke Ochiai; Yasuka Okayama; Hiroki Fusawa; Kazuya Fukasawa; Takashi Iezaki; Eiichi Hinoi
Biochemical and biophysical research communications, Nov. 2020
533(1), 30, 35, 10.1016/j.bbrc.2020.09.002 - αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model.
Paloma Martinez-Redondo; Isabel Guillen-Guillen; Noah Davidsohn; Chao Wang; Javier Prieto; Masakazu Kurita; Fumiyuki Hatanaka; Cuiqing Zhong; Reyna Hernandez-Benitez; Tomoaki Hishida; Takashi Lezaki; Akihisa Sakamoto; Amy N Nemeth; Yuriko Hishida; Concepcion Rodriguez Esteban; Kensaku Shojima; Ling Huang; Maxim Shokhirev; Estrella Nuñez-Delicado; Josep M Campistol; Isabel Guillen-Vicente; Elena Rodriguez-Iñigo; Juan Manuel Lopez-Alcorocho; Marta Guillen-Vicente; George Church; Pradeep Reddy; Pedro Guillen-Garcia; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Protein & cell, Mar. 2020
11(3), 219, 226, 10.1007/s13238-019-00685-7 - mTORC1 Overactivation Leads to Abnormalities in Skeletal Development.
Sayuki Iwahashi; Kazuya Tokumura; Gyujin Park; Shinsuke Ochiai; Yasuka Okayama; Hiroki Fusawa; Kaname Ohta; Kazuya Fukasawa; Takashi Iezaki; Eiichi Hinoi
Biological & pharmaceutical bulletin, 2020
43(12), 1983, 1986, 10.1248/bpb.b20-00619 - MAPK Erk5 in Leptin Receptor‒Expressing Neurons Controls Body Weight and Systemic Energy Homeostasis in Female Mice.
Tetsuhiro Horie; Gyujin Park; Yuka Inaba; Emi Hashiuchi; Takashi Iezaki; Kazuya Tokumura; Kazuya Fukasawa; Takanori Yamada; Manami Hiraiwa; Yuka Kitaguchi; Hikari Kamada; Katsuyuki Kaneda; Tomohiro Tanaka; Hiroshi Inoue; Eiichi Hinoi
Endocrinology, Dec. 2019
160(12), 2837, 2848, 10.1210/en.2019-00090 - The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway.
Kakeru Ozaki; Takanori Yamada; Tetsuhiro Horie; Atsushi Ishizaki; Manami Hiraiwa; Takashi Iezaki; Gyujin Park; Kazuya Fukasawa; Hikari Kamada; Kazuya Tokumura; Mei Motono; Katsuyuki Kaneda; Kazuma Ogawa; Hiroki Ochi; Shingo Sato; Yasuhiro Kobayashi; Yun-Bo Shi; Peter M Taylor; Eiichi Hinoi
Science signaling, Jul. 2019
12(589), 10.1126/scisignal.aaw3921 - Hypoxia affects Slc7a5 expression through HIF-2α in differentiated neuronal cells.
Yuki Onishi; Manami Hiraiwa; Hikari Kamada; Takashi Iezaki; Takanori Yamada; Katsuyuki Kaneda; Eiichi Hinoi
FEBS open bio, Feb. 2019
9(2), 241, 247, 10.1002/2211-5463.12559 - Cartilage Induction from Mouse Mesenchymal Stem Cells in High-density Micromass Culture.
Takashi Iezaki; Kazuya Fukasawa; Takanori Yamada; Manami Hiraiwa; Katsuyuki Kaneda; Eiichi Hinoi
Bio-protocol, Jan. 2019
9(1), e3133, 10.21769/BioProtoc.3133 - mTORC1 in osteoblastic niche regulates progression of acute myeloid leukemia.
Fukasawa Kazuya; Horie Tetsuhiro; Hiraiwa Manami; Yamada Takanori; Iezaki Takashi; Kaneda Katsuyuki; Hirao Atsushi; Hinoi Eiichi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
92(0), 1, SS-47, 10.1254/jpssuppl.92.0_1-SS-47 - Regulation by Smurf2Thr249 phosphorylation of stemness of glioma-initiating cells.
Manami Hiraiwa; Iezaki Takashi; Fukasawa Kazuya; Kitaguchi Yuka; Yamada Takanori; Kaneda Katsuyuki; Nakada Mitsutoshi; Hirao Atsushi; Hinoi Eiichi
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2019
92(0), 1, SS-46, 10.1254/jpssuppl.92.0_1-SS-46 - [Transcription Regulators and Bone Metabolism].
Eiichi Hinoi; Takashi Iezaki; Kazuya Fukasawa; Katsuyuki Kaneda
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019
139(1), 15, 18, 10.1248/yakushi.18-00154-1 - mTORC1 Activation in Osteoclasts Prevents Bone Loss in a Mouse Model of Osteoporosis.
Manami Hiraiwa; Kakeru Ozaki; Takanori Yamada; Takashi Iezaki; Gyujin Park; Kazuya Fukasawa; Tetsuhiro Horie; Hikari Kamada; Kazuya Tokumura; Mei Motono; Katsuyuki Kaneda; Eiichi Hinoi
Frontiers in pharmacology, 2019
10, 684, 684, 10.3389/fphar.2019.00684 - The MAPK Erk5 is necessary for proper skeletogenesis involving a Smurf-Smad-Sox9 molecular axis.
Takashi Iezaki; Kazuya Fukasawa; Tetsuhiro Horie; Gyujin Park; Samuel Robinson; Michio Nakaya; Hiroyuki Fujita; Yuki Onishi; Kakeru Ozaki; Takashi Kanayama; Manami Hiraiwa; Yuka Kitaguchi; Katsuyuki Kaneda; Yukio Yoneda; Takeshi Takarada; X Edward Guo; Hitoshi Kurose; Eiichi Hinoi
Development (Cambridge, England), Jul. 2018
145(14), 10.1242/dev.164004 - Translational Control of Sox9 RNA by mTORC1 Contributes to Skeletogenesis.
Takashi Iezaki; Tetsuhiro Horie; Kazuya Fukasawa; Makoto Kitabatake; Yuka Nakamura; Gyujin Park; Yuki Onishi; Kakeru Ozaki; Takashi Kanayama; Manami Hiraiwa; Yuka Kitaguchi; Katsuyuki Kaneda; Takayuki Manabe; Yasuhito Ishigaki; Mutsuhito Ohno; Eiichi Hinoi
Stem cell reports, Jul. 2018
11(1), 228, 241, 10.1016/j.stemcr.2018.05.020 - Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α.
Tetsuhiro Horie; Kazuya Fukasawa; Takashi Iezaki; Gyujin Park; Yuki Onishi; Kakeru Ozaki; Takashi Kanayama; Manami Hiraiwa; Yuka Kitaguchi; Katsuyuki Kaneda; Eiichi Hinoi
Pharmacology, 2018
101(1-2), 64, 71, 10.1159/000480405 - Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain.
Gyujin Park; Tetsuhiro Horie; Takashi Iezaki; Maika Okamoto; Kazuya Fukasawa; Takashi Kanayama; Kakeru Ozaki; Yuki Onishi; Minoru Sugiura; Eiichi Hinoi
Bioscience, biotechnology, and biochemistry, May 2017
81(5), 1014, 1017, 10.1080/09168451.2017.1280661 - Bone Resorption Is Regulated by Circadian Clock in Osteoblasts.
Takeshi Takarada; Cheng Xu; Hiroki Ochi; Ryota Nakazato; Daisuke Yamada; Saki Nakamura; Ayumi Kodama; Shigeki Shimba; Michihiro Mieda; Kazuya Fukasawa; Kakeru Ozaki; Takashi Iezaki; Koichi Fujikawa; Yukio Yoneda; Rika Numano; Akiko Hida; Hajime Tei; Shu Takeda; Eiichi Hinoi
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Apr. 2017
32(4), 872, 881, 10.1002/jbmr.3053 - The transcriptional modulator Ifrd1 controls PGC-1α expression under short-term adrenergic stimulation in brown adipocytes.
Gyujin Park; Tetsuhiro Horie; Takashi Kanayama; Kazuya Fukasawa; Takashi Iezaki; Yuki Onishi; Kakeru Ozaki; Yukari Nakamura; Yukio Yoneda; Takeshi Takarada; Eiichi Hinoi
The FEBS journal, Mar. 2017
284(5), 784, 795, 10.1111/febs.14019 - The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Yuki Onishi; Gyujin Park; Takashi Iezaki; Tetsuhiro Horie; Takashi Kanayama; Kazuya Fukasawa; Kakeru Ozaki; Eiichi Hinoi
Biochemical and biophysical research communications, Jan. 2017
482(2), 329, 334, 10.1016/j.bbrc.2016.11.063 - Amelioration of the Development of Osteoarthritis by Daily Intake of β-Cryptoxanthin.
Gyujin Park; Tetsuhiro Horie; Kazuya Fukasawa; Kakeru Ozaki; Yuki Onishi; Takashi Kanayama; Takashi Iezaki; Katsuyuki Kaneda; Minoru Sugiura; Eiichi Hinoi
Biological & pharmaceutical bulletin, 2017
40(7), 1116, 1120, 10.1248/bpb.b17-00161 - Transcriptional Modulator Ifrd1 Regulates Osteoclast Differentiation through Enhancing the NF-κB/NFATc1 Pathway.
Takashi Iezaki; Kazuya Fukasawa; Gyujin Park; Tetsuhiro Horie; Takashi Kanayama; Kakeru Ozaki; Yuki Onishi; Yoshifumi Takahata; Yukari Nakamura; Takeshi Takarada; Yukio Yoneda; Takashi Nakamura; Jean Vacher; Eiichi Hinoi
Molecular and cellular biology, Oct. 2016
36(19), 2451, 63, 10.1128/MCB.01075-15 - ATF3 controls proliferation of osteoclast precursor and bone remodeling.
Kazuya Fukasawa; Gyujin Park; Takashi Iezaki; Tetsuhiro Horie; Takashi Kanayama; Kakeru Ozaki; Yuki Onishi; Yoshifumi Takahata; Yukio Yoneda; Takeshi Takarada; Shigetaka Kitajima; Jean Vacher; Eiichi Hinoi
Scientific reports, Aug. 2016
6, 30918, 30918, 10.1038/srep30918 - ATF3 deficiency in chondrocytes alleviates osteoarthritis development.
Takashi Iezaki; Kakeru Ozaki; Kazuya Fukasawa; Makoto Inoue; Shigetaka Kitajima; Takeshi Muneta; Shu Takeda; Hiroyuki Fujita; Yuki Onishi; Tetsuhiro Horie; Yukio Yoneda; Takeshi Takarada; Eiichi Hinoi
The Journal of pathology, Aug. 2016
239(4), 426, 37, 10.1002/path.4739 - 軟骨細胞特異的ATF3欠損マウスの解析
尾崎 翔; 家崎 高志; 深澤 和也; 大西 勇気; 米田 幸雄; 金田 勝幸; 北島 繁孝; 檜井 栄一
日本薬学会年会要旨集, Mar. 2016
136年会(3), 56, 56 - The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.
Takashi Iezaki; Yuki Onishi; Kakeru Ozaki; Kazuya Fukasawa; Yoshifumi Takahata; Yukari Nakamura; Koichi Fujikawa; Takeshi Takarada; Yukio Yoneda; Yui Yamashita; Go Shioi; Eiichi Hinoi
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Mar. 2016
31(3), 573, 84, 10.1002/jbmr.2720 - GDF1 is a novel mediator of macrophage infiltration in brown adipose tissue of obese mice.
Yuki Onishi; Kazuya Fukasawa; Kakeru Ozaki; Takashi Iezaki; Yukio Yoneda; Eiichi Hinoi
Biochemistry and biophysics reports, Mar. 2016
5, 216, 223, 10.1016/j.bbrep.2015.12.008 - Genetic analysis of Runx2 function during intramembranous ossification.
Takeshi Takarada; Ryota Nakazato; Azusa Tsuchikane; Koichi Fujikawa; Takashi Iezaki; Yukio Yoneda; Eiichi Hinoi
Development (Cambridge, England), Jan. 2016
143(2), 211, 8, 10.1242/dev.128793 - Daily intake of β-cryptoxanthin prevents bone loss by preferential disturbance of osteoclastic activation in ovariectomized mice.
Kakeru Ozaki; Maika Okamoto; Kazuya Fukasawa; Takashi Iezaki; Yuki Onishi; Yukio Yoneda; Minoru Sugiura; Eiichi Hinoi
Journal of pharmacological sciences, Sep. 2015
129(1), 72, 7, 10.1016/j.jphs.2015.08.003 - Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation.
Jianwen Wei; Junko Shimazu; Munevver P Makinistoglu; Antonio Maurizi; Daisuke Kajimura; Haihong Zong; Takeshi Takarada; Takashi Lezaki; Jeffrey E Pessin; Eiichi Hinoi; Gerard Karsenty
Cell, Jun. 2015
161(7), 1576, 1591, 10.1016/j.cell.2015.05.029 - Nuclear factor-κB is a common upstream signal for growth differentiation factor-5 expression in brown adipocytes exposed to pro-inflammatory cytokines and palmitate.
Eiichi Hinoi; Takashi Iezaki; Kakeru Ozaki; Yukio Yoneda
Biochemical and biophysical research communications, Oct. 2014
452(4), 974, 9, 10.1016/j.bbrc.2014.09.022 - PI3K/Akt is involved in brown adipogenesis mediated by growth differentiation factor-5 in association with activation of the Smad pathway.
Eiichi Hinoi; Takashi Iezaki; Hiroyuki Fujita; Takumi Watanabe; Yoshiaki Odaka; Kakeru Ozaki; Yukio Yoneda
Biochemical and biophysical research communications, Jul. 2014
450(1), 255, 60, 10.1016/j.bbrc.2014.05.108 - Growth differentiation factor-5 promotes brown adipogenesis in systemic energy expenditure.
Eiichi Hinoi; Yukari Nakamura; Saya Takada; Hiroyuki Fujita; Takashi Iezaki; Syota Hashizume; Satoshi Takahashi; Yoshiaki Odaka; Takumi Watanabe; Yukio Yoneda
Diabetes, Jan. 2014
63(1), 162, 75, 10.2337/db13-0808 - Repression of adipogenesis through promotion of Wnt/β-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.
Yukari Nakamura; Eiichi Hinoi; Takashi Iezaki; Saya Takada; Syota Hashizume; Yoshifumi Takahata; Emiko Tsuruta; Satoshi Takahashi; Yukio Yoneda
Biochimica et biophysica acta, Aug. 2013
1832(8), 1117, 28, 10.1016/j.bbadis.2013.03.010 - Prevention of bone loss after ovariectomy in mice with preferential overexpression of the transcription factor paired box-5 in osteoblasts.
Hiroyuki Fujita; Eiichi Hinoi; Takumi Watanabe; Takashi Iezaki; Misa Takamori; Shinya Ogawa; Yukio Yoneda
Biological & pharmaceutical bulletin, 2013
36(3), 481, 4 - The transcription factor paired box-5 promotes osteoblastogenesis through direct induction of Osterix and Osteocalcin.
Eiichi Hinoi; Eri Nakatani; Tomomi Yamamoto; Takashi Iezaki; Yoshifumi Takahata; Hiroyuki Fujita; Ryo Ishiura; Misa Takamori; Yukio Yoneda
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Dec. 2012
27(12), 2526, 34, 10.1002/jbmr.1708 - The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice.
Tomomi Yamamoto; Eiichi Hinoi; Hiroyuki Fujita; Takashi Iezaki; Yoshifumi Takahata; Misa Takamori; Yukio Yoneda
British journal of pharmacology, Jun. 2012
166(3), 1084, 96, 10.1111/j.1476-5381.2012.01856.x - Positive regulation of osteoclastic differentiation by growth differentiation factor 15 upregulated in osteocytic cells under hypoxia.
Eiichi Hinoi; Hiroki Ochi; Takeshi Takarada; Eri Nakatani; Takashi Iezaki; Hiroko Nakajima; Hiroyuki Fujita; Yoshifumi Takahata; Shinya Hidano; Takashi Kobayashi; Shu Takeda; Yukio Yoneda
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Apr. 2012
27(4), 938, 49, 10.1002/jbmr.1538 - Amelioration by the natural polyamine spermine of cartilage and bone destruction in rats with collagen-induced arthritis.
Takashi Iezaki; Eiichi Hinoi; Tomomi Yamamoto; Ryo Ishiura; Shinya Ogawa; Yukio Yoneda
Journal of pharmacological sciences, 2012
119(1), 107, 11
MISC
- Therapeutic inhibition of CDK8 on abnormal bone development in Achondroplasia model mice
岩橋咲幸; 門田卓也; 深澤和也; 家崎高志; 白波瀬弘明; 北尾達哉; 檜井栄一
日本薬学会年会要旨集(Web), 2022
142nd - Daily oral intake of Royal Jelly prevents cartilage degeneration in osteoarthritis model mice.
岡山靖佳; 落合信介; 堀江哲寛; 家崎高志; 深澤和也; 鎌倉昌樹; 池野久美子; 永松剛; 檜井栄一
日本薬学会年会要旨集(Web), 2022
142nd - CDK8/c-MYC axis as a novel therapeutic target for glioblastoma
深澤和也; 徳村和也; 岩橋咲幸; 家崎高志; 檜井栄一
日本薬学会年会要旨集(Web), 2021
141st - Skeletal development through mTOR complex-dependent and -independent pathways
徳村和也; 岩橋咲幸; 深澤和也; 家崎高志; 檜井栄一
日本薬学会年会要旨集(Web), 2021
141st - Skeletal abnormalities by mTORC1 overactivation
岩橋咲幸; 徳村和也; 深澤和也; 家崎高志; 檜井栄一
日本薬学会年会要旨集(Web), 2021
141st - 加齢に伴う骨恒常性維持機能の低下における間葉系幹細胞のCDK8の役割
山田孝紀; 深澤和也; 堀江哲寛; 徳村和也; 岩橋咲幸; 家崎高志; 檜井栄一; 檜井栄一
日本薬理学雑誌, 2021
156(Supplement) - TGF-βシグナル調節を介したSmurf2のリン酸化修飾によるグリオーマ進展制御
平岩茉奈美; 家崎高志; 深澤和也; 北口裕香; 山田孝紀; 金田勝幸; 中田光俊; 平尾敦; 檜井栄一
日本薬学会年会要旨集(CD-ROM), 2019
139th - 中枢性Erk5がエネルギー代謝調節に与える影響
堀江哲寛; 堀江哲寛; 朴奎珍; 稲葉有香; 家崎高志; 金田勝幸; 井上啓; 檜井栄一
日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 2019
2019 (CD-ROM) - 骨芽細胞性ニッチのmTORC1による白血病進展制御機構
深澤和也; 堀江哲寛; 平岩茉奈美; 山田孝紀; 家崎高志; 金田勝幸; 平尾敦; 檜井栄一
日本分子生物学会年会プログラム・要旨集(Web), 2018
41st - E3ユビキチンリガーゼSmurf2のグリオーマ進展における役割
平岩茉奈美; 家崎高志; 深澤和也; 北口裕香; 山田孝紀; 金田勝幸; 中田光俊; 平尾敦; 檜井栄一
日本分子生物学会年会プログラム・要旨集(Web), 2018
41st - 褐色脂肪細胞において低酸素ストレスがアミノ酸トランスポーターの発現に与える影響
堀江哲寛; 深澤和也; 家崎高志; 朴奎珍; 金田勝幸; 檜井栄一
生体膜と薬物の相互作用シンポジウム講演要旨集, 2017
39th - Glucose Uptake and Runx2 Synergize to Orchestrate Osteoblast Differentiation and Bone Formation (vol 161, pg 1576, 2015)
Jianwen Wei; Junko Shimazu; Munevver P. Makinistoglu; Antonio Maurizi; Daisuke Kajimura; Haihong Zong; Takeshi Takarada; Takashi Iezaki; Jeffrey E. Pessin; Eiichi Hinoi; Gerard Karsenty
CELL, Aug. 2015, Not reviewed, No invitation
162(5), 1169, 1169, 10.1016/j.cell.2015.08.018 - Interferon-related developmental regulator-1 activates osteoclastogenesis through modulating NF-kappa B pathway
Takashi Iezaki; Eiichi Hinoi; Yukio Yoneda
JOURNAL OF PHARMACOLOGICAL SCIENCES, 2013, Not reviewed, No invitation
121, 112P, 112P
Research Themes
- 自己増幅型RNAとナノ脂質粒子DDSを用いた軟骨無形性症治療法開発研究
若手研究
岐阜薬科大学
01 Apr. 2021 - 31 Mar. 2024
家崎 高志, 家崎 高志, 日本学術振興会, 日本学術振興会 - mTORC1 in osteoblastic niche regulates progression of acute myeloid leukemia.
Grant-in-Aid for Scientific Research (B)
Kanazawa University
01 Apr. 2016 - 31 Mar. 2019
檜井 栄一; 家崎 高志, Hinoi Eiichi; Iezaki Takashi, 日本学術振興会, Japan Society for the Promotion of Science - The MAPK Erk5 is necessary for proper skeletogenesis through a molecular axis that involves Smurfs-Smads-Sox9
Grant-in-Aid for Research Activity Start-up
Kanazawa University
26 Aug. 2016 - 31 Mar. 2018
家崎 高志, IEZAKI Takashi, 日本学術振興会, Japan Society for the Promotion of Science - 骨芽細胞と破骨細胞の制御活性を有する新規骨粗鬆症治療薬の開発研究
特別研究員奨励費
金沢大学
25 Apr. 2014 - 31 Mar. 2016
家﨑 高志, 家﨑 高志, 日本学術振興会, 日本学術振興会
